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8461124 Five- and six-membered conformationally locked 2′,4′-carbocyclic ribo-thymidines for the treatment of infections and cancer  
Conformationally locked 2′,4′-carbocylic nucleosides with improved thermal and nuclease stability are disclosed. Oligonucleotides incorporating the locked nucleosides, and methods of treating...
8445457 Oral pharmaceutical solutions containing telbivudine  
A pharmaceutical solution suitable for oral administration comprising β-L-thymidine/2′-deoxy-L-thymidine (telbivudine), a pharmaceutically suitable solvent system, one or more...
8445458 Food composition for prodromal dementia patients  
A composition comprising (a) one or more ω-3 fatty acids selected from DHA, DPA and EPA, (b) uridine or its equivalent, and (c) a methyl donor, useful in the treatment of a person having...
8415322 Modified fluorinated nucleoside analogues  
The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a...
8410075 Mannich base N-oxide drugs  
Disclosed are Mannich base N-oxides of drugs containing acidic N—H groups. Pharmaceutical compositions comprising a therapeutically effective amount of Mannich base N-oxides, or a N-oxide...
8404651 Compositions and methods for treating viral infections  
The present invention provides compositions methods for treating susceptible viral infections, especially hepatitis C viral (HCV) infections as well as co infections of HCV with other viruses such...
8399429 Uracyl cyclopropyl nucleotides  
Compounds of the formula I: including any possible stereoisomers thereof, wherein:R1 is hydrogen or halo;R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is a group of formula R7 is...
8394355 Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow  
The present invention relates to methods for determining whether blood flow is restricted in a blood vessel of an individual suspected of compromised blood flow in the vessel, the method...
8361989 Supporting activities of daily living  
The invention provides a method for supporting operational activities in daily living by providing a combination of (a) long-chain polyunsaturated fatty acids, particularly DHA and/or EPA, and (b)...
8361988 Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use  
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with...
8362078 Method for reducing the severity of neurological disorders  
The present invention relates to the use of polyunsaturated fatty acids andone or more components which have a beneficial effect on total methioninemetabolism selected from the group consisting of...
8343937 Methods and compositions for treating flaviviruses and pestiviruses  
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
8337817 Preparation for transnasal application  
Disclosed is a preparation for transnasal application, which has improved fluidability. Specifically disclosed is a preparation for transnasal application, which comprises at least a complex...
8334270 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...
8329666 Compositions and methods for treating cancer  
Provided herein are methods of treating cancer comprising administering decitabine in combination with compounds that inhibit the deamination enzyme responsible for the inactivation of decitabine.
8329665 Compositions and methods for treating cancer  
Provided herein are compounds used to inhibit the deamination enzyme responsible for the inactivation of therapeutic compounds, and methods of using them.
8324282 Alkylating agent combinations in the treatment of cancer  
This application provides compositions and methods useful in the treatment of certain cancers. In part, this application is based on the recognition that certain molecules that target abasic...
8318756 Methods for administering DPD inhibitors in combination with 5-FU and 5-FU prodrugs  
Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD...
8314064 Uridine administration stimulates membrane production  
The present invention provides methods of stimulating or enhancing production of a cellular membrane, improving a cognitive function or a neurological function, treating or ameliorating a decline...
8299038 Methods and compositions for treating hepatitis C virus  
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
8293778 Heterocyclic antiviral compounds  
The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
8283336 Unit dosage for brain health  
The invention pertains to a composition comprising (i) uridine in nucleobase, nucleoside and/or nucleotide form; (ii) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA); and (iii) a...
8283335 Lipid composition for improving brain function  
The invention pertains to the use of a lipid fraction for the support of brain function. The lipid fraction comprises the medium-chain fatty acids at least 4 g hexanoic acid and/or at least 5 g...
8268800 Certain compounds, compositions and methods  
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
8268348 Combinations and modes of administration of therapeutic agents and combination therapy  
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective...
8258116 Combination therapy for the treatment of HCV infection  
The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic...
8247382 Method for increasing oxytocin release in the epidermis  
A method for increasing oxytocin release through direct action on the epidermal keratinocytes is provided. The method for increasing oxytocin release in the epidermis includes increasing the...
8242087 Phosphate modified nucleosides useful as substrates for polymerases and as antiviral agents  
This invention relates to novel phosphate-modified nucleosides, and methods for producing them, being useful for the prevention or treatment of a viral infection in a mammal, and for preparing...
8236756 Prodrugs cleavable by CD26  
The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the...
8236779 Antiviral nucleosides  
Compounds having the formula I wherein R1, R2 and R3 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV...
8207143 Methods of treating cancer and other conditions or disease states using LFMAU and LDT  
The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease...
8193165 Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections  
The present invention relates to novel compounds according to the general formulas I, II, III, IV or V: wherein B is nucleoside base according to the structure: and the remaining variables as...
8173620 BHQ-caged nucleotide probes photolysable by two-photon excitation  
The disclosure encompasses caged compounds such as caged nucleoside phosphoesters (caged nucleotides). In an embodiment, the caged nucleotides include compounds corresponding to those described by...
8158607 Crystalline form of lamivudine  
The disclosure herein relates to a new Lamivudine polymorphic form, methods of making the same, and pharmaceutical formulations thereof. A (−)...
8158606 β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies  
It has been discovered that β-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided...
8158605 Azacytidine analogues and uses thereof  
The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O);R1 is where the crossing dashed line illustrates the bond formed joining R1 to the molecule of...
8143234 Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function  
The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function or a neurological function,...
8101652 Antitumour combinations containing taxotere and 5-fluorouracil  
Antitumor combinations comprising a taxane and at least one antimetabolite for treating neoplastic diseases are described.
8097595 Modulation of telomere length in telomerase positive cells and cancer therapy  
Induction of telomere shortening, G2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention...
8097600 Method of increasing tear production with purinergic receptor agonists  
A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a...
8076310 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production  
Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or...
8071567 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication  
The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to...
8067391 ODCase inhibitors for the treatment of malaria  
The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives to a subject need thereof. The...
8067392 Compositions and methods for treatment of mitochondrial diseases  
Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing...
8063025 Nucleoside prodrugs and uses thereof  
Compounds having the formula I or II wherein R1, R2, B, and V are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an...
8034375 Combinations and modes of administration of therapeutic agents and combination therapy  
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective...
8017594 Agent against psychosocial stresses  
To provide a novel anti-psychosocial stress agent which is highly safety and can be continuously taken, more particularly, a novel anti-psychosocial stress agent which prevents or alleviates...
8008274 P1-(2′-deoxycytidine 5′-)P4-(uridine 5′-)tetraphosphate, tetra-(alkali metal) salt, for treating sinusitis  
The present invention provides a method of treating edematous retinal disorders. The method comprises administration of a pharmaceutical formulation comprising a hydrolysis-resistant P2Y receptor...
7994143 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates  
The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a...
7964580 Nucleoside phosphoramidate prodrugs  
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt),...