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6090414 |
Method and composition to reduce cancer incidence
The five component composition consisting essentially of: (1) Water soluble antioxidant vitamin C or ascorbic acid, or any of its forms or derivatives, or mixtures thereof. (2) Oil soluble...
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6087398 |
Sickle cell anemia treatment
The present invention provides a method of treating sickle cell anemia comprising the step of administering to an individual in need of said treatment a therapeutically acceptable dose of reducing...
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6063797 |
γ-RAR antagonist ligand or α-RAR agonist ligand as an apoptosis inhibitor
The use of a combination of an alpha RAR receptor-specific agonist ligand and a gamma RAR receptor-specific antagonist ligand to reduce the rate of apoptosis is disclosed.
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6063817 |
Use of substituted (5,6) dihydronaphthalenyl compounds having retinoid-like activity to prevent or reduce ischemic injury
The present invention relates to methods of preventing, or reducing the severity of, an ischemic injury originating in an animal's dermal tissue by applying to the animal a composition comprising a...
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6051605 |
Method of treating psychosis and schizophrenia
This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4...
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6051236 |
Composition for optimizing muscle performance during exercise
A nutritional composition in a dry powder form for optimizing muscle performance during exercise and for enhancing muscle cell repair and recovery following the cessation of exercise. The dry...
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6048843 |
Topical composition containing amino acid in combination with either interferon of thymidine derivatives for treating viral or inflammation diseases
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6048852 |
β-thiopropionyl-aminoacid derivatives and their use as β-lactamase inhibitors
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6046236 |
Carbocyclic sulfonamides
(1) Prostaglandin (PG) E 2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts...
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6042845 |
Anti fungal treatment of nails
There is disclosed a method for the treatment of fungal diseases in nails, which comprises the topical administration to the nail and, if desired, also to the surrounding skin, of (1) a sulfhydryl...
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6025393 |
Method for treatment of inflammatory intestinal diseases
This invention relates to a method for treatment of inflammatory intestinal diseases which comprises administering bucillamine or a salt thereof and pharmaceutical acceptable carriers. Bucillamine...
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6020120 |
Use of N-acetylcysteine to store red blood cells and a method of aging red cells with nitrogen
The invention provides a method of preserving red blood cells. The method comprises treating the red blood cells with about 2 mM to about 35 mM of N-acetylcysteine. The invention further provides a...
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6020379 |
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
In position 7 substituted indenyl-3-acetic acid derivatives and pharmaceutically acceptable salts and amides thereof have anti-neoplastic activity.
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6017959 |
Forms of organic salts of N,N'-diacetylcystine
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6017962 |
Method of depletion of methionine in plasma and solid tumors and uses thereof
The present invention provides a method of depleting methionine in the plasma of an individual in need of such treatment, comprising the steps of: administering to said individual a...
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6015828 |
Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases
This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride...
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6015792 |
Specific eatable taste modifiers
Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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6013672 |
Agonists of metabotropic glutamate receptors and uses thereof
Astrocytes protect neurons from excitotoxic injury by maintaining low extra-cellular glutamate concentrations ([Glu] o ). Compromised astrocytic glutamate uptake has been implicated in acute and...
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6011067 |
Antioxidant composition for the treatment of psoriasis and related diseases
The present invention deals with the combination of several synergistic antioxidants including enzymatic co-factors as adjuncts to therapy of desquamating inflammatory disorders, such as psoriasis....
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6007865 |
Reversing the formation of advanced glycosylation endproducts
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
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6008251 |
Retinoid-like compounds
The present invention relates to a compound of the formula ##STR1## wherein X is --CONH-- or --NHCO--, or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate...
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6001877 |
Phenylalkan(en)oic acid
The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B 4 .
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5998474 |
L-carnitine or derivatives thereof and antioxidants for the prevention and treatment of diseases elicited by oxidative stress to the nervous and cardiovascular system
Therapeutic use is described of L-carnitine, alkanoyl L-carnitines and pharmacologically acceptable salts thereof, in combination with hydrophilic antioxidants or lipophilic antioxidants for the...
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5994402 |
Anti-inflammatory and anti-pyretic method
A method of reducing or inhibiting inflammation and inducing or promoting anti-pyresis comprises administering to a mammal in need of such treatment, an amount of a glutathione depleting agent...
