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4425360 |
Pharmacologically active novel O-substituted pyruvic acid oximes
The present invention provides pyruvic acid oximes of the general formula: ##STR1## wherein R is a hydrogen atom, a C 3 -C 8 cycloalkyl, C 1 -C 6 alkoxy, cinnamyloxy, phenylamino,...
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4424228 |
Antihypertensive agent comprising a thiazolidine carboxylic acid and probenecid
This invention relates to an antihypertensive agent comprising N-(mercaptoacyl)amino acid and probenecid. The concomitant effect of probenecid and N-(mercaptoacyl)amino acid was observed to reduce...
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4419343 |
Composition usable notably as a cosmetic product allowing a tanning of the skin comprising the use of aminoacids
The invention relates to a composition promoting photo-pigmentation and/or photo-protection of the epidermis by exposure to sun or UV rays. The composition comprises at least a natural substance...
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4416898 |
Therapeutic uses of methionine
A method for the treatment of degenerative diseases such as Parkinsonism and aging by the administration of a pharmaceutically effective amount of L-methionine or DL-methionine.
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4409233 |
Highly concentrated preparations of dopa compounds
A highly concentrated aqueous composition of a dopa which comprises a dopa and at least one amino acid selected from the group consisting of methionine, proline, hydroxyproline, serine, threonine,...
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4406893 |
N-Alkoxycarbonyl-N'-[2-nitro-4 or 5-alkylthiophenyl]-N"-[substituted alkyl]-guanidines useful as anthelmintics
Compounds of the formula ##STR1## and their pharmaceutically acceptable salts are disclosed. The compounds are useful as anthelmintics.
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4406902 |
Dipeptidase inhibitors
Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical...
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4391825 |
N-[[6-(Lower alkoxy)-5-(trifluoromethylthio)-1-naphthalenyl]thioxomethyl]-N-(lower alkyl)glycines
Aldose reductase inhibitors of the formula ##STR1## wherein R 1 and R 2 each is lower alkyl, or a therapeutically acceptable salt thereof with an organic or inorganic base, are useful for...
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4391816 |
N-(Naphthalenylthioxomethyl)aminoacid derivatives
Herein disclosed are N-(naphthalenylthioxomethyl)aminoacid derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.
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4389416 |
Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases
Described are compounds of the formula ##STR1## wherein R is hydrogen, loweralkyl, aminomethyl or halo; R 1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or...
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4387094 |
Contraceptive method and composition containing tannic acid
The present invention relates to a novel local contraceptive method according to which the passage of spermatozoa in the cervical canal is prevented, the said method being characterized in that the...
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4387104 |
N-Substituted pyruvic acid hydrazones, preparation thereof and pharmaceutical compositions containing them
A pyruvic acid hydrazone derivative of the formula: ##STR1## wherein R is an aryl radical optionally substituted by lower alkyl or is an aliphatic hydrocarbon radical which can be substituted by a...
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4372974 |
Anticonvulsive compositions and method of treating convulsive disorders
An orally administered pharmaceutical formulation comprising a solid dosage form containing an aliphatic amino acid compound in which the carboxylic acid and primary amine are separated by three or...
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4363766 |
Process for the preparation of sulfur-containing N-benzyl-amino acids and esters
A process for the preparation of sulfur-containing N-benzyl-amino acids of the formula ##STR1## wherein X and Y, which may be identical to or different from each other, are each hydrogen or...
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4348411 |
Combating bacteria with halogenomethylsulphonylphenyl-phthalamic acids
A halogenomethylsulphonylphenyl-phthalamic acid of the formula ##STR1## in which R 1 represents a trihalogenomethylsulphonyl or dihalogenomethylsulphonyl group, R 2 represents hydrogen,...
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4348397 |
Probenecid-dyphylline therapy
There is provided a method of enhancing the retention of dyphylline in the human system. Dyphylline is a known bronchodilator whose pharmacological utility has been considerably restricted by its...
