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9040078 Use of lipid conjugates in the treatment of diseases of the nervous system  
The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple...
9023763 Modification of trehalose-6-phosphate levels in plants  
Compounds which are trehalose-6-phosphate or trehalose-6-phosphonate precursors of formula (I) or agriculturally acceptable salts thereof are provided: (I) The compounds are useful in increasing...
9018003 Modulators of alpha-synuclein toxicity  
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these...
9006188 Co-crystals of dapagliflozin  
The present invention provides novel co-crystal forms of dapagliflozin, namely a dapagliflozin lactose co-crystal and a dapagliflozin asparagine co-crystal, to pharmaceutical compositions...
9006210 Compositions and methods for treating corneal inflammation  
A method of treating corneal inflammation in a subject includes administering to the subject a therapeutically effective amount of a TLR4 antagonist.
9006211 Hypersulfated disaccharide formulations  
Hypersulfated disaccharides with utility in asthma or asthma related disorders are disclosed. The compounds are formulated with agents that enhance the oral delivery of the hypersulfated...
8980303 Antimycotic and prebiotic pharmaceutical composition and a method for treating candidal vaginitis  
The invention relates to medicine and pharmacology, more particularly to a pharmaceutical composition in the form of vaginal suppositories for treating candidal vaginitis and vulvovaginitis,...
8975242 Tigecycline compositions and methods of preparation  
The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise...
8962593 GLA monotherapy for use in cancer treatment  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
8956638 Biocompatible poly (amic acid) and method of preparation thereof  
A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine...
8957047 GLA monotherapy for use in cancer treatment  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
8951989 Hydrogel tissue adhesive having reduced degradation time  
A hydrogel tissue adhesive having decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm...
8946194 One-step processing of hydrogels for mechanically robust and chemically desired features  
The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A...
8940325 Use of synthetic polysulphated oligosaccharides as cleaning agents for a wound  
The present invention relates to the use of at least one compound selected among the synthetic polysulphated oligosaccharides having 1 to 4 ose units and to the salts and complexes thereof as...
8933055 Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants  
The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar-derived surfactant, and an optional foam boosting surfactant. These formulations...
8927504 Combined use of dipeptidyl peptidase 4 inhibitor and sweetener  
The present invention provides a novel therapeutic or preventive method, a pharmaceutical composition and use thereof, that exhibit superior anti-obesity effects (body weight-reducing (losing)...
8895612 Methods and compositions for administration of iron  
The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions...
8895516 Modified saccharides, conjugates thereof, and their manufacture  
Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I):...
8895557 Pharmaceutical formulations of ecteinascidin compounds  
Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are...
8889651 Trehalose derivatives, preparation method and uses thereof  
The invention relates to trehalose derivatives with general formula (I), a preparation method and uses thereof, wherein 6,6′-bis(2,3-dimethoxybenzoyl)-α,α-D-trehalose has anti-colon cancer 26-L5...
8883715 Biocompatible polymers, process for their preparation and compositions containing them  
A process for treating fibroses including administering a therapeutically effective amount of a pharmaceutical composition which includes at least one biocompatible polymer of the following...
8877735 Alkoxylated sucrose esters composition  
Purified alkoxylated sucrose esters of the formula: wherein R is independently selected from: COR′; (CH2CH2O)xH; and (CH2CH2O)x COR′; wherein R′ is a fatty acid compound having from about 2 to...
8871739 Solid acid catalyzed hydrolysis of cellulosic materials  
Provided are methods for the solubilization of cellulose into soluble sugars without the need for high temperatures, high pressures, strong acid solutions, and/or added water. The produced sugars...
8871744 Compounds and methods for selectively targeting tumor-associated mucins  
The present invention relates to pharmaceutical compositions containing tumor-selective targeted inhibitor glycoconjugates. These bioconjugates are ALK5 inhibitors covalently bound to...
8846642 Nutritional composition containing oligosaccharide mixture  
A nutritional composition for administration to an infant which composition comprises, on a dry matter basis, from 2.5 to 15.0 wt % of an oligosaccharide mixture consisting of N-acetylated...
8835403 Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same  
The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic...
