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7605145 |
Micronutrient formulations for treatment of diabetes mellitus
Formulations for minimizing damage to at least one of cells, organs and systems within the body of a subject afflicted with Diabetes Mellitus. The invention additionally encompasses methods for...
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7598230 |
Nucleotide mimics and their prodrugs
The present invention relates to nucleoside diphosphate mimics and nucleoside triphosphate mimics, which contain diphosphate or triphosphate moiety mimics and optionally sugar-modifications and/or...
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7592489 |
Anionic/cationic masonry sealing systems
A composition comprising a mixture, having a maximum molar ratio of acid to base of 0.6 and providing water repellency when applied to a substrate surface without etching of said surface, of A) an...
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7586020 |
Methods for determining effects of maternal treatments on offspring
The present invention provides animal models and methods for the evaluation of maternal treatments that could improve or compromise the epigenetic state, the imprinting, or the DNA methylation and...
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7585852 |
Cobalamine derivatives useful for diagnosis and treatment of abnormal cellular proliferation
The invention relates to cobalamin derivatives having no or low binding affinity to the transport protein transcobalamin II (TCII) and retaining activity as a vitamin B12 substitute, optionally...
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7524831 |
Treatments for Flaviviridae virus infection
The present invention provides methods for treating infections, in a host, by viruses belonging to the Flaviviridae family, such as HCV, comprising administering an Ara-C homologue to the host.
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7485629 |
Composition and method for treatment of joint damage
The invention provides compositions useful for the treatment and/or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial...
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7470818 |
Fluoroalkyl phosphate compositions
A composition comprising a compound of formula (I) or (II):
wherein
r and q are independently integers of 1 to 3; R f is linear or branched chain perfluoroalkyl group having 1 to 6...
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7468432 |
Cobalamin conjugates useful as antitumor agents
The invention provides cobalamin compounds linked to a neutron capture therapy target (e.g. Boron-10 or Gadolinium-157), and optionally linked to a detectable moiety, as well as pharmaceutical...
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7449451 |
Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
Disclosed herein is a method for protecting humans in need of such protection from physical damage caused by ionizing radiation comprising administering to said humans on a defined basis prior to...
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7439349 |
Method for preparation of large volume batches of poly-ICLC with increased biological potency; therapeutic, clinical and veterinary uses thereof
Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for...
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7405204 |
Nucleoside compounds for treating viral infections
Disclosed are compounds, compositions and methods for treating viral infections caused by a Flaviviridae family virus, such as hepatitis C virus.
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7399755 |
Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same
The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary...
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7390509 |
Compositions and methods for nutrition supplementation
The present invention relates to compositions comprising various vitamins and minerals and methods for using these compositions for nutritional supplementation in, for example, pregnant or...
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7384981 |
Preparation for improving the action of receptors
The present invention relates to the use of polyunsaturated fatty acids and one or more components which have a beneficial effect on total methionine metabolism selected from the group consisting...
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7368131 |
Method and composition for treating hypopigmentation of the hair and skin
A method of treating disorders marked by a loss of pigmentation, comprising the step of administering vitamin B12, copper, folic acid, and vitamin C to a patient suffering from a loss of...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7323449 |
Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent...
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7304044 |
Lowering blood glucose, urea, cholesterol, triglycerides and normalizing homocysteine levels by dietary addition of selected essential amino acids and three vitamins
Administration of a dietary supplement consisting of L-Tryptophan (80 mgs), L-Methionine (90 mgs), L-Valine (103 mgs), L-Lysine Monohydrochloride (128 mgs), Vitamin B-12 (0.5 mg), Vitamin B-6 (10...
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7303771 |
Alfalfa sprout powder based supplement
The present disclosure relates to the novel nutritional methods and compositions containing essential alfalfa sprouts powder which reduces certain risk factors of cardiovascular disease...
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7294514 |
Diagnostic method for alzheimer's disease based on holo-transcobalamin II
The invention provides a diagnostic or prognostic assay method for Alzheimer's Disease by assaying a body fluid sample or a test sample derived therefrom for holo-trancobalamin II.
