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8158583 |
Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
Pharmaceutical composition for parenteral administration comprising a meal related insulin peptide and an insulinotropic peptide.
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8142817 |
Composition for restoration of age related tissue loss in the face or selected areas of the body
A treatment method for restoring of age related tissue loss in the face or selected areas of the body is disclosed which includes injecting an injectable composition containing a growth factor and...
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8137697 |
Nanoparticles for protein/peptide delivery and delivery means thereof
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal...
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8128905 |
Stabilized uncoated particles of reversed liquid crystalline phase materials
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
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8128906 |
Stabilized uncoated particles of reversed liquid crystalline phase materials
Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to...
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8119593 |
Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial administration of the ultrarapid insulin,...
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8106007 |
Conjugates of a polypeptide and a pentasaccharide
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being...
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8101569 |
Energy status of an individual by enhanced production of an endogenous fuel source
The present invention relates to a method of improving the energy status of an individual by enhancing the usage of lactate. Improved lactate usage is accomplished through a composition comprising...
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8097584 |
Stabilized formulations of insulin that comprise ethylenediamine
The present invention relates to a pharmaceutical formulation comprising insulin, an insulin analogue or an insulin derivate and ethylenediamine or salts thereof and an antimicrobial preservative...
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8093212 |
Methods of treating nerve-related vision disorders by an insulinomimetic agent
This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes...
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8093211 |
Methods and pharmaceutical compositions for healing wounds
A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a...
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8088734 |
Oral delivery of peptides
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing an active peptide that is amidated at a site that is not naturally amidated.
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8084419 |
Pharmaceutical compositions for sustained drug delivery
Sustained delivery formulations comprising a water-insoluble complex of a peptide and a plurality of ligands are disclosed. The formulations of the invention allow for loading of high...
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8080263 |
Dispersion for pulmonary delivery of a bioactive agent
Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that...
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8075916 |
Poly(organophosphazene) hydrogels for drug delivery, preparation method thereof and use thereof
A biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances are provided.
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8058236 |
Aqueous inhalation pharmaceutical composition
An aqueous inhalation pharmaceutical composition comprising a polypeptide or protein is provided. The composition of the present invention can improve the bioavailability of the polypeptide and...
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8039431 |
Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the...
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8026211 |
Methods and formulations for increasing intestinal function
A method for increasing intestinal function is provided. The method comprising orally and/or enterally administering to a subject in need thereof a therapeutically effective amount of insulin,...
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8017156 |
Long-acting colloidal insulin formulation and its preparation
The invention relates to injectable long-acting insulin formulations for the treatment of types I and II diabetes in humans and animals. The essential object of the invention is to provide an...
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8003605 |
Minimising body weight gain in insulin treatment
A method for minimizing weight gain, preventing weight gain or inducing weight loss in a mammal, said method involving a treatment regimen which comprises administration of an insulin derivative...
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8003606 |
Inhibiting serum response factor (SRF) to improve insulin sensitivity
Described are methods of improving glycemic control/improving insulin sensitivity by administering an inhibitor of serum response factor (SRF) activity, and methods of identifying new compounds for...
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7989419 |
Insulin composition
Pharmaceutical compositions for nasal administration to humans, or to warm-blooded animals, comprise: (A) a therapeutically effective amount of insulin; (B) a permeation enhancer; and (C) a liquid...
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7989417 |
Linkers for radiopharmaceutical compounds
A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a...
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7977310 |
Method for reducing cardiovascular morbidity and mortality in prediabetic patients and patients with type 2 diabetes
This invention relates to a method of reducing cardiovascular morbidity and mortality in a prediabetic or Type 2 Diabetes patient population. The method comprises administering an effective dosage...
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7972798 |
Method for identifying diabetic patients at increased risk for pathological complications
The present invention provides methods for detecting and measuring, in a sample from a subject, the plasma levels of endothelial cell antibodies to diagnose an increased risk of pathological...
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7964183 |
Composition and dosage form comprising a particle formulation and suspending vehicle
A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a...
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7964359 |
Compositions and methods for the enhancement of soluble amyloid beta oligomer (ADDL) uptake and clearance
The present invention relates to methods for enhancing the cellular uptake and clearance of soluble oligomeric Aβ peptide assemblies from the environment surrounding both neuronal and non-neuronal ...
