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7622133 Plant protection agents  
The present invention relates to a microbicide composition for plants, containing at least two active ingredient components in an amount producing synergistic activity, together with an appropriate...
7592373 Amide compounds with MCH antagonistic activity and medicaments comprising these compounds  
Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R 1 , R 2 , and R 3 have the meanings given in claim 1 , pharmaceutical compositions these compounds, and methods of preventing or...
7589124 Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use  
The invention provides novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions and kits comprising at least one nitrosated and/or nitrosylated...
7576129 Carboxylic acid compounds  
The present invention relates to a carboxylic acid compound of formula (I): wherein R 1 is H, alkyl; m is 2, 3; n is 0-2; R 2 is phenyl, naphthyl, benzofuran, benzothiophene; Q is —CH 2...
7538124 Biphenylcarboxamides useful as lipid lowering agents  
Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
7491748 Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient  
A carboxylic acid derivative of formula (I): wherein R 1 is —COOH, —COOR 6 , etc.; A is a single bond, alkylene, etc.; R 2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a...
7476650 Enzyme inhibition  
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of...
7456217 Inhibitors of alpha4 mediated cell adhesion  
The present invention relates to a phenylalanine derivative of Formula (I) wherein X 1 is a halogen atom, X 2 is a halogen atom, Q is a CH 2 R— is a carboxyl group which may be esterified; or a...
7423028 Injectable pharmaceutical compositions comprising sodium diclofenac and β-cyclodextrin  
Injectable pharmaceutical compositions are described comprising sodium diclofenac, a β-cyclodextrin and a polysorbate, suitable for subcutaneous and intramuscular administration.
7399789 Bone targeting compounds for delivering agents to bone for interaction therewith  
The present invention relates to compounds of the formula or pharmaceutically acceptable salts thereof, useful for delivering agents having the capacity to diagnose, treat or prevent bone...
7375120 Peptide deformylase inhibitors  
Novel PDF inhibitors and novel methods for their use are provided.
7365085 Compounds and methods  
Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are...
7351719 Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds  
The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R 1 , R 2 and R 3 have the meanings given in claim 1 . Moreover the...
7345095 Sulfonamide compounds for the treatment of neurodegenerative disorders  
The present invention relates to compounds of the Formula I wherein R 1 , R 2 , R 3 , m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The...
7314888 Compounds and medicinal use thereof  
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
7304037 Cytostatic conjugates with integrin ligands  
The present invention relates to cytostatics which have a tumor-specific action as a result of linkage to α v β 3 integrin antagonists via preferred linking units which can be selectively...
7262223 Amidine derivatives for treating amyloidosis  
The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an...
7247654 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors  
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or...
7223793 Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same  
The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid...
7220749 Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use  
The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated...
7217706 Propanolamine derivatives  
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which...
7208520 Crystals of hydroxynorephedrine derivative  
The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-meth ylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and...
7153869 Substituted amino acids as erythropoietin mimetics  
This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the...
7105564 Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton  
The present invention provides novel compounds having a dual antagonistic activity against thromboxane A2 receptor and prostaglandin D 2 receptor and pharmaceutical compositions comprising them. ...
7071188 Composition and method for improving plant growth  
The present invention relates to plant-protecting active ingredient mixtures having synergistically enhanced action and to a method of improving the growth of plants, comprising applying to the...
7049341 N-benzoylureidocinnamic acid derivatives, processes for preparing them and their use  
N-Benzoylureidocinnamic acid derivatives, processes for preparing them and their use The invention relates to N-benzoylureidocinnamic acid derivatives and to their physiologically tolerated salts...
RE39088 Amide compounds and use of the same  
An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R 1 , R 2 , R 3 and R 4 are H,...
7034045 Monofluoroalkyl derivatives  
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
7030160 Propanolaminotetralines, preparation thereof and compositions containing same  
The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that...
6919369 Serine protease inhibitors  
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
6890942 Acyl sulfonamides as inhibitors of HIV integrase  
The present invention relates a series of compounds of Formula I wherein R 1 , R 2 , R 3 , and B are as defined in the specification. The compounds are useful for the inhibition of HIV...
6869914 Process for the preparation of solvent-free suspensions  
A process for the preparation of a solvent-free suspension of a low-melting point water-insoluble solid agrochemical active ingredient, which comprises suspending 1-40% by weight of a silica-based...
6849648 Phenylene alkyne matrix metalloproteinase inhibitors  
A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G 1 , G 2 , and B are as defined in the application, are selective inhibitors of...
6838482 Fungicidal composition  
The present invention provides a fungicidal composition characterized by containing as active ingredients (a) a compound represented by the formula I: (wherein Ar is a substituted or...
6790865 2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same  
The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R 1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R 2...
6699904 PPAR agonists  
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and...
6696489 2-Methylpropionic acid derivatives and medicinal compositions containing the same  
The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R 1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R 2...
6683110 Methyl esters of substituted 4-oxo-2-butenoic acid for treatment of tuberculosis  
A novel class of methyl esters of substituted 4-oxo-2-butenoic acids and their derivatives are disclosed along with the surprising use property of these compounds as a bacteriostatic agents for...
6680340 Anti-hypercholesterolemic drug combination  
This invention provides a drug combination comprised of a thyroid hormone receptor beta agonist with a fibrate in therapeutically effective amounts, which is useful for reducing cholesterol...
6677360 Biphenyl and biphenyl-analogous compounds as integrin antagonists  
The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of...
6673832 Methods for identifying compounds for treating pain  
The invention provides a method of determining whether a compound alleviates vasoconstriction-independent nerve pain mediated by endothelin-1 (ET-1). The method involves (i) determining whether the...
6673794 Substituted aminomethyl-phenyl-cyclohexane derivatives  
A substituted aminomethyl-phenyl-cyclohexane derivative of formula I or Ia, and their a diastereomer, enantiomer, or of a salt formed with a physiologically tolerated acid. Also disclosed are...
6649639 Antipicornaviral compounds, compositions containing them, and methods for their use  
Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical...
6632836 Carbocyclic potassium channel inhibitors  
The present invention relates to a class of carbocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like.
6630600 3-aryl propionic acid derivatives and analogs  
Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions...
6627656 Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore  
This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: in an amount that...
6599938 Compounds having MIF antagonist activity  
There is disclosed a genus of optionally substituted Schiff base condensation products (and the carba analogs thereof) comprising an amino acid component and a benzaldehyde component, that have MIF...
6593347 Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use  
The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated...
6569901 Alkynyl-substituted propionic acid derivatives, their preparation and use  
The present invention relates to compounds of formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome...
6565892 Synergistic fungicidal composition comprising a compound analogous to strobilurin  
Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): in which: A is the nitrogen atom or the —CH group, B is the —OCH 2 — or —CH 2 O— or...
Matches 1 - 50 out of 331 1 2 3 4 5 6 7 >