Patents in Class 514/562

Matches 51 - 100 out of 717

Match	Document	Document Title
51	7160857	Methods for increasing schwann cell survival Methods for increasing Schwann cell survival are disclosed. The methods of the invention are useful for the treatment of conditions such as peripheral neuropathies, including diabetic neuropathies.
52	7153869	Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
53	7109203	Sulfonamide derivatives Sulfonamide derivitives of the formula I wherein R 1 -R 6 are as defined in the description, processes for their production, their use as pharmaceuticals, particularly for use in the treatment or...
54	7105570	Cysteine derivatives Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional...
55	7105564	Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
56	7101895	Cyclohexyl sulphone derivatives as gamma-secretase inhibitors Compounds of formula I: wherein Ar 1 and Ar 2 are optionally substituted aryl or heteroaryl, L is a bond, ═CH— or —(CHR a ) n —, and X is SCN, SR 1 , S(O)R 1 , (CR a R b ) m SO 2 R 1...
57	7094797	Organ fibrosis inhibitor An organ fibrosis inhibitor, in particular, a liver fibrosis inhibitor is provided, which contains histidine, preferable together with cysteine and/or cystine as active ingredients. Owing to the...
58	7081481	Excitatory amino acid receptor modulators Compounds of the formula (I) in which: R 1 is (CH 2 ) n Y; n is 1 or 2; Y is NHSO 2 R 2 or X 1 —W—X 2 —R 3 ; X 1 is O or NH; W is C═O, C═S, C═NH, or SO 2 ; X 2 is O or NH, provided...
59	7074820	Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
60	7071230	Therapeutic use of D-methionine to reduce the toxicity of noise Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an...
61	7063865	Composition and method for substantially reducing the deleterious effects of alcohol on the body A composition that will substantially reduce the deleterious effects of alcohol on the body and substantially reduce the side effects associated with hangovers (i.e. headaches, dizziness, nausea,...
62	7060697	Immunosuppressant compounds and compositions The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
63	7056889	Compounds that bind P2Y2 or P2Y1 receptors The invention provides peptides and compounds that can bind to P2Y 2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.
64	7052683	Composition to detoxify formaldehyde in gaseous state, in aqueous solutions, and to protect human cell lines against formaldehyde A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors...
65	7049342	Substituted phenylpropionic acid derivatives The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and...
66	7048918	Insect bait Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively...
67	7045152	Treating pulmonary disorders with gaseous agent causing repletion of GSNO Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas,...
68	7034045	Monofluoroalkyl derivatives The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
69	7022737	Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill...
70	7015232	Stabilization of quinapril using magnesium oxide The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms...
71	7012098	Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective...
72	7001738	Method for assaying protein nitrosylation Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain...
73	6984661	Urea linker derivatives for use as PPAR modulators The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each...
74	6974828	Propanoic acid derivatives as intergrin receptor antagonists Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the...
75	6974833	Synergistic compositions comprising ascobate and lysine for states related to extra cellular matrix degeneration Methods for the treatment of diseases or pathological states related to the degradation of the extracellular matrix, such as degenerative diseases atheriosclerosis, cancer, infection or other...
76	6953812	Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
77	6951890	Preventing and/or treating cardiovascular disease and/or associated heart failure Methods are provided for reducing copper values for, by way of example, treating, preventing or ameliorating tissue damage such as, for example, tissue damage that may be caused by (i) disorders of...
78	6946474	Nitrogen-containing compounds and their use as glycine transport inhibitors The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such...
79	6936636	5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
80	6932985	Azide method and composition for controlling deleterious organisms Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and...
81	6927236	Coniosulfides and their derivatives, processes for preparing them, and their use as pharmaceuticals The present invention relates to compounds of the formula which are formed during fermentation by the microorganism Coniochaeta ellipsoidea Udagawa, DSM 13856, or by one of its mutations...
82	6919375	Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
83	6919369	Serine protease inhibitors Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
84	6916837	Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them Amidino derivatives represented by the following general formula (I): {where X is a group represented by R 1 SO 2 NR 2 — (wherein R 1 represents optionally substituted C 6-14 aryl, etc....
85	6897237	MMP-12 inhibitors A compound of the formula (I): wherein R 1 is hydroxy and the like; R 2 is optionally substituted lower alkyl and the like; R 3 is hydrogen atom and the like; R 4 is optionally substituted...
86	6890942	Acyl sulfonamides as inhibitors of HIV integrase The present invention relates a series of compounds of Formula I wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
87	6890918	Pharmaceutical compositions including ACE/NEP inhibitors and bioavailability enhancers A pharmaceutical composition comprising an inhibitor of angiotensin converting enzyme and neutral endopeptidase, such as sampatrilat, and at least one bioavailability enhancer such as an organic...
88	6887903	N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them The compounds of formula 1 wherein R and R 2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear...
89	6881727	Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
90	6881424	Highly acidic metalated organic acid A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a...
91	6875765	Arylsulfonamide ethers, and methods of use thereof The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are...
92	6875764	Urea and thiourea compounds useful for treatment of coccidiosis The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered....
93	6875792	Dosage form of L-Methionine S-Sulfoximine Methods for the treatment of both diseases susceptible to the inhibition of mammalian glutamine synthetase and progressive hyperammonemic encephalopathy comprising administering L-methionine...
94	6849626	Aza-amino acid derivatives (factor Xa inhibitors 15) The invention relates to semicarbazides of the general formula I where R 1 , R 2 , R 3 , R 4 and I have the meaning indicated in claim 1. The compounds of the formula I can be employed...
95	6846843	β-thioamino acids Thio-alpha-amino acids of general formula (I), wherein R 1 , R 2 and R 3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The...
96	6844012	Use of selenium for treating patients suffering from systemic inflammatory response syndrome (SIRS), and composition for implementing said treatment The invention concerns the use of at least a molecule containing selenium, in an amount corresponding to a daily dose of about 2 to 40 mg, even 80 mg of atomic selenium equivalent, on its own or...
97	6844320	Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
98	6841173	Compositions and methods directed towards sore muscles and joints Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
99	6838095	Ionic silver complex The invention relates to a substantially non-colloidal solution made by combining ingredients comprising (a) water; (b) a source of free silver ions; and (c) a substantially non-toxic,...
100	6838472	Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention...

Matches 51 - 100 out of 717

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