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4340603 |
Novel inotropic prodrugs
Novel, transient inotropic prodrug forms of the N-(2-phenylethyl)-ω-phenylalkylamines, notably of dobutamine, have (i) the structural formula (I): ##STR1## with the proviso that at least one R 1 ,...
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4338333 |
Ethanamine derivatives their preparation and use in pharmaceutical compositions
The compounds of formula (II): ##STR1## in which R 1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido,...
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4329363 |
Substituted mercapto acid amides and their use
The present application discloses a method of correcting an imbalance of immune homeostasis caused by cytostatic treatment or radiotherapy by administering to a patient in need of such treatment an...
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4321275 |
Method of inducing luteolysis using 16-aryloxy-17,18,19,20-tetranor-prostanoic acid derivatives
The disclosure relates to novel 17,18,19,20-tetranor-prostanoic acid derivatives having prostaglandin-type properties, to a method for their manufacture, and also to pharmaceutical or veterinary...
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4318919 |
Combating bacteria with tetrachlorophthalamic acids
Tetrachlorophthalamic acids of the formula ##STR1## in which R 1 represents a trihalogenomethyl, trihalogenomethoxy or trihalogenomethylmercapto group, R 2 represents hydrogen, halogen or a...
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4315031 |
Thiosubstituted amino acids
This invention relates to thiosubstituted cyclic amino acids, to a process for their preparation and to pharmaceutical compositions containing them together with an inert non toxic pharmaceutical...
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4310545 |
Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino) phenyl compounds
This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
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4309443 |
Cinnamic acid derivatives, their preparation, and pharmaceutical compositions containing them
A compound of the formula (I): ##STR1## or a pharmaceutically acceptable ester, amide or salt thereof wherein R 1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl,...
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4305958 |
Cysteine derivatives
This invention relates to the compounds: N-(mercaptoacy)-cysteine represented by the following formula wherein Z is selected from the group consisting of CH 3 --CH<, (CH 3 ) 2 C<, (CH 2 ) 2...
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4296128 |
Carboxylic acid hydrazides and processes for their manufacture
New carboxylic acid hydrazides of the formula ##STR1## in which R represents an optionally esterified carboxy group, and salts of the compound of the formula I, in which R represents carboxy,...
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4294850 |
Fungicidal acylanilides
New acylanilides of the formula ##STR1## wherein R 1 represents alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen, R 2 represents hydrogen, alkyl of 1 to 3 carbon atoms,...
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4283386 |
Method for hair care
Preventive as well as therapeutic treatment to alleviate the symptoms of disturbed keratinization, consisting of the topical application of a solution, gel, lotion, cream, ointment, stick, powder...
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4281018 |
Novel 4-[(carboxyl- and sulfamyl-substituted alkyl)-amino]benzoic acids and analogs
This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.
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4276284 |
Prevention of collagenase induced disease by treatment with collagenase inhibitors
Certain ulcers and disease conditions resulting in tissue destruction, such as those found near the cornea of the eye, and those found in the stomach, and damaged joint tissue of rheumatoid...
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4273785 |
Benzaldehydes, alkanophenones, and benzophenones and derivatives thereof containing a 4-monoalkylamino group
Novel 4-monoalkylamino-benzaldehydes, 4-mono-alkylamino-alkanophenones, and 4-monoalkylamino-benzophenones, and derivatives and salts thereof, are disclosed which are useful as anti-atherosclerotic...
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4271187 |
Substituted phenyl alanine antihypertensive agents
A compound of the formula ##STR1## possesses antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their...
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4269822 |
Antiseptic dentifrice
An antiseptic dentifrice is provided which contains an enzyme system comprising an oxidizable amino acid substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen...
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4258058 |
Phenoxyalkylcarboxylic acid compounds and thrombocyte-aggregation inhibition
Phenoxyalkylcarboxylic acid compounds of the formula ##STR1## wherein R is hydrogen or lower alkyl R 1 is alkyl or aryl, aralkyl or aralkenyl radical, the aryl moiety of which can be...
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4243679 |
S-(3-Methyl-2-butenyl)cysteine
S-(3-methyl-2-butenyl)cysteine ##STR1## or a pharmaceutically acceptable salt thereof. The compound is an expectorant and can be applied in the form of capsules or dragees, solutions, syrups or...
