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6265442 |
Treatment of neurological diseases by increasing brain concentrations of kynurenic acid
Neurological diseases such as Huntington's caused by the toxic effects of excetatory amino acids are alleviated by administering metabolic precursors of kynurenic acid to afflicted individuals....
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6261565 |
Method of preparing and using isoflavones
The invention provides for a refinement of phytochemicals in order to tailor the refined end product to particular human dietary needs. More particularly, a composition is prepared by extracting...
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6251942 |
Compositions and methods for alleviating impaired mental function, memory loss and reducing recovery time in anaesthetized mammals
Composition and methods of alleviating impaired mental function and memory loss in mammals and reducing the recovery time from anaesthesia in age mammals, comprising treating the mammal with a...
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6245802 |
Method for treating pain
The present invention provides a method for treating pain comprising administering to a mammal an analgesic composition comprising duloxetine and one or more NSAIDs or acetaminophen.
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6239177 |
Tranilast-containing preparation for external application and method of producing the same
An external preparation containing tranilast which is excellent in the release of the active ingredient contained therein, achieves a high percutaneous absorption, fully ensures the effective drug...
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6217914 |
Ascorbic acid composition and method for treatment of aging or damaged skin
An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which...
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6214879 |
Allosteric inhibitors of pyruvate kinase
Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the...
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6211197 |
Prostaglandin receptor ligands
Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar 1 --W--Ar 2 ...
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6211213 |
Stable microbicide formulation
Stable microbicidal compositions containing a 3-isothiazolone compound, organic oxidants, copper salts and water are disclosed. Also disclosed are methods of stabilizing 3-isothiazolone compositions.
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6211234 |
Substituted phenyl compounds
Compounds of formula (I) are described wherein R 1 is hydrogen, -(lower alkyl) q (CO 2 R 6 or OH), --CN, --C(R 7 )NOR 8 , NO 2 , --O(lower alkyl)R 9 , --C.tbd.C--R 10 , --CR 11 C(R 12 )(R...
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6210686 |
Dietary supplement and method for lowering risk of heart disease
Yeast-derived fiber has been demonstrated, as described herein, to effectively improve the serum lipid profile in humans, when provided as a dietary supplement, without some of the disadvantages...
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6207712 |
Plant volatile elicitor from insects
The invention relates to fatty acids conjugated to amino acids and their derivatives that elicit the production and/or release of plant volatiles compounds which attract and/or retain beneficial...
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6207694 |
Pharmaceutical compositions and methods for managing scalp conditions
This application relates to a pharmaceutical composition for the prevention, treatment, and management of scalp conditions, such as dandruff, seborrheic dermatitis, psoriasis, folliculitis, and...
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6177089 |
Use of at least one sulphonic acid for stimulating renewal and/or epidermal repair and for combatting cutaneous aging and conditions
The use of specific sulphonic acids or hydrates thereof in or for the preparation of a cosmetic or dermatological composition for achieving various effects on the skin, such as promoting...
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6162835 |
Stable active-ingredient combination for the disinfection and cleaning of contact lenses, and packing and process for the preparation thereof
Contact-lens disinfectant containing (a) magnesium monoperphthalate and (b) sodium cumenesulphonate, (c) sodium alkylbenzenesulphonate, (d) isotridecanol ethoxylate and (e)...
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6159988 |
Arylcycloalkyl derivatives, their production and their use
Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R 1 -R 4 have the meanings given in the specifications and show an activity against...
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6150413 |
Triaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active triaromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or...
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6150412 |
Catechol derivatives
The invention relates to compounds of formula (I) ##STR1## wherein R 1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R 2 is --A--R 4 , wherein A is a branched or...
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6143787 |
Pharmaceutical composition containing 4-oxo-butynic acids
The present invention relates to a pharmaceutical composition comprising, as active principle, a compound of formula: ##STR1## in which the groups A and B are chosen, independently of each other,...
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6139879 |
Fungicidal and bactericidal compositions for plants containing compounds in the form of heavy metal
The present invention relates to heavy metal chelate compositions, which are used as fungicides and bactericides, and methods of using the compositions. In particular, the present invention relates...
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6139827 |
Wear cosmetic composition
The present invention provides a cosmetic composition, that includes: (A) a polymer having repeating units resulting from the polymerization of the following monomers: (1) an alkyl acrylate...
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6121306 |
Method of making (1S, 4R)-1-azabicyclo[2.2.1]heptan-3-one and (1R, 4S), 1-azabicyclo[2.2.1]heptan-3-one
Racemic (±)-1-azobicyclo[2.2.1]heptan-3-one may be efficiently resolved into its (1S,4R)- and (1R,4S)-1-azabicyclo[2.2.1]heptan-3-one isomers by formation of di-p-toluoyl hemitartrate salts by...
