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7605178 |
Therapeutic compounds
Disclosed herein are compounds of the formula
therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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7563819 |
Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
The invention provides compounds for use in photochemotherapy or diagnosis, said compounds being branched alkyl esters or substituted alkyl esters of 5-aminolevulinic acid, or derivatives or...
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7544349 |
Personal care compositions
There are described personal care compositions containing a) one or more dibenzoylmethane sunscreening agents; and b) a photostablising amount of a salicylate ester of formula (1):...
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7511095 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs...
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7504091 |
Antiperspirant compositions
antiperspirant compositions comprise an antiperspirant active and a carrier oil in which the carrier oil comprises an aromatic ester oil obeying the general formula:
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7485662 |
Therapeutic agent for diabetes mellitus
An object of the present invention is to provide a therapeutic agent for diabetes mellitus or insulin resistance improving agent, or to provide foods and drinks, food and drink additives, and feeds...
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7485315 |
Compositions comprising a compound of low solubility and a lipophilic amino acid derivative, uses thereof and process for dissolving a compound of low solubility
The invention relates to a process for dissolving at least one compound of low solubility in water, the said process comprising the essential step of mixing the compound of low solubility with at...
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7482378 |
Physiological cooling compositions
The present invention provides, in one aspect, a physiological cooling composition comprising at least one cyclohexane carboxamide, at least one acyclic carboxamide, and at least one stereoisomer...
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7479507 |
Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
3,5-di-substituted-4-hydroxybenzylidene phosphonates and sulfonates useful in treating inflammatory disease, particularly osteoarthritis, and elastomeric particles for oral delivery of drugs are...
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7473705 |
Hexafluoroisopropanol substituted ether derivatives
The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I):
wherein R 1 to R 3 are as defined in the description and in the claims, as well as...
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7473416 |
Medicaments for asthma treatment
A method and apparatus are disclosed for treating asthma and other respiratory conditions. A medicament comprising a surface active phospholipid (SAPL) is prepared in the form of a fine powder and...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7407779 |
Modification of solid 3-sn-phosphoglycerides
Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A 2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine,...
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7407648 |
Merocyanine derivatives for cosmetic use
The use is described of merocyanine derivatives of formula (1), wherein R 1 and R 2 are each independently of the other hydrogen; C 1 -C 22 alkyl; cyclo-C 3 C 8 alkyl; or unsubstituted or C 1 -C...
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7405233 |
Ureido substituted benzoic acid compounds and their use for nonsense suppression and the treatment of disease
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA...
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7399786 |
Derivatives of amino acids for treatment of obesity and related disorders
Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in...
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7388029 |
Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
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7387789 |
Transdermal delivery of non-steroidal anti-inflammatory drugs
The present invention provides a transdermal drug delivery system which comprises: a therapeutically effective amount of a non-steroidal anti-inflammatory drug; at least one dermal penetration...
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7384978 |
Compounds and methods for delivery of prostacyclin analogs
This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis,...
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7378442 |
Chemical entities with multiple modes of anti-inflammatory action
The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory...
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7368478 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula:
wherein G 1 and G 2 are each independently...
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7358276 |
2-Oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
The invention concerns 2-oxo-1-pyrrolidine derivatives of formula I,
wherein the substituents are as defined in the specification, as well as their use as pharmaceuticals.
The compounds of the...
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7316815 |
Polyamino acid derivatives and use thereof in compositions for treating keratin fibers
The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR 3 ; R 1 represents in particular a hydrogen...
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7303760 |
Method for treating multi-drug resistant tumors
Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug...
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7300955 |
Method and materials for treatment of Alzheimer's disease
The invention provides the combined use of an inhibitor of formation or release of β-amyloid and a nitric oxide releaser for the treatment or prevention of Alzheimer's disease.
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7250157 |
Dermatological compositions and methods
Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin...
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7223784 |
Compounds for the modulation of the glycolysis enzyme and/or transaminase complex
The invention relates to compounds for the modulation of the glycolysis enzyme complex and of the transaminase complex, pharmaceutical compositions containing such compounds as well as uses of such...
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7214710 |
Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.
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7204994 |
Juvenile hormone compositions and methods for making same
The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a...
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7199141 |
Drugs for chronic pains
Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B) b0 —(C) c0 —NO 2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1,...
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7192940 |
Ether compounds
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias,...
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7189747 |
Method of treating noninflammatory cartilage damage
The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula
and pharmaceutically acceptable salts...
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7169811 |
Composition based on ethyl ester of linoleic acid and triethyl ester of citric acid for topical use in the treatment of seborrhea and acne
The present invention relates to a composition for topical use for treating and improving the aesthetic conditions of the skin, which comprises, as an active ingredient, a mixture of ethyllinoleate...
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7160920 |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO 2 group or a...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7148239 |
Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed...
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7128930 |
Compositions and methods for treating sexual dysfunction
Methods for treating sexual dysfunction are disclosed. The methods generally comprise the administration of an NO donor and an antioxidant; the active ingredients can be administered topically to...
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7128926 |
Ester compound and use thereof
It is an object of the present invention to provide a novel ester compound and the use thereof as a sex attractant. The present invention provides a compound represented by formula (I) described...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7115660 |
Methods for inhibiting angiogenesis and tumor growth
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-α v β 3 are inhibited by an inhibitor compound of formula (I): wherein G 1 and G 2 are each independently...
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7091242 |
Beta-amino acid derivatives as integrin receptor antagonists
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of...
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7074820 |
Amidino derivatives and their use as thrombin inhibitors
There is provided compounds of formula I,
wherein R 1 , R 2 , R 3 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
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7053150 |
Segmented polymers and their conjugates
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
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7053120 |
Use of carboxy compounds such as 2(4-acetoxyphenyl)2-chloro-N-methyl-ethylammonium chloride as anti-inflammatory agents
The present invention relates to the use of specific carboxy compounds, more specifically to the use of 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride, in the treatment of inflammatory...
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7014864 |
Formulations comprising lipid-regulating agents
The present invention is directed to a formulation comprising a lipid-regulating agent dissolved in at least one structured lipid as the primary solvent medium for said agent. One or more...
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7001603 |
Gelled two phase cosmetic compositions
The present invention relates to anhydrous two phase emulsified composition comprising a nonaqueous hydrophilic external phase, and an internal oil phase, each phase being gelled by a condensation...
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6987128 |
Compounds of the N-acylamino amide family, compositions comprising same, and uses
The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing,...
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6984389 |
Using heat shock proteins to improve the therapeutic benefit of a non-vaccine treatment modality
The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an α-2-macroglobulin (α2M) preparation with a...
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6974834 |
Process for preparing enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene
This invention relates to a process for the synthesis of enantiomerically enriched (1S,4R) 1-acetoxy-4-hydroxycyclopent-2-ene of Formula I, a compound useful as an intermediate in the synthesis of...
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6943148 |
Methods for delivering therapeutics across blood-barrier and for altering receptor binding affinity
The present invention relates to amphiphilic drug-oligomer conjugates capable of traversing the blood-brain barrier (“BBB”) and to methods of making and using such conjugates. An amphiphilic...
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