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5626883 |
Ascorbic acid compositions providing enhanced human immune system activity
A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be...
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5627168 |
Pharmaceutical composition for and a method of using a combination of an uricosuric agent and an EAA antagonist
The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a...
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5618823 |
Glutathione as chemoprotective agent
The use of glutathione (GSH) as chemoprotective agent against neurotoxicity induced by antitumor drugs active on the mitotic fuse is herein described.
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5607974 |
Treatment of diseases associated with cysteine deficiency
Patients suffering from a pathological condition resulting in reduced intracellular cysteine levels are treated with a cysteine source capable of being transported to the cellular cytoplasm....
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5602119 |
Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
Succinoylamino hydroxyethylamino sulfamic acid derivative compounds which are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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5601806 |
Methods for scavenging active oxygen compounds and preventing damage from ultra violet B rays using taurine analogues
Taurine analogues are used for scavenging active oxygen compounds and preventing and minimizing damage to the skin from ultraviolet rays. The taurine analogues have the following formula: ##STR1##...
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5599817 |
Xanthine derivatives as diuretic agents
A method for stimulating diuresis comprising administering a composition comprising 8-(3-oxocyclopentyl)-1,3-di-n-propyl-7H-purine-2,6-dione and, optionally, a loop diuretic, is disclosed.
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5597848 |
Benzenesulfonamide derivatives and use thereof
A benzenesulfonamide derivative represented by the following general formula: ##STR1## wherein R 1 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group or a halogen atom; R 2 ...
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5596011 |
Method for the treatment of macular degeneration
Macular degeneration is an age-related eye disease for which there is no known treatment to date that has been shown to be effective at treating or preventing the onset or progression of the...
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5595982 |
Equine nutritional supplement
A nutritional supplement and a method of use therefor in equine are disclosed. The equine nutritional supplement alleviates various chronic or acute conditions in equine associated with hormonal...
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5589504 |
Treatment of newborn jaundice
Based on the discovery that the human bilirubin/phenol UDP-glucuronosyltransferase ugt1 gene complex contains an electrophile responsive element and the knowledge that the rat NADP(H):quinone...
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5587399 |
Method for preparing medical foods for the nutritional support of infants/toddlers with metabolic diseases
The present invention involves a method of preparing a nutritional product in which a powder base containing fats, carbohydrates, vitamins, minerals and trace elements is mixed with specific amino...
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5583101 |
Use of nitrogen oxide species and adducts to inhibit skeletal muscle contraction
A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease...
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5580542 |
Method of testing for nephritis
Disclosed is an acetyltransferase activity measuring agent which contains an arylamine derivative. As the arylamine derivative, sodium p-aminohippurate can be used preferably. Use of the...
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5580577 |
Method of treating the symptoms of human rhinovirus infection
A method of treating viral infection comprises the step of administering to a patient harboring a disease-inducing virus other than HIV-1, the virus being one for which an intracellular thiol...
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5578629 |
Benzamide-containing inhibitors of farnesyl-protein transferase
The present invention comprises peptidomimetic compounds which comprise a suitably substituted aminoalkylbenzamide moiety. The instant compounds inhibit the farnesyl protein transferase enzyme and...
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5559150 |
N,N-disulfonylated aminobenzene carboxlic acids and the use thereof as thrombin inhibitors
The present invention is directed to novel compounds that are non-peptidic thrombin inhibitors. The compounds have the structure: ##STR1## and pharmaceutically acceptable salts thereof; wherein R 1...
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5550146 |
Medical foods for the nutritional support of infant/toddler metabolic diseases
The present invention relates generally to a generic powder base rich in fats, carbohydrates, vitamins and minerals and trace elements which can be readily admixed with specific amino acids to...
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5547990 |
Disinfectants and sanitizers with reduced eye irritation potential
It has been found that certain combinations of substituted imidazoline-based amphoterics and quaternary ammonium compounds show markedly reduced irritation profile in addition to providing...
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5545669 |
Anti-inflammatory compounds
This invention relates to the novel compounds and pharmaceutical compositions of Formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need...
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5545670 |
Composition and method for the treatment of chronic fatigue syndrome
This invention relates to a composition and method for the treatment of myalgic encephalomyelitis known as chronic fatigue syndrome. The composition consists essentially of specific amounts of...
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5543425 |
Method of inhibiting platelet aggregation using phenyl amidine thio derivatives
This invention relates to a method of inhibiting platelet aggregation comprising administering compounds having the following formula ##STR1##
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5536723 |
S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically...
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5534545 |
Parenteral amino acid formulations for the inhibition of systemic hypotension associated with nitric oxide production
An anti-hypotensive formulation comprising an essentially arginine-free or low arginine (less than about 0.1%, most preferably, about 0.01%) containing mixture of amino acids is provided. The...
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5527824 |
Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis
Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.
