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4418059 |
Nucleoside ester compositions
A composition comprising a nucleosidic anti-tumor agent esterified with a carboxylic acid-containing steroid is described. These steroid ester derivatives of, for example, a deoxyuridine compound...
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4416875 |
Ester derivatives of deoxyfluorouridine
New ester derivatives of deoxyfluorouridine of the general formula: ##STR1## wherein R and R 40 , may be identical or different, and may be hydrogen, halogen or methyl and n is 3 or 4. These...
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4415563 |
Vehicle composition containing 1-substituted azacyclononan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4407792 |
Sustained release ophthalmic drug dosage
The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of...
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4402947 |
Pesticidally active nikkomicin heavy metal salts
Arthropodicidally and fungicidally active heavy metal salts of nikkomicin are produced by reacting nikkomicin with a water-soluble heavy metal salt in an aqueous medium.
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4386076 |
(E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof
A novel compound, (E)-5-(2-halogenovinyl)-arabinofuranosyluracil; a process for producing the same comprising reacting 5-vinylarabinofuranosyluracil with a halogen; and use of the same as an...
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4383990 |
Antiviral agents, their preparation and use
The compound of formula (I): ##STR1## wherein X is CFCl; and C 1 -6 alkanoyl esters and/or phosphate esters thereof, is active against herpes viruses.
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4368138 |
Water soluble thymidine derivative
Thymidine may have its solubility in water increased by as much as 10 times or even more by combining the thymidine with a solubilizing agent, such as a salicylate derivative selected from...
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4361571 |
3-Carbamoyl-6-aminopyridinium and analogues, and their use in treating skin disorders
Systemic as well as topical treatment to alleviate the symptoms of skin disorders characterized by inflammation or disturbed keratinization comprising as the principal active ingredient, one or...
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4344937 |
Antiviral agent comprising 1-β-D-arabinofuranosylthymine
An antiviral agent comprising 1-β-D-arabinofuranosylthymine as a therapeutically efficacious component in a pharmaceutical form for absorption through the alimentary canal of the human or lower...
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4331662 |
Methods for the treatment of viral infections
Compositions for inhibiting cell growth, particularly compositions for the reatment of virus infections, are provided comprising the nucleoside 2'-azido-2'-desoxycytidine.
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4247544 |
C-5 Substituted uracil nucleosides
Compounds of the formula ##STR1## wherein R o is --CHCH--CH 3 or --CHCH--CF 3 and R is β-D-ribofuranosyl, β-D-2-deoxyribofuranosyl or β-D-arabinofuranosyl are useful as antiviral agents.
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4210638 |
Antiviral composition and method of treating virus diseases
Pharmaceutical compositions suitable for the treatment of Herpes or Herpes-like viruses are disclosed, wherein the compositions contain 5-trifluoromethyl-2'-deoxycytidine and a cytidine deaminase...
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4148889 |
Treatment of viral infections
The compound 5-methoxymethyldeoxyuridine has been found to have useful therapeutic properties. Animal tests have shown antiviral activity against herpes simplex viruses, e.g., in treatment of...
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4128639 |
Nitrosourea analogs of thymidine
Alkyl and haloalkyl nitrosourea analogs of thymidine are useful in the treatment of cancers in mice.
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4115544 |
Ocular system made of bioerodible esters having linear ether
An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate controlling...
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4093716 |
Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
The known compound 5'-amino-5'-deoxythymidine and the pharmaceutically acceptable acid addition salts thereof are potent inhibitors of herpes simplex virus and compositions containing one or more...
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4000260 |
Anti herpes simplex viral compounds and their synthesis
The compounds 5'-amino-2',5'-dideoxy-5-iodouridine; 5'-amino-2',5'-dideoxy-5-bromouridine; and the pharmaceutically acceptable acid addition salts thereof have been found to be potent inhibitors of...
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3989815 |
Novel N-bis-azacyclopentan-2-onyl alkanes
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable...
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3989816 |
Vehicle composition containing 1-substituted azacycloheptan-2-ones
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable...
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3472931 |
PERCUTANEOUS ABSORPTION WITH LOWER ALKYL AMIDES
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3397268 |
Process of treating herpes simplex with 1-beta-d-arabinofuranosylcytosine
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3323994 |
5-iodouracil-2'-desoxyriboside-3', 5'-diesters and process for preparing them
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3317384 |
Treatment of topical viral infections with glucocorticoids and nucleosides
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3173836 |
Method and compositions for the treatment of cutaneous herpetic infections
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