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9012396 Use of lipid conjugates in the treatment of conjunctivitis  
In one embodiment, the invention provides a method of suppressing, inhibiting, preventing, or treating conjunctivitis in a subject, comprising the step of administering an effective amount of a...
8999340 Methods for treating multiorgan, systemic degos' disease with a complement inhibitor  
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and/or an inhibitor of interferon alpha, and the use of the compositions in methods for...
8992963 Immobilised biological entities  
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting...
8987231 Sulodexide for use in the treatment of pathologies wherein metalloproteinases are involved  
The present invention describes sulodexide or at least one of its components for use in the reduction of circulating matrix metalloproteinase (MMPs), in particular MMP-9. Sulodexide and its...
8969319 Agent for applying to mucosa and method for the production thereof  
An agent for applying to mucosa capable of persistently exerting a therapeutic effect on disorders such as inflammation and lesions in the mucosa even by a lower frequency of administration...
8937052 Therapeutic protocols using hyaluronan  
The present invention relates generally to the field of therapeutics and in particular, chemotherapy. Even more particularly, the present invention provides therapeutic strategies which reduce the...
8912167 Heparin-based compositions and methods for the inhibition of metastasis  
The invention provides the use in combination of a heparin containing composition that has anticoagulant activity when used alone, such as an unfractionated heparin or low molecular weight...
8906883 Treatment of oral mucositis by administering an ionic complex of chitosan and a negatively charged polysaccharide selected from heparin, heparan sulfate and dextran sulfate  
A composition having an ionic complex of chitosan and a negatively charged polysaccharide, selected from the group consisting of heparin, heparan sulfate and dextran sulfate, for use in the...
8906882 Lipid conjugates in the treatment of allergic rhinitis  
Provided herein are methods of treating, suppressing, inhibiting, or preventing allergic rhinitis in a subject comprising the step of administering to a subject a compound comprising a lipid or...
8901103 Use of lipid conjugates in the treatment of diseases  
This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes...
8883715 Biocompatible polymers, process for their preparation and compositions containing them  
A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following...
8883761 Use of lipid conjugates in the treatment of diseases associated with vasculature  
This invention provides for the use of compounds represented by the structure of the general formula (I): whereinR1 is a linear, saturated, mono-unsaturated, or poly-unsaturated, alkyl chain...
8865412 Methods and assays for oversulfated glycosaminoglycans  
Methods and assays for oversulfated glycosaminoglycans are provided. In an embodiment, the present disclosure provides a method for detecting oversulfated glycosaminoglycan (OS-GAG) in a heparin...
8865681 Use of lipid conjugates in the treatment of diseases or disorders of the eye  
In one embodiment, the invention provides a method of treating, reducing the incidence, reducing the severity or pathogenesis of an eye disease or disorder in a subject, including, inter alia,...
8859523 Crosslinked compounds and methods of making and using thereof  
Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) the oxidative coupling of two or more thiol compounds...
8859526 Methods for treating bleeding disorders using sulfated polysaccharides  
Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with...
8834913 Medical implants and methods of making medical implants  
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane...
8809302 Therapeutic approaches for treating alzheimer'S disease  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial...
8778886 Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits  
A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to...
8765152 Pharmaceutical or neutraceutical formulation  
The invention relates to a pharmaceutical or nutraceutical formulation comprising a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter and a...
8765672 Method of modulating release of biomolecules having heparin-binding affinity  
The present invention relates to a method of modulating a release of biomolecules having heparin-binding affinity, and more specifically, to a method of modulating a release of biomolecules having...
8765714 Sulphated hyaluronic acid for treating degenerative osteoarthritis  
This invention relates to oral and intra-articular formulations based on sulphated hyaluronic acid which are effective in the treatment of degenerative osteoarthritis.
8741873 Controls and kit for thrombocyte activity tests  
The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.
8716225 Kallikrein inhibitors and anti-thrombolytic agents and uses thereof  
Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or...
8715953 Analysis of sulfated polysaccharides  
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including...
8703739 Intravascular indwelling catheter lock solution containing weak acid and container containing the same  
A catheter lock solution which is a catheter lock preparation having a bacteriostatic property at physiological osmotic pressure without practically containing a bacteriostatic component such as a...
