Match Document Document Title
5643891 Treatment of viral infections  
Treatment of animals or humans carrying or infected with HTLV-I, HTLV-I (including HTLV-I-associated leukemias or lymphomas), non-A, non-B hepatitis virus, hepatitis B virus, EBV, equine...
5616567 2'-Cyano pyrimidine nucleoside compounds  
The pyrimidine compounds of the present invention are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein, R1 represents a hydroxyl or an amino...
5614505 Method of treating cancer with homo-oligonuleotides of 5-FU 5'-monophosphate  
Homo-oligomeric 5-fluorouridine and 5-fluorodeoxyuridine (FrUn and FdUn, n=oligomer length) are synthesized and used as a polymeric drug delivery system for production of FdUMP, the potent...
5612060 Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy  
An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms as shown by improved allograft survival rates is disclosed. The therapy comprises the synergistic...
5607925 Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides  
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment...
5604209 Synergistic antiviral compositions  
Antiviral agents which comprises as active ingredients one or more 2',3'-dideoxyribonucleosides or phosphoric esters thereof and 6-benzyl-1-ethoxymethyl-5-substituted uracil derivative of the...
5591722 2'-deoxy-4'-thioribonucleosides and their antiviral activity  
2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.
5587362 L-nucleosides  
A compound, and a pharmaceutical composition comprising an effective mount to treat HBV or EBV of a compound, of the formula: ##STR1## wherein R is selected from the group consisting of...
5585363 Circumvention of human tumor drug resistance  
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
5583117 Acylated uridine and cytidine for elevating tissue uridine and cytidine  
General methods for delivering exogenous cytidine or uridine to the tissue of an animal comprising the administration of acylated cytidine or acylated uridine, respectively, are disclosed. Methods...
5578590 Pharmaceutical composition preparation for use in inhibiting protein kinase C  
The present invention provides a method of inhibiting protein kinase C in a mammal having a tumor system which contains protein kinase C, which mammal is undergoing cytostatic therapy. The method...
5574021 Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides  
2',3'-Dideoxy-2',2'-difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals.
5571800 Method for inhibiting allograft rejection by the administration of 6-azauridine or its triacetate derivative  
A method for suppressing the rejection of an allograft comprising administering azaribine at a time when the recipient of the allograft begins to mount a reject reaction against the allograft.
5571798 Synergistic antiviral nucleoside combinations  
An antiviral composition comprising in combination an effective antiviral amount of 3'-fluoro-2',3'-dideoxy nucleoside compound I of the formula ##STR1## wherein B is adenine, thymine, guanine,...
5567689 Methods for increasing uridine levels with L-nucleosides  
A method of increasing intracellular and plasma uridine levels comprising the coadministration or sequential administration of a compound from at least two of the following groups: 1) uridine...
5567688 L-nucleosides for the treatment of hepatitis B-virus  
A method for the treatment of a human infected with HBV that includes administering an HBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is selected from the group...
5565438 L-nucleosides for the treatment of epstein-bar virus  
A method for the treatment of a human infected with EBV that includes administering an EBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is 5-methyluracil, and R' is...
5559101 L-ribofuranosyl nucleosides  
This invention relates to α and β L-ribofuranosyl nucleosides, processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat various diseases in...
5552440 Use of L-canavanine as a chemotherapeutic agent for the treatment of pancreatic cancer  
A pharmaceutical composition of canavanine, and a method treatment of cancer, particularly pancreatic cancer with L-canavanine is disclosed.
5545629 5-ethoxy-2'-deoxyuridines  
A composition comprising 5-ethoxy-2'-deoxyuridine is disclosed which is useful as an antiviral agent.
5543401 UDPG as a rescue agent in cancer therapy after the administration of antipyrimidine or related anti-tumor agents with or without BAU  
A method of rescuing healthy cells of a cancer patient being treated with antipyrimidine antitumor compounds, or related compounds. Rescue is accomplished by administering UDPG after administering...
5538975 1,3-oxathiolane nucleoside compounds and compositions  
The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to...
5521163 Antiviral pyrimidine nucleosides and methods for using same  
1'-Deoxy-5-ethyl-4'-thio-β-uridine as a compound including its physiologically functional derivatives, pharmaceutical compositions containing it and methods of treating herpes virus infections are...
5506215 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides  
A 2',3'-deoxy-3'-fluoro-pyrimidine nucleoside having the formula: ##STR1## wherein R1 is OH or NH2 ; R2 is CF3, CH2 CH2 CH3, ##STR2## CH2 OCH3, CH2 SCH3, CHCH2 CHCH--CH3, C.tbd.CH, C.tbd.C--CH3...
5496810 Pyrimidine deoxyribonucleoside potentiation of combination therapy based on 5-fluorouracil and interferon  
The applicants have discovered a method of treating malignancies which comprises administering effective amounts of 5-fluorouracil, interferon-α and a compound formula (I): ##STR1## wherein R is...
5492899 Infant nutritional formula with ribo-nucleotides  
An improved enteral nutritional formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adjuncts such as activated sugars) at a level of at...
5484809 Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid  
The oral delivery of many classes of drugs is facilitated by converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate...
