Matches 351 - 400 out of 512 < 1 2 3 4 5 6 7 8 9 10 11 >
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4609673 Carboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides carboxylic acid derivatives of the general formula: ##STR1## wherein R is a hydrogen atom, alkyl, a metal cation or an ammonium or alkylammonium ion, R 1 is a...
4599354 Composition and method for producing prolonged pain relief  
A composition and method for producing lasting pain relief in a body by injection. The composition consists essentially of a sterile, stable suspension of butyl aminobenzoate in a non-toxic,...
4599353 Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma  
Ocular hypertension and glaucoma can be effectively controlled in primates through topical application of an effective amount of an eicosanoid or an eicosanoid derivative to the surface of an...
4576962 Prostaglandin analogues  
The 13,14-didehydro-15-oxo analogues of natural prostaglandins possess high cytoprotective activity and low diarrheogenic activity, low anti-hemostatic activity and low smooth muscle contraction...
4570006 Amidine compound, process for producing same and anti-complement agent comprising same  
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin,...
4562204 Trans-Δ.sup.2 -prostaglandin D derivatives, process for their preparation and compositions containing them  
Trans-Δ 2 -prostaglandin D derivatives of the formula: ##STR1## wherein [A] is a group of the formula: ##STR2## X is ethylene or cis-vinylene, C 13 -C 14 -C 15 is: (i) a group of the formula:...
4562207 Prostaglandin analogue  
A novel prostaglandin analogue of the formula: ##STR1## [wherein the symbol represents β-configuration, the dotted line ---------- represents α-configuration, and the double bond between C 13 ...
4560703 Clavulone derivatives, process for preparing the same, and use of said compounds  
Novel clavulone derivatives of the formula: ##STR1## wherein R 1 and R 2 combine together to form a keto group or either one of R 1 and R 2 is hydrogen atom and another one of them is hydroxy...
4560786 Δ.sup.8,9 -Prostaglandin derivatives, their preparation and use as medicinal agents  
Δ 8 ,9 -Prostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is ##STR3## wherein R...
4547521 16-Methoxy-16-methyl prostaglandin E.sub.1 derivatives, a process for preparing them and their use as gastroprotective agents  
The present invention is directed to new 16-methoxy-16-methyl prostaglandin E 1 derivatives of the following general formula ##STR1## wherein R stands for a (C 1 -4) alkyl group or a non-toxic...
4543353 Ester and amide derivatives of 13,14-didehydro prostaglandins  
Esters of 13,14-didehydro prostaglandins have been prepared.
4517202 Prostaglandin analogues  
Prostaglandin analogues of the general formula: ##STR1## (wherein R 1 represents a hydrogen atom or a straight- or branched-chain alkyl group, Y 1 represents a carbonyl or hydroxymethylene group,...
4515810 Composition of matter  
A pharmaceutical composition of matter useful as a topical medicament which comprises an E-type prostaglandin compound or other water unstable active ingredient in a quick-breaking foam formulation...
4514396 15-Cycloaliphatic derivatives of 13,14-didehydro-carboprostacyclins and process for their preparation  
13, 14 didehydro-15 cyclic prostacyclins have been prepared.
4510323 Cis-bicyclo[3.3.0]octane derivatives, medicaments containing them and processes for their preparation and use  
Cis-bicyclo[3.3.0]octane derivatives corresponding to the formula ##STR1## wherein R 1 is hydrogen, a lower alkyl group or a cation and wherein R 2 represents a cyclohexyl or an adamantyl group....
4508735 Anti-arrhythmic N-alkanoylaminoalkyl fluorenes  
9-(N-alkanoylaminoalkyl)-fluorenes are anti-arrhythmic agents.
4505905 Cyclobutanone antibacterials  
Certain 7-oxobicyclo[3.2.0] hept-2-en-2-carboxylic acids, esters, and salts thereof useful as antibacterial agents or as intermediates for antibacterial agents, and methods for making and using them.
4503068 Use of prostaglandin analogues to treat cytodamage  
The prostaglandin analogues 16S-methyl-6-oxo-PGE 1 methyl ester, 17S,20-dimethyl-6-oxo-PGE 1 methyl ester, 15S-methyl-6-oxo-PGE 1 and non-toxic salts thereof, ...
