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6020308 Methods for improving therapeutic effectiveness of treatment of vascularization disorders  
The present invention is directed to the use of an inhibitor of NO activity, such as a nitric oxide scavenger or an NO synthase inhibitor, as as an adjunct to treatment of inappropriate tissue...
6020370 Bridged cyclic amino acids as pharmaceutical agents  
6017961 Ketamine and n-butyl-p-aminobezoate in PLO  
The present invention relates to a novel ointment combining Ketamine and n-butyl-p-aminobenzoate (BAB) that is self-administered topically by a subject to alleviate Neuropathic pain, Sympathetic...
6017957 Partial agonists of the strychnine insensitive glycine modulatory site of the N-methyl-D-aspartate receptor complex as neuropsychopharmacological agents  
A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which...
6017900 Topical composition containing hyaluronic acid and nsaids  
A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology or trauma of skin or exposed tissue of...
6015834 In vivo treatment of mammalian cells with a cell membrane permeant calcium buffer  
A method of reducing the damaging effect of an injury to mammalian cells by treatment of the cell or mammalian tissue in vivo with a cell membrane permeant calcium buffer. The method comprises...
6015828 Chemical modification of chloride channels as a treatment for cystic fibrosis and other diseases  
This invention relates generally to medical treatment methods. Specifically, the invention relates to methodology for the correction of defective chloride transport by activation of chloride...
6013672 Agonists of metabotropic glutamate receptors and uses thereof  
Astrocytes protect neurons from excitotoxic injury by maintaining low extra-cellular glutamate concentrations ([Glu]o). Compromised astrocytic glutamate uptake has been implicated in acute and...
6011066 Method for treating septic shock  
A method for the treating septic shock in a patient comprises administering to the patient a therapeutically-effective amount of a composition comprising a compound having the formula (I): ##STR1##...
6007865 Reversing the formation of advanced glycosylation endproducts  
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent...
6008188 Cytokine potentiator and pharmaceutical formulation for cytokine administration  
A cytokine activity enhancer comprising an ethanolamine derivative of the following general formula (I) or a salt thereof, or comprising it along with cytokine or a cytokine production promoter;...
6007808 Pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders  
The present invention refers to pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders.
6008249 Pharmaceutical, orally applicable composition  
A pharmaceutical, orally applicable composition is described, whereby the solid composition contains at least one active ingredient, at least one disintegrant, as well as at least one usual...
6004958 Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention  
The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction....
6001876 Isobutylgaba and its derivatives for the treatment of pain  
The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid in pain therapy.
6001877 Phenylalkan(en)oic acid  
The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B4.
5993779 Method for producing non-human animal having spinal cord injury  
A method for producing a non-human animal suffering from a spinal cord injury, which comprises interrupting an aorta at least at two sites, thereby forming an isolated segment of the aorta...
5993864 Chlorine dioxide chelate compositions and method of use  
A novel chelate complex allows the formation of stable solutions of molecular chlorine dioxide. The chelate complexes are composed of the electron-deficient chlorine dioxide molecule, which can...
5993863 Alimentative infusion liquids for administration through peripheral vein  
The present invention aims at providing an alimentative infusion liquid which has improved stability and preservability and can be administered through a peripheral vein. The infusion liquid...
5990165 Pharmaceutical compounds  
A pharmaceutical compound of the formula: ##STR1## in which n is 1 or 2, R1 is --CO2 H, R2 is hydrogen or C1-4 alkyl and R3 is hydrogen, C1-10 alkyl, C2-10 alkenyl, optionally substituted phenyl,...
5985859 Methods of inhibiting bacterial sialidase  
A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO2 H, PO2 H, or SO2 H; B is N; R1...
5985926 Method for inhibiting intracellular viral replication  
There is disclosed a method of preventing or delaying the occurrence of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV) seropositive humans by administering an...
5981284 Technique for acceleration of apoptotic cell death  
A first embodiment of a cell culture system has a cell death accelerator comprising one or more cell death inducing substances, including serum albumin, hemoglobin, glycine and glutamic acid. In a...
5973004 L-carnitine, acetyl-L-carnitine, and pantothenic acid or ubiquinone, combined for prevention and treatment of syndromes related to ineffective energy metabolism  
A combination can be of L-carnitine and acetyl-L-carnitine, preferably with pantothenic acid or ubiquinone, is administered orally or as a parenteral injection in domesticated animals, especially...
