|
Match
|
Document |
Document Title |
|
|
5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
|
|
|
5480909 |
Method for inhibiting generation of free-radicals
Certain incidents in mammals trigger the generation of free-radicals which are associated with cell death. Animals experiencing such medical incidents are dosed with pyruvate salts or esters in an...
|
|
|
5478835 |
Tricyclic compounds and intermediates thereof
Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R 1 , R 2 , R 3 and R 4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio,...
|
|
|
5472980 |
Parental administration of pyruyate precursors
A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino...
|
|
|
5462726 |
Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives...
|
|
|
5460799 |
Lipophilic contrast agents for diagnostic image analysis
The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these...
|
|
|
5459134 |
(Fused) benz (thio) amides
A novel (fused) benz(thio)amide of the general formula: ##STR1## or a non-toxic salt thereof, wherein R 4 represents: (i) when B represents a closed ring, a group of the general formula: ##STR2##...
|
|
|
5455274 |
Hydroxyamidine derivatives
The invention relates to the compounds of the formula ##STR1## wherein the C(=NOH)-NH 2 group may be in tautomeric form, and pharmaceutically acceptable salts thereof, in which: R 1 is amino...
|
|
|
5455271 |
Tight-binding inhibitors of leukotriene A.sub.4 hydrolase
Inhibitors of leukotriene A 4 hydrolase are disclosed, corresponding to Formula I, below: ##STR1## wherein the depicted --NH 2 group is in the (S) configuration; --W is --CH 2 SH, --CH 2 NH 2 ...
|
|
|
5451606 |
Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment
The present invention concerns a compound of formula (I) ##STR1## wherein: X is selected from H and OH; R is a residue which, linked to the ##STR2## group, forms an amino acid; the enantiomers...
|
|
|
5447956 |
Treatment of leukemia with a imidazo carbamate
Use of Methyl N-[6-(3,4,5-trimethoxybenzyloxy)imidazo [1,2-6]pyridazin-2-yl]carbamate or pharmaceutically acceptable salt to treat lymphocytic leukemia is disclosed.
|
|
|
5441976 |
Pharmacological use of certain cystine derivatives
A pharmaceutical preparation and method for the treatment of diseases due to defects in the immune system using cystine derivatives.
|
|
|
5411757 |
Palatable balanced amino acid-modified diet
In the present invention, L-amino acids comprise the medical food which provides a source of protein-equivalent of free purified L-amino acids in a palatable powdered form which can be incorporated...
|
|
|
5411964 |
Phenylalanine-glycine compounds having anti-tumor activity, process for preparation thereof, and pharmaceutical composition containing said compounds
A phenylalanine-glycine compound of formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a...
|
|
|
5411956 |
Lipolytic enzyme inhibitors
A lipolytic enzyme inhibitor is disclosed which comprises as an active ingredient at least one of a basic protein, a basic polypeptide and salt thereof. The inhibitor is useful as a dieting agent...
|
|
|
5403505 |
Cleaning and disinfecting agent containing an N-substituted propylene glutamic acid or derivative thereof, and an antimicrobially active compound
An aqueous cleaning and disinfecting concentrate comprising A) at lease one reaction product of a) an N-substituted propylene diamine of formula I R 1 --NH--(CH 2 ) 3 --NH 2 ...
|
|
|
RE34878 |
Hypoglycemic agent
A compound of D-phenylalanine derivative for hypoglycemic use, represented by the general formula ##STR1## R 1 is selected from hydrogen, alkyl of 1 to 5 carbon atoms, aryl of 6 to 12 carbon...
|
|
|
5397803 |
Use of glutamine to reduce rate of pathogenic microorganism infection
The invention relates to a method for treating catabolic, gut-associated pathological processes including intestinal mucosal and pancreatic atrophy and enhanced gut permeability, impairment of host...
|
|
|
5391575 |
Method for treating neurofibromatosis
The present invention provides methods for treating neurofibromatosis in humans by administering to an afflicted host pharmaceutical compositions containing a therapeutically effective amount of a...
|
|
|
5389359 |
Pharmaceutical preparation containing L-aspartate or L-asparagine for preventing ethanol toxicity, and process for preparation thereof
Compositions containing L-aspartate or L-asparagine for use as additives to foods, soft drinks, vitamins, and the like are described. A method for preventing ethanol toxicity in a human subject is...
|
|
|
5380759 |
Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia
Methyl N-[6-(3,4,5-trimethoxybenzloxy) imidazo [1,2-6]pyridazin-2-yl]carbamate is disclosed which is used to treat leukemia.
|
|
|
5374537 |
Protection of moist stratified squamous epithelia against damage from noxious luminal agents
The present invention is related to the protection of moist stratified squamous epithelia against damage from exposure to noxious luminal agents. Protection of moist stratified squamous epithelia...
|
|
|
5373023 |
Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them
The invention provides compounds which are tetrahydronaphthalene derivatives of the formula (I) ##STR1## wherein R 1 represents a halogen atom, a cyano group, a nitro group, an unbranched (C 1 -C...
|
|
|
5362747 |
2-nitroaryl and 2-cyanoaryl compounds as regulators of nitric oxide synthase
2-Nitroaryl or 2-cyanoaryl compounds of the formula ##STR1## pharmaceutical compositions thereof, intermediates useful in the preparation of these compounds, and methods for treating disorders of...
|
|
|
5360821 |
Method of use of pantothenic acid to improve the athletic performance and sense of well being of a human being
An object of the present invention is to enable an individual to achieve an improvement in the sense of well-being and in the athletic strength resulting in an improvement of the exercise and...
