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4894364 |
Method and materials for sensitizing neoplastic tissue to radiation
Tumors are sensitized to radiation by administration of 5-chlorodeoxycytidine (5-CldC) or 5-halo-2'-halo-2'-deoxy-cytidine or -uridine derivatives. Tetrahydrouridane (H 4 U) and/or...
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4892939 |
Oligopeptidyl-5-fluorouridine compounds and process for preparing the same
New 5-fluorouridine compounds of the general formula: ##STR1## wherein n is an integer of 1 to 3, R' stands for a straight or branched chain alkyl group having 1 to 4 carbon atoms or a benzyl...
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4886785 |
Pyrimidine derivatives, pharmaceutical compositions and method of using same
Compounds of the formula ##STR1## wherein A is C 1 -8 -alkylene, R 1 is halogen, C 1 -4 -alkyl or halo-(C 1 -4 -alkyl), R 2 is hydrogen, hydroxy or acyloxy, R 3 is hydrogen or C 1 -4 -alkyl, R 4...
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4882316 |
Pyrimidine derivatives
Compounds of the formula ##STR1## wherein R 1 is halogen, C 1 -4 -alkyl or halo-(C 1 -4 - alkyl), R 2 is hydrogen, hydroxy or acyloxy, R 3 and R 4 each are hydrogen or C 1 -4 -alkyl, R 5 is...
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4880785 |
Topical process for treating herpes infections using 5-isopropyl-2'-β- d
The invention relates to an externally applicable, antiviral pharmaceutical composition accumulating in the skin for treating herpes infections, which composition comprises 0.2-5% by mass of...
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4880782 |
Method of treating viral infections in humans and compositions therefor
A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: ##STR1## wherein X is an azido group, a methoxy radical or a...
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4879276 |
Method for reducing serum uric acid levels
Method for reducing uric acid levels in mammals, comprising administering compounds having the formula: ##STR1## wherein A is selected from the group consisting of ##STR2## and --CH 2 --; X is...
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4874751 |
Antibacterial treatment
Treatment of susceptible gram-negative infections in animals is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the...
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4868157 |
Dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives as host resistance enhancers in AIDS-immunocompromised hosts and methods of use
Disclosed are specific dipeptidyl 2-amino-1,2-dideoxy-D-glucoses which, either alone, or in combintion with an anti-AIDS drug, e.g. azidothymidine, protect an immunocompromised human host,...
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4868162 |
Antiviral agent
A method of inhibiting viral replication in a cell comprising administering an effective amount of an esterified derivative of 5-halogenated-2'-deoxy-uridine expressed by the following formula (I)...
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4868155 |
Dipeptidyl 4-0-,6-0-acyl-2-amino-2-deoxy-D-glucose compositions and methods of use in AIDS-immunocompromised human hosts
Disclosed are specific dipeptidyl 4-0, 6-0-acyl-2-amino-2-deoxy-D-glucose derivatives which, either alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, protect against...
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4868161 |
Method for promoting nerve regeneration
A method for promoting regeneration of damaged nerve tissue, comprising administering, either alone or in combination, an effective amount of an antimitotic agent or a proton-withdrawing buffer to...
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4866035 |
Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
Disclosed are specific dipeptidyl saccharide derivatives which alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, provide protection against opportunistic infection in human...
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4866036 |
Dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose compositions and methods of use in aids-immunocompromised human hosts
Disclosed are specific dipeptidyl 5-0, 6-0-Acyl-2-amino-2-deoxy-D-glucofuranoses, which, either alone, or in combination with an anti-AIDS drug, e.g. azidothymidine, provide protection in human...
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4863906 |
2'-deoxy-5-ethynyluridine-3',5'-diestens for treatment of VZV and CMV infections
The present invention relates to the use of 2'-deoxy-5-ethynyluridine and its pharmaceutically acceptable derivatives in the treatment and prophylaxis of varicella zoster virus and cytomegalovirus...
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4851391 |
5-ethyl-2-deoxyuridine and urea composition for the treatment of viral diseases
Novel medicinal agent for the topical treatment of viral diseases, containing 5-ethyl-2'-deoxyuridine as the antivirally active compound and urea as the penetration-promoting compound, in an...
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4841039 |
2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
A compound which exhibits antiviral activity towards HTLV-III/LAV, having the formula: ##STR1## wherein R 4 is O or NH; R 5 is a C 2 -4 alkyl group or a C 3 -4 cycloalkyl group, wherein ...
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4828838 |
Treatment of human viral infection
Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically...
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4804651 |
Methods and compositions for the treatment of psoriasis
Disclosed are methods and compositions employing azidothymidine for the treatment of psoriasis. Oral, parenteral or topical dosage forms are administered to affected individuals in therapeutically...
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4789666 |
Cytidine-diphosphocholine salts, particularly suitable for oral use
New cytidine-diphosphocholine (CDP-choline) salts with long-alkyl chain sulphonic acids suitable for injectable pharmaceutical formulations, but more specifically for oral formulations. Said salts...
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4780452 |
F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof
This invention discloses a group of compounds of formula (I) ##STR1## wherein R 1 is hydrogen, halo, C 1 -4 alkyl, C 1 -4 alkoxy, COOR 4 (R 4 is H or C 1 -4 alkyl) or trifluoromethyl; R 2 , R 5 ...
