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7378443 |
Fatty acid analogues for the treatment of cancer
A fatty acid analogue of the general formula: R 1 -[x i -CH 2 ] n —COOR 2 , wherein R 1 is: a C 2 -C 24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C 2...
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7294651 |
Inhibition of exoprotein production using isoprenoid compositions
Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the...
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7230029 |
Fatty acid analogues for the treatment of proliferative skin disorders
The present invention relates to fatty acid analogues of the general formula (I): R 1 -[x i -CH 2 ] n —COOR 2 wherein R 1 is; a C 1 –C 24 alkene with one or more double bonds and/or with one...
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RE39576 |
Enzyme inhibitors
A compound of formula (I)
wherein
R 1 is a C 1-6 straight or branched chain alkyl group, a C 2-6 alkenyl group, a C 2-6 alkynyl group, a C 3-6 cycloalkyl group or a C 3-6 cycloalkylC...
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7199156 |
Composition and method to treat solid tumors
A method to treat an animal, including a human, having a solid tumor. The method provides a lipophilic lathyrogen. The method administers a therapeutically effective amount of the lipophilic...
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RE39403 |
Method for supplying bioavailable methionine to a cow
The present invention relates to a method for supplying bioavailable methionine to a cow which comprises supplying to the cow an ester of methionine or methionine amide and/or an ester of the...
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7105570 |
Cysteine derivatives
Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional...
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7030158 |
Therapeutic compounds
A group of new compounds, N-(all-trans-Retinoyl)-L-cysteic acid, N-(13-cis-Retinoyl)-L-cysteic acid, N-(all-trans-Retinoyl)-L-cysteinesulfinic acid, N-(13-cis-Retinoyl)-L-cysteinesulfinic acid,...
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7026356 |
Fatty acid analogues for the treatment of diseases caused by the pathological proliferation of smooth muscle cells
The present invention relates to novel fatty acid analogues of the general formula (I): CH 3 —[CH 2 ] m —[x i —CH 2 ] n —COOR, wherein n is an integer from 1 to 12, and wherein m is an...
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6946474 |
Nitrogen-containing compounds and their use as glycine transport inhibitors
The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such...
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6903052 |
Nematicidal compositions and methods
The invention concerns the use of certain compounds related to fatty acids to control nematodes that infest plants or the situs of plants. Nematodes that parasitize animals can also be controlled...
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6872749 |
Method for supplying bioavailable methionine to a cow
The present invention relates to a method for supplying bioavailable methionine to a cow which comprises supplying to the cow an ester of methionine or methionine amide and/or an ester of the...
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6852756 |
Use of pleuromutilin derivatives for transdermal treatment of bacterial diseases
Described is a method for transdermally controlling a bacterial infection in a non-human animal which comprises the step of topically applying to the non-human animal a medicament comprising...
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6806261 |
Methods for treating certain diseases using naaladase inhibitors
The present invention relates to methods for regulating the release of TGF-β from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a...
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6803057 |
Hydrogen peroxide disinfectant with increased activity
An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations...
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6638978 |
Antimicrobial preservative compositions and methods
The present invention discloses an antimicrobial preservative composition and methods of using the same. The antimicrobial preservative composition includes a glycerol fatty acid ester, a binary...
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6552079 |
Integrin antagonists
Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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6534495 |
Serine protease inhibitors
The invention relates to a compound having the formula (I): R 1 SO 2 —B—X—Z—C(O)—Y, B is a bond, an amino acid of the formula —NR—CH[(CH 2 ) p C(O)OH]—C(O)— or an ester derivative...
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6525097 |
Method of treating a cancerous condition by enhancing the effectiveness of the human immune system
There is disclosed a method of treating a cancerous condition in a person in need of such treatment, which comprises enhancing the effectiveness of the person's immune system by the administration...
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6441036 |
Fatty analogues for the treatment of obesity, hypertension and fatty liver
The present invention relates to novel fatty acid analogous of the general forumla I: CH 3 —[CH 2 ] m —[x i —CH 2 ] n —COOR, as defined in the specification, which can be used for the...
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6420429 |
Brain targeted low molecular weight hydrophobic antioxidant compounds
Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and...
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6417232 |
Fatty acid analogues for the treatment of primary and secondary restenosis
The present invention relates to novel fatty acid analogues of the general formula (I): CH 3 —[CH 2 ] m —[X i —CH 2 ] n —COOR, wherein n is an integer from 1 to 12, and wherein m is an...
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6399628 |
N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting alpha- amyloid peptide release and/or its synthesis by use of such compounds
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions...
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6369106 |
Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to...
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6365628 |
Fatty analogues for the treatment of diabetes
The present invention relates to novel fatty acid analogues of the general formula (I): CH 3 —[CH 2 ] m —[x i —CH 2 ] n —COOR, as defined in the specification, which can be used for the...
