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4690948 |
Halogenated resorcylic acid lactone derivatives
Ring opened halogenated Resorcyclic Acid Lactone (RAL) derivatives having the structure: ##STR1## are used to increase rumen fermentation efficiency.
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4686235 |
Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents
Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophlic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds...
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4683244 |
Sebosuppressive cosmetic preparations containing alkoxy or alkylbenzyloxy benzoic acids or their salts
A cosmetic preparation for the treatment of seborrhea containing an antiseborrheically effective amount of a p-alkoxy or p-alkybenzyloxy benzoic acid or salt thereof having the formula ##STR1##...
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4670465 |
Arachidonic acid analogs
Long chain unsaturated hydrocarbon derivatives, having from 13 to 21 carbon atoms, which are substituted at the 1-position by a phenoxy, phenylthio or a phenyl that bear a carboxylic acid group at...
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4663308 |
Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract
Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the...
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4661505 |
Leukotriene antagonists
This invention provides novel alkane derivatives which are leukotriene antagonists, formulations of those derivatives, and a method of using those derivatives for the treatment of conditions...
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4656192 |
Tropolone derivatives, processes for the preparation thereof and the use thereof as anti-tumor agents
New tropolone derivatives of the general formula: ##STR1## wherein R 1 represents H or an alkyl group, R 2 represents an alkyl, aryl, aralkyl or heterocyclic group and R 3 represents an alkoxyl,...
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4624851 |
Treatment of symptoms of neoplastic diseases
The method of treating neoplasms in lower animals and humans by administering thereto fluorine containing acids or their non-toxic salts or esters.
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4621098 |
Thioethers and pharmaceutical compositions containing them
The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy,...
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4613620 |
Novel oxiodinium and thiaiodinium compounds
Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.
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4609675 |
Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
Dry granulate pharmaceutical compositions containing 85 to 99 percent by weight of ibuprofen and 1 to 15 percent, by weight of Croscarmellose sodium, types A and/or B (cross-linked sodium...
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4594443 |
Derivatives of 4-phenyl-4-oxo-buten-2-oic acid and therapeutic use thereof
Compounds of the formula (I): ##STR1## in which R 1 represents alkyl containing from 1 to 18 carbon atoms, R 2 represents hydrogen or alkyl containing from 1 to 8 carbon atoms and R represents...
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4588744 |
Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide
There is disclosed a method and composition of matter for treating mammalian inflammatory viral infections, acne, dermatitis, and arthritic conditions comprising the application of...
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4582857 |
Novel p-oxybenzoic acid derivatives, processes for their production and their use as drugs
P-oxybenzoic acid derivatives of formula (1) ##STR1## wherein R 1 is hydrogen, or straight or branched alkyl of one to four carbon atoms; n is 1 or 2; X is ##STR2## and R 2 is --OH or...
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4567184 |
Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are independently hydrogen, alkyl, carboxy, alkylcarboxy, arylcarboxy, alkyl carbalkoxy,...
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4562287 |
2-(4-Biphenylyl)-4-hexenoic acid and derivatives thereof having anti-inflammatory activity
Therapeutic compositions having anti-inflammatory and analgesic activity, containing as active compound 2-(4-biphenylyl)-4-hexenoic acid and/or derivatives thereof, characterized by low toxicity...
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4545990 |
Anti-acne composition
A composition for the local treatment of acne comprises from 1 to 20 weight percent of benzoyl peroxide and at least one other active principle selected from collagenic palmitoyl acid,...
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4537906 |
Substituted phenylalkenoic acids and esters
Substituted phenylalkenoic acids and esters of the formula: ##STR1## having useful pharmaceutical activity are disclosed.
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4536313 |
Peroxygen compound
Increased energy costs have stimulated a demand for peroxygen compounds that are effective at ambient to hand-hot temperatures, but peroxyacids and acyl peroxides tend to suffer from one or more of...
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4535183 |
Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation
This invention is directed to novel ether compounds of formula (I) ##STR1## which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in...
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4520133 |
Monohydroxy-benzoyl peroxide and compositions for treating acne
Monohydroxy-benzoyl peroxide of the formula ##STR1## possesses both antibacterial and comedolytic activity and is useful in compositions for the treatment of acne.
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4504494 |
Preparation of anthralin solutions or suspensions in aromatic esters and their use for diseases of the skin and nails
An oxidation-stable composition is useful for the treatment of diseases of the skin and nails, which comprises a solution of dispersion of anthralin in an aromatic ester of the formula: ##STR1##...
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4500731 |
Derivatives of 4-phenyl-4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and therapeutic uses for them
A compound of the formula I: ##STR1## in which R 1 and R 2 in any position on the benzene ring are different from each other, and independently represent a hydroxy group or an alkoxy group...
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4499108 |
Stable pleasant-tasting albuterol sulfate pharmaceutical formulations
Albuterol sulfate syrups that are pleasant-tasting and stable upon prolonged storage.
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4477467 |
Insect repellent
An insect repellent is disclosed which comprises, as essential ingredients, N,N-diethyltoluamide as a repellent component, and an aromatic proton donor in which the aromatic rings are substituted...
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4454339 |
9-Fluoroprostaglandin derivatives, and use as medicinal agents
9-Fluoroprostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is the residue ##STR3##...
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4439449 |
Medicament for diminution of oxalate development and excretion in urine
A method for the treatment of undesired uroliths with benzoic acid is disclosed.
