Matches 301 - 350 out of 440 < 1 2 3 4 5 6 7 8 9 >
Match Document Document Title
4933326 Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity  
Heparin fractions which are a mixture of oligosaccharides containing 6-12 monosaccharides are described. The oligosaccharides contain reducing end groups composed of iduronic acid 2-sulfate or...
4900723 Method of preventing or reducing venous thrombosis using a thromboxane A.sub.2 receptor antagonist in conjunction with heparin and combination  
A method is provided for preventing or reducing deep vein thrombosis and/or pulmonary embolism by administering a thromboxane A 2 receptor antagonist in conjunction with heparin. A combination of...
4895838 Method for provoking angiogenesis by administration of angiogenically active oligosaccharides  
A method for causing or increasing angiogenesis is described. The method involves administering to a subject, such as a human being in need of angiogenesis an angiogenically effective amount of an...
4889808 Method of enchancing t-PA and SCU-PA production  
Disclosed herein is a method of enhancing the production of tissue plasminogen activator (t-PA) and single chain urokinase plasminogen activator (SCU-PA) by normal human lung diploid fibroblast...
4882318 Method for decreasing tumor metastasis  
The invention relates to pharmaceutical compositions intended to decrease the incidence of tumor metastasis in patients who suffer from malignant diseases. The pharmaceutical compositions of the...
4863907 Crosslinked glycosaminoglycans and their use  
Crosslinked glycosaminoglycans or salts thereof prepared by crosslinking glycosaminoglycan or salts thereof with a polyfunctional epoxy compound wherein a crosslinking index is 0.005 or more per 1...
4840940 Method for reducing the occurrence of distal anastomotic intimal hyperplasia using fractionated heparin  
A method is provided for reducing the occurrence of anastomotic intimal hyperplasia in grafts of artery, vein, biologic or synthetic conduits having end-to-side distal anastomosis. The method...
4840941 Method for inhibiting infection of human T-cells  
Method of treatment of diseases caused by retroviruses which comprises administering therapeutically effective amount of a natural or synthetic oligo- or polysaccharide having at least one...
4840626 Heparin-containing adhesion prevention barrier and process  
An improved adhesion-preventative barrier fabric comprising an oxidized regenerated cellulose (ORC) fabric (or matrix having equivalent properties) which is drapable, conformable, adherent to body...
4833200 Antithrombogenic medical material and method of preparing same  
An antithrombogenic medical material with a remarkable antithrombogenic property and histocompatibility as well as sufficient physical strength, formed by fixing a heparinized collagen to a...
4826827 Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs  
Short chained ligosaccharides of high structural homogeneity constituted essentially by hexasaccharides of the formula: ##STR1## in which R represents a hydrogen atom or the --SO 3 31 group....
4822615 Antithrombic resin composition  
An antithrombic resin composition comprising is disclosed which comprises synthetic resin having dispersed therein a solution obtained by dissolving an anticoagulant in a solvent. The composition...
4816446 Heparin derivatives  
The invention comprises heparin derivative compounds which possess a low density lipoprotein lowering action without a significant anticoagulent effect, and are therefore useful in the treatment of...
4808570 Compositions and method for improving wound healing  
The healing of wounds is promoted by contacting the wound surfaces with a suspension of collagen and a glycosaminoglycan that is chemotactic for fibroblasts and/or endothelial cells. Typical...
4806595 Method of preparing antithrombogenic medical materials  
In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine...
4804652 Mucopolysaccharides having biological properties, preparation and application thereof as drugs  
Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerization,...
4789733 Purification of blood coagulation factor VIII by precipitation with sulfated polysaccharides  
Efficient precipitation and removal of the proteins fibrinogen and fibronectin from blood plasma fractions, expecially cryoprecipitate, while leaving high yields of blood coagulation factor VIII in...
4783447 Process for producing natural heparan sulphate and dermatan sulphate in substantially pure form, and their pharmaceutical use  
A process for producing natural heparan sulphate and dermatan sulphate for mixtures of proteoglycans from the aorta, myocardium and particularly vascularized organs, based on a series of...
4777161 Medicaments favoring the properties of blood flow and their use in therapeutics  
The medicaments of the invention contain in their active principle, oligosaccharides of low molecular weight corresponding to or including heparin fragments.
4774231 Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications  
1,4αdisaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A...
4762715 Antiherpetically active lipstick and the use thereof for the treatment of disorders of the lips and other areas of the face casued by human herpes viruses  
The invention relates to an antiherpetic lipstick which is characterized by a content of an antiherpetically active combination of at least one sulphatised polysaccharide or sulphatized polymer, or...
4760131 Wound-healing composition  
A soft tissue wound healing composition comprising an aqueous mixture of fibrillar collagen, heparin, and undegranulated platelets or platelet releasate. The composition is applied topically to the...
4757057 Oligo-heteropolysaccharides having a heparin-like activity method for their preparation and pharmaceutical compositions based thereon  
A oligo-heteropolysaccharide is disclosed which is very active against thrombotic syndromes and is prepared starting from depolymerized heparin fractions wherein the active groups, more...
4757056 Method for tumor regression in rats, mice and hamsters using hexuronyl hexosaminoglycan-containing compositions  
Regression of established malignant tumors in rats, mice and hamsters is achieved with a combination of the heparin fragment hexuronyl hexosaminoglycan sulfate (HHS) together with a steroid such as...
