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8895002 Hemojuvelin fusion proteins and uses thereof  
The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also...
8865168 Methods and compositions to regulate hepcidin expression  
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to...
8778878 Use of ferritin to treat iron disorders  
Methods and compositions for treating an iron disorder in a patient are presented, including methods for delivering a therapeutically effective amount of iron to the brain. Iron disorders that may...
8703695 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8658592 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8637023 Hemojuvelin fusion proteins  
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to...
8586525 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8586528 Biologically active peptides and their new uses  
Novel peptides are disclosed with their use as a pharmaceutical composition. A method is also disclosed for making pharmaceutical compositions and treatment of an individual.
8435941 Mini-hepcidin peptides and methods of using thereof  
Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.
8324159 Erythropoietin receptor peptide formulations and uses  
The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat...
8293236 Use of modulators of compounds of TGF-β superfamily to regulate hepcidin-mediated iron metabolism  
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular methods of using agonists and antagonists of TGF-β superfamily members to...
8105615 Lactoferrin as an adjuvant in cancer vaccines  
The present invention relates to methods of treating cancer by administering a composition of lactoferrin (LF) in combination with cancer vaccines.
8080520 Composition and method for treating iron deficiency anemia  
A composition comprising heme iron and/or heme iron polypeptide in combination with ionic iron(s) and/or chelated iron(s). Administration of effective dosages of the present composition provides a...
8071542 Use of ferritin to treat iron deficiency disorders  
The present inventors have demonstrated the presence of H-ferritin receptors on endothelial cells in culture and on rat brain rat brain microvasculature, identifying H-ferritin as a means for...
8048850 Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use  
In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and...
7968091 Methods and compositions to regulate iron metabolism  
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to...
7893024 Enhancement of iron chelation therapy  
The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of...
7867481 Method of treating anemia by administering IL-1ra  
The invention relates to methods of treating a blood disorder in a mammal with an interleukin-1 (IL-1) inhibitor. The invention also relates to methods of treating a blood disorder in a mammal...
7550263 Method for the production of fusion proteins in transgenic mammal milk  
Desirable fusion proteins can be produced in and purified from the milk of transgenic animals. The peptides are made as fusion proteins with a suitable fusion partner such as human...
7504377 Nitric oxide-blocked cross-linked tetrameric hemoglobin  
The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the...
7459429 Method of treating disturbances of iron distribution in inflammatory intestinal diseases  
The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in chronic inflammatory intestinal diseases.
7459436 Treatment of disturbances of iron distribution  
The present invention relates to the use of erythropoietin for the treatment of disturbances of iron distribution in heart diseases.
7417023 Targeted delivery of bioaffecting compounds for the treatment of cancer  
A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the...
7312198 Protein compositions for promoting wound healing and skin regeneration  
Methods for stimulating proliferation and inhibiting death of cells in the epidermis and dermis of wounded and non-wounded as well as transplanted mammalian skin and transplanted skin cell...
7285526 Interferon antagonists useful for the treatment of interferon related diseases  
The present invention relates to a process for ameliorating or preventing diseases that are caused, in part, by an increased level of, and/or an abnormal responsivity to, interferon. Alzheimer's...
7244702 Purified Cys moiety for iron reductase, and method for obtaining and using same  
The invention comprises a preparation of X-S-Cys-X, moiety, BRAUNMYCIN Î>>, where X maybe naturally linked peptide or glycan residues essential for iron-reductase activity, as well as methods of...
7204999 Method of production of nanoparticle and nanoparticle produced by the method of production  
The method of the production of a nanoparticle of the present invention includes a step of forming a nanoparticle including a compound of ametal ion in a cavity part of aprotein, in a solution...
7169758 Use of hepcidin as a regulator of iron homeostasis  
The invention concerns the use of hepcidin for the diagnosis and therapy of disorders of iron homeostasis. Hepcidin can be used in the treatment of disorders resulting from iron overload, while...
7160855 Enhancement of iron chelation therapy  
The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of...
6984624 Composition containing an iron complexing protein and a precursor of nitrogen monoxide metabolism and/or a chemical donor of nitrogen monoxide and uses thereof  
The invention concerns a pharmaceutical composition or a food supplement containing at least an iron complexing protein optionally in the presence of at least an iron salt, and at least a...