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6353012 |
15-Hydroxyeicosatetraenoic acid-related compounds and methods of use
HETE derivatives and methods of their use for treating dry eye are disclosed.
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6284792 |
Formulation of valnemulin
The preparation of an improved galenic delivery form of valnemulin, which is notable for its good tolerance and stability in storage, is described. The new delivery form in question is a...
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6284258 |
Long-acting, chemical-resistant skin emollients, moisturizers, and strengtheners
The present invention relates to compounds that are two-part molecules, and compositions containing such compounds, in which one part is designed to become covalently bonded to the skin (bonding...
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6277883 |
Method of treating male impotence by enhancing the effectiveness of the human immune system
There is disclosed a method of treating male impotence in a person in need of such treatment, which comprises enhancing the effectiveness of the person's immune system by the administration to such...
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6136331 |
Cosmetic preparations containing fluorinated oils
A cosmetic containing fluorine-containing oil represented by the following formula do not inhibit the oil repellency of powder treated with a fluorine-containing compound, is excellent in affinity...
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6130250 |
Veterinary use of a pleuromutilin derivative
Use of the compound of formula I (as described in the specification) in the therapy of veterinary diseases, the expression of which is enhanced by increasing stock density.
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6046236 |
Carbocyclic sulfonamides
(1) Prostaglandin (PG) E 2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts...
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6046237 |
Non-β-oxidizable fatty acid analogues, their uses as therapeutic active medicaments
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5977160 |
Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
The invention involves a method for treating a human survivor of a heart attack and provides further improvement in survival following the heart attack by the early initiation and long-term...
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5968727 |
Pyruvate compounds and methods for use thereof
The invention comprises a novel pyruvate compound for the treatment of prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs ethanol intoxication...
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5932229 |
Oxa diacids and related compounds for treating skin conditions
Described are the use of compounds of Formula (I), depicted below, as active principals for treating skin conditions; compositions containing these compounds; and methods of treating skin...
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5925668 |
Thioctic metabolites and methods of use thereof
The present invention provides compounds with antioxidant activity effective in treating free radical mediated diseases.
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5874469 |
Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
Fluoroalkyl hydrocarbons as vehicles for pharmaceutical drugs are disclosed. These vehicles are particularly well-suited for delivering drugs which are insoluble in water or chemically unstable in...
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5863931 |
Amidino derivatives and their use as nitric oxide synthase inhibitors
Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R 1 is a C 1 -6 straight or branched chain alkyl group, a C 2 -6 alkenyl group, a...
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5861435 |
Method for preventing settlement of aquatic fouling organisms
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
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5843755 |
Group of antitumor compounds and method for producing the same
A mold belonging to the genus Ascochyta is cultivated with a medium to obtain a culture. A compound having a structure represented by the following formula and having an antitumor activity, which...
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5827883 |
Dermatological use of vitamin D derivatives
A method of using vitamin D derivatives of the formula ##STR1## wherein X is CH 2 or H,H; Y is a moiety --CH(CH 3 )--(A) n --C(O)--OR 1 (a) --CH(CH 3 )--CH 2 ...
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5821237 |
Compositions for visually improving skin
The subject invention relates to compositions which are useful for improving the visual appearance of skin, especially facial skin. The composition contains certain primary actives including at...
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5780489 |
Method for treating amyotrophic lateral sclerosis
The invention provides a method for treating amyotrophic lateral sclerosis in a patient which comprises administering to the patient an effective amount of a non-cysteine glutathione precursor or a...
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5679332 |
Hair keratin-reducing cysteine esters and compositions for permanent shaping of hair based on same
The hair shaping composition for permanent shaping of hair contains a cysteine ester of the formula (I): HS--CH 2 --CH(NH 2 )--COO--CH 2 --CH 2 --R (I) as a keratin-reducing material, wherein...
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5667776 |
Treatment for biological damage using tumor necrosis factor and a free-radical scavenger
Damage to cells, tissue and other body parts in a mammalian host may be treated by using a tumor necrosis factor in conjunction with at least one biological modifier, which may be a free radical...
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5637619 |
Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines
The present invention relates to novel 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hyd
razines and 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-methylhydrazines, and their use to treat...
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5602164 |
Anti-obesity drugs
Obesity is treated by the administration to a subject of a compound having the general formula (I): R 4 --(CH 2 ) n --CO--N(R 1 )--CH(R 2 )--CO(--R 3 ), wherein R 1 represents H or CH 3 ; R 2 ...
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5571794 |
Non-invasive novel method fo cosmetic lip augmentation
A cosmetic treatment for inducing upper and lower lip augmentation in humans, wherein an active ingredient encouraging vasodilatation, preferably an ultra highly diluted homeopathic, ultra highly...
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5536723 |
S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines
The invention relates to novel S-nitroso derivatives of ACE inhibitors and to pharmaceutical compositions comprising the S-nitrosothiol derivatives of the invention together with a pharmaceutically...
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