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9040502 Anti-XDR-TB drug, anti-MDR-TB drug, and combination anti-tuberculosis drug  
A method for treating an individual infected with XDR-TB, the method including administering to the individual an anti-XDR-TB drug which comprises a compound having a structure expressed by...
9040501 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
9029346 Irreversible inhibitors of DNA polymerase beta  
Methods and compounds are disclosed for irreversibly inhibiting a DNA repair enzyme that possesses lyase activity.
9029413 Treatment of viral infections by modulation of host cell metabolic pathways  
Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets...
9012427 Pharmaceutical combinations comprising a thionucleotide analog  
Disclosed herein are pharmaceutical compositions that can include a thionucleotide analog for use in combination therapy with other agents. Also disclosed herein are methods of treating diseases...
9012428 Uracyl spirooxetane nucleoside phosphoramidates  
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate useful in the treatment of patients infected with the hepatitis C virus (HCV).
9006209 Uracyl spirooxetane nucleoside phosphoramidates  
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate which inhibits the hepatitis C virus (HCV).
9006208 Agent for treatment of dry eye characterized by combining P2Y2 receptor agonist and hyaluronic acid or salt thereof, method for treating dry eye, and use of the P2Y2 receptor agonist and hyaluronic acid or salt thereof  
An agent for treatment of dry eye comprising a combination of a P2Y2 receptor agonist at a therapeutically effective concentration and hyaluronic acid or a salt thereof at a therapeutically...
8957046 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8951987 Certain compounds, compositions and methods  
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
8951988 Azidothymidine quinoline conjugated compound, preparation method therefor and application thereof in anti-hepatoma therapy  
The invention provides the Zidovudine-conjugated quinoline compound N-((1-(2-(hydroxy-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydrop yrimidin-1(2H)-yl)-tetrahydrofuran-3-yl)-1H-1,2,3-triazol-4- yl)meth...
8951985 Compounds and pharmaceutical compositions for the treatment of viral infections  
Provided herein are compounds, compositions and methods for the treatment of liver disorders, including HCV infections. In one embodiment, compounds and compositions of nucleoside derivatives are...
8916538 Solid forms of a thiophosphoramidate nucleotide prodrug  
The present application relates to solid state forms, for example, crystalline forms of 2′-C-methyluridine-5′-(O-phenyl-N—(S)-1-(isopropoxycarbonyl) ethyl)thiophosphoramidate, pharmaceutical...
8906880 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8883759 Anti-tumor effect potentiator  
There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following...
8877734 Seleny-methyluracil compounds, radiosensitizer and pharmaceutical composition using them  
Provided are novel selenyl-methyluracil compounds and a pharmaceutical composition for enhancing the effect of radiation treatment. The composition contains at least one compound selected from the...
8877731 Azido nucleosides and nucleotide analogs  
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing...
8846639 Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity  
In certain embodiments, the present invention provides oligomeric compounds having favorable toxicity profiles and therapeutic indexes. Compounds of the present invention comprise bicyclic...
8846636 Nucleoside analogues with quaternary carbon stereogenic centers and methods of use  
The disclosure provides nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moieties with quaternary centers at the 3′ position, the pharmaceutical formulations comprising...
8836218 Methods of treatment using combination therapy  
Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a...
8815830 Nucleosides with antiviral and anticancer activity  
The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods...
8791089 Supporting activities of daily living  
The invention provides a method for supporting operational activities in daily living by providing a combination of (a) long-chain polyunsaturated fatty acids, particularly DHA and/or EPA, and (b)...
8765713 Method for determination of sensitivity to anti-cancer agent  
A marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker, wherein the marker for determining sensitivity to an anti-cancer...
8765712 Agent for preventing and treating pityriasis versicolor  
The present invention concerns an agent for prevention and treatment of pityriasis. The agent according to the present invention comprises at least one transaminase inhibitor effectively...
8759319 Lipid composition for improving brain function  
The invention pertains to the use of a lipid fraction for the support of brain function. The lipid fraction comprises the medium-chain fatty acids at least 4 g hexanoic acid and/or at least 5 g...
8735372 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8716346 Alkylating agent combinations in the treatment of cancer  
This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic...
