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5891909 |
Amidinohydrazones as protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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5889051 |
Stabilization of prostaglandin drug
A stable solid dispersion of prostaglandin drug, particularly Misoprostol, (±)methyl 7- 3(α)-hydroxy-2-β-(4 (RS)-4-hydroxy-4-methyl-trans-1-octen-1-yl)-oxycyclopent-1α
-yl!hepta noate,...
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5846957 |
Use of an ester of inositoltrisphosphate for the preparing of medicaments
The present invention relates to the use of an ester of inositoltrispbosphate for the preparing of a medicament effective against retroviral diseases.
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5843999 |
2-phenylazulene derivatives and a manufacturing method of these compounds
A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R 1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom,...
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5827883 |
Dermatological use of vitamin D derivatives
A method of using vitamin D derivatives of the formula ##STR1## wherein X is CH 2 or H,H; Y is a moiety --CH(CH 3 )--(A) n --C(O)--OR 1 (a) --CH(CH 3 )--CH 2 ...
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5827897 |
Stimulating the differentiation of predipocytic cells and therapies based thereon
The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II...
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5817694 |
16-methyl-11,16-dihydroxy-9-oxoprost-2,13-dien-1-oic acid and derivatives
Analogs of the prostaglandin PGE 1 are disclosed. These compounds exhibit uterotonic properties, enhancing the response to PGF 2 α in isolated rat uteri. The compounds also exhibit other...
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5814301 |
Use of prostacyclin derivatives to prevent or to treat disorders of the microcirculatory system when x-ray, NMR or ultrasonic contrast media are administered
Use of a prostacyclin derivative of general formula I ##STR1## in which R 1 , X, Y, Z, A, W, D, E, R 2 and R 3 may have different meanings, for the production of a pharmaceutical agent to prevent...
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5811443 |
Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma
Combinations of at least one clonidine derivative and at least one prostaglandin are used to treat glaucoma and ocular hypertension without some of the side effects typically associated with...
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5807892 |
Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
Certain prostaglandin analogues are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandin analogues.
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5792796 |
Methods for treating anxiety and panic
The instant invention is novel uses of known cyclic amino acids. Such compounds as gabapentin are useful in the treatment of anxiety and in the treatment and/or prevention of panic attacks.
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5773472 |
Method and means for prevention of cataract
The present invention is related to the use of thiol-binding prostaglandins or prostaglandin-like substances containing alpha beta unsaturated ketone, esp. Prostaglandins of type A or J and...
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5773471 |
Treatment of optic nerve disorder with prostanoic acid compounds
The present invention provides a method for treatment of optic nerve disorder by the administration of a prostanoic acid compound in an amount effective in treatment of optic nerve disorder to a...
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5770622 |
Method of preserving materials using 4-methylene-2-amino-cyclopentane-1-carboxylic acids
The invention relates to cyclopentane- and -pentene-β-amino acids, processes for their preparation and their use as medicaments, and to prevent contamination of materials such as wood and leather.
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5767154 |
5-trans-prostaglandins of the F series and their use as ocular hypotensives
The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following structure...
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5767151 |
3,3-(disubstituted) cyclohexan-1-ylidine acetate dimers and related compounds
The present invention relates to novel 3,3-(disubstituted)-cyclohexan-1-ylidene acetate dimers of Formula (I): ##STR1## and related compounds, pharmaceutical compositions containing these...
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5760075 |
Method and means for prevention and treatment of secondary cataract
The present invention relates to a method for treatment or prevention of secondary cataract, comprising contacting the surface of the eye with an effective amount of a therapeutically active and...
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5750549 |
Cycloalkyl tachykinin receptor antagonists
The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R 3 , R 6 , R 7 , R 8 , R 11 , R 12...
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5739160 |
Cyclopentane- and -pentene-β-amino acids
New Cyclopentane- or cyclopentene-beta-aminoacid derivatives and their isomers, acid additional salts and metal salt complexes have strong antimicrobial and broad-spectrum antimycotic acitivity. As...
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5739161 |
Agent for treating hepto.biliary diseases
The object of the present invention is to provide a pharmaceutical composition for treatment of hepato.biliary disease reduced in side effect such as diarrhea, which comprises...
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5728733 |
N-acyl-ethylene triacetic composition for treating abnormal keratinization
Disclosed is the novel use of N-acyl-N,N',N'-ethylene-diaminetriacetic acids and N-acyl-N,N',N'-(ethylenedioxy) diethylenedinitrilotriacetic acids as active ingredients in preventative as well as...
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5721273 |
Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension
9-Halo-13,14-dihydroprostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
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5719184 |
3,3-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds
The present invention relates to novel 3,3-(disubstituted)cyclohexan-1-carboxylate dimers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating...
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5719182 |
Endothelin receptor anatagonists
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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5700835 |
3-Oxa-D-prostaglandins for lowering IOP
Compositions containing 3-Oxa-D-prostaglandins and methods of their use in treating glaucoma or ocular hypertension are disclosed.
