|
Match
|
Document |
Document Title |
|
|
7622503 |
Selective androgen receptor modulators and methods of use thereof
This invention provides SARM compounds and their use in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related...
|
|
|
7622134 |
Substrate for volatile delivery systems
Volatile impregnated substrates, such as wicks and mats, that can be used in a dispensing device that uses a heat source or otherwise uses active means to promote the release of the volatile...
|
|
|
7579374 |
Agent for improving bone metabolism
The present invention relates to an improver for bone metabolism comprising one or at least two of chain isoprenoid fatty acid esters and preferably to an improver for bone metabolism whose...
|
|
|
7550505 |
Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists...
|
|
|
7547728 |
Treating muscle wasting with selective androgen receptor modulators
This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating,...
|
|
|
7468360 |
Therapeutic amides and related compounds
Disclosed herein is a compound having a structure:
Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
|
|
|
7449599 |
Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase...
|
|
|
7414152 |
N-substituted p-menthane carboxamides
Cooling compounds are provided having the formula:
wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4...
|
|
|
RE40259 |
Alpha-aminoamide derivatives useful as analgesic agents
The present invention relates to novel and known alpha-aminoamide compounds, to a process for their preparation, to pharmaceutical composition containing them and to their use as therapeutic...
|
|
|
7345095 |
Sulfonamide compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula I
wherein R 1 , R 2 , R 3 , m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. The...
|
|
|
7317066 |
Liquid crystal polymers
Liquid crystal polyester derived from phenylene-naphthalene monomers and one or more comonomers display an improved balance of properties, including low melt viscosity, fast cycle time in molding,...
|
|
|
7291620 |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme...
|
|
|
7258868 |
Volatile releasing substrates and methods for preparing them
Substrates are provided for use in a heating and/or blowing device that dispenses volatile material. The substrates are a porous medium (such as porous ceramic) having their interior pores coated...
|
|
|
7169810 |
Guanidine and amidine acid derivatives and analogs and methods of using the same
The present invention releates to certain novel guanidine or amidine acid derivatives and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated...
|
|
|
7138130 |
Substrate for volatile delivery systems
Volatile impregnated substrates, such as wicks and mats, that can be used in a dispensing device that uses a heat source or otherwise uses active means to promote the release of the volatile...
|
|
|
7109243 |
Inhibitors of cathepsin S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
|
|
|
7084178 |
Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described.
The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the...
|
|
|
7067141 |
Pesticidal treatment materials
The short term effectiveness of pesticidal articles, for example pesticide impregnated textile covers for use in combating dust mite infestation, is improved by the additional presence of a quick...
|
|
|
6951884 |
Fluorobenzamides and uses thereof
The invention relates to fluorobenzamide derivatives of the formula
wherein R 1 , R 2 , R 3 R 4 , R 5 , R 6 and R 7 are as defined herein. =,
The compounds of the invention are selective...
|
|
|
6946426 |
Process to prepare aqueous formulations
Provided is a method of formulating hydrophobic pesticides comprising emulsifying an aqueous phase and a water-immiscible phase to form a formulation; wherein the aqueous phase is comprised of...
|
|
|
6919375 |
Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof.
|
|
|
6861448 |
NAD synthetase inhibitors and uses thereof
Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar 1 —X—Ar 2 —Y—L—Z—Q, wherein Q is Q 1 Ar 3 or Ar 3 Q 1 ;...
|
|
|
6826033 |
Aminoalcohol derivatives
The present invention relates to a compound formula (I) wherein X 1 is bond or —O—CH 2 —, (II) or (III) R 1 is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl,...
|
|
|
6767922 |
IL-8 receptor antagonists
This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
|
|
|
6713509 |
Controlled release formulation for treating COPD
This invention relates to a controlled or sustained release formulation designed to deliver a PDE4 inhibitor for treating an inflammatory disease such as asthma or COPD and the like.
|
|
|
6670400 |
Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT 1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their...
|
|
|
6656968 |
(Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors
Compounds of the formula are provided wherein R 1 , R 2 , R 3 and R 4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C 1 -C 8 alkyl, C 1 -C 6 alkoxy,...
|
|
|
6617351 |
Amide, carbamate, and urea derivatives
The present invention provides certain amide, carbamate and urea derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of...
|
|
|
6586467 |
Preparation of phosphatase inhibitors
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B; R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification. Such...
|
|
|
6569899 |
4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient
Aminobutylic acid derivatives of the formula (I) wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds...
|
|
|
6566403 |
N-acetonylbenzamide fungicides
This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.
|
|
|
6562842 |
Protease inhibitors
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or...
|
|
|
6552075 |
Therapeutic compounds and methods of use
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
|
|
|
6528543 |
Urea derivatives
Glucokinase activating compounds of the formula wherein R 1 and R 2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio,...
|
|
|
6525091 |
Substituted diarylureas as stimulators for Fas-mediated apoptosis
Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers,...
|
|
|
6495604 |
Cycloalkene derivatives, process for producing the same, and use
The present invention provides a compound represented by the formula: wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally...
|
|
|
6465494 |
Methods for treatment of cystic fibrosis
Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of cystic fibrosis.
|
|
|
6465457 |
Carbonate, carbamate, thiocarbonate dithiocarbonate and thiocarbomate derivatives useful as fungicides
Fungicidal compounds of formula (I): wherein W is CH 3 O.CH═CCO 2 CH 3 , CH 3 ON═CCONR 3 R 4 or CH 3 ON═CCO 2 CH 3 and stereoisomers thereof; n is 0 or 1; X is oxygen or sulphur; Z is NR...
|
|
|
RE37873 |
Phenylacetic acid derivatives, preparation thereof and intermediates therefor, and compositions containing them
Phenylacetic acid derivatives of the formula I
|
|
|
6458781 |
Substituted diarylalkyl amides as calcium channel antagonists
The present invention provides compounds that block calcium channels and have the Formula I: The present invention also provides pharmaceutical compositions containing the compounds of Formula I...
|
|
|
6448260 |
Endothelin receptor antagonists
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
|
|
|
6407100 |
Fungicidal aromatic oximes
The invention relates to novel compounds of the formula in which R 1 is C 1-4 alkyl and (Y—X) is CH 2 , C 1-2 alkylthio-CH═ or C 1-2 alkyl-ON═ and Z is an aldimino or ketimino group, and...
|
|
|
6395737 |
Malonic acid derivatives, processes for their preparation, for their use and pharmaceutical compositions containing them
New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I, wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings...
|
|
|
6384017 |
Methods for treating sex hormone-dependent conditions with Lhrh antagonists
Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one...
|
|
|
6355673 |
Substituted diaminocarboxylic acids
Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
|
|
|
6294573 |
Reverse hydroxamate inhibitors of matrix metalloproteinases
Compounds having the formula ##STR1## are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase...
|
|
|
RE37302 |
Peptide
The invention employs GLP-1(7-37), GLP-1(7-36)amide, and certain related compounds in combination with an oral hypoglycaemic agent for treating diabetes mellitus.
|
|
|
6265432 |
Flourine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as...
|
|
|
6211234 |
Substituted phenyl compounds
Compounds of formula (I) are described wherein R 1 is hydrogen, -(lower alkyl) q (CO 2 R 6 or OH), --CN, --C(R 7 )NOR 8 , NO 2 , --O(lower alkyl)R 9 , --C.tbd.C--R 10 , --CR 11 C(R 12 )(R...
|
|
|
6194454 |
Cyano containing oxamic acids and derivatives as thyroid receptor ligands
The present invention provides novel compounds of the Formula ##STR1## and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs...
|