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5288704 |
Synergistic composition comprising a fibroblast growth factor and a sulfated polysaccharide, for use as antiviral agent
A pharmaceutcial composition is provided for use in the prevention or treatment of viral infections caused by enveloped viruses. The composition comprises a fibroblast growth factor, a sulfated...
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5288711 |
Method of treating hyperproliferative vascular disease
This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of a combination of rapamycin and...
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5280016 |
Non-anticoagulant heparin derivatives
A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by...
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5264425 |
Glycosaminoglycan salts and pharmaceutical compositions containing them
Salts of glycosaminoglycans (heparin, its fractions or fragments which are supersulfated, dermatan sulfate, heparan sulfate, and modified heparins) with bases of formula (I), ##STR1## wherein R 1 ,...
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5262403 |
Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
The present invention comprises a method for impeding the formation of tumor metastasis or tumor invasiveness in a host. Such inhibition comprises administration to the host of a glycosaminoglycan...
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5256538 |
Detection of early platelet activation and prediagnosis of thrombotic events
The present invention relates to a highly sensitive diagnostic/prediagnostic test to identify persons at risk of a thrombotic event. Thrombotic events include myocardial infarction, deep venous...
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5244672 |
Composition containing liposomes stabilized by a stabilizing support based on atelocollagen and glycosaminoglycans
The invention relates to a composition containing liposomes, stabilized by a stabilizing support comprising a mixture of atelocollagen and glycosaminoglycans in a relative proportion preferably...
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5240701 |
Method of performing angioplasty procedures
In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing a non-emulsion, homogeneous...
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5236910 |
Use of glycosaminoglycans in the treatment of diabetic nephropathy and diabetic neuropathy
The object of the present invention is the manufacture of a medicine for the use of glycosaminoglycans in the prevention and treatment of some pathologies caused by diabetes, like diabetic...
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5213788 |
Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for...
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5206223 |
Method for inhibiting heparanase activity
Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits...
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5204323 |
Heparin and hirudin antidotal compositions and methods
The invention provides an antidote to blood anticoagulants comprising Factor VIII or fragments of Factor VIII which retain its activity or a substance which increases its concentration in blood.
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5204321 |
Heparin neutralization with platelet factor 4
Circulating heparin in a mammal may be neutralized without substantial depletion of platelets or leukocytes by administering to the mammal a heparin neutralizing amount of purified PF4 or rPF4 or a...
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5164378 |
Supersulfated heparins
A process for the depolymerization and supersulfation of heparin and the so obtained supersulfated heparins are disclosed. The process comprises treating heparin with oleum containing from 2 to 6%...
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5159051 |
Biostable polyurethane
A thermoplastic polyurethane having prolonged biostability has tertiary amino groups in the polymer chain. Protonation of the amino groups with an aqueous acid causes the polymer to absorb up to...
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5159050 |
Polyurethane and medical article therefrom
A thermoplastic polyurethane has tertiary amino groups in the polymer chain. Protonation of the amino groups with an aqueous acid causes the polymer to absorb up to 1,000% by weight of water and...
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RE34077 |
Blood substitute
A blood substitute suitable for replacing blood in mammalian subjects when performance of surgical procedures at hypothermic temperatures is described. The blood substitute comprises water,...
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5141928 |
Ophthalmic medication
Glycosaminoglycan polysulfates (GAGPS) have been found to be useful in ophthalmic medications in the prevention and treatment of eye injuries. Particularly useful are GAGPS having a molecular...
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5135919 |
Method and a pharmaceutical composition for the inhibition of angiogenesis
Fumagillin and its salts have an angiogenesis inhibiting activity and are useful for prophylaxis and treatment of diseases induced by abnormally stimulated neovascularization. The invention also...
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5130143 |
Use of a low affinity-heparin fraction in conjunction with t-PA for thrombolytic therapy
A composition for thrombolytic therapy includes a tissue-type plasminogen activator (t-PA) and a low affinity heparin fraction. The composition is administered intravenously to allow the t-PA to...
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5106734 |
Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin
A method is provided for controlling production of low molecular weight heparin (LMW-heparin) when depolymerizing heparin with heparinase in a reaction mixture in a reactor. Depolymerization to a...
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5104860 |
Heparin derivatives and process for their preparation
New heparinic derivatives having anticalculous activity, devoid of the anticoagulant and antithrombotic activity characteristic of the heparins, obtained by treating commercial or purified or low...
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5098707 |
Imidazole compounds and their use as transglutaminase inhibitors
Compositions useful for thrombolytic therapy comprising a plasminogen activator such as tPA or streptokinase together with an imidazolium salt having the formula ##STR1## in a pharmaceutically...
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5096892 |
Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin
Anigiogenesis is controlled by administering to a mammal an effective amount of an inhibitor of arylsulfatase. Preferably, the arylsulfatase inhibitor is administered in a pharmaceutically...
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5082831 |
Total body washout solution and method of use
The present invention is concerned with improved aqueous asanguineous perfusates, blood substitutes for profound hypothermia, and method of using the same. The perfusates comprise: TBL ...
