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7612112 |
Methods of treatment using a gastric retained gabapentin dosage
A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
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7612045 |
Compounds, compositions and methods for controlling biofilms and bacterial infections
The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention...
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7608640 |
Glycine betaine and its use
The present invention provides pharmaceutical uses of betaines, and especially glycine betaine, such as for the treatment of thromboses not induced by hyperhomocystenemia or homocystinuria, of...
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7605182 |
Compounds that selectively bind to membranes of apoptotic cells
The invention relates to compounds that selectively bind to phospholipid membranes having the features of membranes of apoptotic cells, pharmaceutical compositions comprising the same and...
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7605166 |
Methods and compositions for treating rheumatoid arthritis
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an...
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7592371 |
External preparation
It is an object of the present invention to provide an external preparation having enhanced transdermal penetration of a mast cell degranulation inhibitor. It is also an object of the present...
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7579020 |
Controlled release arginine α-ketoglutarate
An oral formulation of arginine α-ketoglutarate is disclosed which formulation is comprised of arginine α-ketoglutarate and one or more excipient materials. A wide range of different controlled...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7550628 |
Process for preparing phenolic acid salts of gabapentin
The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are...
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7544715 |
Tumor imaging compounds
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
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7534818 |
Method of reducing alopecia and bladder toxicity of cyclophosphamide
The present invention discloses a method for reducing alopecia and bladder toxicity associated with the anti-cancer agent cyclophosphamide. The method comprises administering to an individual, in...
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7517909 |
Amino acids with affinity for the α2δ-protein
This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the...
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7507765 |
Geranyl compounds
This invention provides compounds having excellent antitumor activity, which are represented by the following formulae
in which R 1 , R 2 , R 3 , m, n and R 4 have the significations as given...
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7504422 |
Polyamine compounds
This invention relates to methods for treating retinopathy and repairing tissue damage. The methods include administering to a subject in need thereof an effective amount of one or more compounds...
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7498292 |
Combinatorial libraries of autoinducer analogs, autoinducer agonists and antagonists, and methods of use thereof
The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In...
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7488755 |
Derivatives of glycinergic R(+)-2-amino-3-hydroxypropanoic acid
The use of R(+)-2-amino-3-hydroxypropanoic acid derivatives, nitrogen substituted by a (C 1 -C 6 )alkyl, (C 3 -C 6 )alkenyl, 3-oxo(C 5 -C 6 )alkyl, 3-oxo(C 4 -C 6 )alken-2-yl, phenyl(C 1 -C 6...
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7485623 |
Reduction of breast density with 4-hydroxy tamoxifen
A method of treatment comprises administering 4-hydroxy tamoxifen percutaneously to a patient having dense breast tissue. The 4-hydroxy tamoxifen may be formulated in a hydroalcoholic gel or an...
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7482026 |
Compositions and methods directed towards sore muscles and joints
Chemical formulations and methods for reducing muscle and joint soreness are disclosed. A representative chemical formulation includes compounds such as a selenium-compound, chondroitin sulfate,...
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7468390 |
Methods of treatment and pharmaceutical composition
The invention relates a pharmaceutical composition comprising a combination of:
(i) the AT 1-antagonist valsartan or a pharmaceutically acceptable salt thereof; and (ii) a NEP inhibitor or a...
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7459446 |
Treatment of diabetes with copper binding compounds
Novel methods of treating a patient for diseases, disorders, and conditions including diabetes mellitus, comprising administering, for example, copper binding compounds.
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7456312 |
Phenolic acid salts of gabapentin in solid dosage forms and methods of use
The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions....
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7456216 |
Methods for the preparation and formulation of l-carnitine valproate salts
The present invention relates to methods for preparing an L-carnitine valproate salt and administering this compound to a subject in need of treatment with valproate. Pharmaceutical compositions...
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7445801 |
Stable bicarbonate-based solution in a single container
Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a...
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7432299 |
Method of treatment for sexual dysfunction
Use of an alpha-2-delta ligand, or a pharmaceutically acceptable derivative thereof, for the manufacture of a medicament for the treatment of premature ejaculation.
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7429673 |
TRPV1 agonists, formulations containing them and uses thereof
The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C 6 -C 12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl...