6960560 Iron chelator delivery system  
An iron chelator delivery system is disclosed. The system comprises iron chelator and a lipid carrier, e.g., a liposome. Methods for preparing and administering the iron chelator delivery system...
6844317 Methods for oxygen transport comprising a high oxygen affinity modified hemoglobin  
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
6710028 Method for treating disturbances in iron metabolism using a combination of erythropoietin and iron  
A pharmaceutical composition comprising 250-20,000 U of an EPO preparation and 5-20 mg of a Fe(III) complex is disclosed. This pharmaceutical composition is useful in treating anaemias as well or...
6649591 Polydithicarbamate-containing non-targeting marcomolecules and the use thereof for therapeutic and diagnostic applications  
In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in...
6576221 Iron-containing nanoparticles with double coating and their use in diagnosis and therapy  
The present invention relates to iron-containing nanoparticles having a modular structure, their production, and their use for diagnostic and therapeutic purposes. The nanoparticles according to...
6569831 Recombinant lactoferrin, methods of production from plants and uses  
The invention concerns the use of a recombinant nucleotide sequence containing a cDNA coding for a lactoferrin, in particular human lactoferrin, or the derived proteins, and elements enabling a...
6518240 Composition and method for preparing amino acid chelates and complexes  
Compositions and methods of preparing amino acid chelates and complexes are disclosed and described. Specifically, by (a) combining a hydrated metal sulfate salt with an amino acid ligand to form...
6358918 Preparation comprising thiol-group-containing proteins  
There is disclosed a stable, virus-safe, pharmaceutical preparation comprising thiol-group-containing proteins which are heat-treated and processed such that at least 40% of the thiol groups are...
6333311 Useful properties of human lactoferrin and variants thereof  
The invention provides compositions containing human lactoferrin, or lactoferrin variants deleted for one or more arginine residues in the amino-terminal region of the protein (i.e., in the first...
6333306 Pharmaceutical combination preparations containing erythropoietin and iron preparations  
The present invention is directed to a pharmaceutical combination preparation comprising 2,000-7,000 U of recombinant human erythropoietin (EPO) and 5-20 mg of an Fe(III) complex, wherein the...
6139882 Method of producing iron-whey-proteolysate complex  
A carbonate- and/or bicarbonate-iron-whey-proteolysate complex includes 1 to 1,000 atoms of iron and one or more molecules of carbonate and/or bicarbonate per one molecule of whey-protein as...
6124258 Iron-casein complex and process for preparing the same  
Iron-casein complexes and methods for preparation thereof without iron characteristic astringent taste even by heat sterilization and having high iron supplying effect.The iron-casein complexes...
5994346 Use of exochelins in the preservation of organs for transplant  
Exochelins can be used to prevent damage to organs for transplant from the formation or presence of the .circle-solid.OH radical. In particular, the invention is directed to the administration of...
5906977 Conjugate for treating inflammatory diseases  
The present invention relates pharmaceutical compositions comprising a conjugate of an active substance, a linker and a carrier for the treatment and/or diagnosis of inflammatory diseases. The...
5871735 Isoferritin as a marker for pathological pregnancy  
The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a...
5792458 Mutant diphtheria toxin conjugates  
A potent and specific immunotoxin is prepared by coupling an inactivated diphtheria toxin to a binding moiety such as a monoclonal antibody or transferrin. The immunotoxins are specific for human...
5725864 Composition for suppressing infection and growth of human immunodeficiency virus  
The invention relates to compositions and methods for inhibiting infection or suppressing growth of human immunodeficiency virus. The composition comprises, as an effective component, an...
5393737 Cytotoxic drug conjugates for treatment of neoplastic diseases  
A novel composition of matter comprising a ligand-carbohydrate-cytotoxic drug conjugate is produced by the steps of (1) reacting a carbohydrate with a ligand, (2) reacting the product of step (1)...
5352447 Immunotoxins for treatment of intracranial lesions and as adjunct to chemotherapy  
A potent and specific immunotoxin is prepared by coupling a binding-site inactivated diphtheria toxin (CRM 107) to a new binding moiety consisting of transferrin or a monoclonal antibody against...
5342607 Receptor mediated endocytosis type magnetic resonance imaging contrast agents  
A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including...

Matches 1 - 50 out of 73 1 2 >