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7622502 |
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases.
The...
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7622501 |
Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula...
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7544711 |
Use of nitroderivatives in urinary incontinence
The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other...
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7378437 |
Drugs for diabetes
Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B) b0 —(C) c0 —NO 2 wherein A contains the radical of a drug having an...
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7235237 |
Methods of treating vascular diseases characterized by nitric oxide insufficiency
The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an...
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7199154 |
Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The...
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7186753 |
Pharmaceutical compounds
Compounds or their salts of general formula (I): A—B—N(O) s wherein: s is an integer equal to 1 or 2; A=R—T 1 —, wherein R is the drug radical and T 1 =(CO) t or (X) t′ , wherein X=O,...
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7166638 |
Statin derivatives
Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular...
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7166605 |
Probucol nitro-derivatives
Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases.
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7163958 |
Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID,...
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7160920 |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO 2 group or a...
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7115661 |
Methods and compositions for mitigating pain
Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount...
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6987129 |
Compounds and methods for the treatment of urogenital disorders
The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial...
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6916835 |
Nitrate esters and their use for neurological conditions
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated...
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6872751 |
Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof
The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises...
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6844320 |
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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6677374 |
Nitrate esters and methods of making same
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated...
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6627632 |
Compositions and methods for the treatment of anorectal disorders
Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O 2 − ) scavengers, β-adrenergic agonists,...
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6559180 |
Nitroglycerin-menthol potentiation for treatment of angina
The strength of a nitroglycerin dosage to be administered to patients suffering from angina can be reduced when a portion of the dosage is replaced with menthol containing substances (MCS). MCS and...
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6534546 |
Aniline derivatives possessing an inhibitory effect of nitric oxide synthase
Compounds represented by the general formula (1): (where R 1 is SR 6 or NR 7 R 8 , where R 6 is typically an alkyl group having 1-6 carbon atoms, R 7 is a hydrogen atom, an alkyl group...
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6528068 |
Cosmetic composition containing N-acyl neutral amino acid esters of lower alcohols
An N-long-chain acyl neutral amino acid ester containing a straight-chain or branched-chain, saturated or unsaturated acyl group having from 6 to 22 carbon atoms, where the hydrocarbon group of the...
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6514934 |
Imidazoline α-adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use
The present invention is directed to nitrosated or nitrosylated α-adrenergic receptor antagonists, compositions comprising α-adrenergic receptor antagonists that are optionally substituted with...
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6492332 |
Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell...
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6472425 |
Methods for treating female sexual dysfunctions
The present invention provides methods for treating female sexual dysfunctions by administering to a female individual a therapeutically effective amount of at least one compound that donates,...
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6472390 |
Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure
Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a...
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6413496 |
Pharmaceutical compositions and devices for their administration
A device for providing pharmaceutical doses comprising a container, filled with a pharmaceutical composition including a pharmaceutically active agent in a solution of liquified...
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6380244 |
Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers
Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers...
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6335365 |
Fireproof, non-exploding nitroglycerine and solid mixtures containing anhydrous lactose
The present invention relates to fireproof, non-explosive solids mixtures containing nitroglycerin and anhydrous lactose that do not have to be classified as an explosive in accordance with...
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6333350 |
Use of nitric oxide donors and/or substrates or nitric oxide inhibitors for regulating cervical dilatation and extensibility
The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at...
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6221915 |
Pharmaceutical compositions
The present invention relates to a pharmaceutical composition comprising a nitrate vasodilator and a compound of formula I: ##STR1##
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6211233 |
Prostaglandin pharmaceutical compositions
Compounds of the general formula A--X 1 --NO 2 , or their pharmaceutical compositions, wherein A contains a prostaglandin residue, X 1 is a bivalent connecting bridge.
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6180664 |
Pentaerythritol derivatives, their production and use and intermediates for their synthesis
The invention describes novel compounds derived from pentaerythritol of general formula I, XIV, XVI, XIX and XXII, the substituents being as defined in the description, which can be used as...
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6160021 |
Method for treating epidermal or dermal conditions
A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject, a treatment which modulates the level of nitric oxide (NO) in the skin.
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6113921 |
Topical and transdermal delivery system utilizing submicron oil spheres
The present invention relates to a delivery system which includes a bioactive drug or cosmetic substance presented in the form of submicron oil spheres alone, or drugs or cosmetic substances in a...
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6040341 |
Compounds and their compositions having anti-inflammatory and anti-thrombotic activities
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6040340 |
Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors
A method is provided for the improvement of implantation rates and/or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective...
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6013667 |
Benzenesulfonylamine compounds, process for preparing them and pharmaceutical compositions
Compounds of formula (I): in which: R a and R b , identical or different, represent hydrogen or alkyl or together form a bond, R C represents hydroxyl optionally substituted alkoxy, or...
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5981579 |
Use of nitrovasodilators for treatment of disease or stress conditions in a non-human mammal
This invention relates to methods of treating or controlling a disease or stress condition such as laminitis in a non-human mammal by topically applying to the limb of the mammal a nitrovasodilator...
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5965529 |
Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both,...
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5962413 |
Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor
Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase...
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5861426 |
Nitro compounds of the formula A-X.sub.i -NO.sub.2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A--X 1 --NO 2 or their salts, wherein: A is R(COX u ) t , wherein...
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5859053 |
Acetylsalicylic acid nitrates
The invention relates to new derivatives of acetylsalicylic acid (called ASA in the following), which contain an NO 3 structure. They are therapeutically active either as the intact active...
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5807847 |
Nitrate esters
Aliphatic Nitrate esters having a sulfur or phosphorus atom β or γ to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a...
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5780495 |
Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihidro-3H-pyrrolo ...
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5744124 |
Nitroglycerin-containing hydrophilic aqueous pumpable spray composition
A hydrophilic aqueous pump spray composition for treating angina pectoris comprising 0.15 to 0.50 weight/% of nitroglycerin, 24.50 to 24.85 weight/% of ethanol, 32.00 weight/% of...
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5705527 |
Amino acid derivatives
An amino acid compound of the formula: R 1 NH--CH(R 2 )--COHN--A--ONO 2 , wherein R 1 represents a hydrogen atom, a C 1 -C 7 alkanoyl group, a C 1 -C 6 alkoxycarbonyl group, a C 6 -C 10 ...
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5700947 |
Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo...
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5698589 |
Water-based topical cream containing nitroglycerin and method of preparation and use thereof
A stable, uniform, water-based topical cream containing nitroglycerin, a penetration enhancer, water, a thickener and an emulsifier is provided. Also provided are the method of preparing the cream...
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5674894 |
Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.
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5646181 |
Method and compositions for treating impotence
Pharmaceutical compositions in topical or parenteral form containing organic nitrites are effective in treating male impotence and erectile dysfunction through topical or intracavernosal...
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