|
|
|
5356620 |
Pharmaceutical compositions containing N-(3,4-dimethoxycinnamoyl) anthranilic acid
In preferred embodiments this invention provides a pharmaceutical composition and a method for the treatment of allergic conjunctivitis or allergic rhinitis. The composition is an aqueous solution...
|
|
|
5346690 |
Composition of a superparamagnetic or ferromagnetic particle and an X-ray contrast agent for MRI
There is provided a magnetic resonance contrast medium comprising magnetically responsive particles and a physiologically tolerable osmoactive agent.
|
|
|
5344843 |
Cat-1 inhibitors, pharmaceutical compositions and methods of use
The invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate,...
|
|
|
5324731 |
Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism...
|
|
|
5321030 |
Creatine analogs having antiviral activity
The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses,...
|
|
|
5304574 |
Methods of treatment of clinical conditions using pantothenic acid
A method for treating human beings suffering from chronic bronchial asthma, acute rhinitis, disseminated lupus erythematosus, or neurodermatitis which comprises administering to said human being a...
|
|
|
5304575 |
Use of bezafibrate for treating diabetes
Bezafibrate is used for the treatment of normolipidaemic diabetes mellitus type II.
|
|
|
5292722 |
Intravenous solution that diminishes body protein loss
The present invention provides compositions and methods of decreasing the nitrogen loss in a mammal which is normally associated with the administration of isocaloric solutions. Specifically, the...
|
|
|
5288703 |
Method for enhancing gut absorption
The present invention provides a method for enhancing the gut absorption in a mammal. Specifically, gut absorption in a mammal can be enhanced by the administration of glutamine, or glutamine...
|
|
|
5283260 |
Method for reducing insulin resistance in mammals
A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino...
|
|
|
5270326 |
Treatment for tissue ulceration
Compounds of the formulas ##STR1## wherein R 1 is H and R 2 is alkyl (3-8C) or wherein R 1 and R 2 taken together are --(CH 2 ) n -- wherein n=3-5; R 3 is H or alkyl (1-4C); R 4 is a...
|
|
|
5258398 |
Antithrombotic diaminoalkanoic acid derivatives
This invention relates to novel diaminoalkanoic acid derivatives that inhibit platelet aggregation and thrombus formation in mammalian blood thereby being useful in the prevention and treatment of...
|
|
|
5256695 |
Acyl amidine and acyl guanidine substituted biphenyl derivatives
Novel compounds are disclosed having the formula ##STR1## where A is ##STR2## and wherein R 1 , R 2 and R 3 are as defined herein. These compounds inhibit the action of angiotensin II and are...
|
|
|
RE34414 |
Physiologically active substance P-23924, its production and use
The compound of the formula: ##STR1## wherein R 1 is hydrogen, methyl or hydroxymethyl, R 2 is hydrogen or methoxy, R 3 is hydroxy or methoxy, and R 4 is hydrogen or a group ##STR2## is novel,...
|
|
|
5254592 |
Multiply substituted anilines, phenols and pyridines-immunomodulating agents
In accordance with the present invention, certain multiply substituted anilines, phenols and pyridines and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by...
|
|
|
5254587 |
Methods for treating AIDS
The present invention provides methods for treating AIDS-related diseases by administering to an afflicted host pharmaceutical compositions containing a therapeutically effective amount of...
|
|
|
5248697 |
Enhancement of glutathione levels with glutamine
A method of maintaining and/or enhancing tissue or plasma levels of glutathione is provided. Treatment of a mammal with a supranormal amount of glutamine, or a glutamine equivalent, prevents the...
|
|
|
5244922 |
Methods for treating viral infections
The present invention provides methods for treating viral diseases in humans by administering to an afflicted host pharmaceutical compositions containing a therapeutically effective amount of a...
|
|
|
5232937 |
Derivatives of N-phenylbenzamide with anti-ulcer and anti-allergy
Derivatives of N-phenylbenzamide with general formula (1) in which R 1 is a cyano, nitro, halogen, hydrozy, C 1 -C 4 alkyl methyl, methoxy or tetrazol-5-yl group, R 2 is hydrogen, hydroxy, or...
|
|
|
5232948 |
Substituted monocyclic aryl compounds exhibiting selective leukotriene B.sub.4 antagonist activity
Monocyclic aryl compounds having selective LTB 4 antagonists properties and comprising an amido substituent, a substituent group having a terminal carboxylic acid or derivative thereof and a...
|
|
|
5230890 |
Urethane derivatives from amino acids, a process for their preparation and cosmetic or pharmaceutical compositions for use in the treatment of dry skin
A urethane derivative from amino acids has the formula ##STR1## wherein R represents --CH 2 OH, --CHOH--CH 3 or --(CH 2 ) 3 --NH--CO--NHY, Y represents --H or --COOR', R' represents linear or...
|
|
|
5223529 |
N-phenylamides and medicinal products containing them
Compounds of formula: ##STR1## in which R 1 is (a) a phenyl radical or a substituted phenyl radical, (b) a chain --CH(R 8 )--COOR 4 , (c) a chain --CH 2 --CO--NR 5 R 6 or (d) a phenylalkyl...
|
|
|
5220050 |
Peptide mimetic compounds useful as platelet aggregation inhibitors
This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to...
|
|
|
5219886 |
Mercapto-acylamino acids
Novel mercapto-acylamino acids of the formula ##STR1## wherein Q is hydrogen or R 7 CO--; R 1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R 2 is hydrogen; lower alkyl; cyclolower...
|
|
|
5214056 |
1,3,2-dioxathiolane oxide derivative
A 1,3,2-dioxathiolane oxide derivative is represented by the following formula: ##STR1## wherein X represents --S(O)-- or --S(O) 2 --; R 1 represents a hydrogen atom, an alkali metal atom, a...
|