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7279465 |
Use of amphiphilic nucleoside phosphonoformic acid derivatives for the treatment of viral infectious diseases
The invention relates to a method for treating infectious diseases which are elicited by viruses which are pathogenic to humans comprising the step of administering an amphiphilic...
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7268119 |
Tricyclic nucleosides or nucleotides as therapeutic agents
Nucleosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
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7262224 |
Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof
A cosmetic composition is shown for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, in the form of a lotion or cream which includes as a major component...
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7241731 |
Oligopeptides for promoting hair growth
The present invention provides oligopeptides having morphogenesis promoting activity and in particular, hair promoting activity. The oligopeptides may be in monomer form, monomer having a reactive...
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7232805 |
Cobalamin conjugates for anti-tumor therapy
The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker...
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7229636 |
Cyanocobalamin low viscosity aqueous formulations for intranasal delivery
A stable pharmaceutical mercury-free aqueous solution of cyanocobalamin comprised of cyanocobalamin and water wherein said solution of cyanocobalamin is suitable for intranasal administration, has...
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7205007 |
Peri-operative and peri-procedure nutritional supplementation
The invention provides a nutritional supplement system and program for patients undergoing or who have undergone a surgical or other invasive or stressful procedure, or who have suffered an injury....
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7202229 |
Aspirin formulation for cardiovascular health
The invention relates generally to an aspirin formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for maintaining cardiovascular...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7141233 |
Radionuclide labeling of vitamin B12 and coenzymes thereof
A compound useful for in vivo imaging of organs and tumors is provided of formula:
wherein
is a cobalamin,
is derived from a corrin carboxylic acid group of said cobalamin, Y is a...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7115579 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7109181 |
Joint lubrication with P2Y purinergic receptor agonists
The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises...
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7105499 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are...
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7105495 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG dinucleotide-containing compounds. The methods according to the invention enables both decreasing the...
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7101860 |
Composition and method for inhibiting platelet aggregation
This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The...
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7101842 |
Targeted delivery of drugs for the treatment of parasitic infections
Targeting agents such as transferrin and transcobalamin can be conjugated with anti-protozoan drugs for the treatment of protozoan infections. Any suitable anti-protozoan drug can be used,...
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7094770 |
3′-or 2′-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a...
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7091190 |
Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically...
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7084126 |
Methods and compositions for enhancing cellular function through protection of tissue components
Methods and composisions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and cofactors,...
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7064113 |
Resin composition, method of molding the same, and method of recycling resin composition
A resin composition, which comprises a biodegradable polymer and a biodegradable liquid crystalline polymer. The resin composition is useful for producing molded resin articles having good...
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7063865 |
Composition and method for substantially reducing the deleterious effects of alcohol on the body
A composition that will substantially reduce the deleterious effects of alcohol on the body and substantially reduce the side effects associated with hangovers (i.e. headaches, dizziness, nausea,...
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7056894 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases, and uses thereof
The present invention provides compounds having the formula:
wherein A is chosen from a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group; both B and C are...
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7053065 |
Vitamin B12 and pemetrexed disodium combination therapies
A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
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7045151 |
Method and composition for improving fertility health in female and male animals and humans
In a new pharmaceutical combination, the herb, Vitex agnus - castus (chasteberry), enhances hormone balance by increasing progesterone release and, therefore, ovulation frequency. The...
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7034012 |
Composition and method for prevention and treatment of arrhythmias
A composition of biochemical substances for the treatment of arrhythmia in a human susceptible to arrhythmia, and its method of administration, comprising at least one ascorbate compound selected...
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7022680 |
Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
The present invention provides compounds having the formula:
wherein A is a nitrogen-, oxygen-, or sulfur-linked aryl, alkyl, cyclic, or heterocyclic group, the group being further substituted...
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6995145 |
Methods and compositions for modulating drug activity through telomere damage
The invention provides methods and compositions for modulating the activity of therapeutic agents for the treatment of a cancer by administering one or more agents that (either alone or in...
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