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4434178 |
Antiperspirants
Aluminum compounds containing organic groups of the formula ##STR1## when R 1 and R 2 are as hereinafter set forth are disclosed as having activity as antiperspirants. Antiperspirant compositions...
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4425359 |
Fluoro-prostaglandins and process for their preparation
Fluoro-prostaglandin compounds are disclosed, such as, for instance, 18,19,20-trinor-17-cyclohexyl-16(S,R)-fluoro-PGF 2 α. The fluoro-prostaglandins of the present invention have the same...
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4410546 |
Antiallergic compositions
An antiallergic composition comprising, as the effective ingredient, a compound represented by the following general formula ##STR1## wherein R is n-butyl group or n-pentyl group, the compound...
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4407825 |
Novel bis- and poly-disulfides having immunostimulant activity
Compounds of formula R 1 O--(CH 2 ) m --S--S--(CH 2 ) p --S] x S--(CH 2 ) n --OR 2 wherein R 1 and R 2 are, independently, hydrogen, C 1 -5 alkyl or a physiologically-hydrolyzable and...
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4401624 |
Buffered solutions which have a reduced corrosive nature
A method is disclosed for preparing and using buffered aqueous solutions of carboxylic acids and metal salts of carboxylic acids. Such solutions are useful as mold inhibitors in bread, cakes, and...
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4393075 |
Quinone compounds and their use in suppressing the production of SRS-A in mammals
New quinone compounds of the formula: ##STR1## wherein R 1 is methyl or methoxy, or the two R 1 groups jointly represent --CHCH--CHCH--; X is --CHCH-- or --CC--; Y 1 is hydrogen,...
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4389238 |
Flowable herbicide and pesticide formulation
Novel herbicide and pesticide formulations in flowable form are disclosed and are prepared by combining free acid forms of the active ingredients with unreactive aluminum hydroxide gels.
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4380549 |
Topical treatment of dry skin
Preventive as well as therapeutic treatment to alleviate the symptoms of disorders characterized by cracking, flaking, or scaling of the skin consisting of the topical application of a solution,...
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4371547 |
2-Benzylideneglutaraldehydes useful as disinfectants
2-Benzylideneglutaraldehydes of the formula ##STR1## wherein R 1 , R 2 and R 3 independently are hydrogen or a substituent selected from the group consisting of halo, lower-alkyl, phenyl,...
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4370160 |
Process for preparing silicone microparticles
Microparticles, such as microspheres and microcapsules, comprising a solid organopolysiloxane are prepared by irradiating a dispersion of discrete entities with ultraviolet light. The discrete...
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4364924 |
Alkali metal salts of poly(vinylbenzoic acid) as dental plaque barrier agents
Compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprises certain alkali metal salts of poly(vinylbenzoic acid) in pharmaceutically...
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4362891 |
Alkanoic acid derivatives
An alkanoic acid compound is disclosed of formula: ##STR1## and certain of its physiologically acceptable salts and esters. The alkanoic acid compound and its salts and esters have an unexpectedly...
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4361580 |
Aluminum ibuprofen pharmaceutical suspensions
Aluminum ibuprofen pharmaceutical liquid suspensions having improved resistance to dissolution rate reduction upon storage containing aluminum ibuprofen, a suspending agent have a particle size...
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4337273 |
Methods of increasing coronary blood flow through vasodilation by flurbiprofen
Novel treatments are disclosed for increasing circulating coronary blood flow. These treatments are useful for individuals who are expected to otherwise exhibit symptoms of reduced coronary...
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4337258 |
2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
2,4-Dioxo-4-substituted-1-butanoic acid derivatives of the formula: ##STR1## where R is hydrogen or C 1 -4 alkyl; and L is a lipophilic group consisting essentially of (1) ##STR2## where R'...
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4323568 |
Pharmaceutically active (omega-aminoalkoxy)bibenzyls
(Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.
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4309421 |
Stabilized parenterally administrable solutions
Solutions of anti-inflammatory acrylacetic and arylpropionic acid derivatives are stabilized by addition of phospholipids. The solutions are suitable for parenteral administration; they are well...
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4292319 |
Antiphlogistic pharmaceutical compositions and method of use
Pharmaceutical compositions containing a non-steroidal anti-inflammatory compound and 5,11-dihydro-11-[(4-methyl-1-piperazinyl)-acetyl]-6H-pyrido[
2,3-b]-[1,4]be nzodiazepin-6-one or a non-toxic...
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4289750 |
Therapy of conditions which may be associated with altered renal function and dosage forms therefor
The invention concerns a method of treating a subject suffering from abnormal distribution and retention of body fluids such as may be the result of altered renal function, which comprises the step...
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4289761 |
Combination of 5-oxa-17-phenyl-PGF.sub.1 α's estrogenic compounds for menses induction
This invention provides a method for inducing menses and interrupting early pregnancy in female primate mammals, especially humans, which comprises the concomitant administration of a...
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4281018 |
Novel 4-[(carboxyl- and sulfamyl-substituted alkyl)-amino]benzoic acids and analogs
This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.
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4271191 |
Method of treating hyperuricemia and gout
The present application relates to the treatment of hyperuricemias, including the prevention and treatment of gout, using the compound Itanoxone or a pharmaceutically-acceptable salt thereof. The...
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