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8168232 Formulations and methods of using nitric oxide mimetics in cancer treatment  
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics,...
8101658 Nitric oxide donating prostamides  
Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
8067464 Compositions and methods using apocynin compounds and nitric oxide donors  
The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least...
8062653 Controlled release of nitric oxide and drugs from functionalized macromers and oligomers  
The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain...
8048875 Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker  
Bethanechol, diltiazem, or a combination thereof is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and hemorrhoids. The agents induce a...
7943667 Potentiating the effect of compound comprising nitric oxide  
Treatment of or prophylaxis against the occurrence of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction or infection in the lungs comprises administration into the...
7883714 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use  
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID,...
7759392 Pharmaceutical compounds  
Compounds or their salts of general formula (I): A-B—N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X═O, S, NR1c, R1c is H or ...
7736636 Method for treating occlusive vascular diseases & wound healing  
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of Nicotine, nicotinic acid analogs thereof,...
7723382 Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof  
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups,...
7678391 Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype  
The present invention relates to methods and formulations for inhibiting, treating and preventing a malignant cell phenotype, cell, tumor and/or disease. Administration of nitric oxide mimetics,...
7622502 Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors  
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The...
7622501 Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors  
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula...
7544711 Use of nitroderivatives in urinary incontinence  
The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other...
7378437 Drugs for diabetes  
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)b0—(C)c0—NO2 wherein A contains the radical of a drug having an antiinflammatory or ana...
7186753 Pharmaceutical compounds  
Compounds or their salts of general formula (I): A—B—N(O)s wherein: s is an integer equal to 1 or 2; A=R—T1—, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R1c is H ...
7166638 Statin derivatives  
Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular...
7166605 Probucol nitro-derivatives  
Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
7163958 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use  
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID,...
7160920 Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders  
Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a ...
7115661 Methods and compositions for mitigating pain  
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount...
6987129 Compounds and methods for the treatment of urogenital disorders  
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial...
6916835 Nitrate esters and their use for neurological conditions  
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated...
6872751 Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof  
The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises...
6844320 Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor  
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
6677374 Nitrate esters and methods of making same  
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated...
6627632 Compositions and methods for the treatment of anorectal disorders  
Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, β-adrenergic agonists, cA...
6559180 Nitroglycerin-menthol potentiation for treatment of angina  
The strength of a nitroglycerin dosage to be administered to patients suffering from angina can be reduced when a portion of the dosage is replaced with menthol containing substances (MCS). MCS and...
6534546 Aniline derivatives possessing an inhibitory effect of nitric oxide synthase  
Compounds represented by the general formula (1):  (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1-6 carbon a...
6528068 Cosmetic composition containing N-acyl neutral amino acid esters of lower alcohols  
An N-long-chain acyl neutral amino acid ester containing a straight-chain or branched-chain, saturated or unsaturated acyl group having from 6 to 22 carbon atoms, where the hydrocarbon group of the...
6514934 Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use  
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with a...
6492332 Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation  
This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell...
6472425 Methods for treating female sexual dysfunctions  
The present invention provides methods for treating female sexual dysfunctions by administering to a female individual a therapeutically effective amount of at least one compound that donates,...
6472390 Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure  
Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a...
6413496 Pharmaceutical compositions and devices for their administration  
A device for providing pharmaceutical doses comprising a container, filled with a pharmaceutical composition including a pharmaceutically active agent in a solution of liquified...
6380244 Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers  
Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers...
6335365 Fireproof, non-exploding nitroglycerine and solid mixtures containing anhydrous lactose  
The present invention relates to fireproof, non-explosive solids mixtures containing nitroglycerin and anhydrous lactose that do not have to be classified as an explosive in accordance with...
6333350 Use of nitric oxide donors and/or substrates or nitric oxide inhibitors for regulating cervical dilatation and extensibility  
The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at least...
6221915 Pharmaceutical compositions  
The present invention relates to a pharmaceutical composition comprising a nitrate vasodilator and a compound of formula I: ##STR1##
6211233 Prostaglandin pharmaceutical compositions  
Compounds of the general formula A--X1 --NO2, or their pharmaceutical compositions, wherein A contains a prostaglandin residue, X1 is a bivalent connecting bridge.
6180664 Pentaerythritol derivatives, their production and use and intermediates for their synthesis  
The invention describes novel compounds derived from pentaerythritol of general formula I, XIV, XVI, XIX and XXII, the substituents being as defined in the description, which can be used as...
6160021 Method for treating epidermal or dermal conditions  
A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject, a treatment which modulates the level of nitric oxide (NO) in the skin.
6113921 Topical and transdermal delivery system utilizing submicron oil spheres  
The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a...
6040341 Compounds and their compositions having anti-inflammatory and anti-thrombotic activities  
6040340 Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors  
A method is provided for the improvement of implantation rates and/or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective...
6013667 Benzenesulfonylamine compounds, process for preparing them and pharmaceutical compositions  
Compounds of formula (I): in which: Ra and Rb, identical or different, represent hydrogen or alkyl or together form a bond, RC represents hydroxyl optionally substituted alkoxy, or optionally...
5981579 Use of nitrovasodilators for treatment of disease or stress conditions in a non-human mammal  
This invention relates to methods of treating or controlling a disease or stress condition such as laminitis in a non-human mammal by topically applying to the limb of the mammal a nitrovasodilator...
5965529 Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor  
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
5962413 Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor  
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
5861426 Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities  
New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A--X1 --NO2 or their salts, wherein: A is R(COXu)t, wherein t is...
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