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5698590 |
Prostaglandin derivatives
Prostaglandin E 1 ester derivatives of the formula (I): ##STR1## wherein the R' groups are the same as each other and are C4-12 alkyl; or cyclodextrin clathrates thereof, liposome formulations...
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5698598 |
EP.sub.2 -receptor agonists as agents for lowering intraocular pressure
The invention relates to the use of EP 2 receptor agonists as potent ocular hypotensives, and are particularly suitable for the management of glaucoma. In particular said compounds are represented...
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5696166 |
Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
Compositions containing a HETE derivative and methods of use for treating dry eye are disclosed.
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5686487 |
Treatment of cataract with 15-keto-prostaglandin compounds
A method for treatment of a cataract which comprises administering, to a subject in need of such treatment, a 15-ketoprostaglandin compound in an amount effective in treatment of cataract.
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5681850 |
Method of treatment of impotence with prostaglandin E1 derivatives
The invention describes prostaglandin E1 derivatives as pharmacologically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration.
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5656663 |
External skin treatment agent composition containing isocarbacyclins as active ingredient
An external skin treatment agent composition containing an active ingredient comprising a prostacyclin, and/or its optical isomer, having the formula (I): ##STR1## (wherein, R 1 is a hydrogen...
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5656635 |
5-trans-alcohols and their use as ocular hypotensives
The invention relates to the use of alcohol derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are encompassed by the following...
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5627209 |
Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension
9-Haloprostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
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5616614 |
Naphthylalkylamines
The invention relates to a compound selected from those of general formula (I): ##STR1## in which R, R 1 , R 2 and R 3 are as defined in the specification, an optical isomer, and an addition salt...
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5616607 |
Hepoxilin analogs
Compounds of the general structure ##STR1## are disclosed, wherein X is O, C n , NH, or S, wherein n is 1, 2, 3 or 4; R1 is OH, CH 3 , CH 2 OH, N 3 or CH 2 N 3 ; R3 is H or CH 3 ; R5 is Y-R2,...
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5610182 |
Pharmaceutical composition for the therapy of cerebral thrombosis
A pharmaceutical composition effective for the therapy of cerebral thrombosis, particularly acute cerebral thrombosis, which is in the form of a fat emulsion containing an isocarbacyclin having a...
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5605931 |
Protective prostaglandins for use in conjunction with chemotherapeutic agents
Prostaglandins of the PGE type can be administered in a therapeutically effective amount to protect tissue from injury resulting from chemotherapeutic agents by administering the PGE-type...
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5599837 |
Treatment for hypertension or glaucoma in eyes
The present invention relates to a 15-deoxyprostaglandin derivative of the formula (I): ##STR1## in which ##STR2## is a 5 membered ring which is selected from a group consisting of ##STR3## R 1 is...
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5597809 |
Treatment of optic neuritis
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
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5591727 |
Insecticidal composition
The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol...
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5574066 |
Intraocular pressure reducing 15-acyl prostaglandins
A method, compositions and compounds for lowering intraocular pressure involving 15-acyl prostaglandins.
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5571825 |
Method of selectively inhibiting prostaglandin G/H synthase-2
The present invention provides a method of selectively inhibiting prostaglandin G/H synthase-2 that comprises administering to a patient in need of such inhibition an inhibiting amount of a...
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5565490 |
P-hydroxyaniline derivatives, their preparation and their use
p-Hydroxyaniline derivatives of the formula I ##STR1## where the substituents have the following meanings: R 1 is hydrogen, or unsubstituted or substituted alkyl; R 2 and R 3 independently of...
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5565492 |
Prostaglandin combinations in glaucoma therapy
Disclosed is the use of combinations of F and E series prostaglandins and their respective derivatives and analogues, as well as pharmaceutically acceptable salts and esters thereof in the...
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5554649 |
Controlling agent for fabric pest insects
A controlling agent for fabric pest insects characterized by containing, as an active ingredient, a carboxylic acid ester represented by the formula (I): ##STR1## wherein R represents an allyl or...
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5547968 |
Treatment of ocular hypertension with a synergistic combination
A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of (a) a...
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5534547 |
Prostaglandins of the D series, and tranquilizers and soporifics containing the same
The present invention provides novel prostaglandins D, that is, 13,14-dihydro-15-keto-PGDs, whieh have an excellent sedative and sleep-inducing activity, and so they are useful for tranquilizer...
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5516796 |
Thioprostaglandins and -prostaglandin-like compounds and therapeutic uses thereof
Thiosubstituted prostaglandin derivatives and related compounds having the general structure ##STR1## useful as intraocular pressure reducing agents; pharmaceutical compositions containing such...
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5514712 |
Use of oils of chaulmoogra in the cosmetic and pharmaceutical domain, particularly in dermatology, for harmonizing pigmentation of the skin
The present invention relates to the use of oils of chaulmoogra and derivatives thereof, particularly in the form of esters or salts, for preparing a cosmetic or pharmaceutical, particularly...
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5510382 |
Method for composition for treatment of gastric and duodenal disorders
The invention is related to the field of treating gastric and duodenal disorders and more specifically to the use of certain 13,14-dihydro-prostaglandin E derivatives, especially of PGE 2 , which...
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