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6174876 |
Use of boswellic acid for treating brain tumors
The present invention relates to the use of pure boswellic acid, a physiologically acceptable salt, a derivative, a salt of said derivative or a vegetable preparation containing boswellic acid for...
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6172110 |
Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have the following formulae:...
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6140361 |
Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof
2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to...
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6133261 |
Amino acid derivatives useful to treat stroke
The invention provides a therapeutic method for treating or preventing stroke and other ischemic disorders, as well as novel compounds and pharmaceutical compositions useful for carrying out such...
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6127570 |
Fungicidal substituted 2-hydroxybenzophenones
Substituted 2-hydroxybenzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
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6127417 |
Stable derivatives of ubiquinole, processes for their production and pharmaceutical use thereof
New stable derivatives of ubiquinole are described, having general formula (I), along with processes for their production and their pharmaceutical use, in particular in the treatment of...
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6124359 |
Materials and methods for killing nematodes and nematode eggs
Methods and compositions for the control of nematodes are disclosed. Specifically, fatty acid ester compounds have been found to advantageously control nematodes at concentrations which are...
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6124358 |
Pharmaceutical composition containing rhein or diacerhein with improved bioavailability
Provided is a pharmaceutical composition based on rhein or diacerhein. The composition is intended for administration by the oral, rectal or cutaneous (percutaneous or transdermal) route, and...
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6121319 |
Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
This invention is a method and composition for the inhibition of VCAM-1, and in particular for the treatment of cardiovascular or inflammatory disease, including atherosclerosis, that includes the...
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6080739 |
Colchicine-skeleton compounds, their use as medicaments and compositions containing them
The present invention relates to colchicine and thiocolchicine derivatives which can be obtained from these molecules by functionalization of the C-7 to ketone or functionalization of the amino...
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6071923 |
Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases
This invention relates to the novel retinoyloxy(aryl-substituted)-alkylene butyrate compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or...
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6054479 |
Preservative compositions and methods for using the same
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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6046238 |
Method for treating or preventing the spread of acne vulgaris
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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6043277 |
Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of gastrointestinal disorders, cutaneous ulcers and wounds
This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative...
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6022895 |
Substituted amino compounds and their use as substances having an analgesic effect
Substituted amino compounds of general formula (I) ##STR1## are described, as are a method of preparing them and their use as drugs, especially as analgesics.
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6015832 |
Methods of inactivating bacteria including bacterial spores
Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based...
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RE36520 |
HMG-CoA reductase inhibitors
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##
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6010693 |
Anti-fouling compositions and fouling control of harmful aquatic organisms
There are disclosed a controlling agent and an antifouling composition against harmful aquatic organisms, which include a particular N-phenylisothiazolone derivative of the formula: ##STR1##...
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5985927 |
Medicaments for the selective treatment of tumor tissues
Medicinal products for the selective control of tumor tissue and a method for control of such tumor tissue by administration of such product to a host. The products comprise: (a) two different...
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5985923 |
Composition for treating poultry litter
The composition for the treatment of poultry litters comprises at least an edible surfactant emulsifying agent, for example an ethoxylate obtained from castor oil. It may also be combined with a...
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5962525 |
6,7-disubstituted-2-aminotetralines active as immunomodulators and pharmaceutical compositions containing same
6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of...
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5958975 |
Antiodor, antimicrobial and preservative compositions and methods of using same
Therapeutic treatment as well as prophylactic measures are provided by topical application of compositions containing an aryl 2-acetoxyethanoic acid to eradicate or prevent the development of...
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5939455 |
Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives
This invention provides a method of augmenting the therapeutic activity of an oxyalkylene-containing compound, butyric acid, a butyric acid salt or butyric acid derivative by administering an...
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5908862 |
Water-miscible esters of mono--and diglycerides having antibacterial activity and their use in inhibiting infection
A process of treating a bacterial infection in a subject in need of such treatment including the step of administering to the subject an effective bactericidal amount of diacetyltartaric acid...
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5895785 |
Treatment and prevention of disorders mediated by LA-paf or endothelial cells
The invention refers to the composition of substances to prevent and treat endothelial cell-mediated disorders with pathological differentiation of endothelial cells, for example, in response to...
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5869348 |
Methods for the preparation of antibodies directed against dithiocarbamates and the use thereof for detection of nitric oxide in body fluids
In accordance with the present invention, ELISA methods for the measurement of NO levels in mammalian body fluids utilizing monoclonal antibodies directed against dithiocarbamates and related iron...
