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7307101 Use of 20-HETE synthesizing enzyme inhibitors as therapy for cerebral vascular disease  
A method for treating cerebral vascular diseases in a human or non-human animal is disclosed. The method involves inhibiting 20-HETE synthesizing enzyme activity sufficiently to increase or prevent...
7217737 Method and compositions for inhibiting cell proliferative disorders  
The present invention concerns compounds and their use to inhibit the activity of a receptor tyrosine kinase. The invention is preferably used to treat cell proliferative disorders such as cancers...
7034045 Monofluoroalkyl derivatives  
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions,...
7012095 Compounds for modulating cell proliferation  
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of Formula (I).
6946426 Process to prepare aqueous formulations  
Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of...
6908925 Treating skin wrinkles/fine lines with calcium channel inhibitors  
A regime or regimen for loosening/slackening and/or relaxing cutaneous and/or subcutaneous human skin tissue, advantageously for cosmetically/therapeutically treating skin wrinkles and fine lines,...
6852328 Method and device for protection of wooden objects proximate soil from pest invasion  
A method and device are disclosed which prevents the decay and deterioration of wooden objects caused by pests by using a controlled release device. This controlled release device utilizes polymers...
6849661 Treatment of abnormal increases in gastrointestinal motility with (R)-verapamil  
The present invention is directed to methods of treating, preventing, and/or managing abnormal increases in gastrointestinal motility, and intestinal conditions that cause the same. Such conditions...
6800659 Compounds for modulating cell proliferation  
Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I:
6780508 Powder particles with smooth surface for use in inhalation therapy  
Carriers for use in the preparation of mixtures for inhalation powders intended for pulmonary administration of micronized drugs by means of a dry powder inhaler and the method for their...
6713509 Controlled release formulation for treating COPD  
This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
6703420 Amino-thio-acrylonitriles as MEK inhibitors  
This invention relates generally to amino-thio-acrylonitriles of formula Ia or Ib: as MEK inhibitors, pharmaceutical compositions containing the same, and methods of using the same as for...
6635663 Pesticidal emulsifiable concentrate  
The present invention provides a low-irritant pesticidal emulsifiable concentrate comprising (a) 1 to 60% by weight of at least one pesticidal active ingredient compound selected from the group...
6602907 Treatment of breast cancer  
Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which...
6558696 Desoxypeganine  
The invention relates to a transdermal therapeutic system (TTS) containing desoxypeganine (1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazoline) as the active component, wherein the TSS includes a back...
6552066 Protein tyrosine kinase inhibitors for treating osteoarthritis  
Disclosed is a method of treating an individual or animal with osteoarthritis. The method comprises administering to the individual or animal a therapeutically effective amount of a protein...
6514934 Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use  
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with...
6509379 Phenylacetic acid derivatives, process and intermediate products for their preparation, and their use as fungicides and pesticides  
Phenylacetic acid derivatives of the formula I where the variables are as disclosed herein, their salts, processes and intermediates for their preparation, and their use for controlling harmful...
6482854 Glaucoma treatment  
Elevated glutamate levels are associated with glaucoma, and damage to retinal ganglion cells can be controlled by administering to the patient a compound capable of reducing glutamate induced...
6458846 Ion channel modulating agents  
The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of oxime derivatives represented by general formula (I) that...
6436937 Use of desoxypeganine in the treatment of Alzheimer's dementia  
The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.
6426366 Pharmaceutical compositions comprising tyrphostins  
Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is 0 or, when Ar has formula (i) above, then...
6376224 Pharmaceutical compositions for eliminating membrane-mediated cell resistance  
The invention relates to a pharmaceutical composition containing an inhibitor for diaphragm pumps and a photoaffinity-marked chemotherapeutic agent. Said composition is suitable for eliminating...
6365609 Substituted 3,3-diamino-2-propenenitriles, their preparation and use  
Described are substituted cyanoenamines of formula I wherein Z, R 1 , R 2 and R 3 are defined in the description, compositions thereof and methods for preparing these compounds. These...
6362205 Substituted 3,3-diamino-2-propenenitriles, their preparation and use  
Described are substituted cyanoenamines of formula I wherein Z, R 1 , R 2 and R 3 are defined in the description, compositions thereof and methods for preparing these compounds. These...