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4780454 |
Anti-protozoal treatment
3'-Azido-3'-deoxythymidine is disclosed as an effective treatment for giardiasis.
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4780453 |
Treatment of feline viral infections
Treatment of cats carrying or infected with the Feline Leukemia virus or having antibodies to the Feline leukemia virus is disclosed using the compound 3'-azido''-deoxythymidine or a...
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4764506 |
N.sup.6 -(benzothien-3-yl)ethyl adenosine; N.sup.6 -(benzothien-3-yl)ethyl adenosine, S-oxide; and N.sup.6 -(benzothien-3-yl)ethyl S,S-dioxide adenosine
Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl adenosine, S,S-dioxide compounds or pharmaceutically acceptable acid addition salts having highly desirable...
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4762823 |
Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
A method for synthesizing monofluoromethyl- and difluoromethyluracil nucleosides from the corresponding thymine nucleosides is developed. These compounds which contain a partially fluorinated...
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4755535 |
Compositions comprising 1-substituted azacycloalkenes
This invention provides compositions comprising a physiologically-active agent and an azacycloalkene having at least one double bond in the ring and of the general formula ##STR1## wherein X and Y,...
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4710492 |
3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients...
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4689321 |
Oxo propenyl nucleosides and nucleoside related analogs
Certain 3-oxo-prop-1-enyl purine and pyrimidine derivatives and the corresponding nucleosides have been prepared. These compounds exhibit interesting and valuable cytotoxic activity. This...
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4681873 |
4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds
4-Amino-3-halo-1-β-D-ribofuranosyl-2-(1H)-pyridinone, 4-amino-3-halo-1-(2-deoxy-β-D-pentofuranosyl)-2(1H)-pyridin
one, and nucleosides and...
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4666892 |
Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
The invention relates to 5-substituted-1-(2'-deoxy-2'-substituted-beta-D-Arabinofuran
oysyl) pyrimidine compounds and their use in a method for the treatment of hepatitis B viruses.
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4659698 |
Pharmaceutical compositions based on xylosides and lyxosides of purine and pyrimidine bases used in a method of treating viruses
Pharmaceutical compositions which contain a xyloside or a lyxoside of a purine or pyrimidine base selected from the following compounds: 1-(β-D-xylofuranosyl)-cytosine,...
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4636508 |
5-pyrimidinecarboxyamides and treatment of leukemia therewith
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: ##STR1## wherein R 1 is hydrogen or an alkoxy group having...
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4600573 |
Compositions and method for alleviating the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea
This disclosure describes the preparation of therapeutically effective compositions of matter containing a nucleoside such as thymidine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) which are...
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4599404 |
2-deoxy-5-fluorouridine derivative and a process for producing the same and an antitumor agent comprising the same
A 2'-deoxy-5-fluorouridine derivative represented by the formula; ##STR1## wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon...
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4594339 |
Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides
Veterinarian composition for the treatment of herpes virus in animals comprising a pyrimidine nucleoside, or veterinarianically acceptable acid addition salte thereof, of the formula ##STR1##...
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4585761 |
Antibiotics, a process for their preparation and their use as plant protection agents
A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very...
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4560553 |
Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
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4503045 |
2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives, a process for the preparation of the derivatives and anti-tumor agents containing the derivatives
2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives possessing strong anti-tumor activity with weak toxicity and represented by the general formula: ##STR1## wherein R stands for an alkyl...
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4490366 |
2'-Deoxy-5-fluorouridine derivative and a process for producing the same and an antitumor agent comprising the same
A 2'-deoxy-5-fluorouridine derivative represented by the formula; ##STR1## wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon...
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4489065 |
Chondroitin drug Complexes
A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine,...
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4474753 |
Topical drug delivery system utilizing thermosetting gels
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes a...
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4474748 |
Medicaments potentiated with phenyl alkanols
Antimicrobial compositions are provided wherein there is obtained an enhancement of activity by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is...
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4474751 |
Ophthalmic drug delivery system utilizing thermosetting gels
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
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4472386 |
5-Fluoro-(β-uridine or 2'-deoxy-β-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same
5-Fluoro-(β-uridine or 2'-deoxy-β-uridine) derivatives having an acyl group at the 3-position of the molecule. These compounds are useful as carcinostatic agent. This disclosure relates to such...
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4444762 |
Vehicle composition containing 1-substituted azacyclopentan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4434788 |
Enhancer of anti-tumor effect
A nucleoside selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine enhances, when administered to a tumor-bearing animal under an anti-tumor treatment, the anti-tumor effect...
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4425335 |
Ester derivatives of alkoxybenzoyldeoxyfluorouridine
New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula ##STR1## wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the...
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4424211 |
2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical compositions and method of use
The novel substance E-5-(2-bromovinyl)-2'-deoxyuridine and its corresponding iodovinyl derivative are gifted with specific antiviral activities towards herpes simplex virus. They may be synthesized...
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4423040 |
Vehicle composition containing 1-substituted azacyclohexan-2-ones
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound...
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4419351 |
Platinum-dioxopyrimidine complexes
A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a...
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