8691788 Compounds and pharmaceutical compositions for the treatment of viral infections  
Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives...
8691789 Probe of iodine-123 marker thymidine (FLT)analogue [123I]-IaraU  
A tumor radiation probe of iodine-123 marker thymidine (FLT) analogue [123I]-IaraU is disclosed. Commercial available uridine is used as the raw material for the synthesis of the precursor. A...
8664181 Dual acting prodrugs  
A prodrug comprising at least two different pharmaceutically and/or diagnostically active compounds independently bound by cleavable linkers and a protein-binding moiety which is capable of...
8658618 Methods for preventing or reducing neurotoxicity associated with administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs  
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD...
8658619 Methods of treating subclinical sun damage  
Provided are methods of treating subclinical sun damage and of inducing a chemocytotoxic response in skin. Methods of treating subclinical sun damage include the steps of: topically administering...
8648054 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication  
The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to...
8618075 Certain compounds, compositions and methods  
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
8609623 Pharmacological modulation of telomere length in cancer cells for prevention and treatment of cancer  
Acyclic nucleoside analogs such as acyclovir, ganciclovir, penciclovir and the corresponding pro-drugs, i.e., valacyclovir, valganciclovir and famciclovir, respectively have been identified as...
8609628 Fused pentacyclic polyethers  
Disclosed are polycyclic polyether compounds of formula I and pharmaceutical compositions comprising such compounds. wherein R, OR1, and R2 are as defined herein. Also disclosed are methods of...
8609677 Molecules for the photodynamic treatment of tumors and hyperplasias  
This invention relates to pharmaceutical compositions comprising a sulfonated biological precursor of thymidine, such as a precursor of 4-thiothymidine (4-TT), and their use in the photodynamic...
8609066 Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow  
The present invention relates to methods for determining whether blood flow is restricted in a blood vessel of an individual suspected of compromised blood flow in the vessel, the method...
8604000 Palatable nutritional composition comprising a nucleotide and/or a nucleoside and a taste masking agent  
The present invention relates to the use of a taste masking agent selected from the group of cellulose; starch; xanthan gum; gellan gum; alginate; galactomannans such as fenugreek, guar gum, tara...
8580753 Modulation of telomere length in telomerase positive cells and cancer therapy  
Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention...
8580765 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8536151 Process for preparing lamivudine polymorph form  
The invention relates to a process for the preparation of stable lamivudine polymorph form and to a composition comprising thereof.
8530484 Method and kit for treatment/prevention of hair loss  
The method includes the steps of cleansing of the scalp sufficiently to remove material which would otherwise block antiviral medication from reaching hair follicles, heating the scalp to increase...
8524685 Anti-angiogenic therapeutics efficacy enhanced by nanoformulation  
Preparation of nano-conjugated Tunicamycin enhances the efficacy of the drug Tunicamycin. The invention provides several nanoformulations such as Tunicamycin encapsulated in peptide nanotubes,...
8518882 Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same  
The present invention is directed to methods of ameliorating hippocampal dysfunction and improving or inhibiting decline in intelligence or cognitive or hippocampal-dependent memory of a subject...
8518908 Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting of nucleic acids  
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these...
8513205 Potent chimeric NRTI-NNRTI bifunctional inhibitors of HIV-1 reverse transcriptase  
The present invention relates to compounds, in particular, dual antagonists comprising a nucleoside reverse transcriptase inhibitor (NRTI) or a nucleoside competitive reverse transcriptase...
8492362 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-varicella zoster virus agents and methods of use  
The present invention relates to prodrug forms of β-L-1-[5-(E-2-Bromovinyl)-2-(hydroxymethyl)-1,3-dioxolan-4-y l)]uracil (L-BHDU) and their use to treat viral infections of Varicella Zoster Virus,...
8481510 Uracyl spirooxetane nucleosides  
Compounds of the formula I: including any possible stereoisomers thereof, wherein: R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is R7 is optionally substituted phenyl,...
8481503 Combination cancer therapy with an AKT inhibitor and other anticancer agents  
The invention relates to combination anticancer therapy with certain Akt inhibitor and other anticancer agents such as anticancer antimetabolites, anticancer antibiotics, plant-derived anticancer...