8703738 Biotinylated hexadecasaccharides, preparation and use thereof  
The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or...
8691793 Modified macromolecules and associated methods of synthesis and use  
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking and methods of making and using thereof.
8680075 Methods and compositions for inhibiting cellular proliferation and surgical adhesion  
A method for inhibiting cellular proliferation of fibroblasts and/or glioma cells in a mammal includes administering a composition to a mammal wherein the composition includes an amount of an...
8673880 Prevention and/or treatment of neurodegenerative disorders  
A pharmaceutical composition for use in the prevention and/or treatment of a neurodegenerative disorder comprising a compound comprised of one or more disaccharide units, the or each disaccharide...
8658620 Pharmaceutical composition, use of 2-iminopyrrolidine derivative for production of pharmaceutical composition, and kit for treatment or amelioration of heart diseases  
One embodiment of the present invention is a pharmaceutical composition comprising at least one specific 2-iminopyrrolidine derivative and at least one other compound (B). Another embodiment of...
8642082 Pharmaceutical compositions for the oral administration of heparin or derivatives thereof  
Pharmaceutical compositions suitable for the oral administration of heparin or derivatives thereof, particularly controlled-release oral pharmaceutical compositions containing heparin with...
8637087 Treatment of interstitial cystitis using (6aR, 10aR)-Δ8-tetrahydrocannabinol-11-OIC acids  
The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, which are useful in treating interstitial cystitis and relieving symptoms thereof. The invention uses...
8613929 Methods and compositions for targeting agents into and across the blood-brain barrier and other endothelial cell microvascular barriers  
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic...
8609632 Low molecular weight heparin composition and uses thereof  
Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such...
8607989 Filter composites for drug detoxification  
A filter and a method of forming a suture structure. The filter includes layered structure(s) interior to the filter. Each layered structure includes a carbon structure comprising carbon and a...
8604003 Promoter for hard tissue formation  
The present invention provides an agent which induces acceleration of hard tissue formation, acceleration of cell differentiation and increase in cellular alkaline phosphatase activity, by...
8597957 Evaluating heparin preparations for pharmaceutical use  
The disclosure features methods of analyzing preparations of heparin, and materials derived from heparin using strong anion exchange high performance liquid chromatography (SAX-HPLC).
8592393 Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization  
Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
8569262 Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization  
Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.
8546354 Acylated decasaccharides and their use as antithrombotic agents  
The instant invention relates to decasaccharides of formula (I): wherein Ac represents an acetyl group and R represents a group of formula —OH or —OSO3−, in their acid form or in the form of any...
8541393 Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin  
The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to...
8529889 Methods and compositions related to the modulation of intercellular junctions  
The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for...
8524688 Use of sulfated glycosaminoglycans for establishing effective labor in women  
A method of treating protracted labor in a pregnant woman comprises administering to a pregnant woman an effective amount of a depolymerized low molecular weight heparin treated with periodate to...
8518909 Sulfated heptasaccharide and its use as an antithrombotic agent  
The instant invention relates to the heptasaccharide of formula (I): in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its process of preparation. The...
8512969 Methods for analyzing a heparin sample  
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing...
8507461 Non-absorbable non-digestible polymer compounds  
The present invention relates to compounds which are capable of exerting an inhibitory effect on the Na+ glucose cotransporter SGLT in order to hinder glucose and galactose absorption, as well as...
8501212 Immobilised biological entities  
There is described inter alia a medical device having a surface which comprises a coating layer, the coating layer being a biocompatible composition comprising an anti-coagulant entity capable of...
8501711 Acylated 1,6-anhydro decasaccharide and its use as an antithrombotic agent  
The instant invention relates to the decasaccharide of formula (I), wherein Ac represents an acetyl group: in its acid form or in the form of any one of its pharmaceutically acceptable salts, and...
8501701 Use of lipid conjugates in the treatment of disease  
The invention relates to methods of use for compounds in treating, reducing the incidence, reducing the severity or pathogenesis of an intestinal disease or condition in a subject, including,...