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9029414 Triterpenoid compounds and methods of use thereof  
The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain,...
8975228 Use of boswellic acids for the prophylaxis and/or treatment of damage to and/or inflammation of the islets of Langerhans  
Disclosed are methods and compositions related to the use of boswellic acids (such as acetyl-11-keto-β-boswellic acid, 11-keto-β-boswellic acid, β-boswellic acid, acetyl-β-boswellic acid,...
8921419 Triterpenoids and compositions containing the same  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8901169 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have...
8865689 Methods and compositions for treating hyperuricemia and metabolic disorders associated with hyperuricemia  
Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective...
8853256 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8835493 Oligo-benzamide compounds for use in treating cancers  
The present invention provides bis- and tris-benzamide compounds in the treatment of breast, brain and ovarian cancers.
8802718 Composition for preventing the occurrence of cardiovascular event in multiple risk patient  
Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular...
8802727 Pharmaceutically acceptable salts of betulinic acid derivatives  
The present invention relates to certain novel salts of Betulinic acid derivatives, to process for preparing such compounds, to use the compounds in treating diseases or disorders mediated by HIV...
8790925 Methods of generating hyper iNOS expressing cells and uses thereof  
A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to...
8785494 Calcium sensing receptor modulating compounds and pharmaceutical use thereof  
The invention relates to novel calcium-sensing receptor (CaSR) modulating trifluoromethylphenylene cyclopentylene compounds represented in formula (I) and derivatives thereof, to said compounds...
8778990 Betulinic acid derivatives and methods of use thereof  
This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as...
8772273 Formulations and uses of retinoic acid receptor selective agonists  
The invention provides retinoic acid receptor (RAR) selective agonists and formulations thereof for the treatment of disease or for inducing a medically beneficial effect.
8734769 1L1RL-1 as a cardiovascular disease marker and therapeutic target  
This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to...
8691868 Neprilysin inhibitors  
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds...
8673910 Proteasome inhibitors for selectively inducing apoptosis in cancer cells  
The subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical...
8653086 Naphthamides as anticancer agents  
A compound (particularly useful for inhibiting cancer) according to formula I: or a pharmaceutically acceptable salt thereof, wherein:x is 0 or 1;R1-R6 are each independently H, —CN, —NO2, —NO,...
8633243 Forms of CDDO methyl ester  
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for...
8629169 4-substituted-3-phenylsulfanylmethyl-bicyclo[3.1.0]hexane compounds as mGluR 2/3 antagonists  
A mGlu2/3 receptor antagonist of the formula: its uses, and methods for its preparation are described.
RE44704 Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents  
The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for...
8618163 Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity  
The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.
8592426 Aryl-benzocycloalkyl amide derivatives  
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the...
8563003 Method for the treatment of malignant and infectious chronic diseases  
The present invention relates to methods of treatment useful in chronic diseases, by means of the rupture of tolerance to self-antigens and increasing autoimmune response against these antigens....
8557835 Statin-carboxyalkylether combinations  
The invention is a pharmaceutical composition comprising a carboxyalkylether which lowers triglycerides and elevated HDL, and a statin which inhibits HMG-CoA reductase, thereby reducing LDL, said...
8536120 Ghrelin/growth hormone releasing peptide/growth hormone secretatogue receptor antagonists and uses thereof  
The present invention provides novel compounds that have been demonstrated to be modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, iso forms and...
8524769 Process for producing a fraction enriched up to 100% of 3-O-acetyl-11-keto-beta-boswellic acid from an extract containing a mixture of boswellic acids  
The invention relates to a process for producing a fraction enriched upto 100% of 3-O-acetyl-11-keto-β-boswellic acid. An organic solvent extract of gum resin from Boswellia species is first...
8524214 Polyal drug conjugates comprising variable rate-releasing linkers  
Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.
8518914 HMG-CoA reductase and farnesyl-pyrophosphate synthase inhibitors for the treatment of conditions related to prenylated proteins in cells  
The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated...
8476315 N-hydroxy C29-amide derivatives of oleandrane  
The present invention encompasses novel triterpene compounds of general formula I, wherein R3a, R3b, R11a, R11b, R31 and R32 are defined as in claim 1, which are suitable for the prevention and/or...
8455544 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8435497 Formoterol of and ciclesonide combination  
The invention relates to pharmaceutical compositions containing combinations of formoterol and ciclesonide and the use of such pharmaceutical compositions in medicine, in particular, the...
8420697 Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom  
The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible...
8389573 Glycyrrhetinic acid derivatives  
The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an...
8362073 Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals  
The present invention relates to compounds of the formula I, wherein A, Y, Z, R3 to R6, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active...
8349887 Methods of treating cachexia with macrocyclic modulators of the ghrelin receptor  
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue...
8318425 Inhibition of HIV-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein  
Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid...
8314145 High purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one and process for the synthesis thereof  
The invention relates to a new process for the synthesis of high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from...
8313744 Composition for the prevention and treatment of absence seizures comprising PKC agonist as an effective ingredient  
The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by...
8309601 Forms of CDDO methyl ester  
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for...
8268240 Ciclesonide-containing sterile aqueous suspension  
The present invention provides methods of manufacturing a sterile ciclesonide-containing aqueous suspension comprising the step of sterilization by autoclaving a ciclesonide-containing aqueous...
8232295 Treating vascular events with statins by inhibiting PAR-1 and PAR-4  
The present invention relates to new methods for treating and/or preventing vascular events by inhibiting G-coupled Protease Activating Receptor (PAR)-1 and/or PAR-4 with the administration of...
8202903 Use of aminaphtone for the preparation of a medicament for treating arteriopathies  
The subject of the present invention is the use of aminaphtone for the preparation of a medicament for treating arteriophaties, in particular arteriophaties of a degenerative inflammatory type....
8163806 Controlled release of biologically active compounds from multi-armed oligomers  
The present invention relates to the discovery of biodegradable multi-armed oligomers wherein the end groups of these oligomers have been functionalized with biologically active molecules. The...
8129429 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8088824 Forms of CDDO methyl ester  
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for...
8088823 Tuberculosis treatment using pleuromutilin derivatives  
A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
8067394 Synthesis and biological activities of new tricyclic-bis-enones (TBEs)  
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The...
8022104 Formulations of ladostigil tartrate  
Disclosed are formulations of ladostigil tartrate, including pharmaceutical compositions, process for the manufacture, and use thereof.
7968596 Preparation and diabetic use of Gibberellins  
The present invention relates to application of compounds of formula (1) (Gibberellins) and their derivatives for the preparation of a pharmaceutical composition or medicaments for the treatment...
7964614 Systemic inflammatory markers as diagnostic tools in the prevention of atherosclerotic diseases and as tools to aid in the selection of agents to be used for the prevention and treatment of atherosclerotic disease  
The invention involves methods for characterizing an individual's risk profile of developing a future cardiovascular disorder by obtaining a level of the marker of systemic inflammation in the...

Matches 1 - 50 out of 408 1 2 3 4 5 6 7 8 9 >