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5869067 |
Bi-aromatic compounds and pharmaceutical and cosmetic compositions
The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
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5866604 |
Thiol derivatives with metallopeptidase inhibitory activity
Compounds of formula (I) wherein R, R 1 , R 2 , R 3 , R 4 , m and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them...
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5863947 |
Phenylglycine derivatives useful for treating disorders of the central nervous system
A pharmaceutical compound of the formula: ##STR1## in which R 1 is hydrogen, hydroxy or C 1 -6 alkoxy, R 2 is hydrogen, carboxy, tetrazolyl, --SO 2 H, --SO 3 H, --OSO 3 H, --CONHOH, or...
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5863931 |
Amidino derivatives and their use as nitric oxide synthase inhibitors
Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R 1 is a C 1 -6 straight or branched chain alkyl group, a C 2 -6 alkenyl group, a...
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5861431 |
Incontinence treatment
The present invention provides a method of treating incontinence in a patient that has a bladder and a urethra. The urethra forms a lumen for draining the bladder. The method comprises the steps of...
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5852055 |
Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
An improved process for the production of a pharmaceutical composition comprising p-hydroxyacetanilide and L-cysteine or a compound which is converted thereto in vivo comprises mixing...
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5849335 |
Composition and method for providing glutamine
A nutritional composition for providing glutamine to a human or animal. The protein source of the composition includes carob protein which is rich in glutamine. A source of Met may also be...
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5843997 |
Excitatory amino acid receptor antagonists
The present invention provides novel compounds that affect excitatory amino acid receptors and are useful in the treatment of neurological disorders. This invention also provides synthetic methods...
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5833955 |
Diagnostic tests to assess a persons oral malodor capacity and potential for developing periodontitis
Oral malodor and periodontitis are common problems affecting a large percentage of the population. The present invention provides a method of assessing an individual's oral malodor producing...
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5834517 |
Meadowfoam sulfosuccinates in personal care applications
The present invention deals with a process for cleaning and conditioning hair and skin which comprises the contacting of hair or skin woth an effective concentration of certain novel meadowfoam...
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5827886 |
Composition for relief of arthritis-induced symptoms
A composition and method of using it for ameliorating inflammatory reactions and painful and other symptoms of the diseases of arthritis, lumbago, low back pain, myalgias and neuralgias. The...
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5824681 |
Organic salts of N,N'-diacetyl cystine
New crystalline organic salts of N,N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their...
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5821237 |
Compositions for visually improving skin
The subject invention relates to compositions which are useful for improving the visual appearance of skin, especially facial skin. The composition contains certain primary actives including at...
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5817695 |
Nutritional product with high fat, low carbohydrate and amino acid imbalance
A nutritional product is provided for cancer patients comprising, as per caloric requirement, a low concentration of carbohydrate, a high concentration of fat and an imbalance of amino acids...
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5807894 |
Syrup containing N-acetyl-cysteine
A syrup containing N-acetyl-cysteine, stable for at least two years, having pleasant taste and smell, consists of an aqueous solution of NAC, a sweetening agent and a thickening agent. The solution...
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5804582 |
Method for the treatment of diseases due to defects the immune system
New crystalline organic salts of N,N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their...
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5783593 |
Inhibitors of squalene synthetase and protein farnesyltransferase
The present invention provides a compound of the formula ##STR1## which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia,...
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5780508 |
Pharmacological preparations comprising a cystine derivative
The invention concerns pharmaceutical preparations for stimulation of the immune system which comprise a cystine derivative as active ingredient.
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5776503 |
Amino acid solutions for treatment of peritoneal dialysis patients
The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to...
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5767119 |
Method of treating neurodegenerative diseases using an AMPA excitatory amino and an uricosuric agent
The present invention is a pharmaceutical composition having a combination of an uricosuric agent such as probenecid or the like and an excitatory amino acid antagonist useful for treating a...
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5767091 |
Analgesic effect enhancing preparations
The present invention provides an analgesic effect enhancing preparation capable of enhancement of the effect of analgesics, the preparation comprising as an active ingredient the following amino...
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5767157 |
Arthritic pain prevention method and compositions
Disclosed is the method of determining the effectiveness of an agent for the prevention of pain in a person's joints, comprising the steps of a) administering to a susceptible subject a quantity...
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5763474 |
Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones
The compounds of the formula: ##STR1## wherein R 1 is straight chain alkyl, branched chain alkyl cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R 2 and R 3 are, independently,...
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5763481 |
Vinylcarboxylic acid derivatives
Compounds of the formula ##STR1## wherein R 1 is C 3 -C 8 cycloalkyl, halo-C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, halo-C 3 -C 8 cycloalkyl-C 1 -C 6 alkyl, --Si(R 3 )...