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5861435 |
Method for preventing settlement of aquatic fouling organisms
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
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5853731 |
Thromboxane A2 Receptor antagonism and antioxidant action of cinnamophilin and its derivatives, their pharmaceutical compositions and uses
A pharmaceutical composition which possesses vasorelaxing effect of aortic contraction, relaxing effect of tracheal contraction, and antioxidative properties, is disclosed. It contains a...
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5811416 |
Endothelin antagonist and/or endothelin synthase inhibitor in combination with a progestin, an estrogen, a cyclooxygenase inhibitor, or a nitric acid donor or substrate
A pharmaceutical composition for and methods of treatment of menstrual disorders, e.g., dysmenorrhea, in a non-pregnant female, preterm labor, preeclampsia and/or fetal growth retardation in a...
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5811458 |
Phenyl propane derivatives as antibiotics and lipoxygenase inhibitors
The invention relates to phenyl propane derivatives of the general formulae: ##STR1## or their mixtures, in which R 1 and R 2 are a branched or straight-chained alkyl residue of the general...
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5801197 |
Rotamase enzyme activity inhibitors
This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme...
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5716639 |
Lipophilic carrier preparations
The invention relates to a lipophilic carrier preparation having a continuous lipid phase, comprising a polar lipid material in combination with a non-polar lipid, and optionally a polar solvent,...
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5710176 |
Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative...
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5700450 |
Methods for enhancing melanin synthesis in melanocytes using diacyglycerols and uses thereof
Methods for enhancing melanin synthesis in melanocytes, thereby increasing the melanin content of melanocytes with subsequent transfer of the melanic pigments to keratinocytes resulting in...
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5698592 |
Materials and methods for controlling nematodes
Methods and compositions for the control of nematodes are disclosed. Specifically, fatty acid ester compounds have been found to advantageously control nematodes at concentrations which are...
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5676926 |
Process for the production of DTPA-tetraesters of terminal carboxylic acids
The invention relates to a process for the production of diethylenetriaminepentacarboxylic acid tetraesters of general formula I ##STR1## in which R 1 and Z have different meanings.
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5665774 |
Immunosuppressive compounds
This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit...
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5665766 |
Ester of an organic nitrate and a salicylate
A pharmaceutical product for the relief of the symptoms of angina pectoris and the like comprises an ester of an organic nitrate and a salicylate or derivative thereof having anti-platelet activity.
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5658942 |
Octahydronaphthalene oxime compounds for cholesterol synthesis inhibition
Compounds of formula (I): ##STR1## in which: R represents hydrogen, methyl or hydroxy; X represents an alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or heterocyclic group; A represents a single bond,...
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5652261 |
Method for the treatment and protection of the skin
The present invention relates to a method for the treatment and protection of human and animal skin which contains vitamin E in a high dose and, in addition, may optionally further contain vitamin...
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5652265 |
Production of rhein and rhein derivatives
Methods for the production of rhein and rhein derivatives from aloin-containing substances are described. The oxidation of aloe yellow sap to form aloe-emodin is described, as are the further steps...
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5646185 |
Tumor treatment method
Disclosed is a method of treating a solid tumor, where the tumor contains regions of hypoxic cells, either because of poor vascularization in the tumor or because of vasoconstrictive or...
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5643949 |
Phenyl alpha acyloxyalkanoic acids, derivatives and their therapeutic use
Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is...
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5637614 |
6,7-disubstituted-2-aminotetralines and pharmaceutical compositions containing the same
6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of...
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5622990 |
Ibuprofen lysinate pharmaceutical formulation
Pharmaceutical ibuprofen lysinate dry granulation formulations comprising about 90% w/w ibuprofen lysinate are useful for the preparation of tablets containing ibuprofen lysinate.
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5614548 |
Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions
Quaternary amine-containing ether lipid analogs of the formula R 1 --X--R 2 --N + (R 3 ) (R 4 ) (R 5 ) Z - are disclosed. R 1 represents a hydrophobic group and R 2 represents the backbone...
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5607978 |
Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime,...
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5593971 |
Method for preventing onset of hypertension employing a cholesterol lowering drug
A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone...
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5574066 |
Intraocular pressure reducing 15-acyl prostaglandins
A method, compositions and compounds for lowering intraocular pressure involving 15-acyl prostaglandins.
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5571834 |
Pharmaceutical composition useful for the treatment of cardiovascular diseases
A pharmaceutical composition is described comprising ibopamine and an ACE-inhibitor. Such composition is useful in the treatment of cardiovascular diseases, more particularly of hypertension and...
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