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4636508 5-pyrimidinecarboxyamides and treatment of leukemia therewith  
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: ##STR1## wherein R1 is hydrogen or an alkoxy group having from...
4600573 Compositions and method for alleviating the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea  
This disclosure describes the preparation of therapeutically effective compositions of matter containing a nucleoside such as thymidine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) which are...
4599404 2-deoxy-5-fluorouridine derivative and a process for producing the same and an antitumor agent comprising the same  
A 2'-deoxy-5-fluorouridine derivative represented by the formula; ##STR1## wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon...
4594339 Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides  
Veterinarian composition for the treatment of herpes virus in animals comprising a pyrimidine nucleoside, or veterinarianically acceptable acid addition salte thereof, of the formula ##STR1##...
4585761 Antibiotics, a process for their preparation and their use as plant protection agents  
A method of combating arthropods, comprising applying to the arthropods, or to a habitat infested therewith an arthropodicidally effective amount of an antibiotic which (a) is colorless, very...
4560553 Use of eucalyptol for enhancing skin permeation of bio-affecting agents  
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
4503045 2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives, a process for the preparation of the derivatives and anti-tumor agents containing the derivatives  
2'-Deoxy-3',5'-di-O-alkylcarbonyl-5-fluorouridine derivatives possessing strong anti-tumor activity with weak toxicity and represented by the general formula: ##STR1## wherein R stands for an...
4490366 2'-Deoxy-5-fluorouridine derivative and a process for producing the same and an antitumor agent comprising the same  
A 2'-deoxy-5-fluorouridine derivative represented by the formula; ##STR1## wherein R represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 4 carbon...
4489065 Chondroitin drug Complexes  
A chondroitin or a chondroitin sulfate covalently or ionically bonded to a drug substance of the group consisting of chloramphenicol, methotrexate, adriamycin, vinblastine, vincristine, vindesine,...
4474748 Medicaments potentiated with phenyl alkanols  
Antimicrobial compositions are provided wherein there is obtained an enhancement of activity by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is...
4474753 Topical drug delivery system utilizing thermosetting gels  
This invention relates to a unique drug delivery system for application to the skin which drug delivery system is a liquid at room temperature, but when administered topically to the skin becomes...
4474751 Ophthalmic drug delivery system utilizing thermosetting gels  
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which...
4472386 5-Fluoro-(β-uridine or 2'-deoxy-β-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same  
5-Fluoro-(β-uridine or 2'-deoxy-β-uridine) derivatives having an acyl group at the 3-position of the molecule. These compounds are useful as carcinostatic agent. This disclosure relates to such...
4444762 Vehicle composition containing 1-substituted azacyclopentan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a...
4434788 Enhancer of anti-tumor effect  
A nucleoside selected from the group consisting of 3'-deoxyguanosine and 3'-deoxyuridine enhances, when administered to a tumor-bearing animal under an anti-tumor treatment, the anti-tumor effect...
4425335 Ester derivatives of alkoxybenzoyldeoxyfluorouridine  
New ester derivatives of alkoxybenzoyldeoxyfluorouridine of the general formula ##STR1## wherein R stands for an alkoxy group having 1 to 4 carbon atoms, m for 1 or 2, and n for 3 or 4 with the...
4424211 2'Deoxy-5-(2-halogenovinyl)-uridines, pharmaceutical compositions and method of use  
The novel substance E-5-(2-bromovinyl)-2'-deoxyuridine and its corresponding iodovinyl derivative are gifted with specific antiviral activities towards herpes simplex virus. They may be...
4423040 Vehicle composition containing 1-substituted azacyclohexan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a...
4419351 Platinum-dioxopyrimidine complexes  
A platinum-[2,4-dioxopyrimidine] complex and pharmaceutical composition suitable as an anti-tumor, anti-bacterial and anti-viral agent and process for the manufacture thereof comprising reacting a...
4418059 Nucleoside ester compositions  
A composition comprising a nucleosidic anti-tumor agent esterified with a carboxylic acid-containing steroid is described. These steroid ester derivatives of, for example, a deoxyuridine compound...
4416875 Ester derivatives of deoxyfluorouridine  
New ester derivatives of deoxyfluorouridine of the general formula: ##STR1## wherein R and R40, may be identical or different, and may be hydrogen, halogen or methyl and n is 3 or 4. These...