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5756545 |
Biphenysulfonamide matrix metal alloproteinase inhibitors
Compounds of the formula ##STR1## wherein R 1 includes alkyl, halo, nitro, amino, cyano, alkoxy, and alkoxycarbonyl; R 2 is alkyl and substituted alkyl; and R 3 is OH or NHOH are useful for...
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5739163 |
Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists
This invention relates to novel compounds containing basic and acidic termini, pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using...
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5733539 |
Bait for fishes and shellfishes
The invention discloses a bait for fishes and shellfishes characterized in that the bait comprises a matrix material containing a microorganically fermented product of a plant residue obtained by...
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5733909 |
Diphenyl stilbenes as prodrugs to COX-2 inhibitors
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions...
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5728736 |
Reduction of hair growth
Mammalian hair growth is reduced by applying to the skin a dermatologically acceptable composition including an inhibitor of arginase.
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5726165 |
Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, or solvate thereof, wherein, R o represents an aryl group, optionally substituted; X represents O or S; R 1 and...
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5723493 |
Naphthyloxyacetic acid
(1) Naphthyloxyaetic acid represented by the compound of the formula (I): ##STR1## and non-toxic salts thereof, (2) process for the preparation of the compounds represented by the compound of the...
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5716990 |
Drug delivery systems
Nitrogen mustard pro-drugs of the formula ##STR1## are disclosed where R is the residue of an α-amino acid RNH 2 and M is a disubstituted amino "mustard" group, useful in antibody directed enzyme...
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5712309 |
Composition for treatment of hangovers
A composition for reducing the symptoms of hangover, including therapeutically effective amounts of L-methionine and L-alanine, or pharmaceutically acceptable salts thereof as active ingredients.
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5708029 |
High blood pressure relief method and compositions
Disclosed is the method of determining the effectiveness of an agent for the relief of elevation of the blood pressure, comprising the steps of a) administering to a susceptible subject a...
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5703127 |
Composition, dosage unit, and method for treating stomach disorders
A dosage unit for treating stomach disorders, comprises an effective dosage of L- or DL-Methionine, and an effective dosage of a sweetener.
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5696164 |
Antifungal treatment of nails
There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl...
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5691381 |
Hydroxamic and carbocyclic acids as metalloprotease inhibitors
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition...
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5691380 |
Stable n-acetylcysteine compositions and methods for treating human skin therewith
The present invention relates to topical compositions comprising N-acetylcysteine demonstrating improved odor stability. These compositions are useful for treating and visibly improving the...
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5690967 |
Compositions for improved topical delivery of lactic acid
Compositions for improved topical delivery of lactic acid comprising lactic acid and an amphoteric or pseudoamphoteric agent.
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5686492 |
Disubstituted p-fluorobenzenesulfonamides
Described herein are disubstituted p-fluorobenzenesulfonamides, containing a CF 3 group, of general formula I ##STR1## which are suitable as NMR diagnostic agents.
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5663208 |
Antifungal wound healing compositions and methods for preparing and using same
This invention pertains to therapeutic antifungal-wound healing compositions. The compositions comprise a therapeutically effective amount of an antifungal agent and a wound healing compositions....
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5658957 |
Immunostimulating wound healing compositions and method for preparing and using same
This invention pertains to therapeutic immunostimulating-wound healing compositions. The compositions comprise a therapeutically effective amount of an immunostimulating agent and a wound healing...
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5658943 |
Phenylalanine derivatives as endothelin antagonists
Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in...
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5652274 |
Therapeutic-wound healing compositions and methods for preparing and using same
This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells. In one embodiment, the therapeutic wound healing composition comprises (a)...
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5650418 |
Therapeutic lysine salt composition and method of use
A therapeutic lysine-based composition and methods for its use in the prevention and treatment of cardiovascular disease is disclosed. The composition includes at least one ascorbate compound,...
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5650428 |
Arylsulfonamide derivative and pharmaceutical compositions and use thereof
An arylsulfonamide derivative of the formula (I): ##STR1## wherein R 1 is unsubstituted phenyl or naphthyl, or phenyl substituted by 1 to 3 same or different substituents selected from the group...
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5648393 |
Treatment of male impotence with s-nitrosylated compounds
Methods of relaxing corpus cavernosum smooth muscle, treating disease states responsive to prevention or relaxation of undesirable contractions of corpus cavernosum smooth muscle and of treating...
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5646177 |
Glutathione derivatives of anthracyclines
Disclosed herein are new anthracyclines which are derived from conjugation with glutathione, for example from conjugation of adriamycin, daunomycin and menogaril with glutathione: compounds 7 I, 7...
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5637616 |
Method for treating diseases mediated by proteases
A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid,...
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5629343 |
N-(mercaptoacyl) peptidyl derivatives as antidegenerative agents
Novel N-(mercaptoacyl)peptidyl compounds are useful as inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative...
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