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5525628 |
Salts of a glutathione alkylester and anaminoacids
Crystalline non-hygroscopic salt of glutathione alkylester of the formula (I) ##STR1## wherein AA is an amino acid are disclosed.
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5525629 |
Inhibition of cytokine production
Hydroxamic acid derivatives of formula (I): ##STR1## wherein R 1 represents hydrogen or an (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, phenyl, substituted phenyl, phenyl(C 1 ...
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5508045 |
Method and agents for control and management of labor during pregnancy
A method for control, management and inhibition of a preterm labor by providing to a pregnant woman a donor of nitric oxide. Management and inhibition of preterm labor is achieved by administering...
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5492917 |
Endothelin antagonists incorporating a cyclobutane
Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary...
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5491170 |
β-carboxy sulfonamide ACAT inhibitors
β-Carboxy sulfonyl compounds of the formula ##STR1## wherein R 1 is aryl, R 3 is hydrogen or alkyl, R 3 and R 4 are hydrogen or alkyl, Y is --O--, --S--, or --NR 2 --, and R 5 is alkyl or...
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5482942 |
(3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
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5478835 |
Tricyclic compounds and intermediates thereof
Disclosed is a tricyclic compound represented by the formula (I): ##STR1## wherein each of R 1 , R 2 , R 3 and R 4 independently represents hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio,...
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5476846 |
Substituted sulfonamides, process of preparation and medicines containing same
The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined...
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5474757 |
Prevention of acetaminophen overdose toxicity with organosulfur compounds
A method of preventing acetaminophen (APAP)-induced hepatotoxicity utilizing diallyl sulfide (DAS) and diallyl sulfone (DASO 2 ) is disclosed. DAS and DASO 2 are prepared as an oral dosage form or...
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5472979 |
1,2,3,4-tetrahydronaphthalene compounds
its enantiomers and its addition salts with a pharmaceutically acceptable base, and medicinal products containing the same are useful as anti-thrombotic.
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5470834 |
Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of the formula, ##STR1## wherein: R 1 is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino...
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5468777 |
Method and agents for preventing and reversing the staining of teeth
The present invention relates to methods and agents for preventing and reversing the staining of teeth caused by the nonenzymatic browning of proteins in the oral cavity. Suitable agents for the...
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5464869 |
Use of dimercaptan acids, salts and metabolites thereof as antiretroviral treatments
A method for the prophylaxis or treatment of retroviruses in warm-blooded animals comprising administering to said warm-blooded animal a therapeutically effective amount of a dimercaptan acid,...
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5462726 |
Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives...
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5459134 |
(Fused) benz (thio) amides
A novel (fused) benz(thio)amide of the general formula: ##STR1## or a non-toxic salt thereof, wherein R 4 represents: (i) when B represents a closed ring, a group of the general formula: ##STR2##...
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5451405 |
Skin treatment composition
It should be understood that the specific forms of the invention herein illustrated and described are intended to be representative only. Changes, including but not limited to those suggested in...
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5446065 |
Sulfonamides of phenylalkylamines or phenoxyalkylamines processes for their preparation and medicaments containing these compounds
Compounds of the formula I ##STR1## in which R 1 signifies an aryl, aralkyl or an aralkenyl group, the aryl radical of which can, in each case, be substituted one or more times by halogen, cyano,...
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5444090 |
Method of reducing the rate of hair growth
The rate and character of mammalian hair growth is altered by the topical application to the skin of a composition containing an organic inhibitor of the enzyme L-asparagine synthetase.
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5441983 |
Treatment of infection by enveloped virus with calix(N)arene compounds
A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring...
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5430064 |
Treating AIDS and HIV infection with methionine
This invention concerns novel safe compositions containing as an active antioxidant or antiinflammatory agent and thiol-repleting agent, the amino acid methionine, and/or one or more related...
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5411757 |
Palatable balanced amino acid-modified diet
In the present invention, L-amino acids comprise the medical food which provides a source of protein-equivalent of free purified L-amino acids in a palatable powdered form which can be incorporated...
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5411991 |
Method of reducing hair growth employing sulfhydryl active compounds
A method of reducing the rate of mammalian hair growth includes topically applying a composition containing a sulfhydryl reactive compound to the skin.
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5409939 |
Phenyl amidine thio derivatives useful as platelet aggregation inhibitors
This invention relates to compounds having the following formula ##STR1## which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of...
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5409956 |
Indan derivative and thromboxane antagonist containing the same
The present invention relates to indan derivatives represented by the formula (1) or pharmaceutically acceptable salts thereof: ##STR1## [wherein R 1 represents C1 to C12 alkyl, benzyl, styryl,...
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5407951 |
Sulphonamidocycloalkane compounds, pharmaceutical compositions containing them, and methods of use thereof
The present invention provides sulphonamides of the general formula: ##STR1## wherein R 1 and R 2 , which can be the same or different, are hydrogen or halogen atoms or C 1 -C 6 -alkyl,...
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