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6414020 |
Amidino protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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6403643 |
Use of 2,5-dihydroxybenzenesulfonic derivatives for the normalization of endothelial function
A method for the use of 2,5-dihydroxybenzenesulfonic derivatives for normalizing endothelial function is disclosed. Preferred 2,5-dihydroxybenzenesulfonic derivatives are calcium dobesilate,...
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6399659 |
Hydrazine oxoacetamide derivative and insecticide
The present invention relates to a hydrazine oxoacetamide derivative or its salt which exhibits an excellent insecticidal effect even at a low concentration. The hydrazine oxoacetamide derivative...
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6365625 |
Compound for inhibiting HIV infectivity
This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation...
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6319903 |
Anticonvulsant derivatives useful in treating cluster headaches
Anticonvulsant derivatives useful in treating cluster headaches are disclosed.
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6274622 |
Method of treating diabetic ophthalmopathy
This invention relates to a method of treating patients afflicted with diabetic ophthalmopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
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6274632 |
Derivatives of 4,4-difluorobut-3-enylsulfinic acid and their use as pesticides
The invention relates to compounds of the formula (I): CF 2 CX--CH 2 --CH 2 --S(O)--R wherein X represents hydrogen, halogen or lower alkyl, and R represents a group OR 1 or NR 2 R 3 ...
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6262038 |
Germicidal composition
A germicidal composition suitable for cleaning fruits, vegetables, skin and hair, includes a mixture of fruit acids and a surfactant. The surfactant may be an anionic surfactant (such as sodium...
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6255353 |
Inhibition of angiogenesis
Certain simple chemical agents, referred to herein as nitrone related therapeutics or "NRTs", when administered to a patient susceptible to neovascularization (angiogenesis), can intervene and...
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6225295 |
Method of treating acetaminophen overdose
A method of treating patients suffering from acetaminophen overdose is disclosed. The method comprises administering to a patient in need of treatment an effective amount of a thiol or reducible...
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6197817 |
Phenylpropionic acids and esters: compounds and methods for inducing beta-blockade for the treatment of cardiac disorders
Disclosed are compounds of the formula: ##STR1## R represents hydrogen or is a C-3 to C-6 cycloalkyl or C-4 to C-10 straight or branched carbon chain alkyl-cycloalkyl or a group --B--D, where B is...
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6177411 |
Method for treating heavy metal poisoning
This invention relates to a method of treating patients afflicted with heavy metal poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or...
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6169116 |
Amino-tetralines, pharmaceutical compositions containing them and their pharmaceutical uses
Compounds of formula I ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the description, are useful as pharmaceuticals.
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6165997 |
Phospholipids having antimicrobial activity with or without the presence of antimicrobials
A pharmaceutical formulation for stimulating growth of Gram-positive Bacilli and increasing the acidity in vagina comprises sucrose and/or maltose, optionally with other sugars, viscous base, and...
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6147111 |
Phenyl derivatives useful as endothelin receptor antagonists
Novel phenyl derivatives which are useful as endothelin receptor antagonists.
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6107345 |
Benzocyclobutane compounds
A compound of formula (I): ##STR1## wherein: Z 1 , Z 2 , Z 3 , Z 4 , which may be identical or different, represent a group as defined in the description, X represents oxygen, S(O) p , --(CH 2 )...
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6106821 |
Fly attractant compositions
The invention relates to fly attractant compositions that comprise at least one volatile short chain carboxylic acid, at least one organic sulfide and at least one nitrogen heterocycle. In a...
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6100247 |
Method of treating diabetic neuropathy
This invention relates to a method of treating patients afflicted with diabetic neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
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6071961 |
Antimicrobial composition and methods of use therefor
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6043274 |
Method of treating diabetic cardiomyopathy
This invention relates to a method of treating patients afflicted with diabetic cardiomyopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or...
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6034126 |
Method for treating glycol poisoning
This invention relates to a method of treating patients afflicted with glycol poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or...
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6001873 |
Process for preparing a high purity epoxy resin
This invention relates to a process for preparing a high purity epoxy resin comprising reacting an aromatic compound containing hyroxyl or amino group with an excess amount of an epihalohydrin in...
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5998479 |
Method of treating adult respiratory syndrome
This invention relates to a method of treating patients afflicted with Adult Respiratory Distress Syndrome (ARDS). The method includes administering to a patient in need of treatment an effective...
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5985859 |
Methods of inhibiting bacterial sialidase
A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO 2 H, PO 2 H, or SO 2 H; B is...
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5916922 |
Phenyl glyoxamides as SPLA2 inhibitors
A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA 2 mediated release of fatty acids for treatment of conditions such as septic shock.
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5910323 |
Insecticide compositions
This invention provides a novel aqueous pesticide formulation having a fungicidal bicarbonate-containing inorganic salt ingredient which enhances the efficacy of an insecticidal ingredient for...
