|
Match
|
Document |
Document Title |
|
|
8173384 |
Methods for analyzing or processing a heparin sample
The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and...
|
|
|
8168599 |
Composition and method for healing tissues
The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is...
|
|
|
8163717 |
Dual chain synthetic heparin-binding growth factor analogs
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
|
|
|
8153591 |
Protein biomaterials and biocoacervates and methods of making and using thereof
The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates...
|
|
|
8153147 |
Heparin coating of biological tissue
The present invention discloses an in vitro method to provide biological tissue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an...
|
|
|
8106007 |
Conjugates of a polypeptide and a pentasaccharide
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being...
|
|
|
8101196 |
Polysaccharide biomaterials and methods of use thereof
The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example,...
|
|
|
8092818 |
Medical devices having bioactive surfaces
According to an aspect of the present invention, medical devices are provided, which contain (a) a substrate and (b) a polymeric region disposed over the substrate which contains at least one block...
|
|
|
8088753 |
Heparin conjugates and methods
Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the...
|
|
|
8076312 |
Use of lipid conjugates in the treatment of disease
This invention provides a method of preventing asthma, allergic rhinitis, or chronic obstructive pulmonary disease in a subject comprising the step of administering to a subject a compound...
|
|
|
8071570 |
Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method...
|
|
|
8071571 |
Orlistat compositions
A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
|
|
|
8071569 |
Oxidized heparin fractions and their use in inhibiting angiogenesis
The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from about 1% to about 100% of hydroxyl...
|
|
|
8063026 |
Method of palliating lower urinary tract infections by treatment with mannan oligosaccharides
Provided herein are methods of using mannan oligosaccharides, to treat, palliate, relieve, prevent and/or eliminate urinary tract infections of humans. A mixture of oligosaccharides derived from...
|
|
|
8057535 |
Implantable medical device
The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an...
|
|
|
8057816 |
Compositions and methods of administering paclitaxel with other drugs using medical devices
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs...
|
|
|
8048442 |
Modified heparin-based coatings and related drug eluting stents
Systems comprising modified heparin-based coatings to form coatings on medical devices are provided. The systems improve the suitability of the heparin-based coatings.
|
|
|
8026209 |
Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced...
|
|
|
8003623 |
Mixtures of sulfated oligosaccharides
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method...
|
|
|
7981871 |
Modified macromolescules and associated methods of synthesis and use
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive...
|
|
|
7981873 |
Use within transplantation surgery
The present invention is within the field of transplantation surgery. More closely, the present invention relates to use of a clotting preventing agent in the production of a drug for...
|
|
|
7976860 |
Implant and process for its production
The present invention relates to an implant having a structured material component and having a protein matrix which has a pore structure. The structured material component is moreover at least...
|
|
|
7968527 |
Inhibition of FGF signaling
Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in...
|
|
|
7968082 |
Evaluating mixtures of low molecular weight heparins by NMR
Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
|
|
|
7939512 |
Multistep process for the physical depolymerization of heparin and products obtained therefrom
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two ...
|
|
|
7928089 |
Mucoactive agents for treating a pulmonary disease
The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and...
|
|
|
7875596 |
Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
Dermatan sulfates and/or O-desulfated heparins useful in treating and preventing heparinoid-induced autoimmune responses, in particular heparin-induced thrombocytopenia (HIT) and its associated...
|
|
|
7829549 |
Methods for treating bleeding disorders using sulfated polysaccharides
Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with...
|
|
|
7820722 |
Permeation enhancers
A pharmaceutical composition comprising a drug and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more...
|
|
|
7820638 |
Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density
A method for lubricating an implant or graft prior to implantation into a target implant site which enhances the lubricity of the implant or graft and promotes bone growth. The method comprises the...
|
|
|
7811999 |
Use of lipid conjugates in the treatment of diseases
This invention provides a method of treating a subject suffering from an obstructive respiratory disease, including the step of administering to a subject a compound comprising a lipid or...
|
|
|
7812007 |
Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
|
|
|
7812005 |
Glycosaminoglycans for treatment of emotional dysfunctions
The present invention relates to the use of glycosaminoglycan fractions having an average molecular weight of 2400 (±200) D for the preparation of pharmaceutical compositions suitable for the ...
|
|
|
7799338 |
Plaster for topical use containing heparin and diclofenac
Plaster for topical use having an analgesic activity and at the same time being able to re-absorb haematomas, comprising: a substrate layer;an adhesive layer in the form of a hydrogel matrix...
|
|
|
7790700 |
Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the...
|
|
|
7781416 |
Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in...
|
|
|
7772196 |
Use of lipid conjugates in the treatment of diseases
This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes...
|
|
|
7737130 |
Pharmaceutical compositions for topical use in treatment of skin or mucous injuries
The present invention describes new pharmaceutical compositions in treatment of skin and/or mucous injuries, new therapeutic use of compounds and use of compositions and compounds in treatment of...
|
|
|
7737131 |
Multifunctional and biologically active matrices from multicomponent polymeric solutions
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
|
|
|
7732427 |
Multifunctional and biologically active matrices from multicomponent polymeric solutions
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
|
|
|
7709461 |
Methods and products related to pulmonary delivery of polysaccharides
The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in...
|
|
|
7700563 |
Synthetic heparin-binding factor analogs
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two...
|
|
|
7696182 |
Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin
The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to...
|
|
|
7691829 |
Composition and method for healing tissues
The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is...
|
|
|
7687479 |
Methods and producing low molecular weight heparin
The invention relates, in part, to methods and products related to producing low molecular weight heparin.
|
|
|
7687249 |
Polysaccharide derivatives with high antithrombotic activity in plasma
The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N...
|
|
|
7655445 |
Methods for synthesis of sulfated saccharides
The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the...
|
|
|
7625552 |
Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces
According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the...
|
|
|
7598224 |
Dual chain synthetic heparin-binding growth factor analogs
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
|
|
|
7585642 |
Methods for evaluating the quality of a heparin sample
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...
|