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5985860 |
System for transdermal delivery of pain relieving substances
Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other...
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5981595 |
Sulfonyl urea and carbamate ACAT inhibitors
A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted...
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5977160 |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
The invention involves a method for treating a human survivor of a heart attack and provides further improvement in survival following the heart attack by the early initiation and long-term...
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5972993 |
Composition and method for treating rosacea and sensitive skin with free radical scavengers
A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the...
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5965588 |
Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors
Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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5962421 |
Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases
A method for prevention of cell death, and method comprising simultaneously topically applying N-acetylcysteine and levulose as an application in an amount effective to result in a synergistic...
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5955505 |
Glutamic acid receptor agonist
A method comprising administering a sulfonamide derivative to a patient requiring activation of glutamate receptors, the sulfonamide derivative represented by the formula ##STR1## wherein A is a...
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5952367 |
Method of treating pain cause by bursitis tendinitis arthritis
Disclosed herein is a method of treating pain caused by bursitis, tendinitis, arthritis, and the like, comprises ingesting an effective amount of a non-steroidal anti-inflammatory drug, and...
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5948780 |
Method for treating and preventing heart failure and ventricular dilatation
Matrix metalloproteinase inhibitors are useful for preventing and treating heart failure, and ventricular dilatation in mammals.
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5945450 |
Naphthalene derivative
Naphthalene derivatives represented by formula I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C 7 -C 11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C 1 ...
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5935994 |
Nutritionally balanced dermal composition and method
A composition and method for enhancing the appearance of the skin, the composition containing a mixture of essential amino acids, a penetrant, a neucleotide, vitamin C and vitamin E.
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5932229 |
Oxa diacids and related compounds for treating skin conditions
Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin...
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5929114 |
Arylthio compounds
Arylthiol and dithiobisarylamide antibacterial and antiviral agents have the general formula ##STR1## where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O,...
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5919824 |
Aminophenol derivatives
Aminophenol derivatives represented by the following formula (1): ##STR1## wherein X is O or S; A is alkylene, R 1 is phenyl, etc., R 2 and R 3 are H or alkyl; R 4 is substituted...
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5916913 |
Inhibition of wound contraction with paclitaxel, colchicine and penicillamine
The present invention uses Paclitaxel and/or Colchicine in an appropriate carrier to inhibit wound contraction. Paclitaxel is an antimicrotubule agent that is currently used as a cancer...
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5916922 |
Phenyl glyoxamides as SPLA2 inhibitors
A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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5912019 |
Compounds for reducing ischemia/reperfusion injury
Disclosed herein are compositions containing NO donors, inhibitors of iNOS induction, and endopeptidase inhibitors, and methods for their use for combating injury induced by ischemia and...
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5912248 |
Excitatory amino acid receptor antagonists
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO 2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
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5906985 |
Pharmaceutical compounds
Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R 1 is hydrogen, C 1 -10 alkyl, C 2 -10 alkenyl, C 2 -10 alkynyl, phenyl, naphthyl, C 1 -10 alkyl-phenyl,...
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5889053 |
Farnesyl transferase inhibitors, preparation thereof and pharmaceuticals compositions containing said inhibitors
Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R 1...
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5889040 |
Composition for increasing protein concentration in a mammal
The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with an anabolic protein composition, produces a synergistic effect in...
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5885610 |
By-pass rumen product
A method and composition which is rumen stable but intestine soluble, and therefore useful in dietary supplementation of ruminant animals with bioavailable but rumen stable forms of essential amino...
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5883126 |
Pharmacological use of certain cystine derivatives
A method for the treatment of restenosis using certain cystine derivatives and a pharmaceutical preparation comprising these derivatives.
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5882688 |
Composition for the protection of fresh sea food from melanosis and method therefore
A composition to be applied in the preservation of edible sea products exposed to melanization is disclosed; said composition being composed of potassium or sodium bisulfite, organic acids...
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5877212 |
Molecular complex and control-release of alpha hydroxyacids
Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release...
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5874433 |
Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
Inhibitor of the use of tetrahydrobiopterin as a cofactor for nitric oxide synthase, e.g., substituted 4-phenyl(hydropyridines) such as...
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