Matches 401 - 450 out of 512 < 1 2 3 4 5 6 7 8 9 10 11 >
Match Document Document Title
4309441 13-Thiaprostaglandin derivatives  
13-Thiaprostanoic acid derivatives of the general formula I ##STR1## wherein A is --CO-- or --CHOH--; B is --CH 2 CH 2 -- or --CHCH--; Q is 1,4-phenylene or 1,4-naphthylene; R 1 is H or OH; R...
4301146 Stabilization of 16-oxygenated prostanoic acid derivatives  
A stable solid dosage form of the compound ±methyl(7-[3(α)-hydroxy-2-β-(4(RS)-4-hydroxy-4-methyl-tra ns- 1-octen-1-yl)-oxycyclopent-1α-yl]heptanoate, said solid dosage form comprising from...
4301175 E-Type prostaglandin compositions  
PGE-type compounds are stabilized in a composition comprising a mixture of triacetin and ethanol. This composition surprisingly and unexpectedly retains virtually all of the stability of triacetin...
4294849 Prostaglandin analogues  
Prostaglandin analogues of the formula:- ##STR1## (wherein R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, the wavy line indicates...
4289785 Method and compositions involving prostaglandins  
5-Oxa-17-phenyl-18,19,20-trinor-PGF 1 α alkyl esters and 5-oxa-17-phenyl-18,19,20-trinor PGF 1 α amide are combined with certain other prostaglandins in synergistic combinations to induce...
4289761 Combination of 5-oxa-17-phenyl-PGF.sub.1 α's estrogenic compounds for menses induction  
This invention provides a method for inducing menses and interrupting early pregnancy in female primate mammals, especially humans, which comprises the concomitant administration of a...
4268522 13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof  
The invention discloses certain novel 13,14-dihydro-15-alkenyl prostaglandins and 13,14-dihydro-15-alkynyl prostaglandins and analogs of each as well as the novel intermediates employed in their...
4258057 Prostaglandin derivatives of the Δ2,4-11-deoxy-PEG series  
The present invention relates to novel prostaglandin derivatives of the formula I ##STR1## which are structurally related to the naturally occurring prostaglandins and in which R 1 denotes (a)...
4256745 New prostane derivatives and process for their preparation  
Prostan-1-ol esters and intermediates for their preparation are described; the former compounds exhibit improved organ specificity and a longer duration of activity at lower dosages than the...
4254145 Topical application of prostaglandin hypotensive agents  
Pharmaceutical compositions useful as vasodilators whose activity may be restricted to the site of application by control of the dose applied which comprises a prostaglandin selected from the group...
4246280 20-Alkoxy-16-alkyl-prostadienoic acid derivatives  
There are disclosed 20-alkoxy-16-alkyl-prostadienoic acid derivatives of the formula: ##STR1## wherein A represents ##STR2## R and R 5 , which may be the same or different, each represents a...
4239778 Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation  
Novel azaprostanoic acid analogs of the formula ##STR1## wherein: R is C 1 to C 8 alkyl or benzyl; and a has a value of from 0 to 6 inclusive, and their pharmaceutically acceptable salts and...
RE30439 Treatment of genital tract diseases of domestic animals with prostaglandins  
The treatment of purulent diseases of the female genital track of domestic animals by administration of an amount of a domestic animal luteolytic-uterine smooth muscle stimulating prostaglandin...
4235930 Novel acetylenic prostaglandins and processes for the preparation thereof  
Prostane derivatives of the formula ##STR1## wherein R 1 is the residue OR 2 and R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or is NHR 3 wherein R 3 is an acyl group...
4229445 Synergistic arthropodicidal compositions and methods of use  
A synergistic arthropodicidal composition comprising (a) a benzodioxole derivative of the formula ##STR1## in which R represents alkyl, alkenyl, alkynyl, aryl or aralkyl, plus (b) at least one...
4228152 Polymers containing prostaglandin radicals, process for their preparation and use thereof  
There are disclosed non-toxic polymers having a molecular weight between 1,000 and 1,500,000 and containing prostaglandin radicals directly connected or connected through an oxyalkylenic,...
4223011 Therapeutic compositions containing polymers having polyunsaturated acid radicals  
A polymer having a molecular weight between 1,000 and 1,500,000 characterized in that it contains the radical of a polyunsaturated acid selected from the group consisting of 8,11,14-eicosatrienic...
4217362 Anilide derivatives as antidepressants  
Anilide derivative compounds of the formula ##STR1## e.g., trans-N-(2-hydroxycyclopentyl)-3',4'-dichloropropionanilide, have been found to possess potent Central Nervous System (CNS)...
4211793 Triethyl citrate solutions of PGE-type compounds  
Degradation of E-type prostaglandin compounds is prevented by dissolving those compounds in triethyl citrate.
4210669 Prostanoic acid derivatives  
Prostanoic acid derivatives of the formula, ##STR1## wherein R 1 is hydrogen or C 1 -4 alkyl, R 2 is C 4 -8 alkyl and >CZ is >C0 or ##STR2## are prepared by reacting a cyclopentane of...
4209444 New prostaglandin-like diketals  
Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof, wherein A and D each are ketalized carbonyl groups; B is --CH 2 --,...
4208428 Prostaglandin analogues  
The invention relates to prostaglandin analogues of the general formula: ##STR1## (wherein A represents a grouping of the formula: ##STR2## B represents an alkylene group containing from 1 to 7...
4207315 Process for treating proliferative skin diseases using certain diamino compounds  
A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals,...
