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7629364 |
Compounds that abrogate DNA-damage-induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments
The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically,...
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7589125 |
2,4-dihydroxybenzoic acid derivatives
The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the...
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7504091 |
Antiperspirant compositions
antiperspirant compositions comprise an antiperspirant active and a carrier oil in which the carrier oil comprises an aromatic ester oil obeying the general formula:
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7504428 |
2-phenyl-3,3,3-trifluoro-2-hydroxy-propionic acid derivatives
The present invention a method of treating anxiety by administering compounds that are active on the GABA B receptor, having formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as...
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7488757 |
Invisible antimicrobial glove and hand antiseptic
An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual,...
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7459585 |
Benzene derivatives and pharmaceutical use thereof
The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory...
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7445790 |
External preparations for skin
The present invention is a skin treatment composition that characteristically contains an alkyl benzoate represented by the following general formula (1). This provides a skin treatment...
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7399766 |
Soluble amide & ester pyrazinoylguanidine sodium channel blockers
The present invention provides a pyrazinoylguanidine compound represented by formula (I):
where the structural variables are as defined herein. The compounds are useful for promoting hydration...
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7307078 |
Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel polycyclic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7229949 |
Safe delivery system for agriculturally active material
A safe delivery system of agriculturally active material is formed using an encapsulation process. A microencapsulated suspension of agriculturally active material includes an encapsulating agent...
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7230003 |
Aromatic prodrugs of propofol, compositions and uses thereof
Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7125869 |
Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel polycyclic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7122543 |
Substituted benzoic acid derivatives having NF-κB inhibiting action
A substituted benzoic acid derivative which is represented by the following formula (I) and has an NF-κB inhibiting action (in the formula, R 3 , R 4 and R 5 each independently represents a...
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7074826 |
R-NSAID esters and their use
The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in...
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6974584 |
Pesticidal compositions containing plant essential oils against human body louse
Pesticidal compositions for the control of human body louse containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling human body louse...
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6949585 |
Cyclooctanone derivatives and cyclodecanone derivative, and use thereof
The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is...
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6943196 |
NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient
An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R 1 , R 2 , and R 3 are each independently H, alkyl having 1 to 5...
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6936637 |
Prevention of apoptosis in non-cancerous cells
Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis....
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6894076 |
Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the...
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6881756 |
Method for treating skin disorders
The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol...
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6858653 |
Pesticidal compositions containing plant essentials oils against termites
Pesticidal compositions for the control of mites in stored food products containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling...
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6825233 |
Compounds having retinoid-like activity
There are provided compounds represented by the formula I or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, wherein the various substituents...
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6811772 |
Composition, method, and apparatus to attract bees
Applicant's invention includes an improved bee attracting composition. Applicant's invention further includes a bee attracting device formed from his improved bee attracting composition....
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6797694 |
Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca ), and the use of such compounds for the...
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6790864 |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6787573 |
Antiviral therapy
The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general...
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6703014 |
Attractants and repellants for colorado potato beetle
A method has been discovered for attracting Colorado potato beetles to an area of object or area, which method involves treating the object or area with a Colorado potato beetle attracting...
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6703421 |
Methods of using phenylmethylbenzoquinone and hydroquinone compounds for treatment of myocarditis, dilated cardiomyopathy and heart failure
A method for prevention or treating myocarditis, dilated cardiomyopathy and heart failure comprising administering to a patient in need of such treatment a NF-κB inhibitor in a therapeutically...
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6696484 |
Method and compositions for regulation of 5-alpha reductase activity
Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5α-reductase inhibitor, such as natural and synthetic flavanoids,...
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6689811 |
Method of using caffeic acid phenethyl ester and analogs thereof as radiation sensitizers
A method of potentiating radiation therapy in a subject in need thereof comprises administering a potentiating agent such as caffeic acid phenethyl ester (CAPE) or an analog thereof to the subject...
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6660755 |
Substituted diaryl or diheteroaryl methans, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
Compounds of the formula Y 3 (R 4 )—X—Y 1 (R 1 R 2 )—Z—Y 2 (R 2 )—A—B where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid...
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6635293 |
Finely dispersed carotenoid suspensions for use in foods and a process for their preparation
A stable product containing finely a dispersed carotenoid for use in supplementing aqueous systems, such as foods, beverages, and personal care products, with the carotenoid. An emulsifier is...
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6610744 |
Methods of treatment with compounds having RARα receptor specific or selective activity
Retinoid compounds which act specifically or selectively on RAR α receptor subtypes in preference over RAR β and RAR Γ receptor subtypes, posses desirable pharmaceutical properties associated...
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6610747 |
Phenoxybenzylamine derivatives as SSRIs
A compound of general formula (I) wherein R 1 and R 2 are H, C 1 -C 6 alkyl or (CH 2 ) d (C 3 -C 6 cycloalkyl) wherein d=0, 1, 2 or 3; or R 1 and R 2 together with the nitrogen to which they...
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6608061 |
Bisaryl compound and medicament for cancer treatment comprising the same
A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 ...
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6576660 |
Methods and compositions for regulation of 5-α-reductase activity
Compounds that inhibit 5-alpha-reductase are provided. The compounds are used to treat prostate cancer, breast cancer, obesity, skin disorders and baldness.
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6566397 |
Acyclic isoprenoid ether derivatives as chemotherapeutics
A method of and compositions for suppressing the growth of tumor cells in a patient are disclosed. In one embodiment, the method comprises treating the patient with an effective amount of an...
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6534099 |
Pesticidal compositions containing menthyl salicylate
Pesticidal compositions against pests comprising menthyl salicylate. Pesticidal compositions for the control of household insects containing menthyl salicylate with one or more plant essential...
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6534546 |
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
Compounds represented by the general formula (1): (where R 1 is SR 6 or NR 7 R 8 , where R 6 is typically an alkyl group having 1-6 carbon atoms, R 7 is a hydrogen atom, an alkyl group...
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6503944 |
Anhydrous skin care composition
A new composition has been created which provide convenient solution for dry skin care needs. The composition is anhydrous and takes the form of a solid stick. The components of this product are: ...
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6455585 |
Esters derived from substituted phennyl-cyclohexyl compounds
New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new...
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6441034 |
Insect repellent
A crystal clear, transparent insect repellent in gel form contains N,N-diethyl-m-toluamide (DEET), water, a lower alcohol, preferably ethanol, carboxypolymethylene as a gelling agent,...
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6428801 |
Methods for controlling dust mites and the allergens produced by dust mites
Alcohol based aerosol spray compositions which contain 1-20% of an alcohol-soluble polymer which, on evaporation, leaves on a sprayed surface a film which acts as a barrier to dust, dust mites and...
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6420429 |
Brain targeted low molecular weight hydrophobic antioxidant compounds
Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and...
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6414017 |
Inhibition of hair growth
Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of an enzyme involved in arachidonic acid metabolism.
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6403536 |
Composition and method for reducing odor of substituted naphthalenes
A chemical composition and method useful in the treatment of stored potatoes is disclosed. The chemical composition includes a mixture of a substituted naphthalene compound and an odor-neutralizing...
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6376542 |
Aqueous miticide compositions containing benzyl benzoate
Compositions and methods for killing dust mites and cleaning carpets and other textile fabrics are disclosed. A miticide composition concentrate for mixing with water and optionally with a carpet...
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6368608 |
Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof
Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: and are useful for the treatment of a wide variety...
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