Match Document Document Title
8173384 Methods for analyzing or processing a heparin sample  
The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and...
8168599 Composition and method for healing tissues  
The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is...
8163717 Dual chain synthetic heparin-binding growth factor analogs  
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
8153591 Protein biomaterials and biocoacervates and methods of making and using thereof  
The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates...
8153147 Heparin coating of biological tissue  
The present invention discloses an in vitro method to provide biological tissue with a heparin coating comprising the following steps; linking a biotin reagent to biological tissue, linking an...
8106007 Conjugates of a polypeptide and a pentasaccharide  
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being...
8101196 Polysaccharide biomaterials and methods of use thereof  
The invention includes a medical hydrogel made from polymerized polysaccharide macromers. The macromers are preferably polysaccharides decorated with polymerizable groups, for example,...
8092818 Medical devices having bioactive surfaces  
According to an aspect of the present invention, medical devices are provided, which contain (a) a substrate and (b) a polymeric region disposed over the substrate which contains at least one block...
8088753 Heparin conjugates and methods  
Heparin conjugates and methods of making and use thereof are disclosed. An illustrative heparin conjugate includes a composition wherein a bile acid is bonded to heparin through the 3-carbon of the...
8076312 Use of lipid conjugates in the treatment of disease  
This invention provides a method of preventing asthma, allergic rhinitis, or chronic obstructive pulmonary disease in a subject comprising the step of administering to a subject a compound...
8071570 Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them  
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method...
8071571 Orlistat compositions  
A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity.
8071569 Oxidized heparin fractions and their use in inhibiting angiogenesis  
The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from about 1% to about 100% of hydroxyl...
8063026 Method of palliating lower urinary tract infections by treatment with mannan oligosaccharides  
Provided herein are methods of using mannan oligosaccharides, to treat, palliate, relieve, prevent and/or eliminate urinary tract infections of humans. A mixture of oligosaccharides derived from...
8057535 Implantable medical device  
The invention provides an implantable medical device comprising a fibrous polymer body comprising a plurality of electrospun poly(urethane) fibers, a support filament wrapped around the body, an...
8057816 Compositions and methods of administering paclitaxel with other drugs using medical devices  
Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs...
8048442 Modified heparin-based coatings and related drug eluting stents  
Systems comprising modified heparin-based coatings to form coatings on medical devices are provided. The systems improve the suitability of the heparin-based coatings.
8026209 Methods and compositions for targeting agents into and across the blood-barrier and other endothelial cell microvascular barriers  
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic inflammation-induced...
8003623 Mixtures of sulfated oligosaccharides  
The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method...
7981871 Modified macromolescules and associated methods of synthesis and use  
Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive...
7981873 Use within transplantation surgery  
The present invention is within the field of transplantation surgery. More closely, the present invention relates to use of a clotting preventing agent in the production of a drug for...
7976860 Implant and process for its production  
The present invention relates to an implant having a structured material component and having a protein matrix which has a pore structure. The structured material component is moreover at least...
7968527 Inhibition of FGF signaling  
Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in...
7968082 Evaluating mixtures of low molecular weight heparins by NMR  
Methods for analyzing mixtures of polysaccharides, for example heparin such as enoxaparin are described. In some instances, the mixtures are analyzed using 1D NMR and/or 2D NMR.
7939512 Multistep process for the physical depolymerization of heparin and products obtained therefrom  
The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two γ-ray irradiations and wherein between two ...
7928089 Mucoactive agents for treating a pulmonary disease  
The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and...
7875596 Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses  
Dermatan sulfates and/or O-desulfated heparins useful in treating and preventing heparinoid-induced autoimmune responses, in particular heparin-induced thrombocytopenia (HIT) and its associated...
7829549 Methods for treating bleeding disorders using sulfated polysaccharides  
Methods for treating bleeding disorders using non-anticoagulant sulfated polysaccharides (NASPs) as procoagulants are disclosed. NASPs can be administered as single agents, or in combination with...
7820722 Permeation enhancers  
A pharmaceutical composition comprising a drug and a permeation enhancer that comprises a multi-carbon backbone having a functional group and also one or more side chains which have one or more...
7820638 Method of applying hyaluronic acid to implant or graft to enhance lubricity and cellular density  
A method for lubricating an implant or graft prior to implantation into a target implant site which enhances the lubricity of the implant or graft and promotes bone growth. The method comprises the...
7811999 Use of lipid conjugates in the treatment of diseases  
This invention provides a method of treating a subject suffering from an obstructive respiratory disease, including the step of administering to a subject a compound comprising a lipid or...
7812007 Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them  
Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.
7812005 Glycosaminoglycans for treatment of emotional dysfunctions  
The present invention relates to the use of glycosaminoglycan fractions having an average molecular weight of 2400 (±200) D for the preparation of pharmaceutical compositions suitable for the ...
7799338 Plaster for topical use containing heparin and diclofenac  
Plaster for topical use having an analgesic activity and at the same time being able to re-absorb haematomas, comprising: a substrate layer;an adhesive layer in the form of a hydrogel matrix...
7790700 Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect  
Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the...
7781416 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect  
Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in...
7772196 Use of lipid conjugates in the treatment of diseases  
This invention provides a method of treating a subject suffering from a dermatologic condition, including, inter alia, psoriasis, contact dermatitis, and seboreic dermatitis, the method includes...
7737130 Pharmaceutical compositions for topical use in treatment of skin or mucous injuries  
The present invention describes new pharmaceutical compositions in treatment of skin and/or mucous injuries, new therapeutic use of compounds and use of compositions and compounds in treatment of...
7737131 Multifunctional and biologically active matrices from multicomponent polymeric solutions  
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
7732427 Multifunctional and biologically active matrices from multicomponent polymeric solutions  
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention...
7709461 Methods and products related to pulmonary delivery of polysaccharides  
The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in...
7700563 Synthetic heparin-binding factor analogs  
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two...
7696182 Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin  
The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to...
7691829 Composition and method for healing tissues  
The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is...
7687479 Methods and producing low molecular weight heparin  
The invention relates, in part, to methods and products related to producing low molecular weight heparin.
7687249 Polysaccharide derivatives with high antithrombotic activity in plasma  
The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N— acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N...
7655445 Methods for synthesis of sulfated saccharides  
The present invention provides methods, processes and reaction mixtures, which produce sulfated heparosan polysaccharides. This invention also provides methods and reaction mixtures for the...
7625552 Bioactive polymers for imparting bioactive character to hydrophobic medical article surfaces  
According to an aspect of the present invention, bioactive polymers are provided which have (a) a hydrophilic bioactive portion and (b) at least one hydrophobic polymer group that is linked to the...
7598224 Dual chain synthetic heparin-binding growth factor analogs  
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
7585642 Methods for evaluating the quality of a heparin sample  
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity...