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4753801 |
Sustained release tablets
The present invention provides sustained release tablets in unit dosage form comprising an active agent which has low aqueous solubility.
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4732915 |
Process for increasing solubility of drug
An osmotic system is disclosed for the delivery of haloperidol at a controlled rate over a prolonged period of time.
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4720506 |
Immunomodulating agent
Phenylacetic acid derivatives of the formula: ##STR1## wherein R 1 is hydrogen or ##STR2## wherein R 5 is an alkyl group of 1-6 carbon atoms or an aryl group; R 2 and R 3 are independently...
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4716173 |
Method of treatment of malaria by one time interference
A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate,...
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4708952 |
Method of treatment of the infectious and viral diseases by one time interference
A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate,...
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4707497 |
Phenylethanolaminotetralines, a process for their preparation and pharmaceutical compositions containing them
A novel phenylethanolaminotetraline having lipolytic activity of formula ##STR1## wherin X represents hydrogen, halogen, a trifluoromethyl or a lower alkyl group and R represents hydrogen, a lower...
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4696914 |
Material for improving the fertility of mammals and process for its production
The fertility of female mammals can be improved by dispensing once or within a short time repeatedly a high dosage of tyrosine. The dispensation can be carried out at will intravenously or orally.
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4695588 |
Fluorinated amino acids
Novel substituted α-fluoromethyl-α-amino alkanoic acids and esters thereof are disclosed. The novel compounds have biological activity including decarboxylase inhibition.
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4692465 |
2-phenylethylamine derivatives
Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R 1 and/or R 2 wherein...
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4687782 |
Nutritional composition for enhancing skeletal muscle adaptation to exercise training
A combination of amino acids (carnitine, glutamine, isoleucine, leucine and valine) provide diet supplements which employ branched amino acids (BAA) to promote muscle adaptation to strenuous...
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4675339 |
Spherical amino acid preparation
The present invention relates to a spherical amino acid having an average particle size of about 1 mm or below and a process for the preparation thereof.
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4673691 |
Human weight loss inducing method
A human weight reduction method in which 2,4-dinitrophenol and a thyroid hormone preparation are administered to the patient. The dinitrophenol is administered in dosages sufficient to elevate the...
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4670254 |
Gel preparations for topical application of diclofenac sodium
Anti-inflammatory, stable and painless topical gel preparations comprising diclofenac sodium as the active ingredient; water, ethanol and a glycol as the solvent medium; a carboxyvinyl polymer...
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4663350 |
Unsaturated diphenylazomethine derivatives, their preparation and pharmaceutical compositions containing them
Diphenylazomethine derivatives of formula (I) ##STR1## wherein R 1 is hydrogen or methyl and R 2 is an --OH,--OM (M=alkaline metal or alkaline earth metal), --NH 2 or --O(C 1 -4 alkyl) group,...
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4656192 |
Tropolone derivatives, processes for the preparation thereof and the use thereof as anti-tumor agents
New tropolone derivatives of the general formula: ##STR1## wherein R 1 represents H or an alkyl group, R 2 represents an alkyl, aryl, aralkyl or heterocyclic group and R 3 represents an alkoxyl,...
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4647587 |
Method for treatment of antidiuresis employing serine derivatives
Diuretics containing an efficient amount of L- or DL-threo-3-(3,4-dihydroxyphenyl)-serine or a pharmaceutical acceptable salt thereof are applied orally or parenterally. They are effected...
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4629737 |
Secondary amines and use in pharmaceutical compositions
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R 1 is...
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4624852 |
Process and composition for treating neurological disorders and aging
Choline or a choline precursor is administered to a patient together with an amino acid which is a precursor to a neurotransmitter in order to give a synergistic result for the two components.
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4602040 |
Meclofenamic acid topical pharmaceutical composition
A clear gel and a cream pharmaceutical composition containing meclofenamic acid are disclosed. The clear gel composition is prepared by dissolving meclofenamic acid in polyethylene glycol...
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4598093 |
4-amino-tetrahydro-2-naphthoic acid derivatives
4-Amino-1,2,3,4-tetrahydro-2-naphthoic acid derivative of the formula: ##STR1## wherein X is halogen atom, n is 1 or 2, R 1 is hydroxy group, lower alkoxy group or amino group, and R 2 is...
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4587356 |
Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives
The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound. Illustrative of the process is the reaction of...
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4585796 |
Novel phenethanolamines
The tertiary amines of the formula ##STR1## wherein n represents a whole number of 1 to 5; X 1 represents phenyl or phenyl mono-, di- or tri-substituted by R 1 , R 2 and R 3 ; X 2 ...
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4578404 |
Pharmaceutical composition for treating nephritis and method for treating nephritis
Disclosed herein are a pharmaceutical composition for treating nephritis, comprising at least one compound selected from the group consisting of the derivatives of N-(dihdyroxybenzylidene)amino...
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4564636 |
Diphenylazomethines and pharmaceutical compositions containing them
Diphenylazomethines of the formula (I) ##STR1## in which R represents --(CH 2 ) 4 OH, --(CH 2 ) 2 --CHOH--CH 3 , --CH 2 --CHOH--C 2 H 5 , --CH 2 --CHOH--CH 2 --COOH, --CH 2 --CHOH--CH 2 ...
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4560553 |
Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
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4552898 |
[3.2.0]Bicycloheptanone oxime ethers with valuable therapeutic properties
Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters,...
