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5817639 |
Purine 4'-thioarabinonucleosides
The present invention provides a novel purine 4'-thioarabinonucleoside represented by the following formula 1!: ##STR1## wherein B represents a purine base other than adenine. Also disclosed are a...
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5811408 |
2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
The present invention relates to 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides having excellent antitumor activity, represented by formula I!: ##STR1## wherein B...
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5807841 |
HIV protease inhibitors useful for the treatment of AIDS
Compounds of formula ##STR1## are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds,...
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5804567 |
Method of increasing the effectiveness of anti-metabolites
A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-β-arabinofuranosylcytosine and...
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5804571 |
Method for protection from AZT side effects and toxicity
S-ω(ω-aminoalkylamino)alkyl dihydrogen phosphorothioates or pharmaceutically acceptable derivatives thereof are useful in protecting a patient undergoing AZT treatment for AIDS and AIDS-related...
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5792773 |
L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection
The present invention relates to the discovery that certain β-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high...
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5789387 |
Methods and compositions for treating fungal infections in mammals
Methods of treating fungal infections are disclosed. The methods comprise administering a chitin synthesis inhibitor to a mammal in a continuous fashion so that at least a minimum effective...
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5770593 |
Method of determining a pharmaceutical combination preparations for use in anti-neoplastic therapy
The present invention provides a pharmaceutical combination preparation, wherein it contains at least two active materials, the first active material being an inhibitor of protein kinase C and the...
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5763418 |
3'-substituted nucleoside derivatives
The invention relates to a 3'-substituted nucleoside derivative represented by the following general formula (1): ##STR1## wherein B means a nucleic acid base which may have a substituent, Z...
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5760013 |
Thymidylate analogs and the use thereof
Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): ##STR1## wherein R 1 is...
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5756478 |
Method for reducing toxicity of D-nucleoside analogs with L-nucleosides
The present invention relates to novel methods for reducing toxicity associated with the administration of conventional "D" nucleoside compounds, including anti-HIV nucleosides and related...
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5747473 |
L-nucleoside analogues and pharmaceutical compositions
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5736526 |
Mixtures of DDI and D4T with hydroxycarbamide for inhibiting retroviral replication
A method and composition for inhibiting the spread of a retrovirus such as HIV in a human cell population in which a retrovirus such as HIV is present has been found. The spread of the retrovirus...
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5736531 |
Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides
The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives...
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5731290 |
Method of improving the immune response
The invention provides diet supplements for pre-operative treatment of patients due for surgery.
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5728684 |
Determination of prodrugs metabolizable by the liver and therapeutic use thereof
A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or...
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5725875 |
Protective skin composition
A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound,...
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5723490 |
THF-containing sulfonamide inhibitors of aspartyl protease
The present invention relates to a class of THF-containing sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these...
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5723449 |
Methods and compositions for inhibiting uridine secretion
Methods and pharmaceutical compositions effective to increase intracellular and plasma uridine concentrations are disclosed. Certain compositions and methods of using such compositions have been...
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5719132 |
Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
The present invention is directed to the use of pharmaceutical compositions containing anti-retroviral effective amounts of (a) d4T and (b) 5-fluorouracil or a prodrug, or salt thereof.
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5705492 |
3'-O-aminoacyl ARA uridines, method of making, and antiviral activity
Pyrimidine nucleoside derivatives of formula ##STR1## wherein R 1 represents aryl, R 2 represents lower alkyl, R 3 represents an acyl group derived from an amino acid and R 4 represents...
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5703058 |
Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a 5-carboxamido or...
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5700590 |
Nutritional formula with ribo-nucleotides
An improved enteral formula containing ribo-nucleotide equivalents (RNA, mono-, di- and triphosphate nucleotides, nucleosides and adducts such as activated sugars) at a level of at least 10 mg/100...
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5698532 |
Pyrimidine nucleosides and methods for treating viral infections with same
This invention is directed to the novel pyrimidine derivative 1- 5- 2(S)-(2,4-dichloro-5-methoxyphenoxy) propionamido!-2,5-dideoxy-2-fluoro-β-D-arabinofuranosly!-5-
ethyluraci l and its use as an...
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5691320 |
Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic...
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5679684 |
Hydroxyalkylammonium-pyrimidines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the...
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5676973 |
Topical compositions containing LYCD and fluorouracil
A topical composition comprising LYCD together with known topically active useful medicinal agents such as antiwrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne,...
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5672594 |
L-erythrosyl nucleosides
This invention relates to α and β-L-erythrosyl nucleosides of the formula (I), wherein the nucleoside substitution on the erythrosyl carbohydrate molecule comprises a substituted or unsubstituted...