4499085 Method of anoxia treatment using prostaglandin analogues  
The invention provides a new method for the treatment of anoxia of brain cells using a PGI 1 derivative of the formula: ##STR1## wherein R 1 represents hydrogen or lower alkyl and R 2 represents...
4496587 Inhibition of bacterial toxin release by prostaglandins  
The present invention provides a method for inhibiting the synthesis and release of toxins from bacteria which comprises contacting the bacteria with an antitoxic prostaglandin.
4493846 Bicyclooctane derivatives  
A compound of the formula ##STR1## wherein X 1 is a free or esterified carboxyl group, a hydroxymethyl group, a cyano group, a group of the formula: ##STR2## (R a and R b are each independently...
4489092 Prostanoic acid derivatives and their preparation  
Prostanoic acid derivatives of the formula ##STR1## wherein R 1 is an acid, ester, amide or hydroxyalkylene group; R 2 and R 3 are H or alkyl; R 4 and R 5 are both CH 3 or one is Cl and the...
4479966 6,9-Methano-PGI2 analogues  
Prostaglandin I 2 analogues of the formula: ##STR1## [wherein the symbol between the carbon atoms in positions 5 and 6 represents a single or double bond, Y represents ethylene or...
4474751 Ophthalmic drug delivery system utilizing thermosetting gels  
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
4466980 Thiaprostaglandin E.sub.1 derivatives, process for production thereof, and pharmaceutical use thereof  
A novel compound selected from the group consisting of 7-(or 6- or 4-)thiaprostaglandin E 1 derivatives of the formula (I). ##STR1## wherein A represents --CH 2 -- or ##STR2## in which n is 0, 1...
4464358 Homocyclic derivatives  
Compounds of the formula: ##STR1## wherein R 1 stands for hydrogen or a defined hydrocarbyl or halogenoalkenyl radical, R 2 stands for a defined hydrocarbyl, halogenoalkenyl or furylmethyl...
4459310 Method for cholesterol lowering  
This invention encompasses a new use for 16-loweralkyl-16-hydroxy prostaglandins such as misoprostol. This class of prostaglandin has been found useful in lowering cholesterol blood levels in...
4454339 9-Fluoroprostaglandin derivatives, and use as medicinal agents  
9-Fluoroprostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is the residue ##STR3##...
4447428 Prostanoid compounds and pharmaceutical compositions  
Prostanoid compounds are described having the formula: ##STR1## where A is a cyclopentane ring, which is substituted by oxo and/or hydroxy or etherified hydroxy and may be saturated or unsaturated;...
4425359 Fluoro-prostaglandins and process for their preparation  
Fluoro-prostaglandin compounds are disclosed, such as, for instance, 18,19,20-trinor-17-cyclohexyl-16(S,R)-fluoro-PGF 2 α. The fluoro-prostaglandins of the present invention have the same...
4423051 4-[(Cycloalkyl or cycloalkenyl substituted) amino, alkylamino or alkenylamino]benzoic acids, salts and derivatives thereof  
This disclosure describes novel 4-[(cycloalkyl or cycloalkenyl substituted)amino, alkylamino or alkenylamino]-benzoic acids, salts and derviatives of these such as cycloalkylamino,...
4423068 (3.2.0) Bicycloheptanone oxime ethers with therapeutic properties  
Compounds useful in treating cardiovascular disorders are the carboxylic acids depicted in formulas (1) and (2) ##STR1## as well as their pharmaceutically acceptable, non-toxic salts and esters,...
4410545 Carbonate diester solutions of PGE-type compounds  
Stable compositions of PGE-type compounds are achieved by dissolving those compounds in carbonate diester solvents which may contain water up to the solubility limit of the carbonate diester.
4409239 Propylene glycol diester solutions of PGE-type compounds  
Stable compositions of PGE and PGE-type compounds are achieved by dissolving these compounds in propylene glycol diesters of short chain fatty acids.
4400393 Novel bicyclooctane compounds  
A novel bicyclooctane derivative represented by the formula: ##STR1## wherein R 1 is hydrogen or C 1 -4 alkyl, X is ethylene or vinylene, and Y 1 and Y 2 are independently hydrogen or a...
