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6028109 |
Use of agonists of the peroxisome proliferator activated receptor alpha for treating obesity
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6011066 |
Method for treating septic shock
A method for the treating septic shock in a patient comprises administering to the patient a therapeutically-effective amount of a composition comprising a compound having the formula (I): ##STR1##...
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5990165 |
Pharmaceutical compounds
A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R 1 is --CO 2 H, R 2 is hydrogen or C 1 -4 alkyl and R 3 is hydrogen, C 1 -10 alkyl, C 2 -10 alkenyl, optionally...
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5985927 |
Medicaments for the selective treatment of tumor tissues
Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different...
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5985860 |
System for transdermal delivery of pain relieving substances
Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other...
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5973006 |
Fluoro-substituted benzoylpropionic acid derivatives
A fluoro-substituted benzoylpropionic acid compound of formula (I) either as a single optical isomer or as a mixture of optical isomers ##STR1## wherein R is hydroxy, amino, hydroxylamine, --OR',...
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5968925 |
Process for continuous sintering of granules
The invention relates to a process for continuous sintering of granules for the preparation of pellets, in particular medicament formulations in tablet form.
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5958979 |
Stabilized medicaments containing thyroid hormones
The present invention relates to stabilized medicaments containing thyroid hormone the stabilizing component of which is sodium thiosulfate in a mass ratio of thyroid hormone to sodium thiosulfate...
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5958978 |
Specific cyclooxygenase 2 inhibitor and anti-inflammatory agent
The invention relates to a specific cyclooxygenase 2 inhibitor which comprises, as an active ingredient, 2-(2,6-dichloro-4-hydroxyanilino)phenylacetic acid represented by the following formula (1):...
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5932575 |
Cardiac diseases improving agents
This invention relates to cardiac diseases improving agents substantially free from antagonistic action to type 1 receptor of angiotensin II which participates to hypotensive action. Particularly,...
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5932618 |
Anti-viral agents and methods relating to the use thereof
Compounds having utility as anti-viral agents in general and, more specifically, to methods for treating a viral condition in an animal are disclosed. The compounds are naphthalene derivatives, and...
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5929120 |
Guainidino, formamidino, amino and related compounds for inhibiting osteoclast-mediated bone resorption
Compounds of the following general structure X--Y--Z-Aryl-A--B, ##STR1## which inhibit osteoclast mediated bone resorption.
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5929115 |
Anti-inflammatory eye drop
An anti-inflammatory eye drop comprises (a) 0.05 to 0.7 weight/volume % of diclofenac sodium; (b) 1 to 10 weight/volume % of γ-cyclodextrin; (c) 1 to 20 weight/volume % of polyvinyl...
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5916922 |
Phenyl glyoxamides as SPLA2 inhibitors
A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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5916573 |
Topical treatment of the skin with a grapeseed oil composition
A grapeseed oil composition for topical application to the skin comprising: a) about 1 to about 99% by weight of grapeseed oil; b) at least one hydrating agent; and c) water. Hydrating agents...
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5912248 |
Excitatory amino acid receptor antagonists
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO 2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
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5891909 |
Amidinohydrazones as protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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5888518 |
Method for preventing and treating coccidiosis
A method for preventing and treating parasitic infections in animals by administering a lysine analog, such as EACA, to the animals on a continuous basis. In the preferred embodiment, the method of...
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5889040 |
Composition for increasing protein concentration in a mammal
The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with an anabolic protein composition, produces a synergistic effect in...
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5883124 |
Compositions and methods for treating and preventing pathologies including cancer
Compositions and methods of treating various disorders by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof or derivatives thereof...
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5869067 |
Bi-aromatic compounds and pharmaceutical and cosmetic compositions
The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
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5866605 |
Method for providing a neuroprotective effect to the mammalian eye by administration of chloride channel blockers
Pharmaceutical compositions and a method are disclosed for providing neuroprotective effect to the mammalian eye by administering to the mammalian eye the pharmaceutical composition of the...
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5863913 |
Aromatic compound and pharmaceutical composition
An aromatic compound of the formula (I): ##STR1## specifically, for example, 3- (4-carboxyphenyl)methyl!valeramido!-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a...
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5863947 |
Phenylglycine derivatives useful for treating disorders of the central nervous system
A pharmaceutical compound of the formula: ##STR1## in which R 1 is hydrogen, hydroxy or C 1 -6 alkoxy, R 2 is hydrogen, carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or...
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5861435 |
Method for preventing settlement of aquatic fouling organisms
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
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5861431 |
Incontinence treatment
The present invention provides a method of treating incontinence in a patient that has a bladder and a urethra. The urethra forms a lumen for draining the bladder. The method comprises the steps of...