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5078995 |
Fibrionolytic composition
In accordance with present invention, a method is provided for reducing tissue damaged by ischemia in animal or human. The method comprises injecting an effective amount of an anticoagulant and a...
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5077281 |
Novel use of taurolin
Taurolin compounds are used as blood coagulation-inhibiting agents and as abacterial inflammation-inhibiting agents. The outstanding coagulation-inhibiting action of taurolin is especially suitable...
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5071973 |
Process for preparing of non-thrombogenic substrates
The present invention refers to a method concerning the preparation of hemo-compatible substrates by incorporation, adhesion and/or modification and embodiment of non-thrombogenic endothelial cell...
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5071969 |
Sulphated K5 antigen and sulphated K5 antigen fragments
The invention relates to sulphated K5 antigen and sulphated K5 antigen fragments containing at least 3 monosaccharide units and salts thereof, having interesting antiangiogenic and antitumor...
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5064643 |
Method for treating sickle cell disease
In accordance with the present invention, a method is provided for treating sickle cell anemia. The method comprises injecting an effective concentration of a surface active copolymer into the...
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5061738 |
Blood compatible, lubricious article and composition and method therefor
A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the...
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5047020 |
Ionic heparin coating
A non thrombogenic quaternary ammonium-heparin complex coating for a medical article comprising an amount of at least 50% by weight of one or more cationic quaternary ammonium organic salts having...
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5039529 |
Novel heparin derivatives
A novel complex of (a) a metal ion selected from copper, calcium, manganese, iron, and zinc ions, and (b) a fraction of heparin, heparan sulfate, low molecular weight heparin, low molecular weight...
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5037810 |
Medical application for heparin and related molecules
New uses for heparin, or heparin-like compounds are described that encompass preserving and healing of cells and cell functions arising from transplantations, circumcisions, dermatitides, fissures,...
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5032572 |
Polymers containing cross-linked azo bonds, which polymers are useful for releasing therapeutic agents into the lower gastrointestinal tract
Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are...
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5028597 |
Antithrombogenic materials
An antithrombogenic material is described, comprising an expanded polytetrafluoroethylene base having a collagen layer provided on the surface thereof, and further provided thereon a composite...
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5023078 |
Plasminogen activator-heparin conjugates
A pharmaceutical composition is prepared wherein a biologically active conjugated plasminogen activator is selectively conjugated to at least one heparin fragment having a terminal...
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5021404 |
Angiostatic collagen modulators
Angiostatic compounds are potentiated by collagen matrix metabolism modulators including: a) proline analogs which inhibit proline hydroxylation when substituted for proline in collagen; b)...
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5017370 |
Improved method of performing angioplasty procedures
In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing certain ethylene...
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5013724 |
Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
According to the process of the invention, a glycosaminoglycan is used in the form of a salt soluble in an organic medium and is subjected to the action of a given sulfation agent.
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5001116 |
Inhibition of angiogenesis
Angiogenesis in mammals is inhibited by administration of the active agents (1) heparin or a heparin fragment which is a hexasaccharide or larger or analogous compounds and (2) a steroid having...
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5001062 |
Antithrombogenic article containing lysozyme and heparin adsorbed on a substrate
An article adapted for applications where there is contact with blood and especially in medical applications is prepared by adsorbing the enzyme, lysozyme or derivative thereof, onto a substrate...
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4990502 |
Low molecular weight heparins of regular structure, their preparation and their biological uses.
The compositions of the invention are composed of fragments of heparin consisting essentially of repeated disaccharide sequences corresponding to the regular regions of heparin and possessing a MW...
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4983580 |
Methods and materials for use in corneal wound healing
Improvement in healing of wounds of the corneal stroma is obtained by placing into the wounds a corneal mortar composition comprising an extracellular matrix material and an ophthalmologically...
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4973580 |
Depolymerized dermatan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity and pharmaceutical compositions containing such
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates,...
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4966890 |
Method and composition for arresting angiogenesis and capillary, cell or membrane leakage
A composition and method for arresting angiogenesis, and cell, capillary or membrane leakage comprising a pharmaceutically effective amount of angiostatic steroid and pentosan polysulfate, or a...
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4966894 |
Polysulfated heparins for treating diseases caused by retroviruses
Polysulfated heparins are used for the preparation of drugs for the prophylaxis and therapy of diseases caused by retroviruses.
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4944767 |
Synthetic material apt to stably adsorb high quantities of heparin, and process for the production thereof
Synthetic material apt to stably adsorb high quantities of heparin, consisting of a polyurethane resin, cross-linked with copolymeric chains in correspondence of at least part of its own urethane...
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4945086 |
Smooth muscle cell growth inhibitor
An epithelium-derived inhibitor of the growth of smooth muscle cells is disclosed along with methods for purifying this substance. As initially isolated, the inhibitor comprises a heparan sulfate...
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4942156 |
Low molecular weight heparin derivatives having improved anti-Xa specificity
Ester derivatives of low molecular weight heparin are disclosed. These derivatives exhibit improved Anti-Xa activity in relation to global anticlotting activity.
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