Match Document Document Title
5258369 Treatment of chronic cerebral dysfunction by dsRNA methodology  
Patients having chronic fatigue syndrome having chronic cerebral dysfunction, as characterized by memory lapses occasional seizures and loss of cognitive functions are treated with a dsRNA such as...
5250296 Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine  
Disclosed is an immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine or a salt thereof in combination, which shows a strong therapeutic effect by synergistic action and weak...
5246708 Methods for promoting wound healing with deoxyribonucleosides  
Methods are provided for promoting wound healing in animals by administering compositions containing two or more of the following 2'-deoxyribonucleosides: 2'-deoxyadenosine, 2'-deoxyguanosine,...
5246924 Method for treating hepatitis B virus infections using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil  
The present invention relates to a composition for, and a method of, treating a hepatitis viral infection in a subject using 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil [FEAU].
5231085 Compositions and methods for the enhancement of host defense mechanisms  
The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount of a) a compound associated with the synthesis of polyamines, b) a nucleobase source, c)...
5231174 2'isodideoxy-β-D-nucleosides as stable antiviral agents  
The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'β-D-nucleosides and their derivatives where the base moiety has β-stereochemistry but is transposed from the normal...
5229368 Composition for prevention and (or) treatment of Aids  
A method for treatment of Lymphadenopathy, AIDS and AIDS related complex which comprises administering FK-565 or its pharmaceutically acceptable salt and AZT.
5223263 Liponucleotide-containing liposomes  
Compounds are disclosed for treating AIDS, herpes, and other viral infections by means of lipid derivatives of antiviral agents. The compounds consist of nucleoside analogues having antiviral...
5223490 Reverse transcriptase inhibitors for treating adenocarcinomas  
A reverse transcriptase inhibitor such as 3'-azido-3-deoxythymidine is used for the treatment or prophylaxis of a retrovirus-associated carcinoma such as breast cancer in a human.
5221669 Antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of treating viral infections  
The present invention is directed to antiviral compositions containing α-cyclodextrin sulfates alone and in combination with other known antiviral agents and glucocorticoids and methods of...
5215970 Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds  
A compound of the formula ##STR1## wherein the radicals A, X, R1, R2 and R3 are defined as follows: ##STR2## R2 : H; or R2 constitutes together with R3 with a carbon - carbon bond R3 : H; F; Cl;...
5212161 Derivatives of 2'-deoxyuridine substituted in the 5-,3'-or 5'-position by α-aminacyl groups, process for their preparation and drugs in which they are present  
The present invention relates to novel derivatives of 2'-deoxyuridine substituted in the 5-, 3'- or 5'-position by α-aminoacyl groups, to a process for their preparation and the drugs in which...
5200400 Method for inhibiting allograft rejection using photoactivatable nucleotides or nucleosides  
Method for inhibiting acute rejection of a transplanted organ or tissue by a recipient mammal that includes the steps of administering to the mammal a compound which causes selective sensitization...
5192749 4'-substituted nucleosides  
Nucleosides compounds of Formula I: ##STR1## wherein B is a purine or a pyrimidine; X and X' are H; Y is H; Y' is OH, F or H; or Y' and X' together makes a bond; Z is ##STR2## where n is zero,...
5190926 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents  
A pharmaceutical composition in dosage unit form comprising a therapeutically effective HIV inhibitory amount of a compound having the formula: ##STR1## wherein R1 is selected from the group...
5187163 Anti-viral compounds, dosage forms and methods  
Novel anti-viral compounds comprise phosphate-linked dimers of anti-viral nucleoside derivatives, or salts or esters of such nucleoside dimers. Pharmaceutical compositions containing the dimers...
5171849 2' and 3' Carboranyl uridines and their diethyl ether adducts  
There is disclosed a process for preparing carboranyl uridine nucleoside compounds and their diethyl ether adducts, which exhibit a tenfold increase in boron content over prior art boron...
5166140 Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy  
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
5166327 Process for producing 3'-deoxy-3-'-fluorothymidine  
This invention provides a process for producing 3'-deoxy-'-fluorothymidine, which comprises allowing 3'-deoxy-'-fluoro-5'-mesylthymidine (the stating material) to react with an acetylating agent,...
5164376 Method for treating retroviral infections with aryl-(2-pyrryl) keytone compound  
A method for treating viral infections in a patient with aryl-(2-pyrryl) ketone compound and compositions.
5157114 2',3'-dideoxy-3'-fluoro-5-ethyngluridine  
The present invention relates to a 3'-substituted pyrimidine nucleoside and its use in medical therapy, particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations.
5153180 Fluorinated nucleosides and process for treating retrovirus infections therewith  
A process for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula...
5145840 Treatment of idiopathic thrombocytopaenic purpura  
A method of treating idiopathic thrombocytopaenia purpura with 2',3'-dideoxy-3'-azidonucleosides, in particular 3'-azido-3'-deoxythymidine, is disclosed.
5141735 Substituted amino-benzodiazepines having anitviral activity  
Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.
5137724 Combinations of TS-inhibitors and viral TK-inhibitors in antiherpetic medicines  
The antiviral activity of 5-fluoro-uracil, 5-fluoro-2'-deoxyuridine and similar thymilydate synthetase inhibitors towards herpes viruses can be potentiated dramatically by combining these...