4755379 Polymers substituted by groups conferring anti-coagulant properties on them, process for their preparation, articles and compositions made therefrom and uses thereof  
Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X...
4745105 Low molecular weight heparin derivatives with improved permeability  
Low molecular weight heparin derivatives containing hydrophobic groups and exhibiting improved permeability are disclosed. Said derivatives exhibit anticoagulant activity and improved solubility in...
4745107 Heparin derivatives with improved permeability  
Heparin derivatives containing hydrophobic groups and exhibiting improved permeability are disclosed. Said derivatives exhibit anticoagulant activity and improved solubility in organic solvents.
4745106 Heparin derivatives having improved anti-Xa specificity  
Acetyl ester derivatives of heparin are disclosed. These derivatives exhibit improved Anti-Xa activity in relation to their global anticlotting activity.
4745108 Heparin derivatives having decreased anti-Xa specificity  
Ester derivatives of heparin are disclosed. These derivatives exhibit low anti-Xa activity in relation to global anticlotting activity.
4745180 Solubilization of proteins for pharmaceutical compositions using heparin fragments  
A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is β-interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without...
4738955 Anti-carcinoma therapeutic agent of glycosaminoglycans and cytostatic agents  
A combination consisting of a mixture comprising high-molecular and low-molecular glycosaminoglycan polysulfates as well as a cytostatic agent is effective to obtain improved results in selectively...
4727063 Depolymerized and supersulfated heparin, process for its preparation and pharmaceutical compositions  
Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are...
4717719 Modified glucosaminoglucans having antithrombotic activity  
Pharmaceutical compositions are described which have antithrombotic activity suitable for the prevention and for the therapy of cardiac infarcts, cerebral infarcts and venous thrombosis. They...
4713402 Process for preparing antithrombogenic/antibiotic polymeric plastic materials  
An antithrombogenic/antibiotic plastic material prepared using an organic solvent system containing a specific chlorofluorocarbon compound and petroleum ether.
4710493 Therapeutic agent for the use in cancer treatment  
Good results are obtained in the selective destruction of tumor cells when a glycosaminoglycan polysulfate, except heparin, is combined with a cytostatic drug. The known serious secondary effects...
4707471 Water-soluble aminated β-1,3-bound D-glucan and composition containing same  
Water-soluble aminated β-1,3-bound D-glucan and macrophage-stimulating composition containing as an active constituent such glucan.
4703042 Orally active heparin salts containing multivalent cationic units  
The invention provides novel orally active salts of the formula ##STR1## in which .circle. is the skeleton of a polyol, n is the number of OH's in the polyol (3 to 24); p is ≥3 and ≤n; r is...
4698301 Angiogenic factor production  
New angiogenic factors of low molecular weight (under 1000), useful as treatment agents for wound healing and for biological assaying, made from in vitro cultures of a wide variety of tumor cells...
4692435 Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation  
The invention pertains to a mucopolysaccharide fraction obtainable from heparin or from fractions including heparinic constituents of molecular weights from 2000 to 50,000, which has a Yin-Wessler...
4689323 Covalently bound heparin--antithrombin-III complex  
There is disclosed a process for producing a convalently bound heparin--antithrombin-III complex useful for anticoagulant therapy, a covalently bound heparin--antithrombin-III complex produced by...
4687765 Method and composition for thrombolytic treatment  
The invention relates to a method and composition for thrombolytic treatment. It comprises administering to thrombosis-afflicted patients a low molecular weight heparin in an amount effective to...
4678660 Thermoplastic polyurethane anticoagulant alloy coating  
An antithrombogenic thermoplastic polyurethane product and process for preparing the same which comprises a substrate and at least one layer of a polyurethane alloy complex comprising a...
4678671 Conjugates of anticoagulant and protein  
Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the...
4665088 (E-Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxides  
This invention relates to compounds of the structures: ##STR1## which structure includes its isomers, conventionally designated (E,Z)-4,5,9-trithiadodeca-1,6,11-triene 9-oxide and commonly termed...
4663308 Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract  
Polymers from ethylenically unsaturated monomers, cross-linked by a substituted or unsubstituted divinylazobenzene are useful as carriers or capsules for medicaments, which are degraded by the...
4656161 Increasing the enteral absorbability of heparin or heparinoids  
An enterally absorbable heparin or heparinoid preparation contains a non-ionic surfactant.
4654327 Quaternary ammonium complexes of heparin  
A complex of a therapeutic agent is disclosed in which the therapeutic agent is complexed to an ammonium ion selected from the group consisting of ##STR1## where R 1 and R 2 are the same or...
4652555 Heparin compositions freed of mineral salts, particularly oxalates, and process for obtaining same  
This invention relates to oxalate-free preparations of heparin, particularly in the form of calcium salts of heparin, which can be used for the preparation of injectable solutions of heparin which...
4623539 Nutrient barrier polysaccharide compositions and method of use  
Disclosed are method and composition for periodically coating the internal, food absorbing surface of the small intestine of a mammal by ingesting said composition which is capable of forming at...
4607025 Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof  
1,4 α disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a...
Matches 301 - 350 out of 440 < 1 2 3 4 5 6 7 8 9 >