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5906985 |
Pharmaceutical compounds
Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R 1 is hydrogen, C 1 -10 alkyl, C 2 -10 alkenyl, C 2 -10 alkynyl, phenyl, naphthyl, C 1 -10 alkyl-phenyl,...
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5891909 |
Amidinohydrazones as protease inhibitors
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R 1 -R 4 , R 6 -R 9 , Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or...
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5889050 |
3,3'-dithiobis (propionic acids) and esters thereof
New 3,3'-dithiobis(propionic acids) and esters thereof with immunomodulating effect, processes for their preparation, pharmaceutical compositions containing them and methods of their...
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5882689 |
Control of soilborne fungi in cultivated crops
This invention provides a method for controlling soilborne fungal disease in cultivated field plants such as a peanut crop. Field crop soil is treated with a free-flowing granular fungicide...
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5827837 |
Polyanion anti-inflammatory agents
Selectin binding and inflammation is modulated by a method which utilizes inositol polyaninon.
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5811454 |
4-amino-fluorobenzamides and their use as cytotoxic prodrugs
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) ##STR1## wherein R-NH is the residue of an α-amino acid R-NH 2 or oligopeptide R-NH 2 , and M is a nitrogen...
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5807847 |
Nitrate esters
Aliphatic Nitrate esters having a sulfur or phosphorus atom β or γ to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a...
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5776925 |
Methods for cancer chemosensitization
Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be...
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5760006 |
Anticonvulsant derivatives useful in treating psoriasis
The use of compounds of the following formula I: ##STR1## for treating psoriasis is disclosed.
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5750577 |
Chromotropic acid-formaldehyde and 1-naphthol-formaldehyde polymeric compounds
Novel medicinally-useful compounds are provided herein. These compounds include isomeric cyclic tetramers of formaldehyde and 1-naphthol, and the derivatives or analogues of such cyclic tetramers,...
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5736056 |
Method for enhancing biocidal activity
A treatment for enhancing the activity of biocidal compounds to control the growth of microbes in an aqueous system is disclosed, which comprises adding to said compounds an effective amount of an...
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5728731 |
Anti-herpes virus and cytomegalovirus polyamide oligomers
The oligomers of the present invention are polyamides having a number average molecular weight of <10,000. These oligomers are water-soluble, have a rigid backbone with a predictable anion...
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5719182 |
Endothelin receptor anatagonists
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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5716990 |
Drug delivery systems
Nitrogen mustard pro-drugs of the formula ##STR1## are disclosed where R is the residue of an α-amino acid RNH 2 and M is a disubstituted amino "mustard" group, useful in antibody directed enzyme...
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5631285 |
Synergistic insecticidal compositions
Compounds comprised of 2-(4-tert-butylphenoxy) cyclohexyl prop-2-ynyl sulfite and a synthetic pyrethroid exhibit synergistic pesticidal activity.
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5614554 |
Reverse transcriptase inhibitors and antiviral agents
The present invention provides a reverse transcriptase inhibitor and an antiviral agent comprising at least one member selected from the group consisting of sulfated tyrosines and physiologically...
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5596017 |
Sulfamide derivatives
Novel pesticidal sulfamide derivatives of the formula ##STR1## in which X is halogen or C 1 -C 4 -halogenoalkyl, R 1 is C 1 -C 4 -alkyl or C 1 -C 4 -halogenoalkyl, R 2 is hydrogen or C 1 ...
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5563174 |
Hydrazone compound and insecticide containing said compound as active ingredient
A hydrazone compound of the general formula (I): ##STR1## wherein X is halogen; R 1 is hydrogen, optionally substituted C 1 -C 4 alkyl or optionally substituted C 1 -C 4 alkoxy; R 2 's are...
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5541224 |
Carbanilide anticoccidials
The present invention is directed to anticoccidial methods, animal feed premixes, and animal feeds, employing a specified carbanilide compound. The present invention is also directed to...
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5536748 |
Hydrazone compound and insecticide containing the same as active ingredient
The present invention provides a hydrazone compound of the formula I: ##STR1## wherein R 1 and R 2 are the same or different and are independently hydrogen, C 1 -C 2 alkyl, C 1 -C 2 alkoxy,...
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5510379 |
Sulfonate ACAT inhibitors
β-Carboxy sulfonates of the formula ##STR1## wherein R 1 is aryl, R 3 and R 4 are hydrogen or alkyl, Y is -O-, -S-, or -NR 2 -, and R 5 is alkyl or aryl are potent inhibitors of the enzyme...
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5508305 |
2, 4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals
2,4-disulfonyl α-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous...
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5474712 |
Livestock conditioning shampoo
A livestock conditioning shampoo consists of sodium lauryl sulfate, polyoxyethylene (20) sorbitan monolaurate, d-limonene, polyacrylic acid, acrylic copolymer emulsifier, butylated hydroxytoluene,...
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5468716 |
Bicarbonate fungicide product with a combination of surfactant ingredients
The present invention provides a fungicide composition which contains ingredients which are biocompatible for purposes of agricultural applications, and which are harmless to animals and humans. An...
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