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7615237 |
Percutaneously absorbable preparations
Percutaneously absorbable preparations (preferably nonaqueous ones, particularly matrix-type patches or ointment), containing salt-form acidic drugs and characterized by being improved in the...
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7612068 |
Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives
The present invention relates to compounds of formula I wherein the substituents are as defined below. The compounds of formula I are useful for the treatment of diseases such as schizophrenia,...
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7598416 |
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for...
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7579507 |
Polymorphic crystal of 4′-{2-[ (1S, 2R)—2- hydroxy-2- (4-hydroxyphenyl)-1-methylethylamino]ethoxy} - 3 - isopropyl-3′, 5′ -dimethylbiphenyl- 4 - carboxylic acid hydrochloride
Crystals of a salt of 4′-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl
amino]ethoxy}-3-isopropyl-3′,5′-dimethylbiphenyl-4-carbo
xylic acid. The α type, β type and γ type crystals...
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7541384 |
Mesalamine suppository
The present invention relates to a mesalamine rectal suppository designed to provide improved comfort of use. One embodiment of the invention is a mesalamine rectal suppository containing...
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7521461 |
Benzoic acid derivatives as modulators of PPAR alpha and gamma
A compound of formula (I) wherein R 1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group...
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7517896 |
Aminodicarboxylic acid derivatives having pharmaceutical properties
The invention relates to compounds of formulae (II), (IV), and (VI) as shown below,
wherein the several variable groups are as defined in the specification and claims. Processes for making...
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7514473 |
Calcilytic compounds
Novel Calcilytic compounds and methods of using them are provided.
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7504409 |
Mucin synthesis inhibitors
The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic...
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7468391 |
Methods for treating retinoid responsive disorders using selective inhibitors of CYP26A and CYP26B
The invention provides methods for treating an individual having a retinoid responsive disorder. In one embodiment, a method involves administering to the individual an effective amount of a...
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7442808 |
Antidiabetic bicyclic compounds
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof,...
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7439393 |
Phenethanolamine derivatives for treatment of respiratory diseases
The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino
]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are...
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7427600 |
Active agent delivery systems and methods for protecting and administering active agents
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
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7417060 |
Aminoalcohol derivatives
The present invention relates to a compound formula[I]:
wherein
X is bond, —CH 2 —, —O— or —NH—, R 1 and R 12 are each independently hydrogen, halogen, lower alkyl, etc., R 2 ...
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7390504 |
HDL-boosting combination therapy complexes
A pharmaceutical composition including therapeutically effective amounts of at least one HMG-CoA reductase inhibitor present as a dyhydroxyacid salt and at least one additional therapeutic agent.
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7381747 |
Alpha 2 delta ligands for post-traumatic stress disorder
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs...
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7378102 |
Diclofenac sodium oral pharmaceutical
The present invention relates to a diclofenac sodium oral pharmaceutical containing diclofenac sodium, a nonionic surfactant, a cholic acid derivative as an absorption promoting agent, and a...
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7354955 |
(2S)-amino(phenyl)acetic acid and derivatives as α2δ voltage-gated calcium channel ligands
The present invention relates to a method for treating pain, reflex sympathetic dystrophy, spasticity, and bipolar disorder using ligands of the α 2 δ voltage-gated calcium channel, wherein the...
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7320985 |
Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
A method for stabilizing an arylcarboxylic acid, which comprises adding a heterocyclic base to the arylcarboxylic acid or a pharmacologically acceptable salt thereof, a stabilizer thereof and an...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7285572 |
CaSR antagonist
The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist...
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7276252 |
Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings,...
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7268161 |
Comprehensive pharmacologic therapy for treatment of obesity including cysteine
The comprehensive pharmacologic therapy for treatment of obesity including Cysteine is a procedure which involves the administration of a desired therapeutic range of Diethylpropion and/or...
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7255882 |
Enkephalinase inhibitor and GABA precursor loading as anti-anxiety compositions
Benzodiazepine withdrawal induced anxiety is treated by administration of an enkephalinase inhibitor, and a gamma-aminobutyric acid (“GABA”) precursor, or an endorphin or enkephalin releaser....
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7247652 |
β-benzyloxyaspartate derivatives with amino group on benzene ring
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1):
wherein R is hydrogen, a linear or branched lower aliphatic acyl...
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7241797 |
Method of increasing milk production
The invention relates generally to the use of pharmaceutical compositions to increase milk production alone or in combination with certain biological active ingredients. Specifically, the method...
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7208520 |
Crystals of hydroxynorephedrine derivative
The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-meth
ylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and...
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7169810 |
Guanidine and amidine acid derivatives and analogs and methods of using the same
The present invention releates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated...
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7153869 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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7151117 |
Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions
The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to...
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RE39419 |
Estrogen agonist/antagonist metabolites
This invention relates to compounds that are mammalian metabolites of (−)-cis-6-phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5
,6,7,8-tetrahydro-naphthalene-2-ol. The compounds of the invention...
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7119119 |
Immunoregulatory compounds and derivatives and methods of treating diseases therewith
Compounds are disclosed having the structure of Formula I:
where R 1 , R 3 , and R 4 are independently hydrogen or C 1 to C 4 alkyl, and R 2 is:
where R 5 is selected from the group...
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7115662 |
Certain 5-alkyl-2-arylaminophenylacetic acids and derivatives
Disclosed are the compounds of formula I
wherein R is methyl or ethyl; R 1 is chloro or fluoro; R 2 is hydrogen or fluoro; R 3 is hydrogen, fluoro, chloro, methyl, ethyl, methoxy, ethoxy or...
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7109238 |
Calcilytic compounds
Novel calcilytic compounds and methods of using them are provided.
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7101569 |
Methods of administering levothyroxine pharmaceutical compositions
The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized...
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7048918 |
Insect bait
Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively...
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7034055 |
2-aminoindane analogs
The present invention relates to therapeutically active 2-aminoindane analogs of formula (I):
Also provided is a method of preparing compounds of formula (I), and pharmaceutical compositions...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7030160 |
Propanolaminotetralines, preparation thereof and compositions containing same
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
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7019033 |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula
where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and...
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7001922 |
Peptide deformylase activated prodrugs
The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:
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6992109 |
Method for the treatment of incontinence
The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid to treat incontinence.
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6984389 |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a...
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6979437 |
Pulmonary delivery in treating disorders of the central nervous system
A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the...
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6974833 |
Synergistic compositions comprising ascobate and lysine for states related to extra cellular matrix degeneration
Methods for the treatment of diseases or pathological states related to the degradation of the extracellular matrix, such as degenerative diseases atheriosclerosis, cancer, infection or other...
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6949575 |
Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
The present invention provides compounds of Formula (I) and a method of treating Alzheimer's disease using a compound of Formula (I), wherein: R 1 and R 2 include alkyl and phenylalkyl; R 3 is...
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6949534 |
Cell adhesion inhibitors
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical...
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6942663 |
Laser treatment of cutaneous vascular lesions
Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion....
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6939894 |
Methods for reducing excessive barking of a dog
Methods for reducing excessive barking of a dog are disclosed wherein GABA or SKF97541 is administered.
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