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4681895 |
Novel guanidinomethylcyclohexanecarboxylic acid compounds and anti-ulcer drug containing the same
Novel N-phenyl-trans-4-guanidinomethylcyclohexanecarboxamide compounds of the formula: ##STR1## wherein R is hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof,...
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4678664 |
Mineral oil gels
This invention relates to a gel composition comprising water, mineral oil and two polyoxyethylene-polyoxybutylene block copolymers designated copolymer A and copolymer B wherein said block...
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4673690 |
Acylated enamides and pharmaceutical compositions containing them
The acylated enamide compounds are acylated enamides corresponding to the general formula ##STR1## in which Z represents an electron donor group, n is 1, 2 or 3, and R 1 represents hydrogen,...
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4672058 |
N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N -methylglycinamides
Disclosed herein are tolrestat amides and methods of preparation. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
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4672059 |
N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl and carbonyl]-N-methylglycinamides
Disclosed herein are tolrestat and oxotolrestat amides and methods of preparation. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
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4668703 |
γ-allenyl-γ-aminobutyric acids
This invention is for γ-allenyl-γ-aminobutyric acid derivatives which are γ-aminobutyric acid transaminase inhibitors.
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4666936 |
Amide derivatives of 2-(p-aminobenzyl)-butyric acid and esters thereof having hypolipidemizing activity
Amide derivatives of 2-(p-aminobenzyl)-butyric acid and esters thereof having a hypolipidemizing and hypocholesterolemizing pharmaceutical activity and their preparation are described. Included are...
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4661510 |
α-allenic-α-amino acids as enzyme inhibitors
Novel α-allenic-α-amino acids which are enzyme inhibitors of the suicide or k cat type are disclosed herein.
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4652585 |
N-substituted diaminopropane/glutamic acid reaction products
Compounds which are the reaction products of a C 12 -14 -alkyl N-substituted 1,3-diaminopropane and glutamic acid or its 5-methyl ester, optionally alkoxylated, and optionally their salts, are...
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4639468 |
Derivatives of glycinamide, their preparation and their use
A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C 5 -C 18 , a linear or ramified alkenyl group C 5 , C 6 , C 7 , C 8 , C 9 , C 10 , C 11...
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4629736 |
Fatty acid derivatives and process of producing them
Fatty acid derivatives represented by the general formula ##STR1## and salts thereof. The compounds of this invention have excellent fibrinolytic action and a highly improved solubility.
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4622339 |
Novel norbornane- and norbornene-carboxylic acid amides thromboxan antagonists
Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH 2 --CH 2 -- group, R 1 and R 2 ...
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4618708 |
Amino acid derivative
Derivatives having the general formula: ##STR1## in which the various radicals A,B,X,R 1 , R 2 , R 3 and n have indicated definitions. These compounds have in particular enkephalinase-inhibiting,...
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4616038 |
Combination of thienamycin-type antibiotics with dipeptidase inhibitors
Antibacterial compositions of thienamycin-type compounds and a dipeptidase (E.C.3.4.13.11) inhibitor.
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4613616 |
Polymeric iron chelators
The present invention relates to polymeric iron chelators based upon hydroxamic acids having the general formula: ##STR1## wherein R is hydrogen or lower alkyl. The present compound is useful for...
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4603145 |
Antiatherosclerotic diphenyl alkanamides
This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of...
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4596826 |
Carboxylic acid amide compounds and their derivatives
Described herein are novel carboxylic acid amide compounds or carboximide compounds represented by the general formula: ##STR1## wherein Z represents a group of the formula (1) or (2): ##STR2##...
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4588590 |
Method of treating keratosis and compositions useful therefor
The present invention includes an improved method of treating keratosis comprising periodically applying to the affected area a nail polish composition containing an effective amount of at least...
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4585796 |
Novel phenethanolamines
The tertiary amines of the formula ##STR1## wherein n represents a whole number of 1 to 5; X 1 represents phenyl or phenyl mono-, di- or tri-substituted by R 1 , R 2 and R 3 ; X 2 ...
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4582857 |
Novel p-oxybenzoic acid derivatives, processes for their production and their use as drugs
P-oxybenzoic acid derivatives of formula (1) ##STR1## wherein R 1 is hydrogen, or straight or branched alkyl of one to four carbon atoms; n is 1 or 2; X is ##STR2## and R 2 is --OH or...
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4579866 |
Phenylacetamides as anti-allergy, anti-asthma and anti-inflammatory agents
Compounds of the structure ##STR1## and pharmaceutically acceptable salts thereof, wherein: R 1 and R 2 are independently H, OH, lower alkyl, lower alkoxy, aryloxy, heteroaryloxy, heteroaryl...
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4576951 |
Proglumide, pharmaceutical preparations and compositions including it for use in human pain relief
The subject of the invention is a new use of D,L-4-benzamido-N,N-dipropyl-glutaramic acid (proglumide) in human pain relief. According to the invention proglumide is used both alone, at dosages of...
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4563478 |
Method of tranquilizing
The invention relates to compounds possessing GABA-like sedative and tranquilizing activity, characterized by being of general formula: X 1 OC--(CH 2 ) 2 --NH--(CH 2 ) 3 --CO--X 2 where X 1...
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4544669 |
Compounds and compositions useful for producing analgesia
Alkadienamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched diene having from 11 to 23 carbon atoms; R 1 is H,...
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4544668 |
Compounds and compositions useful for producing analgesia
Methylenealkanamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein X is O or S; R is straight or branched methylene substituted alkane having from 11 to...