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4543251 |
Gel preparations for external application
A gel preparation for external application by being prepared from diclofenac sodium as the active ingredient, water, lower alkanols and glycols as medium, a carboxyvinyl polymer as gelating agent,...
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4537769 |
Stabilization of influenza virus vaccine
This invention concerns stabilized influenza virus vaccines and a method of stabilizing influenza viruses and vaccines by the addition of protein hydrolysates and/or amino acids.
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4537907 |
Hypnotic composition and method of inducing sleep
A hypnotic composition and method of inducing sleep in a mammal by administering to a mammal in a pharmaceutical carrier a hypnotically effective dose of a salt of 2-amino-3-(1-naphthyl) propanoic...
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4529603 |
Pharmaceutical composition and method for treatment of psychomotor excitement
A therapeutic agent for the treatment of psychomotor excitement containing as an active ingredient of L- or DL-erythro-3-(3,4-dihydroxyphenyl)-serine with or without a decarboxylase inhibitor.
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4522807 |
Substantive topical compositions
A highly substantive topical composition in the form of an oil-in-water emulsion containing an octadecene-1/maleic anhydride copolymer.
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4518612 |
Naphthalene and 2-oxo-benzopyran acids and derivatives and pharamaceutical use thereof
There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy,...
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4514383 |
Sunscreen compositions containing vinylogous amides
Novel sunscreen compositions comprising at least one vinylogous amide compound are described as well as methods of protecting the human skin from damaging radiation.
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4497826 |
Antiparkinsonian agent
An antiparkinsonian agent comprising DL- or L-threo-3,4-dihydroxyphenylserine and a decarboxylase inhibitor (e.g. carbidopa and benserazide), which is useful for the treatment of parkinson's...
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4496588 |
Method of treating psoriasis
A novel method of treating psoriasis which comprises administering a halomethyl derivative of α-amino acids of the following general structure: ##STR1## wherein Y is FCH 2 --, F 2 CH--, F 3 ...
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4492706 |
Method of lowering lipid levels
Disclosed herein is a method of lowering lipid levels in a mammal involving the administration of the following N-naphthoylglycine derivatives, or a therapeutically acceptable salt with an organic...
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4486429 |
Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R 1 and R 2 , which may be identical or different...
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4478822 |
Drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for delivering drugs to a body cavity. The drug delivery system comprises a medicament and a polymer such that the drug delivery system is a...
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4474748 |
Medicaments potentiated with phenyl alkanols
Antimicrobial compositions are provided wherein there is obtained an enhancement of activity by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is...
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4472433 |
Phenoxyphenyl acetic acids and their medicinal use
A compound of the formula: ##STR1## wherein R 1 is phenyl substituted with halogen or lower alkyl, and R 4 is a group of the formula C n H 2n in which n is an integer of 1 to 7; or a...
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4472376 |
Pharmaceutical insertion compositions and a process for producing the same
A phamaceutical insertion composition comprising a mixture of an aqueous solution of carboxyvinyl polymer with a water-soluble basic compound and a pharmaceutical ingredient, said mixture being a...
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4470987 |
Process for treatment and prevention of ventricular fibrillation
The risk of ventricular fibrillation in animals is reduced by administering tyrosine, a tyrosine precursor, threonine or mixtures thereof, either alone or in combination with a substance which is...
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4464396 |
4-[N-(Hydroxybenzyl)aminomethyl]cyclohexane-1-carboxylic acid
A novel compound of 4-[N-(hydroxybenzyl)aminomethyl]-cyclohexane-1-carboxylic acid represented by the general formula (I): ##STR1## wherein n is an integer of 1 to 3, or a salt or an ester thereof...
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4447453 |
Anti-peptic ulcer agent
An anti-peptic ulcer agent which contains as an active ingredient aminobenzoic acid compounds of the formula ##STR1## (wherein R 1 , R 2 , and R 3 which may be the same or different represent a...
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4447452 |
N[(2-Naphthalenyl)thioxomethyl]glycine derivatives
Herein disclosed are N-[(2-naphthalenyl)thioxomethyl]glycine derivatives of the formula ##STR1## wherein R 1 is lower alkyl and R 2 is hydrogen, lower alkyl, lower alkoxy, halo or...
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4440785 |
Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation
Novel 2-aminobiphenylacetic acids, esters and metal salts of the formula are disclosed: ##STR1## wherein R represents hydrogen, lower alkyl, sodium or potassium; R 1 represents fluoro, chloro,...
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4439452 |
Class of analgesics and/or anti-inflammatory agents consisting of inhibitors of breakdown of endogenous enkephalin and/or endorphin, and combinations of said analgesics with antipyretic, anti-inflammatory (aspirin-type) drugs
A new class of analgesics is provided by substances that inhibit breakdown of endogenous substance such as enkephalins and/or endorphins. The analgesic effect of an enkephalin breakdown inhibitor...
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4435424 |
Process for improving vigor and mood in normal human patients
The level of a catecholamine in neuronal synapses is increased in order to improve vigor by administering a neutral amino acid composition to a human wherein an increased brain level of a...
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4434160 |
Nutrient solution for complete parenteral feeding and for increased energy production
A nutrient solution for complete parenteral feeding and for increased energy production, for administration to patients in the post-aggression phase, which contains, in aqueous solution, per 25...
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4431670 |
D-Phenylalanine treatment
Method of treating pain, depression and Parkinsons disease using prescribed daily administration of D-phenylalanine alone, which has been found useful as an analgesic in warm blooded animals, as an...
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