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8183395 |
Compositions and methods for treating cancer
Compounds of formulas I-IV: (I), (II), (III) (IV), wherein: R1 and R4-R23 are independently selected from H and 1-3 carbon lower alkyl; and R2 and R3 are independently selected from H, 1-3 carbon...
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8173632 |
Process for the modification of the solid state of a compound and co-amorphous compositions produced with same
The invention provides a process for preparing non-crystalline organic compositions and non-crystalline, co-amorphous blends of organic compounds.
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8153689 |
Pleuromutilin derivatives for the treatment of diseases mediated by microbes
Disclosed are pleuromutilin derivatives of formula (I) and their use in the treatment of diseases mediated by microbes.
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8153690 |
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions...
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8153688 |
Esters of 2-phenylalkanenitriles and antifungal compositions containing them
Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitri
le and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters,...
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8106092 |
Treatment of solid cancers
The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors,...
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8101159 |
In vivo methods of identifying compounds which target suppressed cancer cells
In vitro and in vivo methods for identifying compounds capable of targeting suppressed cancer cells such as micrometastatic cells. The in vitro method includes the steps of comparing the response...
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8101653 |
Therapeutic compositions
Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i)...
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8093291 |
Methods of using and compositions comprising tryptophan hydroxylase inhibitors
Methods and compositions comprising tryptophan hydroxylase inhibitors are disclosed. Particular methods are directed at reducing or avoiding serotonin-mediated adverse effects associated with some...
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8093290 |
Coolant solutions and compositions comprising the same
A solution consisting essentially of menthyl lactate and menthol carboxamide dissolved in a solvent, such as propylene glycol, which solvent is acceptable for food, oral care or cosmetic products...
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8071117 |
Pheromones
The apple leaf midge and raspberry cane midge pheromones have been found to be acetoxyheptadecenone and acetoxyundecanone, respectively, and uses for these and related compounds are provided,...
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8071643 |
Pleuromutilin derivatives for the treatment of diseases mediated by microbes
A pleuromutilin derivative compound of general formula (I)
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8067466 |
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions...
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8026278 |
Inhibitors of pyruvate kinase as therapeutic agents for cancer
The present invention relates to compounds for the inhibition of pyruvate kinase and ATP production which are capable of inhibiting cancer cells proliferation.
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8003698 |
Site-specific inhibitors of histone methyltransferase (HMTASE) and process of preparation thereof
The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where R1 and R1 is —OCH3 or —OH, R2 and R2 is —OH or —OAc; a process...
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7994219 |
Approach to anti-microbial host defense with molecular shields with lipoxin compounds
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example,...
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7993666 |
Methods and compositions for treating pain comprising a statin
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a...
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7985772 |
Derivatives of 3,3-diphenylpropylamines
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for...
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7981930 |
Compositions and kits for treating influenza
Kits comprising an M2 inhibitor selected from amantadine and rimantadine; ribavirin, and a neuraminidase inhibitor (NAi) in an amount that is antivirally effective in the combination, an oral...
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7973079 |
Methods and compounds for treating retinol-related diseases
Compounds that reduce serum retinol levels are used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We...
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7964639 |
Modified retinoid compounds and their uses
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the...
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7951841 |
Retinal derivatives and methods for the use thereof for the treatment of visual disorders
Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided.
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7943159 |
Female sex pheromone of the dogwood borer (DWB), Synanthedon scitula, and attraction inhibitor (antagonist)
A composition for attracting male Synanthedon scitula, containing a male Synanthedon scitula attracting effective amount of Z,Z-3,13-octadecadienyl acetate, optionally E,Z-2,13-octadecadienyl...
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7943666 |
Esters of capsaicin for treating pain
The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent...
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7915309 |
Deuterium-enriched oseltamivir
The present application describes deuterium-enriched oseltamivir, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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7915311 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Approach to anti-microbial host defense with molecular shields with lipoxin compounds
Methods to cause tissue, such as mucosal cells, to express increased amounts of bactericidal permeability increasing protein (BPI) are described. The BPI inducing agents include, for example,...
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7858660 |
Compositions and kits for treating influenza
Compositions, kits and methods are provided for the treatment or prophylaxis of influenza.
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7851505 |
Thiotungstate analogues and uses thereof
The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using...
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7834057 |
Compositions and methods for skin treatment
Compositions for the treatment of the skin. The compositions reduce and/or reverse the visible appearance of skin damage. In the preferred embodiment, the composition includes Retinyl Palmitate...
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7795307 |
Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents
Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: Formula (I)...
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7750044 |
Dimer poly-quaternary ester compounds
The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an alkanolamine to make an ester quaternary compound....
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7750045 |
Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
The present invention provides compositions and methods for prevention and prophylaxis of neurological diseases accompanied by neuronal death. The invention includes synthesis of 5-benzylamino...
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7750043 |
Modified retinoid compounds and their uses
A method of minimizing or reducing the toxicity of a retinoid having a free carboxyl group and the resulting modified retinoids are described. The method comprises the step of esterifying the...
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7687541 |
Prodrugs of diaryl-2-(5H)-furanone cyclooxygenase-2 inhibitors
The invention encompasses the novel compounds of Formula (I) and Formula (II), which are prodrugs that convert in vivo to diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2...
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7645792 |
Prodrugs of propofol, compositions and uses thereof
The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical...
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7622504 |
Esters of 2-phenylalkanenitriles and antifungal compositions containing them
Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitri
le and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters,...
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7605178 |
Therapeutic compounds
Disclosed herein are compounds of the formula therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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7547688 |
Methods for treatment of nocturia
A method for the treatment of nocturia which consists of administering to a mammal in need of such treatment a therapeutically effective amount of a nonsteroidal anti-inflammatory drug consisting...
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7524885 |
Compounds that stimulate glucose utilization and methods of use
The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m and n are as defined for...
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7498359 |
Composition and method for preventing recurrence of stroke
By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in...
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7488753 |
Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof
This invention provides composition comprising a triterpenoidal saponin, comprising two side groups attached to carbon 21, and 22 of triterpenoidal saponin backbone. This invention provides a...
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7485320 |
Liposome for incorporating large amounts of hydrophobic substances
A liposome formulation for stably incorporating high content of hydrophobic substance is disclosed. The liposome includes two phospholipids with different phase transition temperatures such as...
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7473704 |
Cyclohexyl prostaglandin analogs as EP4-receptor agonists
The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in...
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7452556 |
Compositions for the treatment of pilosebaceous gland inflammations comprising aluminum fluoride
The present invention relates to compositions for the treatment of pilosebaceous gland inflammations, especially of the hair follicle and its appendages, in particular of Acne Vulgaris and...
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7449315 |
Bifunctional energy-reversible acyl-compositions
Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include:
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7442718 |
Inhibitors of aspartyl protease
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors...
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7384978 |
Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis,...
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7365097 |
Use of at least one (dihydro)jasmonic acid derivative as a desquamating agent
Disclosed herein is the cosmetic use, as a desquamating agent, of at least one (dihydro)jasmonic acid derivative of a given formula. Further disclosed herein is a cosmetic method for smoothing the...
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7304092 |
Compounds and methods for treating tumors, cancer and hyperproliferative diseases
The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and...
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7285572 |
CaSR antagonist
The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist...
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