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5856359 |
Thyroxine/cyclodextrin complexes and pharmaceutical compositions containing the same
Thyroxine containing pharmaceutical compositions with improved aqueous solubility, stability and enhanced membrane permeation have been prepared by formulating thyroxine with cyclodextrins. These...
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5852056 |
Phenylacetate and derivatives alone or in combination with other compounds against neoplastic conditions and other disorders
Methods of inhibiting IL-6 in a cell by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable derivatives thereof.
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5849737 |
Compositions and methods for treating pain
Compositions and methods for alleviating pain (in particular, neuropathic pain) in a mammalian patient, wherein an effective amount of a physiologically-acceptable salt of a compound of the general...
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5817621 |
External remedy possessing trophoprotective effect
A dermatological composition for external use comprising a lipid ointment base, vitamin A, a salicylic acid or a derivative thereof, D-camphor, a biogenic GABAergic substance, a biogenic...
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5817631 |
Therapeutic uses of melanin
The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the...
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5814655 |
Non-steroidal ophthalmic mixtures
Topical ophthalmic compositions for treatment of the eye are provided which comprise aqueous mixtures of a non-steroidal agent having a pKa, a pH, and a concentration of agent chosen so as to...
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5795915 |
Use of (x-aminomethyl-3,4-dichlorobenzyl) thioacetamide derivatives for inhibiting dopamine reutake and new compounds for this use
The invention relates to the use of a compound selected from: α-(tert-butylaminomethyl)-3,4-dichlorobenzyl!thioacetamide and its laevorotatory isomer, ...
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5795916 |
Composition of external preparation
Disclosed herein is an external preparation composition, in a liquid preparation, cream, ointment or cataplasm plaster, characterized in that the composition contains a water-soluble salt of...
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5789444 |
Method of reducing glutamate neurotoxicity with anthranilic acid derivatives
A method of reducing neurotoxic injury due to acute or chronic neurological insults by administering an anthranilic acid derivative is disclosed.
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5780506 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Phenylacetic acid derivatives, and use as fungicides
The present invention relates to phenylacetic acid derivatives of the formula I ##STR1## and their salts. The invention additionally relates to processes and intermediates for preparing these...
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5776503 |
Amino acid solutions for treatment of peritoneal dialysis patients
The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to...
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5776925 |
Methods for cancer chemosensitization
Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be...
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5767158 |
Endermic liniment
An endermic liniment containing at least one type of phenylalanine compound, and/or its salt, is disclosed. This endermic liniment has a melanin production suppression effect and is superior in...
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5763481 |
Vinylcarboxylic acid derivatives
Compounds of the formula ##STR1## wherein R 1 is C 3 -C 8 cycloalkyl, halo-C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, halo-C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, --Si(R 3 )...
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5739163 |
Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using...
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5739164 |
Pharmaceutical compounds for the treatment of CNS diseases
Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is...
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5733539 |
Bait for fishes and shellfishes
The invention discloses a bait for fishes and shellfishes characterized in that the bait comprises a matrix material containing a microorganically fermented product of a plant residue obtained by...
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5726165 |
Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein, R o represents an aryl group, optionally substituted; X represents O or S; R 1 and...
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5723489 |
Aryloxypropanolamine beta 3 adrenergic agonists
Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein: R 1 to R 9 are as defined herein and m is the integer 0 or 1. These compounds are beta 3 adrenergic...
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5719185 |
Use for GABA agonists for treating emesis
The present invention relates to the use of GABA agonists having an agonist action at GABA B receptors in the treatment of emesis.
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5716989 |
Bicyclo 3.3.0!octane derivatives, process for their production and their pharmaceutical use
The invention relates to bicyclo 3.3.0!octane compounds of formula I, ##STR1## wherein the variable are defined in this specification, as well as their enantiomers, and their salts with...
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5714142 |
Method and compositions for increasing the serum half-life of pharmacologically active agents by binding to transthyretin-selective ligands
Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active...
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5714509 |
Inhibitors of bacterial sialidase and methods of making and using the same
A sialidase inhibitor of the shown formula I: ##STR1## where dashed lines d 1 and d 2 , X 1 , R 1 , R 2 , R 6 , R 3 , R 4 and R 5 are as described in the specification; or an analog,...
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5712307 |
Methods of inducing the production of hemoglobin and treating pathologies associated with abnormal hemoglobin activity using phemylacetic acids and derivatives therof
Compositions and methods of treating anemia, cancer, AIDS, or severe β-chain hemoglobinopathies by administering a therapeutically effective amount of phenylacetate or pharmaceutically acceptable...
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