5470838 Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine  
Methods of delivering exogenous uridine or cytidine to the tissue of an animal comprising the administration of acyl derivatives of uridine or cytidine, respectively, are disclosed. Also disclosed...
5466679 Carboranyl uridines and their use in boron neutron capture therapy  
The invention relates to novel boron-containing nucleosides and amino acids which can utilize the enzymatic systems in tumor cells for incorporating such boron-containing structures into nucleic...
5464826 Method of treating tumors in mammals with 2',2'-difluoronucleosides  
A method of treating susceptible neoplasms in mammals comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR1##...
5449664 Antiviral agents  
Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine;X and X' are H, OH or F, provided that at least one is H;Y and Y' are H, OH, OCH3 or F, provided that at least...
5446031 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivatives  
The present invention relates to a novel 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil derivative represented by the following formula (I), whose concentration in blood as XVAU can be kept...
5432166 Use of 1-(β-D-arabinofuranosyl) -5-propynyluracil for lowering serum cholesterol  
The use of 1-(β-D-arabinofuranosyl)-5-propynyluracil or a pharmaceutically acceptable salt or physiologically labile ester thereof for lowering serum cholesterol, particularly low density...
5432165 Methods for the treatment of infection caused by Hepatitis B virus (HBV)  
The present invention relates to pharmaceutical compositions useful for the treatment of subjects suffering from an infection or disease caused by the hepatitis B virus (HBV). In particular, it...
5430026 2'-deoxy-2',2'-difluoro (4-substituted pyrimidine) nucleosides, bicyclic derivatives,pharmaceutical compositions, and synthetic precursors  
The invention provides certain 2-Deoxy-2,2-Difluoro (4-Substituted) Pyrimidine Nucleosides that are effective as anti-cancer agents and in treating viral infections.
5430045 Method of reducing or preventing bone marrow hypoplasia  
The present invention provides a method for reducing, or preventing, bone marrow hypoplasia in a patient at risk of, or having, same. To this end, when a glutathione intracellular stimulator is...
5422345 No-carrier added radiohalogenated nucleosides  
A composition comprising no-carrier-added 1-(B-D-arabinofuranosyl)-5-(E)-(2-halogenovinyl)uracil wherein the halogen is radioactive iodine or bromine. This composition can be used to diagnose or...
5422343 Prophylactic and therapeutic composition for MRSA infection  
The invention provides an anti-MRSA prophylactic/therapeutic composition containing as an active ingredient at least one nucleic acid component selected from among inosine, guanosine...
5420117 5-substituted uridine derivatives  
This invention provides a 5-substituted uridine derivative of the formula ##STR1## wherein X is F or CF3, R1 and R2 each represent a group --OSi--(R4)(R5)(R6) (wherein R4, R5 and R6 represent C1...
5411947 Method of converting a drug to an orally available form by covalently bonding a lipid to the drug  
The oral delivery of many classes of drugs is facilitated by converting drugs having suitable functional groups to 1-O-alkyl-, 1-O-acyl-, 1-S-acyl, and 1-S-alkyl-sn-glycero-3-phosphate...
5409906 α nucleoside compounds and a method for treating HBV using said compounds  
A compound of the formula ##STR1## wherein the radicals A, X, R1, R2 and R3 are defined as follows: A: ##STR2## X: (a) O (b) S (c) CH2 R1 : H; alkyl containing 1-3 carbon atoms; --CHCH2 ;...
5378693 2'-halomethylidene cytidine, uridine and guanosine compounds and their pharmaceutical compositions  
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment...
5376644 Treatment of adenovical infections with 3'-fluoro-5-halo uracil compounds  
2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2', 3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those...
5370876 Antimicrobial protective skin composition and method for protecting skin from body fluids  
A protective cream composition contains 15 to 40 wt. % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount an antimicrobial compound, 5 to 20 wt. % of a polyol...
5369119 Use of imexon as an immune suppressive and pharmaceutical compositions containing imexon  
The subject of the present invention is the use of imexon for the production of pharmaceutical compositions with an immunosuppressive action. The present invention also provides pharmaceutical...
5356882 Antiviral pyrimidine nucleosides  
Pyrimidine 4'-thionucleosides of the formula I ##STR1## wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C2-6 alkyl, C2-6 alkenyl, C2-6 haloalkenyl or C2-6 alkynyl and...
5346898 Anti-fungal uracil compounds  
Compounds of the formula ##STR1## wherein R3, R4, J, K, Z, and Het are as set forth herein are described.The compounds of formula I are useful as agents in the treatment of fungal infections.
5330976 Antimycotic compositions of nikkomycin compounds and azole antimycotics  
Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a...
5292498 Method of treating lung disease with uridine triphosphates  
A method of hydrating mucous secretions in the lungs of a subject in need of such treatment is disclosed. The method comprises administering to the lungs of the subject a uridine triphosphate such...
5276020 Anti-virals  
Anti-virals wherein a linoleyl, gamma-linolenyl or other unsaturated long chain fatty acyl group is borne directly on a hydroxy or amino group of the sugar/sugar analogue or heterocyclic moiety of...