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7605166 |
Methods and compositions for treating rheumatoid arthritis
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an...
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7550506 |
Amino acid derived prodrugs of propofol, compositions and uses thereof
The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical...
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7504431 |
Sulfonyl amide inhibitors of calcium channel function
Compounds of formula I
its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7446128 |
Agent for treating interstitial cystitis
A compound which can be used as an agent for treating interstitial cystitis. An agent for treating interstitial cystitis, which comprises a phenoxyacetic acid derivative represented by a general...
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7423170 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
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7419974 |
Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
The present invention relates to the compounds of formula (I):
in which A is a group of formula (a) or (b)
in which R represents a hydrogen or halogen atom, an —S(O) z (C 1 -C 4 )alkyl...
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7419970 |
Cosmetic compositions comprising N-acylamino amides
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
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7393873 |
Arylsulfonamide derivatives
N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin...
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7361686 |
Compounds for the treatment of metabolic disorders
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
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7300956 |
Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of...
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7265136 |
Substituted stilbene compounds with vascular damaging activity
A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of...
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7247653 |
Pharmaceutical composition
The present invention relates to a pharmaceutical composition containing a cycloalkene compound, a salt thereof or a prodrug thereof, and a nonionic surfactant and/or a cyclodextrin derivative...
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7238680 |
Topical compositions for veterinary uses
A method of treating a non-human dermatological disorder, wherein the method comprises topically administering to a non-human dermatological disorder a therapeutically effective amount of a topical...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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RE39593 |
1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects
1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I
a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical...
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7202275 |
Malonamic acids and derivatives thereof as thyroid receptor ligands
The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of...
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7049344 |
Highly selective inhibitors of the urokinase plasminogen activator
A method is described for inhibiting urokinase plasminogen activator in a human or animal patient. The method involves administering to the patient a urokinase plasminogen activator inhibiting...
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7037939 |
Compound and derivative of gabapentin
The present invention relates to a compound represented as formula (I):
wherein
A is R2-N(R3R4),
wherein Ar is a substituted or unsubstituted phenyl group, m is an integer between 0...
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7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
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7019033 |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula
where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are hydrogen or substituent groups such as alkyl, and...
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6964982 |
Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino...
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6951844 |
Phenyl naphthol ligands for thyroid hormone receptor
New thyroid receptor ligands are provided which have the general formula I
wherein R 1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C 1-6 ...
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6946486 |
Quaternary ammonium compounds
The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious...
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6936636 |
5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
Compounds of the formula:
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6924308 |
Therapeutic process for inhibiting NF-κB
A therapeutic process is provided for the inhibition of NF-κB in mammals in whose cells NF-κB has been activated by an agency external to said cell.
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6919374 |
Viscosity modulating substance and use thereof
It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell...
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6919092 |
Method for the management of incontinence
A composition and a dosage form are disclosed comprising oxybutynin alone/or accompanied by another drug indicated for therapy. A method is disclosed for administering oxybutynin alone/or...
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6881756 |
Method for treating skin disorders
The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol...
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6858650 |
Stable salts of novel derivatives of 3,3-diphenylpropylamines
The present invention concerns highly pure, crystalline, stable compounds of novel derivatives of 3,3-diphenylpropylamines in the form of their salts, a method for the manufacture and highly pure,...
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6852738 |
Acyl sulfamides for treatment of obesity, diabetes and lipid disorders
A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment,...
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6846492 |
Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
The use of compounds of formula (1) is described, in which compounds R 1 , R 2 and R 3 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 2 -C 20 alkenyl; C 4...
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6838472 |
Substituted urea retinoid agonists
The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention...
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6835719 |
Pesticidal composition
An environmentally safe pesticidal liquid suspension composition including a mixture of sulfur combined with pyrethrins and/or pyrethroids is provided. The pesticidal composition is effective to...
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6826033 |
Aminoalcohol derivatives
The present invention relates to a compound formula (I) wherein X 1 is bond or —O—CH 2 —, (II) or (III) R 1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl,...
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6803378 |
HIV integrase inhibitors
Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.
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6797728 |
Use of intracellular calcium chelators to increase surfactant secretion in the lungs
Pulmonary surfactant is required in order to reduce surface tension in the lungs so that less effort is needed to reinflate the lungs after exhalation. A number of diseases and conditions exist...
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6790864 |
Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted...
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6767922 |
IL-8 receptor antagonists
This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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6730701 |
6-methoxy-2-naphthylacetic acid prodrugs
The present invention provides compositions useful for the treatment of inflammation in humans, and related methods of treatment for the same. In one embodiment the composition is: In another...
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6706743 |
β3 adrenergic receptor agonists and uses thereof
The instant invention provides β 3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds,...
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6696440 |
Treatment of asthma with MEK inhibitors
This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of...
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6692774 |
Synergistic mixtures of selected amino acids
Novel synergistic fungicidal compositions used for protecting seeds, plants and other vegetative material against fungi contain a mixture of one or more compounds selected from group A and one or...
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6680319 |
Isoxazolecarboxamide derivatives
The invention relates to novel N-(substituted phenyl)-N′-[ω-(3-substituted phenyl-4-isoxazolecarbonylamino)alkyl]piperazines, their N-oxides, and pharmaceutically acceptable salts thereof. The...
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6660755 |
Substituted diaryl or diheteroaryl methans, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
Compounds of the formula Y 3 (R 4 )—X—Y 1 (R 1 R 2 )—Z—Y 2 (R 2 )—A—B where the symbols have the meaning defined in the specification, have retinoid, retinoid antagonist or retinoid...
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6638976 |
Method of treating neurodegenerative disorders of the retina and optic nerve head
The use of 3-benzolphenylacetic acids and derivatives, including nepafenac, to treat neurodegenerative retinal disorders is disclosed.
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6630600 |
3-aryl propionic acid derivatives and analogs
Novel 3-aryl propionic acid derivatives and analogs, process and intermediate for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions...
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6627662 |
3-amino-propoxyphenyl derivatives (I)
Compounds of formula (Ia) as potent, β 1 -specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3′,4′-dimethoxyphenyl. R 1 is hydrogen, and R 2 is...
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6620798 |
Synergistic agents for enhancing tissue repair
Methods for the repair, reconstruction and protection of tissue using compositions containing flavonoids and/or flavonols, including simultaneous administration of agents in order to obtain...
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6552079 |
Integrin antagonists
Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating...
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