4397851 2,3-Dihalo-2,3-(disubstituted) propanoate antimicrobial compounds  
Antimicrobial compounds of the formula: ##STR1## wherein Hal is bromine or chlorine; R is C 1 -4 alkyl, straight or branched chain; and one of R 1 and R 2 is hydrogen and the other is selected...
4389414 Prostaglandin compositions  
The mixture of polyethylene glycol having a molecular weight of about 380 to about 630 with the prostaglandins dl-9α,11α,15α-trihydroxy-16-phenoxy-17,18,19,20-tetranor...
4372973 16-Amino-postaglandin derivatives, their acid addition salts, and a process for the preparation thereof  
The invention relates to new 16-amino-prostaglandin derivatives of general formula I, ##STR1## wherein C-15 and C-16 may have either S or R configuration, Z stands for a hydrogen atom or a lower...
4361577 ω-Nor-cycloalkyl-13,14-dehydro-prostaglandins and process for their preparation  
ω-Nor-cycloalkyl-13,14-dehydro-prostaglandin compounds, specifically 5c-9-oxo-11α,15S-dihydroxy-20,19,18-tirnor-17-cyclohexyl-pr ost-5-en- 13-ynoic acid, the esters and salts thereof, having...
4351846 3-Hydroxy and 3-oxo-prostaglandin analogues  
Prostaglandin analogues of the formula: ##STR1## [wherein R 1 represents hydrogen or alkyl of 1 to 12 carbon atoms, R 2 represents a single bond or alkylene of from 1 to 5 carbon atoms, R 3 ...
4340603 Novel inotropic prodrugs  
Novel, transient inotropic prodrug forms of the N-(2-phenylethyl)-ω-phenylalkylamines, notably of dobutamine, have (i) the structural formula (I): ##STR1## with the proviso that at least one R 1 ,...
4338332 Fluoro-prostaglandins  
16-Fluro-13, 14-dehydro-PG 2 series compounds have been prepared.
4325970 15-Acetyl-prostaglandins  
15-acetyloxy-11,16,16,-trimethyl-9-oxo-prosta-5,13-dien-1-oi c acid and lower alkyl esters thereof useful as anti-secretory agents for preventing hyperacidity in the stomach and as an anti-ulcer...
4325967 Cyclopentane derivatives  
Cyclopentane derivatives of the formula: ##STR1## wherein R 1 represents hydrogen or a carboxylic acyl group, and either (i) R 2 represents a group of the formula: --CR 3 R 4 R 5 ...
4322435 Prostacyclin compounds  
Prostacyclin derivatives of formula (I): ##STR1## (wherein R 1 represents a hydrogen atom or a lower alkyl group; R 2 represents an alkenyl group having from 8 to 12 carbon atoms; and n...
4321275 Method of inducing luteolysis using 16-aryloxy-17,18,19,20-tetranor-prostanoic acid derivatives  
The disclosure relates to novel 17,18,19,20-tetranor-prostanoic acid derivatives having prostaglandin-type properties, to a method for their manufacture, and also to pharmaceutical or veterinary...
4317834 Combating arthropods with fluorine-substituted spiro-carboxylic acid benzyl esters  
Fluorine-substituted spirocarboxylic acid benzyl esters of the formula ##STR1## in which R 1 represents hydrogen, cyano or alkyl, alkenyl or alkynyl, with in each case up to 4 carbon atoms, R 2...
4315032 Process for preparation of adjacently disubstituted ketones  
A novel 7-hydroxyprostaglandin E 1 , or a stereoisomer thereof, or a protected derivative thereof, having the following formula: ##STR1## wherein R 8 represents H, CH 3 or C 2 H 5 , R 9 ...
4311707 Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions  
This application discloses a process for producing cutaneous vasodilation which comprises the topical administration to an individual with a vasospastic or ischemic condition of an effective dosage...
4310543 Prostaglandin compositions  
Orally administrable pharmaceutical compositions in the form of a soft gelatin capsule containing a prostaglandin and ascorbic acid or ascorbyl palmitate which are dissolved in polyethylene glycol...
Matches 351 - 400 out of 512 < 1 2 3 4 5 6 7 8 9 10 11 >