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7618955 |
Association of an antithrombotic and aspirin
The present invention relates to a new combination of an antithrombotic and aspirin and to pharmaceutical compositions comprising them.
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7598293 |
Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I),
their derivatives, their analogs, their tautomeric forms, their...
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7592372 |
Liquid drug preparations
Liquid drug preparations characterized by containing fudostein and an acid together with a sweetener such as sugar alcohol, trehalose or a sweetener having a high degree of sweetness. These liquid...
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7589126 |
5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula:
wherein R 1 is a hydrogen atom or an optionally substituted lower alkyl...
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7563822 |
Agents for the prevention or treatment of renal diseases
The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2-
hydroxybenzenesulfonamide derivative represented...
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7560487 |
Use of (R)—ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs
The use of (R)-ibuprofen methanesulfonamide is described for the preparation of medicaments for the treatment and prevention of functional injury resulting from rejection reactions of transplanted...
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7557142 |
Therapeutic use of methionine to reduce the toxicity of platinum-containing anti-tumor compounds
Methods of preventing or reducing ototoxicity in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin or...
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7547450 |
Senior feline food
A feline pet food comprising a dietary level of protein and a supplemental amount of at least one amino acid in an amount sufficient to provide a feline lean body mass protection equivalent to...
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7501452 |
Treatment of xerostomia
Xerostomia is treated with a sulfur-containing antioxidant, such as N-acetylcysteine. Delivery compositions including polyoxyalkylene block copolymers may be used, which may be formulated to...
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7498358 |
Human ADAM-10 inhibitors
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological...
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7482026 |
Compositions and methods directed towards sore muscles and joints
Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
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7476759 |
Matrix metalloproteinase inhibitors
Compounds of Formula (I):
wherein: R 1 is optionally substituted —C 4-12 alkyl, —C 2-10 alkylcycloalkyl, —C 2-6 alkylheterocycloalkyl, —C 2-6 alkylaryl, optionally substituted 5-...
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7470657 |
Cleansing composition containing an amphiphilic polymer
The present patent application relates to a cleansing composition comprising in an aqueous medium at least one surfactant selected from alkylpolyglycosides, maltose esters, glycerolated fatty...
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7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
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7459446 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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7453010 |
Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof
The invention relates to compounds of general formula (I):
where R 1 represents H or a (C 1 -C 4 )alkyl, —CO(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl or —CO-phenyl group, said phenyl...
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7449451 |
Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
Disclosed herein is a method for protecting humans in need of such protection from physical damage caused by ionizing radiation comprising administering to said humans on a defined basis prior to...
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7427619 |
Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
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7423065 |
Therapeutic use of methionine-derivitives to reduce the toxicity of noise
Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an...
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7423064 |
Composition for treating bacterial, viral, fungal diseases, inflammation and pain
The present invention is directed to compositions and methods of treating bacterial, viral, fungal diseases; inflammation or inflammatory-related disorders; pain; and skin conditions. The...
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7399755 |
Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same
The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary...
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7396859 |
Perturbed membrane-binding compounds
The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to...
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7390833 |
Method for treating ADAMTS-5-associated disease
The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a...
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7388030 |
Suppressors of anemia and appetite suppressors and methods for suppressing anemia and suppressing appetite
The present invention provides a method for suppressing hemolytic anemia by selectively ameliorating reticulocyte increase and iron deposition on spleen caused as the side effects of methionine....
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7384979 |
Substituted amino acids as erythropoietin mimetics
This invention relates to a series of substitituted amino acids of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
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7378387 |
Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes
A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of...
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7351703 |
Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators
The present invention relates to compounds of the formula I
in which A 1 , A 2 , R 2 and R 3 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds for...
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7335686 |
Method and composition for treating osteoporosis
This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7326690 |
Modulation of cell fates and activities by phthalazinediones
Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7321001 |
Asthma and allergic inflammation modulators
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7317040 |
Nitric oxide synthase inhibitor phosphate salt
A compound of formula (I):
namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a solvate or physiologically functional derivative thereof,...
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7314889 |
Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I),
their derivatives, their analogs, their tautomeric forms, their...
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7309755 |
Method of producing polycarbonate articles by rotation molding and rotation molded articles made by the method
A method for making a polycarbonate article is described wherein the article is made by rotation molding a melt polycarbonate having a weight average molecular weight from 25,000 to about 36,000....
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7304044 |
Lowering blood glucose, urea, cholesterol, triglycerides and normalizing homocysteine levels by dietary addition of selected essential amino acids and three vitamins
Administration of a dietary supplement consisting of L-Tryptophan (80 mgs), L-Methionine (90 mgs), L-Valine (103 mgs), L-Lysine Monohydrochloride (128 mgs), Vitamin B-12 (0.5 mg), Vitamin B-6 (10...
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7304037 |
Cytostatic conjugates with integrin ligands
The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units which can be selectively...
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7268164 |
Anti-epileptogenic agents
Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and...
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7268135 |
Biaryl sulfonamides and methods for using same
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
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7244749 |
Compositions and methods for lowering plasma lipoprotein(a) and risk factors of cardiovascular diseases
The present invention provides compositions and methods for lowering plasma Lp(a) levels in humans. The present invention provides compositions and methods for lowering the risk factors for...
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RE39734 |
Nutritional or therapeutic compositions to increase bodily glutathione levels
Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance...
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7235237 |
Methods of treating vascular diseases characterized by nitric oxide insufficiency
The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an...
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7217739 |
Method for inducing cell death with carbonyl scavengers
Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7214711 |
Method of treating migraine headache without aura
The present invention relates to methods and compositions for treating selected conditions of the central and peripheral nervous systems employing non-synaptic mechanisms. More specifically, one...
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RE39576 |
Enzyme inhibitors
A compound of formula (I)
wherein
R 1 is a C 1-6 straight or branched chain alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 3-6 cycloalkyl group or a C 3-6 cycloalkylC...
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7199158 |
Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula:
wherein R 1 –R 6 , R 7 , R 7′ , R 8 , R 30 –R 34 , X′, Y, Y′, t, x, and n are as defined herein, are...
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7196118 |
Amidino compounds useful as nitric oxide synthase inhibitors
The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as...
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7196065 |
Enteral formulation
A formulation for enteral administration to a patient is disclosed.
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