5965529 Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor  
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
5962523 Methods of using butyric acid derivatives to protect against hair loss  
The present invention relates to methods of protecting against injury to hair follicles in a mammal by administering an effective amount of butyric acid or a biologically active butyric acid...
5962032 Pharmaceutical compositions for controlling unitary smooth muscle polarization  
Pharmaceutical compositions for regulating unitary smooth muscle polarization containing aqueous solutions based on magnesium, potassium, sodium and optionally calcium salts, at least one sugar and...
5962413 Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor  
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
5958976 Composition and method for reducing stinging in skin  
The invention relates to topical cosmetic or pharmaceutical compositions comprising an anti-stinging effective amount of an amino acid selected from the group consisting of an amino butyric acid,...
5958878 Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors  
The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in...
5955450 Peritoneal dialysis solutions and methods usable to minimize the injury and adverse physiological effects caused by peritonitis  
Peritoneal dialysis solutions are specially formulated for use during and immediately after an episode of peritonitis. The solutions include one or more additives to minimize the injury and...
5952379 Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts  
Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines with mucic acid of formula (I) are disclosed wherein the molar ratio between the carnitine moiety and mucic acid is 2:1. A...
5948780 Method for treating and preventing heart failure and ventricular dilatation  
Matrix metalloproteinase inhibitors are useful for preventing and treating heart failure, and ventricular dilatation in mammals.
5948443 Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease  
The present invention pertains generally to the field of Public Health, including the prevention and treatment of coronary heart disease which is currently the first cause of death in the American...
5945450 Naphthalene derivative  
Naphthalene derivatives represented by formula I!: ##STR1## (wherein A is a hydrogen atom, a hydroxy group, a C7 -C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1 -C12...
5942544 α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors  
The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
5942534 Photodynamic therapy for the treatment of osteoarthritis  
A method of treating a patient who has osteoarthritic disease by administering a therapeutic composition containing a photoactivatable compound, or a precursor thereof, and administering light of a...
5935975 Agonist-antagonist combination to reduce the use of nicotine and other drugs  
A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or an agonist of...
5935988 Tolerability of pharmaceutically active β-amino acids  
The present invention relates to mixtures of α-amino acids and/or derivatives thereof and cyclopentane-β-amino acids and/or derivatives thereof, dipeptides of the abovementioned α-amino acids an...
5935994 Nutritionally balanced dermal composition and method  
A composition and method for enhancing the appearance of the skin, the composition containing a mixture of essential amino acids, a penetrant, a neucleotide, vitamin C and vitamin E.
5932229 Oxa diacids and related compounds for treating skin conditions  
Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin...
5922361 Folic acid enriched dietary supplement compositions for self-regulating stress-reduction  
A food supplement compositions combining suitable precursor substrates with folic acid, whereby methionine is produced in sufficient quantity to produce a sufficient quantity of met-enkephalin...
5919823 Treatment of secondary movement disorders using large neutral amino acids  
The present invention relates to a method of remitting or attenuating the symptoms of movement disorders which can be secondary to treatment of psychiatric disorders with antipsychotic drugs mainly...
5916912 Dietary composition for enhancing metabolism and alleviating oxidative stress  
The metabolic rate of aged cells of a mammalian host is enhanced without a concomitant increase in metabolic production of reactive oxygen species by orally administering to the host an effective...
5916573 Topical treatment of the skin with a grapeseed oil composition  
A grapeseed oil composition for topical application to the skin comprising: a) about 1 to about 99% by weight of grapeseed oil; b) at least one hydrating agent; and c) water. Hydrating agents...
5916922 Phenyl glyoxamides as SPLA2 inhibitors  
A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
5916920 3-substituted Bicyclo 3.1.0!hexane-6-carboxylic acids  
Compounds of the formula ##STR1## in which X represents a bond, S, O or NRa ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
5916921 Therapeutic agents for liver regeneration  
A therapeutic agent for liver regeneration which contains valine as an active ingredient is disclosed that is effective against hepatopathy in hepatitis, fatty liver and drug-induced liver...
5914135 Liquid antacid compositions  
Calcium carbonate liquid antacid compositions containing one or more pH adjusting agents to maintain the pH above 9.0, preferably above 9.5. The resultant antacid liquid possesses superior...
5912248 Excitatory amino acid receptor antagonists  
Compounds of the formula ##STR1## in which X represents a bond, S, SO or SO2 ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.