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4241086 |
Method for treating rheumatism
A method for treating rheumatism and/or arthritis in mammals afflicted therewith by administering an effective amount of N-(2-mercapto-2-methylpropanoyl)-L-cysteine or a pharmacologically...
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4226884 |
L-gamma-glutamyl-taurine as extracted from parathyroid gland and method of treatment using same
A deproteinized, defatted aqueous extract of the parathyroid gland insoluble in benzene, chloroform and carbon tetrachloride is found to be L-gamma-glutamyl-taurine which has vitamin-A type...
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4224339 |
Treatment of disturbed keratinization
Preventive as well as therapeutic treatment to alleviate the symptoms of disturbed keratinization, consisting of the topical application of a solution, gel, lotion, cream, ointment, stick, powder...
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4218465 |
Glyoxylic acid hydrocarbylsulfonylhydrazones and therapeutic compositions
Glyoxylic acid hydrocarbylsulfonylhydrazones and therapeutic compositions containing the same. Said compounds are useful in treating cancer, they being active against leukemia P-388, for example.
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4216225 |
Methylmethioninesulfonium compounds, process for their preparation, and pharmaceutical compositions containing them
Methylmethioninesulfonium compounds of the formula ##STR1## wherein X.crclbar. represents an anion; R 1 represents a hydrogen atom or an acyl group of the formula -COR 3 in which R 3 ...
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4205088 |
Compositions of and new uses for N-acylanilinobutyric acids
Pharmaceutically-acceptable compositions containing, as an active ingredient, at least one N-acylanilinobutyric acid have uses unrelated to the choleretic activity suggested in U.S. Pat. No....
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4196216 |
Novel benzylidene amini-oxyalkyl carboxylic acids and carboxylic acid derivatives
Certain nuclear substituted benzylidene amino oxyalkyl carboxylic acids esters, amides and salts thereof have been found to have a strong anti-inflammatory activity and a potent analgetic activity....
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4176197 |
Method for treating acne vulgaris
The present invention relates to treatment of dermatological conditions. In more particular, it relates to the use of oxygen potentiating compositions not heretofore employed or recognized as...
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4162329 |
Combating fungi with dicarboxylic acid mono-arylhydrazides
Combating fungi with dicarboxylic acid mono-aryl-hydrazides of the formula ##STR1## in which R 1 and R 2 each independently is hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 ...
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4152457 |
Tropone derivatives
Tropone derivatives substituted with an amino-, thio- or oxy-derivative of oxalic acid or acetic acid are disclosed. In addition, the tropone nucleus can be optionally further substituted. The...
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4146638 |
N-(3-phenoxy-2-hydroxy-propyl)-N-(2-phenyl-2-hydroxy-ethyl)-amines
Compounds of the formula ##STR1## wherein R 1 is halogen, hydroxyl, amino, alkyl, alkoxy or acylamido, R 2 is hydrogen, hydroxyl, alkyl, alkoxy or carboxamido, R 3 is hydrogen, halogen,...
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4140797 |
Method for alleviating angiotensin related hypertension
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering to such hypertensive mammals an effective amount of an angiotensin converting...
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4132803 |
Mercaptoacylamidobenzoylglycine mucolytic process and compositions
N-[3-(mercaptoacetylamino)benzoyl]glycine, alkali metal and amine salts thereof are potent topically effective mucolytic agents.
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4130660 |
Method of inhibiting the complement system with trisubstituted naphthalene compounds
1,3,5- or 1,3,6-naphthalenetriyltris(sulfonylimino)-aryl acids and salts, useful as complement inhibitors, and 1,3,5- or 1,3,6-naphthalenetriyltris(sulfonylimino)aryl acid esters which are...
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4122189 |
Medicine for renal diseases
Methyl methionine sulfonium salts having the formula ##STR1## wherein R - represents an inorganic or organic anion are used in remedy for renal diseases and secondary hyper lipoidemia caused by...
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