5132291 Antivirals and methods for increasing the antiviral activity of AZT  
Antiviral purine nucleosides, purine nucleoside analogs and prodrugs of both are provided. Also provided are methods of enhancing the antiviral activity of AZT by administering AZT in combination...
5130302 Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same  
A novel class of pharmaceutically active boronated nucleosides are provided. The nucleosides are boronated at a ring nitrogen of the purine or pyrimidine or analogues thereof. Also provided are...
5130126 Polymer-drug conjugate and a method of producing it  
The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy...
5126149 Method of inducing the production of cytokines  
The present invention provides a method for the stimulation of the production of lymphokines which comprises the administration of an effective amount of a tellurium tetrahalide.
5122517 Antiviral combination comprising nucleoside analogs  
Antiviral and antitumor compositions are disclosed comprising a mixture of AZT, ribavirin, d4T or CS-87 with a compound of general formula: ##STR1## wherein Z is H, OH or NH2, Y is CH, and X is...
5116823 Drug combinations containing AZT  
Combinations of 3'-azido-3'-deoxythymidine (AZT) with 5-fluorouracil (FUra) or its precursor 5-fluoro-2'-deoxyuridine (FUDR) or methoxtrexate (MTX) exhibit increased cytotoxicity and increased...
5108993 Pharmaceutical composition comprising zidovudine and inosiplex or components thereof for the treatment of aids-related syndromes  
The administration of a pharmaceutical mixture consisting of the immunomodulator inosiplex or components thereof (p-acetamidobenzoic acid and inosine), and zidovudine (3'-azio-3'-deoxythymidine,...
5108991 Vehicle composition containing 1-substituted azacycloalkan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a...
5079235 Antiviral compounds  
The present invention relates to certain novel 5-substituted pyrimidine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of varicella zoster virus,...
5077280 Treatment of viral infections  
Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the...
5070078 Antiviral compounds  
2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those...
5049551 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-carbomoyl-5-fluorouracil compounds  
A 5-fluorouracil derivative represented by the formula (1): ##STR1## wherein A represents a group represented by ##STR2## wherein R1 represents a hydrogen atom or OR5 group, R2, R3 and R5 may be...
5047521 5-fluorouracil derivatives  
This invention relates to a novel 5-fluorouracil derivative represented by the formula ##STR1## wherein Ry is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl...
5030619 Synergistic fungicidal composition  
A fungicidal composition comprising a nikkomycin and an echinocandin B. Method of treating a fungal infection comprising administering therapeutically effective amounts of a combination of the...
5028596 1-(β-D-arabinofuranosyl)-5-propynyluracil for treatment of VZV infections  
The invention is a method for using 1-(β-D-arabinofuranosyl)-5-propynyluracil or its salts as the active ingredient in pharmaceutical compositions in the treatment of varicella zoster viral...
5026687 Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds  
A preferred method and dosages for the short and long-term treatment of human retroviral infections, or retroviral-like infections, including acquired immunodeficiency syndrome (AIDS) and other...
5026688 Novel AZT analogs  
The present invention relates to novel ester derivatives of the anti-retroviral compound AZT, and compositions containing same. It also relates to methods of treatment of retroviral infections...
5019560 Method for treating fungal infections with nikkomycin derivatives  
A method of treating a mammal infected with a dimorphic, highly chitinous fungi, the method comprising administering to the mammal therapeutically effective amounts of a nikkomycin derivative...
5011829 Pharmaceutical composition and method of inhibiting virus  
A pharmaceutical composition and a method of inhibiting human immunodeficiency virus (HIV) is disclosed which comprises administering to an HIV infected patient a synergistic combination of...
5010060 Method of treating herpes simplex viral infection employing pyrimidine derivatives  
Compounds of the formula ##STR1## wherein R1 is halogen, C1-4 -alkyl, halo-(C1-4 -alkyl) or C2-4 -alkanoyl, R2 is hydrogen, hydroxy, C1-4 -alkoxy, C1-4 -alkylthio or phenyl-(C1-4 -alkoxy) or, when...
5008252 Process for inhibiting herpes simplex virus-specified thymidine kinase  
The invention relates to a method of selectively inhibiting herpes simplex virus-specified thymidine kinase. The method comprises exposing mammalian cells infected with the virus to an effective...
4997818 Therapeutic method for selectively treating terminal deoxynucleotidyl transferase-positive neoplastic leukemias and lymphomas  
A therapeutic method for specifically treating terminal deoxynucleotidyl transferase-positive neoplastic disease within living subjects is provided which is uniquely effective and selective. The...
4994442 Method for stimulation or repair and regeneration of intestinal gut cells in infants and enhancing the immune response of t-cells  
Nucleosides and/or nucleotides are added to infant formula, both milk and non-milk based, to provide a formula having enhanced physiological properties and also closely resemble human milk....
4992534 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine  
Derivatives of 5-deoxy-fluorouridine are disclosed of formula (1) ##STR1## in which one of R and R is a substituted furanylmethyl or thienylmethyl group; and the other R and R is a lower alkanoyl...
4988678 Combinations of FU and BVU as anti-adenocarcinoma agents  
The antitumor activity of 5-fluorouracil and its precursors against adenocarcinomas can be potentiated without a corresponding increase in toxicity by combining these compounds with...