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7427619 |
Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy
Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of...
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7425649 |
4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for...
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7419981 |
Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly...
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7411083 |
Substituted acetic acid derivatives
The present invention relates generally to substituted acetic acid derivatives and methods of using them.
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7402611 |
Use of amino acids for making medicines for treating to insulin-resistance
The invention concerns the use of monohydroxy or polyhydroxy amino acids, and the lactone forms thereof for making medicines with insulin-analogue and/or insulin-sensitizing effects on peripheral...
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7399776 |
Polyamine compounds for treating chemokine receptor mediated diseases
This invention relates to a method for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, or tissue injuries. The method includes administering to a subject...
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7393974 |
Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
A conversion process of gabapentin hydrochloride into gabapentin comprising: a) dissolution of gabapentin hydrochloride in a solvent in which the gabapentin hydrochloride and the gabapentin are...
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7393872 |
Sodium channel blocker compositions and the use thereof
Methods of treating or preventing chronic pain or convulsion are disclosed by administering to an animal a sodium channel blocker and at least one of gabapentin and pregabalin. Also disclosed are...
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7388030 |
Suppressors of anemia and appetite suppressors and methods for suppressing anemia and suppressing appetite
The present invention provides a method for suppressing hemolytic anemia by selectively ameliorating reticulocyte increase and iron deposition on spleen caused as the side effects of methionine....
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7381747 |
Alpha 2 delta ligands for post-traumatic stress disorder
This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs...
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7381746 |
2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivative
One object of the present invention is to provide a drug that is effective in treatments for and prevention of psychiatric disorders and in treatments for and prevention of neurological diseases,...
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7381713 |
Treatment of cancer by reduction of intracellular energy and pyrimidines
This invention provides a method for treating a cancer subject comprising administering to the subject a combination of ATP-depleting agents at concentrations which deplete the ATP level to at...
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7354954 |
Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy
According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the...
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7348361 |
Solution for diagnosing or treating tissue pathologies
The invention concerns a 5-aminolevulinic acid ester (E-ALA) solution for producing a pharmaceutical preparation useful for diagnosing and/or treating tissue and/or cell pathologies by local...
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7338675 |
Fenugreek seed bio-active compositions and methods for extracting same
A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells. Preferably, the composition of...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7318930 |
Control methods for boring bark beetles
A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described....
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7309719 |
Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same
The present invention provides a stabilized pharmaceutical preparation of a 4-amino-3-substituted-butanoic acid derivative which can be obtained by incorporating an amino acid as a stabilizer.
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7304044 |
Lowering blood glucose, urea, cholesterol, triglycerides and normalizing homocysteine levels by dietary addition of selected essential amino acids and three vitamins
Administration of a dietary supplement consisting of L-Tryptophan (80 mgs), L-Methionine (90 mgs), L-Valine (103 mgs), L-Lysine Monohydrochloride (128 mgs), Vitamin B-12 (0.5 mg), Vitamin B-6 (10...
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7288570 |
Stimulation of in vivo production of proteins
The invention relates to a formulation in the form of a pharmaceutical composition, a food product, a feed product or a dietary supplement, comprising leucine and protein in specific amounts....
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7256216 |
Liquid pharmaceutical compositions
A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5.5 to about 7.0 and additionally a two-component...
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7255882 |
Enkephalinase inhibitor and GABA precursor loading as anti-anxiety compositions
Benzodiazepine withdrawal induced anxiety is treated by administration of an enkephalinase inhibitor, and a gamma-aminobutyric acid (“GABA”) precursor, or an endorphin or enkephalin releaser....
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7247652 |
β-benzyloxyaspartate derivatives with amino group on benzene ring
L-threo-β-benzyloxyaspartate derivatives having a substituent on the benzene ring, represented by the following formula (1):
wherein R is hydrogen, a linear or branched lower aliphatic acyl...
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RE39734 |
Nutritional or therapeutic compositions to increase bodily glutathione levels
Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance...
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7241808 |
Composition for treatment of skin and method for stabilizing the composition
A composition for the treatment of skin comprises a carboxylated, acidic amino acid obtained by acidifying an acidic amino acid with a carboxylic acid. The resultant material, which is also...
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