8828967 Low molecular weight complexes between iron and maltobionic acid, use thereof for intramuscular or subcutaneous administration in the treatment of anemic states, and new pharmaceutical compositions adapted for these uses  
New low molecular weight complexes between iron and maltobionic acid that can be administered parenterally, preferably intramuscularly or subcutaneously, in the treatment of anemic states, caused...
8822432 Equol production accelerating composition  
A composition which can significantly accelerate equol production is provided. When formulated in a pharmaceutical preparation or a food or drink, this composition exerts effects of preventing a...
8822549 Buffered oxygen therapeutic  
An oxygen therapeutic composition, comprising a perfluorocarbon material, a viscosity modifier, a buffer, wherein the buffer stabilizes a pH of the composition at between about 6.5 to about 7.5,...
8815239 Glycoconjugates and use thereof as vaccine against Shigella flexneri serotype 3a and X  
The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine...
8815831 Treatment of Acinetobacter with alginate oligomers and antibiotics  
The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of Acinetobacter, said method comprising using said antibiotic together with an alginate oligomer....
8802650 Methods of using human milk oligosaccharides for improving airway respiratory health  
Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to preterm infants, term infants, toddlers, and children for improving airway defense mechanisms.
8785416 Sulphated disaccharides for the treatment of neurodegenerative and/or neurovascular diseases  
The present invention relates to the use of a series of sulphated disaccharides for the preparation of a medicament for the treatment or prevention of a neurodegenerative and/or neurovascular...
8778907 Lactulose for bowel evacuation  
A method of treating an adult patient in need of bowel evacuation via the administration of one or more doses of a bowel evacuant consisting of a total of from about 180 g to about 220 g of...
8765693 Method of inhibiting premature aging of human skin caused by exposure to infrared radiation  
A method of inhibiting premature aging of human skin caused by exposure to infrared radiation comprising contacting the skin with a composition containing a therapeutically-effective amount of at...
8765665 Albumin-free factor VIII formulations  
A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of...
8765694 Method for treating obesity  
The present invention is directed to methods for treating obesity, reducing excessive body weight, treating an obesity-related condition, treating unwanted localized fat deposits, and treating...
8759398 Phosphorus binder composition for treatment of hyperphosphatemia  
The present invention relates to oral pharmaceutical products which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of...
8759320 Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars  
Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by...
8741871 Trehalose compound, method for producing same, and pharmaceutical product containing the compound  
A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X′ each represents a phenyl, a naphthyl, R1—CHR1— (wherein R1...
8741872 Self-gelling alginate systems and uses thereof  
Kits and compositions for producing an alginate gel are disclosed. The kits and compositions comprise soluble alginate and insoluble alginate/gelling ion particles. Methods for dispensing a...
8728504 Process for solubilizing hydrophobic active ingredients in aqueous medium  
A process for solubilizing hydrophobic active ingredients in aqueous medium, which comprises using, as an assistant, at least one hyperbranched polymer (A) which is obtainable by reacting at least...
8728535 Nutritional supplement for use under physiologically stressful conditions  
In one embodiment of the present invention, a pharmaceutically-acceptable single-dosage formulation consists essentially of about 500 mg of vitamin C; about 400 IUs of vitamin D3; about 125 IUs of...
8728465 Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors  
Compositions comprising dendritic cells pulsed with tumor lysate and at least one toll-like receptor (TLR) ligand which may be used for eliciting a specific immune response in a mammal in need...
8722064 Synthetic glucopyranosyl lipid adjuvants  
Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5,...
8703722 Inhibitors of F18+ E coli binding  
The present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and...
8691776 Synthesis of high molecular weight iron-saccharidic complexes  
A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH)− ions and (ii)...
8691796 Pharmaceutical composition and method for inhibiting inflammation  
A pharmaceutical composition for inhibiting inflammation, comprising (a) hyaluronic acid, (b) a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and (c) a pharmaceutically...
8685439 Method for the treatment and prevention of eyelid swelling  
The invention features novel topical ophthalmic formulations comprising an osmotically active agent and a vasoconstrictor. Suitable osmotically active agents for use in the ophthalmic formulations...
8685942 Sophorolipid analog compositions  
A composition of matter comprising sophorolipids as antimicrobial agents, antifungal agents, biopesticides, for uses as drugs to treat HIV, septic shock, cancer, asthma, dermatological conditions,...