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5491135 |
Compositions of N-(phosphonoacetyl)-L-aspartic acid and methods of their use as broad spectrum antivirals
Compositions and methods are disclosed which utilize the broad spectrum antiviral activity of PALA. This compound and its pharmaceutically acceptable analogs possess potent activity while...
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5480909 |
Method for inhibiting generation of free-radicals
Certain incidents in mammals trigger the generation of free-radicals which are associated with cell death. Animals experiencing such medical incidents are dosed with pyruvate salts or esters in an...
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5476849 |
Methods for glycosylation inhibition using amino-benzoic acids and derivatives
The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent...
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5470879 |
Treatment of non-insulin-dependent diabetes
Antidiabetic composition, characterized in that it contains as active substance, in the free or combined state, at least one mono- or polyhydroxylated amino acid and/or its lactone forms and its...
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5470878 |
Cell signaling inhibitors
Therapeutic compounds have the formula: (X)j-(non-cyclic core moiety), j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate,...
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5462726 |
Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives...
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5462967 |
Feed additive for livestock and feed for livestock
A feed additive which is effective for preventing and/or treating protozoiasis of livestock such as coccidiosis and for suppressing accumulation of fat of livestock is disclosed, which comprises...
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5455271 |
Tight-binding inhibitors of leukotriene A.sub.4 hydrolase
Inhibitors of leukotriene A 4 hydrolase are disclosed, corresponding to Formula I, below: ##STR1## wherein the depicted --NH 2 group is in the (S) configuration; --W is --CH 2 SH, --CH 2 NH 2 ...
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5451402 |
Method for killing yeast and sporular microorganisms with haloperoxidase-containing compositions
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or...
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5447918 |
Gastrointestinal anti-irritant composition comprising sucralfate and methods of use
A composition comprising sucralfate and one or more anti-acid epigastralgic relieving agents in a weight ratio of between 0.5:1.0 to 1.3 sucralfate to anti-acid epigastralgic relieving agent and a...
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5430064 |
Treating AIDS and HIV infection with methionine
This invention concerns novel safe compositions containing as an active antioxidant or antiinflammatory agent and thiol-repleting agent, the amino acid methionine, and/or one or more related...
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5428073 |
Antimicrobial agents which are substituted 2-cyclohexan-1-yl-amine compounds.
There are described new 2-cyclohexan-1-yl-amine derivatives of formula (I) ##STR1## in which A, R 1 , R 2 , R 3 and R 4 have the meaning given in the description, and processes for their...
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5418223 |
Method for lyophilization of cyclophosphamide and product
A process for preparing a pharmaceutical preparation consisting essentially of a lyophilized cake of cyclophosphamide monohydrate and a bulking agent which comprises freezing cyclophosphamide, a...
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5418253 |
Esters of L-carnitine and alkanoyl L-carnitines with glycolic acid or esters thereof and pharmaceutical compositions containing same for treating dermatoses
Ester of L-carnitine and alkanoyl L-carnitines with glycolic acid and esters thereof are disclosed, which are formulated into topically applicable pharmaceutical compositions for the treatment of...
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5415863 |
Topical containing aminocaproic acid for preventing secondary hemorrhage following hyphema
A topical gel formulation containing aminocaproic acid prevents secondary hemorrhage following hyphema without the adverse side effects associated with systemically delivered aminocaproic acid. Of...
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5411757 |
Palatable balanced amino acid-modified diet
In the present invention, L-amino acids comprise the medical food which provides a source of protein-equivalent of free purified L-amino acids in a palatable powdered form which can be incorporated...
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5407793 |
An aqueous heart preservation and cardioplegia solution
A process for preserving a patient's organ for transplantation and cardioplegia during cardiac surgery is disclosed which includes harvesting the patient's organ for transplantation or arresting...
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5405620 |
Pharmaceutical composition for treating mucoviscidosis and chronic pain syndromes deriving from degenerative locomotor diseases or tumorous origin
The pharmaceutical composition according to the invention consists essentially of: i) one or more, pharmaceutically acceptable, water soluble compounds of boron, fluorine, magnesium, vanadium,...
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5393784 |
Treatment of tardive dyskinesia with leucine, isoleucine, valine or mixtures thereof
The present invention relates to a method of remitting or attenuating the symptoms of tardive dyskinesia which can be secondary to treatment of psychiatric disorders with antipsychotic drugs, by...
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5391575 |
Method for treating neurofibromatosis
The present invention provides methods for treating neurofibromatosis in humans by administering to an afflicted host pharmaceutical compositions containing a therapeutically effective amount of a...
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5389359 |
Pharmaceutical preparation containing L-aspartate or L-asparagine for preventing ethanol toxicity, and process for preparation thereof
Compositions containing L-aspartate or L-asparagine for use as additives to foods, soft drinks, vitamins, and the like are described. A method for preventing ethanol toxicity in a human subject is...
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5389369 |
Halo peroxidase containing compositions for killing yeast and sporular microorganisms
Methods and compositions are provided for killing or inhibiting the growth of yeast or sporular microorganisms by contacting the microorganisms, in the presence of a peroxide and chloride or...
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5382590 |
N-phenyl-N-acetamidoglycinamides, their preparation and medicaments containing them
Compounds of formula: ##STR1## in which R 1 represents a hydrogen atom or an alkyl, alkoxycarbonyl or an unsubstituted or substituted phenyl radical, R 2 represents a hydrogen atom or an...