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6096786 |
Immunopotentiatory agent and physiologically acceptable salts thereof
The present invention relates to the use of 4-(2-formyl-3-hydroxyphenoxymethyl) benzoic acid or physiologically acceptable salts thereof as an immunopotentiatory agent, compositions containing such...
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6090851 |
Use of an NADPH-oxidase inhibitor in the treatment of reperfusion injury
The present invention is directed to a method for the prophylactic and therapeutic treatment of reperfusion injury or injury due to a distal reperfusion. The method involves the administration of...
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6083985 |
Medicinal composition
The present invention relates to an antitumor or anti-AIDS composition containing a protein-farnesyltransferase inhibitor and an agent which decreases farnesyl pyrophosphate in vivo as active...
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6071961 |
Antimicrobial composition and methods of use therefor
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6054479 |
Preservative compositions and methods for using the same
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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6048895 |
Aromatic C16-C20 substituted tetrahydro prostaglandins useful as FP agonists
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to the following formula: ##STR1## wherein R 1 , R 2 , R 3 , R 4 ,...
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6048872 |
Arylethanolamine derivatives and their use as agonists of atypical beta-adrenoceptors
The present invention relates to phenethanolamine derivatives of formula (I) wherein R 1 represents an aryl group optionally substituted by one or more substituents selected from halogen, hydroxy,...
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6046238 |
Method for treating or preventing the spread of acne vulgaris
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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6037376 |
Methods for therapy of cancer
Compositions and methods of treating anemia, cancer, AIDS, or severs β-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable...
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6034138 |
Disinfectant composition
The present invention comprises a concentrated solid or semi-solid disinfectant or sterilant composition for use in an aqueous disinfecting or sterilizing solution, comprising an oxidant and a...
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6034110 |
Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid and a PPARγ ligand
A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RXR-selective retinoid, e.g. the compound of the formula:...
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6020374 |
Biologically active synthetic dye compounds
A pharmaceutical composition comprising, in admixture with a pharmaceutically acceptable carrier, a therapeutically effective amount of a polyaromatic ring-containing compound, capable of mimicking...
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6013649 |
Thiol sulfone metalloprotease inhibitors
This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors,...
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6004987 |
Use of ligands which are specific for RXR receptors
The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended...
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6001874 |
Arthropod control composition for plant protection
A non-toxic arthropod control composition is disclosed for application to foliage for plant protection. The composition includes behavior interfering compounds, agricultural oil and/or surface...
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5985918 |
Zinc-based antiirritant creams
The present invention relates to the use of organic salts of zinc in topical formulations. Such organic salts tend to be less water soluble and therefore less likely to result in systemic toxicity,...
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5985927 |
Medicaments for the selective treatment of tumor tissues
Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different...
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5981555 |
Compositions, kits and methods for administration of antilipemic drugs
The present invention concerns composition, kits and methods for reducing the flushing effect (cutaneous erythema) of an antilipemic drug, for treating hyperlipemia, for improving the effectiveness...
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5977176 |
Compositions for the treatment of warts and herpes
Compositions comprising propolis, propolis and salicylic acid, or propolis and either a corticorsteroid such as hydrocortisone or a halogenated corticosteroid with or without salicylic acid, are...
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5977153 |
Solid aldehyde and antimicrobial compositions useful as fixatives, preservatives and embalming agents
Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group...
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5973007 |
Use of inhibitors of retinoic acid activity for wound healing
A method for promoting healing by administration of an inhibitor of the activity of retinoic acid is provided. Preferred compounds for use in such treatment include antagonists of retinoic acid....
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5972993 |
Composition and method for treating rosacea and sensitive skin with free radical scavengers
A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the...
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5958975 |
Antiodor, antimicrobial and preservative compositions and methods of using same
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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5958973 |
Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors
The present invention is directed to compositions of the formula: ##STR1## wherein: R 2 is H, or an alkyl group having 1 to 3 carbon atoms and 0 to 2 hydroxyls; R 3 is H, or hydroxyl; R 4 ...
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5955504 |
Colorectal chemoprotective composition and method of preventing colorectal cancer
A composition for use in preventing colorectal cancer and other neoplastic diseases includes an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof in an amount effective...
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5942531 |
Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation
Pigmentation of the skin, hair and/or nails of individuals is promoted by administering thereto, advantageously topically and advantageously in combination with enzymes exhibiting tyrosinase...
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5942544 |
α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
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5939457 |
Method for reducing skin wrinkles and regulating skin atrophy
A method for reducing signs of aging in human skin. The method includes the steps of (a) topically applying to the skin a hydroxy acid product having at most a hydroxy acid concentration of...
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