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7943572 |
Superior control of blood glucose in diabetes treatment
Methods related to the treatment of diabetes and improving the control of blood glucose levels are provided. In particular, methods are provided for effectively reducing postprandial glucose...
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7884078 |
CPG15 compounds as insulin receptor and insulin-like growth factor receptor agonists
Disclosed herein are CPG15 and CPG15-2 compounds and inhibitors that act as agonists and antagonists of the insulin receptor and insulin-like growth factor receptors, and the use of such...
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7879588 |
Protein-proteophore complexes
The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a...
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7871989 |
Nanoparticles for protein drug delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid as drug carriers, and encapsulating at least one bioactive agent. The nanoparticles are characterized with a...
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7871978 |
Bone tropic peptides
The present invention is directed to the use of bone tropic peptides identified through the use of a phage display library. More particularly, the invention is directed to compositions comprising...
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7871990 |
Nanoparticles for protein drug delivery
The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced...
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7858116 |
Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal
The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free recombinant human insulin isophane and free Recombinant human regular insulin insulin and a mixture...
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7855177 |
Methods and kits for preventing hypoglycemia
Improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits,...
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7846445 |
Methods for production of unstructured recombinant polymers and uses thereof
The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins...
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7829532 |
Method of treating a nerve-related vision disorder in a non-diabetic subject
This invention provides reagents and methods for delivering insulin, insulinomimetic agents, and the like to a vertebrate eye via subconjunctival routes, sub-Tenon's routes, or intravitreal routes...
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7827982 |
Ejection liquid and ejection method
There is provided an ejection liquid which can be ejected stably by an inkjet method even in the case of containing at least one of proteins and peptides and is provided a method and device of...
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7803763 |
Method of purifying preproinsulin
The invention relates to a method for the chromatographic purification of preproinsulins, in which higher molecular weight substances are removed from an aqueous solution of preproinsulin by a...
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7785625 |
Lipophilic-coated microparticle containing a protein drug and formulation comprising same
A solid lipophilic microparticle having an average particle size ranging from 0.1 to 200 μm, comprising a lipophilic substance, hyaluronic acid or an inorganic salt thereof and an active ...
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7744910 |
Compounds and compositions for delivering active agents
Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7735485 |
Dry powder inhalation system for transpulmonary administration
A dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system is characterized by using a combination of: (1) a vessel housing a freeze-dried...
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7731947 |
Composition and dosage form comprising an interferon particle formulation and suspending vehicle
A liquid composition in an osmotic drug delivery system and a dosage form in an osmotic drug delivery system is disclosed comprising an amphiphilic molecule, a non-aqueous liquid solvent, and a...
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7718609 |
Rapid acting and long acting insulin combination formulations
A combined rapid acting-long acting insulin formulation has been developed in which the pH of the rapid acting insulin is adjusted so that the long acting glargine remains soluble when they are...
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7713929 |
Rapid acting and long acting insulin combination formulations
A combined rapid acting-long acting insulin formulation has been developed in which the pH of the rapid acting insulin is decreased so that the long acting glargine remains soluble when they are...
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7709445 |
Colloidal suspension of nanoparticles based on an amphiphilic copolymer
An aqueous suspension, stable in physiological medium, of nanoparticles for delivering active principles such as insulin. The delivery particles are based on a three-block copolymer: polyethylene...
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7695729 |
Nonoral preparation having three-layer structure
The purpose of the present invention is to provide micro- or mili-capsules and film preparations having not only sustained-release function but also targeting and adhesive functions with...
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7691603 |
Intracellular formation of peptide conjugates
The invention includes methods and compositions for forming peptide conjugates intracellularly having a covalent linkage between a modifying group and a glycosylated or non-glycosylated peptide....
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7683029 |
Liquid aerosol formulations containing insulin and aerosol generating devices and methods for generating aerosolized insulin
Liquid aerosol formulations for generating aerosolized insulin include insulin and at least one high volatility carrier which protects the insulin from thermal degradation during vaporization of...
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7659310 |
Methods of enhancing solubility of agents
This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various...
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