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5380759 |
Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia
Methyl N-[6-(3,4,5-trimethoxybenzloxy) imidazo [1,2-6]pyridazin-2-yl]carbamate is disclosed which is used to treat leukemia.
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5374651 |
Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives
Methods and compositions for treating and inhibiting hypotension are provided. A therapeutic regimen useful in the present invention includes an arginine-free parenteral formulation administered...
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5374654 |
9-substituted carbacyclin derivatives, processes for their preparation, and their use as medicinal agents
The invention relates to carbacyclin derivatives of Formula I ##STR1## wherein the various substituents are defined herein, including, inter alia, if R 2 is a hydrogen atom, their salts with...
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5368841 |
Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
A method of treating proliferative diseases of the synovial joint using photodynamic therapy. In particular the method of the invention may be used to destroy synovial tissue in inflammatory joint...
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5366869 |
Multiple coagulation test device and method
A multiple coagulation test device has a plurality of tubes, each tube having associated coagulation detection means, and containing a treatment dosage of a coagulation enhancing agent. Whole blood...
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5366723 |
Method of alleviating toxicity originating from treatment with anticancer platinum compounds
The present invention concerns a method of administering the amino acids L-glutamic acid, L-aspartic acid and L-cysteine for alleviating the toxicity associated with the administration of...
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5356873 |
Method for providing nutritional requirements to patients having a chronic inflammation reaction
The present invention relates to methods for providing nutritional requirements to a patient having a chronic inflammatory reaction by administering to the patient an enteral composition that has a...
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5354771 |
Methods for treatment of sepsis using branch chain amino acids
Methods for treatment of free-radical-mediated tissue injury, particularly sepsis, are provided wherein compositions containing at least one keto analog of a branched-chain amino acid are...
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5350766 |
Method for the prevention and/or palliation of the complications of diabetes using N-alpha orginine acetyl
The invention relates to a method for treating the complications of diabetes mellitus which comprises the administration to an individual afflicted with diabetes mellitus of an effective amount of...
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5344843 |
Cat-1 inhibitors, pharmaceutical compositions and methods of use
The invention relates to compounds of the formula ##STR1## wherein R 1 , R 2 , R 2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate,...
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5334617 |
Amino acids useful as inhibitors of the advanced glycosylation of proteins
The present invention relates to compositions and methods for inhibiting protein aging. Accordingly, a composition is disclosed which comprises an agent or compound capable of inhibiting the...
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5332758 |
Collagen metabolism ameliorant and its use
This invention relates to a collagen metabolism ameliorant containing N-methyl-L-serine as an active ingredient, more particularly, a collagen metabolism ameliorant efficacious against collagen...
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5324504 |
Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI
Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The...
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5324731 |
Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism...
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5321030 |
Creatine analogs having antiviral activity
The present invention relates to the use of analogs of creatine, such as cyclocreatine, as antiviral agents. Analogs of creatine can be used as antiviral agents against a variety of viruses,...
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5310768 |
Method for improving the glutamine content in skeletal muscle and composition therefore
A method of treatment of postoperative and posttraumatic patients for improving the glutamine content in skeletal muscle by administrating alpha-ketoglutarate; also, a composition for carrying out...
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5302609 |
Treatment of diabetic nephropathy
The present invention is a novel method for the treatment of renal hypertrophy and hyperplasia associated with diabetic nephropathy. The method of the present invention generally comprises the...
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5300526 |
Porphyric insecticides
Insecticidal compositions comprising one or more compounds selected from the group consisting of delta-aminolevulinic acid, inducers of delta aminolevulinic acid, and enhancers of...
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5294642 |
Method for improving ventilation during sleep and treating sleep related ventilation abnormalities
A method for improving ventilation during sleep and treating sleep-related ventilation abnormalities. To this end, the present invention provides a method of using branched-chain amino acids as an...
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5292535 |
Hyperosmotic solutions for isonatremic resuscitation
The invention provides a physiologically acceptable solution for treating circulatory shock in mammals which is hyperosmotic as compared to blood plasma. The solution contains a reabsorbable solute...
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5290552 |
Surgical adhesive material
The present invention provides a surgical adhesive comprising, in an aqueous composition, fibrinogen, FXIII, collagen, thrombin, Ca 2 + and optionally, an antifibrinolytic agent. The present...
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5290538 |
Nephro protective infusion solutions
The invention herein is a method of protecting against renal damage in a patient receiving carboplatin, cyclosporine A or cisplatin comprising administering to said patient the following mixture of...
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5286498 |
Rapid extraction of ciguatoxin from contaminated tissues
The present invention relates to methods for the rapid extraction of ciguatoxins from tissue samples. In one embodiment, a tissue sample is extracted with a first solvent to solubilize and extract...
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5286739 |
Parenteral formulations for the inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
An anti-hypotensive formulation comprising an essentially arginine-free or low arginine (less than about 0.1%, most preferably, about 0.01%) containing mixture of amino acids is provided. The...
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5283067 |
Parenteral suspensions
The invention relates to a dry formulation, in particular a dry formulation obtainable by lyophilisation, which is suitable for the preparation of a stable, aqueous suspension for the parenteral...
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5278190 |
Method for improving the quality of sleep and treating sleep disorders
A method for improving the quality of sleep in a chronic renal failure patient is provided. To this end, the present invention provides a method of using branched-chain amino acids as an effective...
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5278189 |
Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
A method is provided for prevention and treatment of cardiovascular disease, such as atherosclerosis, by administering therapeutically effective dosages of a drug comprised of ascorbate,...
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