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7598224 |
Dual chain synthetic heparin-binding growth factor analogs
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
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7585642 |
Methods for evaluating the quality of a heparin sample
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
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7575886 |
Analysis of sulfated polysaccharides
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including...
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7563762 |
Composition and process for stabilizing of biomolecules
The present invention relates in general to the field of biotechnology. The invention particularly relates to a composition and process for stabilizing or preserving biological molecules, as well...
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7560444 |
Polysaccharides for pulmonary delivery of active agents
Formulation for pulmonary delivery of a therapeutic, prophylactic, or diagnostic agent including a low molecular weight heparin and a therapeutic, prophylactic, or diagnostic agent.
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7550444 |
Composition and method for preparing biocompatible surfaces
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some...
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7550443 |
Process and systems for biocompatible surfaces
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are...
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7541445 |
Synthetic heparin pentasaccharides
Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
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7538096 |
Treatment and prevention of abnormal cellular proliferation
This invention provides a method for inhibiting or preventing the abnormal growth of cells, including transformed cells, by administering an effective amount of O-acylated heparin derivative....
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7504113 |
Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic...
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7479505 |
Use of taurolidine to treat tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof....
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7468358 |
Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome
A method and medicament for treating and preventing platelet activation or thrombosis in the presence of heparin-and platelet factor 4-complex reactive antibodies using a 2-O desulfated heparin...
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7468210 |
Cross-linked heparin coatings and methods
A thromboresistant coating for a medical device, method of coating and coated medical device, the coating including an in situ cross-linked co-polymer of a cross-linkable biomolecule, preferably an...
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7462735 |
Amino acid diamides in non α position which are useful as adjuvants for administration of biological active agents
Amino acid diamides in non α position of formula (1), wherein R 1 is selected from amongst the group consisting of the functional groups alkyl, halogen, NO 2 , OH, OCH 3 alone or associated and...
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7449200 |
Nanoparticles for protein/peptide delivery and delivery means
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are...
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7407945 |
Use of sulfated glycosaminoglycans for establishing effective labor in women
The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic...
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7399604 |
Methods and products related to evaluating the quality of a polysaccharide
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
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7393840 |
Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of...
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7332480 |
Compositions for the regulation of cytokine activity
Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the...
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7297343 |
Bioactive medical films
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a...
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7279183 |
Method of reducing thrombosis and complications after arterial angioplasty using stent coated with magnesium-based compound
Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7226914 |
Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections
A method for treating and preventing various infections, including papilloma virus and fungal and parasitic infections is provided. In particular, an effective amount of a sulphated polysaccharide,...
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7214667 |
Drugs against articular failure
The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans....
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7202230 |
Use of hyaluronic acid derivatives in the preparation of biomaterials with a physical haemostatic and plugging activity
The present invention describes the use of polysaccharide derivatives for the preparation of biocompatible and biodegradable biomaterials with absorbent properties for body fluids and physical...
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7202087 |
Anticoagulant composition
A solid heparin tablet composition has a melting point of 25° C. or higher and is a continuous lipid component containing one or more polar lipids, one or more non-polar lipids, optionally one or...
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7196073 |
Imine-forming polysaccharide adjuvants and immunostimulants
The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds...
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7192984 |
Compositions of polyacids and polyethers and methods for their use as dermal fillers
The present invention relates to improved methods for filling the skin for cosmetic or medical purposes. Compositions comprising carboxymethyl cellulose (CMC), polyethylene oxide (PEO) and calcium...
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7157445 |
Administration of enoxaparin sodium to patients with severe renal impairment
Methods having novel enoxaparin sodium dosing regimens for patients with severe renal impairment are disclosed. The methods may be used for one or more of preventing thrombotic episodes, treating...
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7151099 |
Use of taurolidine and/or taurultam for treatment of abdominal cancer and/or for the prevention of metastases
Taurolidine and/or taurultam is administered during and after surgical removal of a cancerous tumor to treat abdominal cancer.
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7132413 |
Anticoagulant/sterilizing compositions and methods
Compositions and methods are provided for preventing formation of thrombosis on a liquid-contacting surface of a liquid delivery system, such as a port, catheter or port-catheter system. The liquid...
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7129224 |
Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the...
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7101859 |
Use of lipid conjugates in the treatment of diseases
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers....
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7078392 |
Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections
A method for treating and preventing various infections, including papilloma virus and fungal and parasitic infections is provided. In particular, an effective amount of a sulfated polysaccharide,...
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RE39192 |
Supplemented and unsupplemented tissue sealants, methods of their production and use
This invention provides supplemented tissue sealants, methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one cytotoxin or cell proliferation...
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7071174 |
Method and composition for inhibiting cholesterol esterase
This invention encompasses methods for manufacturing purified, high molecular weight sulfated polysaccharide compositions that inhibit pancreatic cholesterol esterase and lower cholesterol in the...
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7034061 |
Non-thrombogenic and anti-thrombogenic polymers
Polymers having non-thrombogenic properties can be prepared by copolymerizing monomers of at least three classes selected from (a) monomers having sulphate groups, (b) monomers having sulphonate...
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7034006 |
Use of lipid conjugates in the treatment of disease
The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers....
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7014655 |
Method for conserving biological prostheses, conserved biological prostheses and conserving solutions
The invention concerns a method of conserving biological prostheses, wherein the method includes the following steps: (a) treating biological prostheses with a solution which contains a mixture of...
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7011953 |
Diagnostic assay for type 2 heparin-induced thrombocytopenia
Methods for detecting the presence of antibodies to PF4/heparin/TSP-1 complexes in a biological sample and for diagnosing Type 2 heparin-induced thrombocytopenia are described.
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7008933 |
Process for prophylaxis and therapy of thrombotic processes employing heparin having particular average molecular weights
A process for prophylaxis and therapy of thrombotic processes includes preparing heparin having an average molecular weight ranging from 10 to 11.5 kd; formulating a pharmaceutical preparation...
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7005426 |
Folic acid-polysaccharide complex, its preparation method and pharmaceutical composition containing the same as active component
The present invention relates to folic acid-polysaccharide complexs and method of preparation thereof, more particularly relates to folic acid-Dextran complexs, method of preparation thereof,...
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6979680 |
Glycosaminoglycans having an average molecular weight of 2400 D suitable for the treatment of senile dementia
The present invention relates to the use of glycosaminoglycans having an average/molecular weight of 2,400 D for the preparation of pharmaceutical compositions suitable for the treatment of senile...
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6977248 |
Pharmaceutical preparations for the inhibition of herpes simplex virus 1 entry
Disclosed herein are polysaccharide preparations enriched in 3-OST-3 modified heparan sulfate. Also disclosed are methods of treating herpes simplex viral type-1 infection using the pharmaceutical...
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6969705 |
Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
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6953784 |
Cross-linked polysaccharide drug carrier
A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to...
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6943154 |
Water insoluble derivatives of polyanionic polysaccharides
A water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a nucleophile, and an activating agent, under conditions...
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6924273 |
Chondroprotective/restorative compositions and methods of use thereof
The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery,...
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6908907 |
Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients
This invention provides for the prevention and treatment of tumor growth, metastasis, and cancer-mediated thrombosis through the administration, in combination, of a short or long acting GPIIb/IIIa...
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