6344461 Treating skin wrinkles/fine lines with calcium channel inhibitors  
A regime or regimen for loosening/slackening and/or relaxing cutaneous and/or subcutaneous human skin tissue, advantageously for cosmetically/therapeutically treating skin wrinkles and fine lines,...
6333354 Synergistic combination of PDE inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists  
A diseased state based on acute or chronic obstruction of vessels and/or bronchi, acute or chronic inflammation and/or edema formation is advantageously treated by the combined administration of a...
6291516 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
6265439 Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives  
A class of halogenated phenylacetonitrile alkylaminoalkylphenyl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection...
6262091 Process and agents for controlling harmful fungi  
Compositions for controlling harmful fungi, containing in a solid or liquid carrier a) at least one p-hydroxyaniline derivative of the formula I ##STR1## b) at least one amide compound of the...
6225346 Tyrphostin like compounds  
The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with...
6221861 Reducing pyrophosphate deposition with calcium antagonists  
This invention provides a method of treating an animal with pyrophosphate gout or osteoarthritis comprising administering an effective amount of a calcium antagonist, thereby reducing calcium...
6194464 Imidic acid derivatives and their use as pesticides  
The present invention relates to new imidic acid derivatives of the formula (I) ##STR1## to a plurality of processes for their preparation, and to their use as pesticides.
6194453 Protein kinase inhibitor  
Disclosed herein are compounds of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy or alkoxy of 1-6...
6191165 Pharmaceutical for treatment of neurological and neuropsychiatric disorders  
The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.
6177462 Unsaturated oxime ethers and their use as fungicides and insecticides  
Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein X is N or CH; Y is O, S or NR 6 ; A is independently hydrogen, halo, cyano, (C 1 -C 12 )alkyl, or (C 1 ...
6162830 Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use  
The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of...
6156796 Agricultural/horticultural fungicidal compositions  
The present invention is directed to fungicidal compositions for agricultural and horticultural use, characterized in that the composition comprises a benzamidoxime composed represented by a...
6121316 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives  
2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves...
6114382 Methods for treating inflammatory bowel disease  
The present invention provides novel compositions and methods relating to the treatment of Inflammatory Bowel Disease ("IBD"), most notably, Ulcerative Colitis, Crohn's Disease, Colitis and...
6087389 Endothelin receptor antagonists  
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
6077866 Benzophenone hydrazone derivatives as insecticides  
Novel benzophenonehydrazone derivatives represented by the formula (I): ##STR1## wherein, R 1 is halogen; R 2 is hydrogen or C 1 -4 alkyl; R 3 is cyano, optically substituted C 1 -4 alkyl, C 2...
6057350 Alpha 1a adrenergic receptor antagonists  
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the...
6051605 Method of treating psychosis and schizophrenia  
This invention relates to compounds that are antagonists of dopamine D4 receptors, and to methods of treating psychosis and schizophrenia using a compound that is an antagonist of dopamine D4...
6046235 Sulfur-containing amino acid derivatives  
A sulfur-containing amino acid compound having a high inhibitory activity on LTA 4 hydrolase which is represented by the following formula: ##STR1## wherein R 1 represents H, alkyl, optionally...
5994294 Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses  
Disclosed are nitrosated and nitrosylated α-adrenergic receptor antagonists, compositions of an α-adrenergic receptor antagonist (α-antagonist), which can optionally be substituted with at least...
5981569 Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease  
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or...
5955500 Pharmaceutical compositions containing non-racemic verapamil and process for optimizing the pharmaceutical activity of R- and S-verapamil  
Pharmaceutical compositions containing non-racemic mixtures of verapamil are described, as well as a process of making pharmaceutical compositions containing unequal amounts of R- and S-verapamil....
5880156 Substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing them  
Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical or diagnostic, and pharmaceutical containing them Benzoylguanidines of the formula I ##STR1## are...
5861435 Method for preventing settlement of aquatic fouling organisms  
A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to...
Matches 1 - 50 out of 227 1 2 3 4 5 >