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7619115 |
Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides
Novel ortho-substituted N′-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R 1 -R 9 have the meanings indicated in claim 1 , are SGK inhibitors and can be used for the...
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7605180 |
Nateglinide-containing preparation
The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the...
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7589232 |
Alkynyl aryl carboxamides
The present invention is related to alkynyl aryl carboxamides of Formula (I′) and use thereof for the treatment and/or prevention of an inflammatory disorder, obesity and/or metabolic disorders...
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7582782 |
Organic compounds
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I)
and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions...
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7579376 |
Geranyl compounds
This invention provides compounds having excellent antitumor activity, which are represented by the following formulae
in which R 1 , R 2 , R 3 , m, n and R 4 have the significations as...
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7576129 |
Carboxylic acid compounds
The present invention relates to a carboxylic acid compound of formula (I):
wherein R 1 is H, alkyl; m is 2, 3; n is 0-2; R 2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH 2...
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7569726 |
Indanone derivatives that inhibit prolyl hydroxylase
Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure:
where the definitions of the variables are provided herein.
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7569723 |
Benzoic acid derivatives as non nucleoside reverse-transcriptase inhibitors
Compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The compounds are useful as reverse transcriptase inhibitors against HIV. In particular, the...
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7569605 |
Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
The present invention relates to a method of treating a central nervous system disorder, such as a mood disorder (e.g., major depressive disorder) or an anxiety disorder (e.g., general anxiety...
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7566803 |
Vitamin D receptor modulators
The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These...
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7553873 |
Glutamate aggrecanase inhibitors
The present invention relates to modulators of metalloproteinase activity.
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7550617 |
Compositions and methods for the treatment of renal and cardiovascular disease
Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative...
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7550488 |
Application methods to rapidly alter disease and injury states using molecular transport of B6
The present invention discloses methods of application employing B5/B6 vitamins in molecular transport creams or gels to deliver B6 in a high dose to bring about therapeutic ways in human or mammal...
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7544714 |
Lipid-amino acid conjugates and methods of use
N-fatty acid-amino acid conjugates and J 2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of...
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7544676 |
Sulfamoyl benzamides and methods of their use
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
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7534913 |
Crystalline form of nateglinide
Provided are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes...
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7531575 |
Method of modulating cellular activity and agents useful for same
Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design...
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7507765 |
Geranyl compounds
This invention provides compounds having excellent antitumor activity, which are represented by the following formulae
in which R 1 , R 2 , R 3 , m, n and R 4 have the significations as given...
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7495030 |
(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
(5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid, salts thereof, and compositions containing the same for the delivery of active agents are provided. Methods of administration, treatment of disease...
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7491748 |
Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient
A carboxylic acid derivative of formula (I):
wherein R 1 is —COOH, —COOR 6 , etc.; A is a single bond, alkylene, etc.; R 2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a...
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7488755 |
Derivatives of glycinergic R(+)-2-amino-3-hydroxypropanoic acid
The use of R(+)-2-amino-3-hydroxypropanoic acid derivatives, nitrogen substituted by a (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl, 3-oxo(C 5 -C 6 )alkyl, 3-oxo(C 4 -C 6 )alken-2-yl, phenyl(C 1 -C 6...
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7482483 |
Growth factor-binding compounds and methods of use
Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods...
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7482026 |
Compositions and methods directed towards sore muscles and joints
Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
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7476763 |
Oxo-substituted cyclohexyl-1,4-diamine compounds
Novel cyclohexyl-1,4-diamine compounds corresponding to formula I:
methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
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7476759 |
Matrix metalloproteinase inhibitors
Compounds of Formula (I):
wherein: R 1 is optionally substituted —C 4-12 alkyl, —C 2-10 alkylcycloalkyl, —C 2-6 alkylheterocycloalkyl, —C 2-6 alkylaryl, optionally substituted 5-...
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7476758 |
Process for preparing a phenylalanine derivative and intermediates thereof
The present invention provides a process for preparing a novel phenylalanine derivative of the formula (I): wherein X1 is a halogen atom, X2 is a halogen atom, Q is a group of the formula —CH2—...
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7476755 |
Therapeutic compounds
Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.
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7468390 |
Methods of treatment and pharmaceutical composition
The invention relates a pharmaceutical composition comprising a combination of:
(i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof; and (ii) a NEP inhibitor or a...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7462735 |
Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents
Amino acid diamides in non α position of formula (1), wherein R 1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO 2 , OH, OCH 3 alone or associated and...
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7456217 |
Inhibitors of alpha4 mediated cell adhesion
The present invention relates to a phenylalanine derivative of Formula (I) wherein X 1 is a halogen atom, X 2 is a halogen atom, Q is a CH 2 R— is a carboxyl group which may be esterified; or a...
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7429673 |
TRPV1 agonists, formulations containing them and uses thereof
The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C 6 -C 12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl...
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7427600 |
Active agent delivery systems and methods for protecting and administering active agents
The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active...
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7423066 |
Methods, compounds, and compositions for reducing body fat and modulating fatty acid metabolism
Methods, pharmaceutical compositions, and compounds for reducing body weight, modulating body lipid metabolism, and reducing food intake in mammals are provided. The compounds of the invention...
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7419970 |
Cosmetic compositions comprising N-acylamino amides
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
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7414077 |
Therapeutic intervention to mimic the effect of caloric restriction
Methods are provided for promoting longevity and decreasing the incidence of ageing associated pathologies (e.g. cancer) by the administration of one or more of the following LFFA: linoleic, oleic,...
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7414037 |
Hydrazide-containing CFTR inhibitor compounds and uses thereof
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and...
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7405239 |
Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction
The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes,...
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7384982 |
Disodium salts, monohydrates, and ethanol solvates for delivering active agents
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
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7384979 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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7381731 |
Pharmaceutical composition comprising citrulline
Embodiments of the present invention include compositions and pharmaceutical compositions comprising citrulline and Hmg-CoA reductase inhibitors. Further embodiments relate to the use of such...
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7354954 |
Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy
According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the...
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7338667 |
Pharmaceutical formulation
The present invention concerns an extended release formulation having an accelerating erosion and/or dissolution rate of the surface of the formulation. The formulation comprises a drug having low...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7320988 |
Methods of lowering lipid levels in a mammal
This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7307043 |
Aqueous neonicotinoid compositions for seed treatment
An aqueous composition suitable for applying insecticides or acaricides to plant propagation materials comprising water, an insecticidally or acaricidally effective amount of at least one...
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