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6376543 |
Secondary cataract inhibitor
The present invention relates to a secondary cataract inhibitor comprising as the active ingredient N-(3,4-dimethoxy-cinnamoyl)anthranilic acid represented by the formula: or a pharmaceutically...
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6372790 |
Pharmaceutical composition comprising a combination of metformin and fibrate, and its use for the preparation of medicines intended to reduce hyperglycaemia
A pharmaceutical composition comprising: (i) metformin, optionally in the form one of its pharmaceutically acceptable salts; (ii) a fibrate selected from fenofibrate and bezafibrate; and optionally...
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6362165 |
Hydroxyphenyl derivatives with HIV integrase inhibitory properties
An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts...
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6352718 |
Vasopressin antagonist formulation and process
This invention provides novel formulations for N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)
-3-chlorophenyl]-5-fluoro-2-methyl-benzamide, or a pharmaceutically acceptable salt...
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6352977 |
Substituted β-alanines
The invention is directed to physiologically active compounds of general formula (I): wherein R 1 is hydrogen, halogen, lower alkyl or lower alkoxy; X 1 , X 2 and X 6 independently represent...
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6350783 |
Cleansing composition
The present invention relates to a cleansing composition comprising at least one compound selected from N-long chain acylamino acids represented by formula (I): (wherein n represents 1 or 2; and...
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6350781 |
Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
A preparation suitable for sustained and extended corneal analgesia and for repeated administration consisting of subanesthetic concentrations of lidocaine. A method for corneal analgesia by...
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6342243 |
Method of fattening up a ruminant
An amino acid and/or a peptide are orally administrated to a neonatal ruminant whose fermenting function of the rumen has not yet developed thereby effecting a significant increase in the...
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6331570 |
Active enantiomer of RARγ-specific agonist
Disclosed is the (R)-enantiomer of the formula ##STR1## which has unexpectedly been found to possess all of the biological activity of the racemic compound disclosed in the prior art as an...
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6326516 |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
The invention discloses hydroxamide acids of the formula: ##STR1## which are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS,...
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6326403 |
Diacylhydrazine derivatives as integrin inhibitors
Compounds of the formula I ##STR1## wherein X, Y, Z, R 1 and R 2 are as defined in claim 1, and their salts and solvates, can be used as integrin inhibitors in particular for the prophylaxis and...
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6326398 |
Oxamic acids and derivatives as thyroid receptor ligands
The present invention provides novel compounds of the Formula ##STR1## and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs...
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6323240 |
4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of...
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6322821 |
Veterinary pharmaceutical composition
A composition for preventing and treating milk fever in freshening cows, and a method of administering the composition. The basic composition is a mixture of water, calcium chloride, propylene...
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6323227 |
Substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
This invention relates to compounds of formula ##STR1## which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of...
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6313166 |
Phenyl acetic acid derivatives as pesticides
Compounds of the formula I ##STR1## and the isomers thereof, in which either a) X is an N atom and Y is OR 11 or N(R 12 )R 13 , or b) X is CH and Y is OR 11 , and in which furthermore:...
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6313088 |
8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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6310083 |
Caged amino acid derivatives bearing photolabile protective groups
Derivatives of o-nitromandelyoxycarbonyl (Nmoc) which are capable of releasing an amino acid (or derivative thereof), upon irradiation with ultraviolet (UV) light are disclosed, as well as a method...
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6306911 |
Substituted amino acids as neutral sphingomyelinase inhibitors
This invention relates to a series of substituted amino acids of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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6306873 |
Substituted β-thiocarboxylic acids
This invention relates to compounds of general formula (I): ##STR1## in which Ar is a group selected from: ##STR2## A1, A2, B, C, D, E, Q1-Q3, R1-R9, Z1 and Z2 are as defined in the disclosure, and...
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6303655 |
Preventives or remedies for diseases affecting excessive proliferation of retinal pigment epithelial cells
The present invention relates to an agent for the prevention or treatment of diseases associated with excessive proliferation of retinal pigment epithelial cells such as proliferative...
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6300350 |
Treatment of emphysema using RARy selective retinoid agonists
This invention provides methods of treating emphysema and other diseases associated with alveolar damage by treatment with an RARγ selective agonist. In another aspect, this invention provides...
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6300375 |
Sodium oxamate for the treatment of diabetic conditions
The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents...
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6297280 |
Composition and method for suppressing behavior problems of pets
A composition for suppressing behavior problems of pets, comprising theanine, and optionally one or more compounds selected from the group consisting of highly unsaturated fatty acids and cholines;...
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6284790 |
Methods of potentiating organic nitrates having vasodilating activity and formulations for the same
A method for potentiating an organic nitrate having vasodilating activity by administering to a subject an effective amount of the organic nitrate with a potentiating amount of a thromboxane...
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6277876 |
Matrix metalloproteinase inhibitors
Compounds of the formula (I) ##STR1## where X is a --CO 2 H or --CONHOH group; Y and Z are independently sulphur or oxygen, at least one being sulphur; R 1 is hydrogen, hydroxy, (C 1 -C 6...