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4533657 |
Analgesic dipeptide amides and method of use and composition thereof
A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula HTyrD-AlaNR 2 R 3 wherein R 2 is phenylalkyl or substituted-phenylalkyl and R 3...
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4528397 |
Aminocarboxylic acid derivatives
An aminocarboxylic acid derivative represented by the formula ##STR1## wherein R 1 and R 2 , independently from each other, represent a hydrogen atom or an alkyl group which may have a...
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4525341 |
Method of administering vitamins
A method for administering vitamins to an air-breathing animal consists of introducing the vitaminic aerosol containing a breath freshener into the nose or mouth opening of the animal.
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4515813 |
Lepidoptericidal isothiourea compounds
Lepidoptericidal and herbicidal active compounds having the generic formula ##STR1## wherein R, R 1 , R 2 and R 3 are as disclosed herein. In general, these compounds show enhanced...
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4496588 |
Method of treating psoriasis
A novel method of treating psoriasis which comprises administering a halomethyl derivative of α-amino acids of the following general structure: ##STR1## wherein Y is FCH 2 --, F 2 CH--, F 3 ...
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4486429 |
Amino derivatives of 4-phenyl 4-oxobuten-2-oic acid, pharmaceutical compositions containing them, and methods for preparing and therapeutically using them
Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R 1 and R 2 , which may be identical or different...
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4482572 |
1-Acylamino-1-cyclopentanecarboxylic acids
1-Acylamino-1-cyclopentanecarboxylic acids have been prepared by acylation of certain 1-amino-1-cyclopentanecarboxylic acids and found to have renal vasodilating and diuretic properties.
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4464397 |
Derivatives of lysine and aspartic acid
The compounds of formula ##STR1## where R=H and n=1 or R=(C 6 -C 26 )-acyl and n=2 are useful in the treatment of muscular fatigue and muscular contraction in men and animals and also in the...
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4447449 |
Methods of treating ischemic states
The present invention relates to novel methods of use for known pharmacological anti-allergenic agents including disodiumchromoglycate (DSCG) and related compounds thereof, including generally bis...
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4442117 |
Homoserine derivatives and their use as microbicides
There are described novel homoserine derivatives of the formula (I) ##STR1## which possess valuable microbicidal properties. In the formula: Ar is substituted phenyl or naphthyl; R 1 is C 2 -C 6 ...
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4439449 |
Medicament for diminution of oxalate development and excretion in urine
A method for the treatment of undesired uroliths with benzoic acid is disclosed.
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4439445 |
Cytoprotective use of oxamate derivatives
The present invention provides a method for gastrointestinal cytoprotection using a class of oxamic acids and derivatives thereof.
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4439448 |
Glutamine derivatives
Glutamine derivatives and non-toxic salts thereof have been found to have immunomodulating activities.
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4434160 |
Nutrient solution for complete parenteral feeding and for increased energy production
A nutrient solution for complete parenteral feeding and for increased energy production, for administration to patients in the post-aggression phase, which contains, in aqueous solution, per 25...
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4421765 |
Substituted phenylacetic acid amide compounds
Phenylacetic acid amide compounds of the formula ##STR1## in which R 1 is hydrogen, lower alkyl, lower alkoxy, halogen having an atomic number of not more than 35 or trifluoromethyl, R 2 is...
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4418077 |
Fluorinated amino-butyric acid and diaminobutane derivatives
Fluorinated aminobutyric acid and diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: Y represents hydrogen or...
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4409240 |
Derivatives of dihydroxybenzoic acid and pharmaceutical composition thereof
A novel derivative of dihydroxybenzoic acid represented by the formula (I) ##STR1## wherein R represents ##STR2## or a salt or an ester thereof which has specific pharmacological activities, a...
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4402975 |
Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof
A compound represented by the following formula ##STR1## wherein R 1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X 1 represents an alkylene group having 3 to 6 carbon...
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4399149 |
Fungicides
Use as agricultural fungicides of N-acyl-N-hydroxyalkanoic acid compounds of the formula ##STR1## and salts thereof, wherein each of the symbols has an assigned meaning.
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4386086 |
Method for controlling ectoparasitic Acarina
A method of controlling ectoparasitic Acarina that bore into and through the dermal integument of warm blooded animals by orally administering an 2-aryl-1,3-indandione and derivatives to said...
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4382954 |
Fungicidal N-1-substituted cyclopropyl-N-acyl-2,6-dialkylaniline
Compounds represented by the formula ##STR1## wherein R and R 1 are independently hydrogen or lower alkyl; R 2 is lower alkenyl, lower alkynyl or --CH 2 X wherein X is halogen, hydroxyl, lower...
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4372974 |
Anticonvulsive compositions and method of treating convulsive disorders
An orally administered pharmaceutical formulation comprising a solid dosage form containing an aliphatic amino acid compound in which the carboxylic acid and primary amine are separated by three or...
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4342780 |
Method of depleting endogenous monoamines
2-Amino-2-fluoromethyl-3-(substituted)phenyl propionic acids and derivatives thereof are coadministered with dopamine for the treatment of schizophrenia, mania, tardive dyskinesia, anxiety, or...
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4342781 |
Diphenylpropenamides as SRS-A antagonists
Certain new diphenylpropenamides having a carboxyalkanamido or a carboxyalkenamido group on one of the phenyl rings and their use for antagonizing the spasmogenic activity of the slow-reacting...
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4341798 |
Amide derivatives of p-isobutyl-phenyl-propionic acids and related pharmaceutical compositions
The amide derivatives of p-isobutyl-phenyl-propionic acid, having general formula ##STR1## wherein X is the radical of a substituted amine, of the group comprising lysine, metatrifluorotoluidine,...
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