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5643891 |
Treatment of viral infections
Treatment of animals or humans carrying or infected with HTLV-I, HTLV-I (including HTLV-I-associated leukemias or lymphomas), non-A, non-B hepatitis virus, hepatitis B virus, EBV, equine infectious...
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5616567 |
2'-Cyano pyrimidine nucleoside compounds
The pyrimidine compounds of the present invention are represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein, R 1 represents a hydroxyl or an amino...
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5614505 |
Method of treating cancer with homo-oligonuleotides of 5-FU 5'-monophosphate
Homo-oligomeric 5-fluorouridine and 5-fluorodeoxyuridine (FrU n and FdU n , n=oligomer length) are synthesized and used as a polymeric drug delivery system for production of FdUMP, the potent...
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5612060 |
Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
An improved immunomodulatory therapy for enhancement of depressed host defense mechanisms as shown by improved allograft survival rates is disclosed. The therapy comprises the synergistic...
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5607925 |
Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment...
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5604209 |
Synergistic antiviral compositions
Antiviral agents which comprises as active ingredients one or more 2',3'-dideoxyribonucleosides or phosphoric esters thereof and 6-benzyl-1-ethoxymethyl-5-substituted uracil derivative of the...
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5591722 |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
2'-Deoxy-4'-thio-ribonucleosides, intermediates in their production, and their use as antiviral and anticancer agents are disclosed.
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5587362 |
L-nucleosides
A compound, and a pharmaceutical composition comprising an effective mount to treat HBV or EBV of a compound, of the formula: ##STR1## wherein R is selected from the group consisting of...
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5585363 |
Circumvention of human tumor drug resistance
A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function...
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5583117 |
Acylated uridine and cytidine for elevating tissue uridine and cytidine
General methods for delivering exogenous cytidine or uridine to the tissue of an animal comprising the administration of acylated cytidine or acylated uridine, respectively, are disclosed. Methods...
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5578590 |
Pharmaceutical composition preparation for use in inhibiting protein kinase C
The present invention provides a method of inhibiting protein kinase C in a mammal having a tumor system which contains protein kinase C, which mammal is undergoing cytostatic therapy. The method...
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5574021 |
Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides
2',3'-Dideoxy-2',2'-difluoronucleosides are useful for treating susceptible neoplasms and viral infections in mammals.
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5571798 |
Synergistic antiviral nucleoside combinations
An antiviral composition comprising in combination an effective antiviral amount of 3'-fluoro-2',3'-dideoxy nucleoside compound I of the formula ##STR1## wherein B is adenine, thymine, guanine,...
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5571800 |
Method for inhibiting allograft rejection by the administration of 6-azauridine or its triacetate derivative
A method for suppressing the rejection of an allograft comprising administering azaribine at a time when the recipient of the allograft begins to mount a reject reaction against the allograft.
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5567688 |
L-nucleosides for the treatment of hepatitis B-virus
A method for the treatment of a human infected with HBV that includes administering an HBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is selected from the group...
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5567689 |
Methods for increasing uridine levels with L-nucleosides
A method of increasing intracellular and plasma uridine levels comprising the coadministration or sequential administration of a compound from at least two of the following groups: 1) uridine...
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5565438 |
L-nucleosides for the treatment of epstein-bar virus
A method for the treatment of a human infected with EBV that includes administering an EBV-treatment amount of an L-nucleoside of the formula: ##STR1## wherein R is 5-methyluracil, and R' is...
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5559101 |
L-ribofuranosyl nucleosides
This invention relates to α and β L-ribofuranosyl nucleosides, processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat various diseases in...
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5552440 |
Use of L-canavanine as a chemotherapeutic agent for the treatment of pancreatic cancer
A pharmaceutical composition of canavanine, and a method treatment of cancer, particularly pancreatic cancer with L-canavanine is disclosed.
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5545629 |
5-ethoxy-2'-deoxyuridines
A composition comprising 5-ethoxy-2'-deoxyuridine is disclosed which is useful as an antiviral agent.
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5543401 |
UDPG as a rescue agent in cancer therapy after the administration of antipyrimidine or related anti-tumor agents with or without BAU
A method of rescuing healthy cells of a cancer patient being treated with antipyrimidine antitumor compounds, or related compounds. Rescue is accomplished by administering UDPG after administering...
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5538975 |
1,3-oxathiolane nucleoside compounds and compositions
The invention relates to 1,3-oxathiolane nucleoside analogues and their use in the treatment of viral infections. More specifically, this invention relates to...
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