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6274564 |
Compositions of cobalamin and related corrinoids, and uses thereof
Novel compositions cobalamin and related corrinoids, and uses thereof, are disclosed. The novel compositions include a corrin, a first amino acid having a side chain which includes a basic or...
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6271259 |
Method for improving the brain function, inhibiting glutamate excitotoxicity and rescuing from neuronal death
This invention is characterized by a brain function improving preparation containing theanine not less than 50 μM. It was confirmed that theanine could increase intracellular Ca 2 + concentration...
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6251944 |
Para-substituted phenylene derivatives
The present invention relates to a class of compounds represented by Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of the Formula...
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6245813 |
Use of ubenimex and the pharmaceutical composition containing it for treating virus hepatitis
The present invention relates to the use of Ubenimex or salts thereof and the pharmaceutical composition containing them for the treatment of virus hepatitis, espcially chronic hepatitis B.
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6245795 |
Melanogenesis inhibitor, skin cosmetic composition and bath preparation
An object of the present invention is to provide a melanogenesis inhibitor and a skin cosmetic composition, which are superior in the effect of preventing pigmentation due to inflammation by...
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6245810 |
Amino acid derivatives
A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds...
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6239177 |
Tranilast-containing preparation for external application and method of producing the same
An external preparation containing tranilast which is excellent in the release of the active ingredient contained therein, achieves a high percutaneous absorption, fully ensures the effective drug...
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6221910 |
Glutamine containing oral replacement solution
The invention focuses on a glutamine containing oral replacement solution for endurance exercise and rehydration. The solution uniquely combines the specific amino acid glutamine with a...
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6217914 |
Ascorbic acid composition and method for treatment of aging or damaged skin
An ascorbic acid-based composition and related method for the treatment of aging or photo-damaged skin is disclosed. The composition includes water and ascorbic acid, at least a portion of which...
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6214371 |
Method for breeding highly lactiferous cows by using rumen-protective amino acids
Lysine and methionine which are limiting amino acids of dairy cows are administered to dairy cows to decrease the BUN value that has an adverse effect on the conception rate and to increase the...
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6214876 |
Indene-1-acetamide sPLA2 inhibitors
Indene-1-acetamide compounds of the general formula (I) below; ##STR1## inhibit sPLA 2 mediated release of fatty acids and are useful for treatment of conditions such as septic shock.
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6207712 |
Plant volatile elicitor from insects
The invention relates to fatty acids conjugated to amino acids and their derivatives that elicit the production and/or release of plant volatiles compounds which attract and/or retain beneficial...
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6207710 |
Compounds for inhibiting β-amyloid peptide release and/or its synthesis
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
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6191168 |
Methods for the use of nonprotein amino acids as therapeutic agents
Provided are compositions comprising nonprotein amino acids and modified amino acids, as well as methods for the use of nonprotein amino acids and modified amino acids in inhibiting the growth of...
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6180673 |
Corneal subepithelial opacity (haze) inhibitor
The present invention relates to a corneal subepithelial opacity (haze) inhibitor comprising as the active ingredient N-(3,4-dimethoxycinnamoyl)anthranilic acid represented by the formula: ##STR1##...
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6180133 |
Antioxidant composition for topical/transdermal prevention and treatment of wrinkles
An anti-wrinkle skin treating composition comprises a pressure sensitive matrix patch having dissolved in the adhesive a mixture of antioxidants in the form of a Vitamins C ester and Vitamin E....
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6174918 |
Naphthoquinone antitumor compound and method
The invention provides 1,4-naphthoquinone compounds and a method for inhibiting tumor cell growth in a subject by administering such compounds. The compounds are represented by the structures:...
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6171603 |
Bioaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e):...
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6172112 |
Retinoids and use thereof
The present invention provides new retinoid compounds and uses of the compounds in humans and animals for chemoprevention of skin and/or breast cancer and for therapy of leukemia.
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6159505 |
Compositions for the treatment of migraine, containing potassium, magnesium and pyridoxine
Compositions for the treatment and prevention of migraine or stress headaches wherein there is supplied a combination of potassium, magnesium and pyridoxine optionally in association with other...
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6160017 |
Preventives and remedies for ulcerous colitis and/or crohn's disease
The invention relates to an agent for preventing and treating ulcerous colitis and/or Crohn's disease, comprising conagenin or a pharmaceutically acceptable salt thereof as an active ingredient....
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6156774 |
Beta-thiopropionyl-amino acid derivatives and their use as beta-lactamase inhibitors
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6149925 |
Topical compositions for enhancing glutathione production
The invention provides cosmetic or pharmaceutical compositions for topical application to the skin comprising glutathione-enhancing effective amounts of a glycine compound, a glutamine compound,...
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6143783 |
Excitatory amino acid receptor modulators
The present invention relates to compounds of the formula ##STR1## in which R 1 is defined in the specification, and non-toxic metabolically labile esters and amides thereof are useful as...
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