4201788 Process for alleviating proliferative skin diseases  
A process and pharmaceutical compositions for alleviating proliferative skin diseases such as psoriasis, atopic dermatitis, etc., comprising administering to humans or domesticated animals,...
4200644 Arylthiovinylcyclopropanecarboxylate insecticides  
Arylthiovinylcyclopropanecarboxylates having the general formula ##STR1## are disclosed. The insecticidal efficacy and preparation of the compounds and novel intermediates therefor are also...
4198430 13,14-Dehydro-11-deoxy-prostaglandis  
Optionally active 13,14-dehydro-11-deoxy prostaglandins useful in inhibiting gastric secretions and as anti-asmthmatic agents are disclosed.
4198429 Esters of 5-methyl-10,11-dihydroprostaglandin-A.sub.1  
Prostaglandin esters of the formula ##STR1## have valuable therapeutical properties.
4198405 Prostaglandine derivatives  
Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group. The prostaglandine derivatives have extraordinarily reduced side-effect and...
4192891 Prostacyclin analogs and their use in inhibition of arachidonic acid-induced platelet aggregation and bronchoconstriction  
Prostacyclin analogs are provided having the structure ##STR1## wherein X represents O or OH, R 1 and R 2 are OH or H, provided at least one of R 1 and R 2 is other than hydroxyl, R 3 is H...
4190669 Method for treating psoriasis  
A process for the treatment of psoriasis comprising administering to humans or domesticated animals topically and/or systemically a composition comprising a pharmaceutical carrier and...
4182773 Novel prostaglandin derivatives  
What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R 1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or...
4177285 [1-Oxo-2-thienyl-2-substituted-5-indanyloxy (or thio)]alkanoic acids and derivatives thereof  
[1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio)]alkaoic acid, derivatives thereof, their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in...
4171375 Cyclopentane derivatives and their pharmaceutical compositions  
Cyclopentane derivatives of the formula: ##STR1## wherein R 1 represents hydrogen or a carboxylic acyl group, R 2 represents hydrogen or alkyl of 1 through 12 carbon atoms, and n represents an...
4148916 Derivatives of oxaminic acids and esters  
The invention provides oxaminic acids and esters thereof, useful for the treatment of allergic conditions, a process for the preparation of said compounds and pharmaceutical compositions containing...
4117119 15-Cyclobutyl-prostaglandins  
Prostaglandin analogues of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## X represents trans-vinylene or ethylene and Y represents cis-vinylene or ethylene, R...
4115544 Ocular system made of bioerodible esters having linear ether  
An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling...
4115545 Pharmaceutical composition containing prostadienoic acid for regulating gastric secretion  
Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R 1 is hydrogen or lower alkyl; R 2 and R 6 are hydrogen when Y is a single bond and R 2 and R 6 are absent when Y is a...
4109009 Analgesic, relaxant, and anti-inflammatory cyclopentanol derivatives  
Novel cyclopentanol compounds of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## R' is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms...
4105854 Prostanoic acid derivatives  
This application describes novel 17-(optionally substituted)phenyl-18,19,20-trinorprosta-16-ynoic acid derivatives of the F, E and A series, for example methyl...
4103026 Treatment of peripheral vascular disease by non-intraarterial administration of prostaglandin E.sub.1  
A method of treating peripheral vascular disease in humans by non-arterial, systemic administration of prostaglandin E 1 , its pharmacologically acceptable salts, lower alkyl esters or amide.
4097603 Gastric cytoprotection with non-antisecretory doses of prostaglandins  
The present invention provides a method for prophylaxis of certain gastric inflammatory diseases by administration of gastric cytoprotective prostaglandins. Gastric cytoprotective prostaglandins...
4097496 Novel cyclopentane derivatives  
The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention...
4092425 Restoration of interferon response  
The present invention provides a method for treatment of hyporeactivity to interferon induction in interferon producing animals or animal cells which comprises administering a hyporeactive...
4087544 Treatment of cranial dysfunctions using novel cyclic amino acids  
The present invention is concerned with new cyclic amino acids and with the preparation thereof.
4081553 Cytoprotective prostaglandins for use in human intestinal diseases  
The present invention provides a method for treatment of Crohn's disease, inflammatory bowel disease, infectious enteritis, sprue, and intestinal inflammatory disease secondary to radiation...
4078080 Oral administration of pyrethroids to warm-blooded animals to prevent fly development in their droppings  
The invention is a novel method for the control of flies breeding in manure, comprising orally administering certain pyrethroids to warm-blooded animals to provide pesticidally effective amounts of...
4078081 Cyclopentane derivatives manufacture  
The present invention relates to new cyclopentane derivatives having the formula ##STR1## and to a process for their manufacture. The compounds can be used as medicaments due to their...
4073934 Novel acetylenic prostaglandin analogs  
Optically active and racemic prostaglandin derivatives of the formula ##STR1## wherein R 1 is --OR 5 ; --NHSO 2 CH 3 ; or --O--CH 2 --U--V; R 5 is hydrogen, alkyl, aryl, or a heterocyclic...
4072755 Novel cyclopentanoic acid derivatives  
Novel cyclopentanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and --CH 2 OH, R' is selected from the group consisting of hydrogen, alkyl...
4070482 Prostaglandin antagonists  
2-(1-Hydroxy-2-octynyl)- and 2-(3-hydroxy-1-octynyl)-5-oxocyclopentaneheptanoic acids, their salts and their corresponding lower alkyl esters are disclosed. The compounds inhibit the actions of...
Matches 401 - 450 out of 512 < 1 2 3 4 5 6 7 8 9 10 11 >