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7615574 |
Synergistic composition for treating leukemia
The present invention provides a method of treating acute and chronic myeloid leukemia (AML & CML) and lymphoid leukemia, said method comprising administering a pharmaceutical composition...
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7592478 |
Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof
Novel ligand antagonists of the RAR receptors have the following structural formula (I):
in which A is a CH 2 , CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical...
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7579494 |
Prevention of neutrophil recruitment
Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
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7572829 |
Pharmaceutical compositions useful in prevention and treatment of Beta-amyloid protein-induced disease
The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture...
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7557244 |
Substituted biphenyl carboxylic acids and derivatives thereof
The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R 1 , R 2 , R 3 , R 4 , R 9 , and R 10 given below, and/or a salt or ester thereof....
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7538140 |
Ester compound and medicinal use thereof
A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″)
(wherein
R 1 and R 2 are each hydrogen atom or optionally substituted aryl,...
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7537777 |
Synergistic and residual pesticidal compositions containing plant essential oils
Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils and/or their constituents, plant essential oils and/or their constituents in...
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7495029 |
Prodrugs of (2R)-2-propyloctanoic acid for the treatment of stroke
Disclosed are prodrugs of (2R)-2-propyloctanoic acid, and pharmaceutical compositions comprising them, which may be effective in modulating multiple events in the biochemical cascade of stroke....
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7417059 |
Substituted aromatic-ring compounds, process for producing the same and use
The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production,...
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7407648 |
Merocyanine derivatives for cosmetic use
The use is described of merocyanine derivatives of formula (1), wherein R 1 and R 2 are each independently of the other hydrogen; C 1 -C 22 alkyl; cyclo-C 3 C 8 alkyl; or unsubstituted or C 1 -C...
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7396953 |
Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof
Novel derivatives of fumagalone have the general formula (I):
and are useful angiogenes is inhibitors; these can be formulated into pharmaceutical compositions suited for human or veterinary...
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7368478 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula:
wherein G 1 and G 2 are each independently...
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7361686 |
Compounds for the treatment of metabolic disorders
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
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7314888 |
Compounds and medicinal use thereof
A compound or a salt thereof having the atom corresponding to N 3 and the two or more atoms selected from N 1 , N 2 , N 4 and N 5 , said atoms constitute the pharmacophore represented by the...
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7307102 |
Method of preventing or treating estrogen-dependent diseases and disorders
The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast...
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7288271 |
Chlorogenic acid and an analog thereof for immune system stimulation
The present invention relates to a preparation for stimulating or enhancing an immune system comprising one or more agents that stimulate T-lymphocytes in vivo. Such a preparation can be sued in...
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7282520 |
External preparation
An external preparation characterized by comprising, as selected from gallic acid derivatives of the following formula (I),
wherein R 1 represents a hydrogen atom, an alkali metal, an alkaline...
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7256215 |
Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative
The present invention provides a novel crystalline form of n-butyl[4-[2-[2-hydroxy-5-(N-hydroxycarbamimidoyl) benzenesulfonylamino]ethyl]-2′-methanesulfonyl-3-yloxy] acetate hydrochloride,...
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7244763 |
Compounds that modulate PPAR activity and methods of preparation
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
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7238680 |
Topical compositions for veterinary uses
A method of treating a non-human dermatological disorder, wherein the method comprises topically administering to a non-human dermatological disorder a therapeutically effective amount of a topical...
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7230003 |
Aromatic prodrugs of propofol, compositions and uses thereof
Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof...
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7226946 |
Substituted phenol compounds useful for anesthesia and sedation
The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a...
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7208520 |
Crystals of hydroxynorephedrine derivative
The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-meth
ylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and...
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7192981 |
3,4-dihydroxyhydrocinnamic acid derivative
According to the invention, there is provided a novel 3,4-dihydroxyhydrocinnamic acid derivative, designated DHH105, having blood glucose lowering effects in vivo as a result of the enhancement of...
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7163956 |
Substituted fullerene compositions and their use as antioxidants
This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i)...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7115660 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula (I): wherein G 1 and G 2 are each independently...
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7101910 |
Compounds for the treatment of metabolic disorders
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and...
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7091243 |
Anti-irritants
Alkoxylated esters of dicarboxylic or tricarboxylic acids have an anti-irritating activity measured as a reduction in intracellular leakage of sodium fluorescein of 15% or more at 1:50 dilution or...
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7074826 |
R-NSAID esters and their use
The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7060301 |
In situ mono-or diester dicarboxylate compositions
The present invention relates to in situ compositions of mono- or diester dicarboxylates, methods employing these in situ compositions, and methods of making these in situ compositions. More...
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7053071 |
Induction of apoptosis in cancer cells
The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
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7037914 |
Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I)
(wherein all symbols are as defined in the specification), a non-toxic acid...
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6992095 |
Stilbene compounds comprising an adamantyl group, compositions and methods thereof
The invention relates to novel stilbene compounds having the general formula (I):
as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological,...
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6984389 |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a...
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6972294 |
Compounds, their preparation and use
Disclosed are novel compounds of formula (I)
wherein A 1 , A 2 , Ar, R 5 , R 6 , R 8 , M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment...
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6964982 |
Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino...
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6951844 |
Phenyl naphthol ligands for thyroid hormone receptor
New thyroid receptor ligands are provided which have the general formula I
wherein R 1 is halogen, trifluoromethyl, substituted or unsubstituted aryl, substituted or unsubstituted C 1-6 ...
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6946485 |
Treatment of post-angioplasty restenosis and atherosclerosis with Ras antagonists
Disclosed are methods for inhibiting Ras activity such as cell proliferation associated with vascular injury such as post-angioplasty restenosis and atherosclerosis. Preferred Ras antagonists are...
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6943196 |
NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient
An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R 1 , R 2 , and R 3 are each independently H, alkyl having 1 to 5...
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6936636 |
5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
Compounds of the formula:
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6936266 |
Desquamation/epidermal renewal of the skin and/or combating skin aging
Cinnamic acid and derivatives thereof are well suited for promoting desquamation and/or stimulating epidermal renewal and/or combating intrinsic/extrinsic aging of the skin of a human subject in...
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6930129 |
Methods and devices for providing prolonged drug therapy
Methods and devices for maintaining a desired therapeutic drug effect over a prolonged therapy period are provided. In particular, oral dosage forms that release drug within the gastrointestinal...
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6921777 |
Heteroethynylenic compounds and pharmaceutical and cosmetic compositions containing them
The invention relates to novel heteroethynylenic compounds having the general formula (I):
as well as to the use of these compounds in pharmaceutical compositions intended for use in human or...
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6894076 |
Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the...
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6887896 |
7-[(7-Alkoxy)-chrom-3-en-6-yl]-heptatrienoic acid and 7-[(3-alkoxy)-5,6-dihydronaphthalen-2-yl]-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side...
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6884820 |
5,6,7,8-tetrahydronaphthalen-2-yl-7-fluoroalkyl-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula
where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effect...
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6838480 |
Composition containing sucrafate and a topical anesthetic for humans and animals and method of use thereof
A composition and method of treating plurality of conditions utilizes a combination of sucralfate and a topical anesthetic such as lidocaine. The composition finds utility in treating the symptoms...
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