4415563 Vehicle composition containing 1-substituted azacyclononan-2-ones  
Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a...
4407792 Sustained release ophthalmic drug dosage  
The present invention is directed to an aqueous dispersion of an ophthalmic drug and a high molecular weight polymer which forms a highly viscous gel and can be used to prolong the duration of...
4402947 Pesticidally active nikkomicin heavy metal salts  
Arthropodicidally and fungicidally active heavy metal salts of nikkomicin are produced by reacting nikkomicin with a water-soluble heavy metal salt in an aqueous medium.
4386076 (E)-5-(2-Halogenovinyl)-arabinofuranosyluracil, process for preparation thereof, and uses thereof  
A novel compound, (E)-5-(2-halogenovinyl)-arabinofuranosyluracil; a process for producing the same comprising reacting 5-vinylarabinofuranosyluracil with a halogen; and use of the same as an...
4383990 Antiviral agents, their preparation and use  
The compound of formula (I): ##STR1## wherein X is CFCl; and C1-6 alkanoyl esters and/or phosphate esters thereof, is active against herpes viruses.
4368138 Water soluble thymidine derivative  
Thymidine may have its solubility in water increased by as much as 10 times or even more by combining the thymidine with a solubilizing agent, such as a salicylate derivative selected from...
4361571 3-Carbamoyl-6-aminopyridinium and analogues, and their use in treating skin disorders  
Systemic as well as topical treatment to alleviate the symptoms of skin disorders characterized by inflammation or disturbed keratinization comprising as the principal active ingredient, one or...
4344937 Antiviral agent comprising 1-β-D-arabinofuranosylthymine  
An antiviral agent comprising 1-β-D-arabinofuranosylthymine as a therapeutically efficacious component in a pharmaceutical form for absorption through the alimentary canal of the human or lower...
4331662 Methods for the treatment of viral infections  
Compositions for inhibiting cell growth, particularly compositions for the reatment of virus infections, are provided comprising the nucleoside 2'-azido-2'-desoxycytidine.
4247544 C-5 Substituted uracil nucleosides  
Compounds of the formula ##STR1## wherein Ro is --CHCH--CH3 or --CHCH--CF3 and R is β-D-ribofuranosyl, β-D-2-deoxyribofuranosyl or β-D-arabinofuranosyl are useful as antiviral agents.
4210638 Antiviral composition and method of treating virus diseases  
Pharmaceutical compositions suitable for the treatment of Herpes or Herpes-like viruses are disclosed, wherein the compositions contain 5-trifluoromethyl-2'-deoxycytidine and a cytidine deaminase...
4148889 Treatment of viral infections  
The compound 5-methoxymethyldeoxyuridine has been found to have useful therapeutic properties. Animal tests have shown antiviral activity against herpes simplex viruses, e.g., in treatment of...
4128639 Nitrosourea analogs of thymidine  
Alkyl and haloalkyl nitrosourea analogs of thymidine are useful in the treatment of cancers in mice.
4115544 Ocular system made of bioerodible esters having linear ether  
An ophthalmological bioerodible dosage form for ophthalmic drugs is disclosed. The dosage form comprises particles of 10 to 300 microns made of drug dispersed within a drug release rate...
4093716 Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof  
The known compound 5'-amino-5'-deoxythymidine and the pharmaceutically acceptable acid addition salts thereof are potent inhibitors of herpes simplex virus and compositions containing one or more...
4000260 Anti herpes simplex viral compounds and their synthesis  
The compounds 5'-amino-2',5'-dideoxy-5-iodouridine; 5'-amino-2',5'-dideoxy-5-bromouridine; and the pharmaceutically acceptable acid addition salts thereof have been found to be potent inhibitors...
3989816 Vehicle composition containing 1-substituted azacycloheptan-2-ones  
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing...
3989815 Novel N-bis-azacyclopentan-2-onyl alkanes  
There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing...
3472931 PERCUTANEOUS ABSORPTION WITH LOWER ALKYL AMIDES  
3397268 Process of treating herpes simplex with 1-beta-d-arabinofuranosylcytosine  
3323994 5-iodouracil-2'-desoxyriboside-3', 5'-diesters and process for preparing them  
3317384 Treatment of topical viral infections with glucocorticoids and nucleosides  
3173836 Method and compositions for the treatment of cutaneous herpetic infections