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7612052 |
Combinations comprising epothilones and pharmaceutical uses thereof
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I
wherein A represents O...
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7611733 |
Nanoparticle formulations of platinum compounds
Solid Lipid Nanoparticles of platinum compounds, particularly of antitumor platinum complexes are disclosed. The Nanoparticles of the invention are obtained by a process comprising: a) preparing a...
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7605282 |
Process for the preparation of an oxaliplatin preparation
The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy.
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7589225 |
Preparation of platinum(II) complexes
This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a...
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7582786 |
Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity,...
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7579373 |
Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or...
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7576126 |
Platinum (II) complexes, preparation and use
The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The...
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7576053 |
Methods and compositions for treating degenerative bone disorders
The present disclosure provides methods and compositions using Syk inhibitory compounds for treating degenerative bone disorders and as prophylactic treatment to prevent bone loss. These treatments...
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7572828 |
Identification of anti-HIV compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid
The invention provides methods and pharmaceutical compositions for inhibiting viral replication, particularly retroviral replication. The methods comprise administration of stibonic acid or...
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7569606 |
Platinum complexes with mononitrile-containing ligands
Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming...
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7566798 |
Platinum complexes and methods of use
The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to...
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7563818 |
Photosensitizer functionalised nanoparticles
The present invention relates to self-assembly of a photosensitizer on a nanoparticle. The invention also provides methods for production of functionalized (eg. stabilized) nanoparticles. The...
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7540906 |
Metal salts of hydrolyzed olefin/maleic anhydride copolymers and their use as wood preservatives
Complexes of copper and/or zinc with hydrolyzed olefin/maleic anhydride copolymers were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of...
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7485659 |
Anticancer compositions, and methods of making and using the same
Compositions, containing a ruthenium(III) complex and a heterocycle, methods for their manufacture, medicament containing these compositions and a kit. The invention relates to a composition (A),...
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7470714 |
GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent
An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1):
wherein each R independently...
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7470677 |
Oxidant scavengers
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of...
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7465465 |
Pharmaceutical formulation comprising lanthanum compounds
This invention relates to a chewable lanthanum formulation comprising a pharmaceutically effective amount of a lanthanum compound; and at least one chewable pharmaceutically acceptable excipient....
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7462227 |
Ibuprofen complexes as wood preservatives
Complexes of ibuprofen and copper and/or zinc were solubilized in ammoniacal solution providing preservative solutions that fully penetrate wood. With loss of the ammonia from the wood, the...
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7459482 |
Agent for treatment of cisplatin-resistant cancer
Preparation of a lipophilic platinum complex being dissolved or suspended in an iodized poppyseed oil fatty acid ethyl ester is useful as an agent for treatment of cisplatin-resistant cancers.
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7456215 |
Pharmaceutical gallium compositions and methods
Novel pharmaceutical gallium compositions, including gallium complexes having increased oral bioavailablity relative to uncomplexed gallium salts are disclosed. Such compositions are useful in the...
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7445799 |
Compositions for microbial and chemical protection
An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and...
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7435408 |
Porous particles comprising excipients for deep lung delivery
Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a...
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7435380 |
Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches
A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties...
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7432403 |
Cyclic palladium compounds having coordinated thereto bis (diphenylphosphine) ferrocene ligands which inhibit the activity of proteins and enzymes and treatment of diseases and disorders associated therewith
The invention relates to cyclopalladated compounds containing bis-diphenyiphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of...
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7427416 |
Methods of treating conditions using metal-containing materials
Methods of treating conditions using metal-containing materials are disclosed. Exemplary conditions include bacterial conditions, biofilm conditions, microbial conditions, inflammatory conditions,...
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7410655 |
Anticancer agent
An anticancer agent containing platinum preparation, humic substances, water and sodium chloride. Potassium tetrachloroplatinate is used as a platinum compound and lignohumic acid ammonium salts...
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7396814 |
Metallopeptide compositions for treatment of sexual dysfunction
Metallopeptide compositions are provided for treatment of sexual dysfunction in mammals, including male sexual dysfunction, such as erectile dysfunction, and female sexual dysfunction. The...
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7393871 |
Anionic and neutral complexes of ruthenium (II) with nitrogen oxide
A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The...
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7384916 |
Methods and compositions for preventing and treating aging or photodamaged skin
Disclosed are methods for treating aging and photodamaged skin employing topical application of compositions which comprise at least one peptide manganese complex. Also disclosed are methods...
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7381428 |
Stabilized lanthanum carbonate compositions
Stabilized lanthanum carbonate compositions containing a monosaccharide or disaccharide stabilizing agent are disclosed. Subjects having hyperphosphatemia can be treated by administering a...
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7378077 |
High dose radionuclide complexes for bone marrow suppression
The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases,...
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7351747 |
Skin treatment for relief of itch
A method for treating skin itch in an individual in need of such treatment, by topically administering an amount effective for relieving said itch of an additive selected from the group consisting...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7326421 |
Device and methods for sequential, regional delivery of multiple cytotoxic agents and directed assembly of wound repair tissues
An implantable delivery system includes a macrostructure formed of bioresorbable material selected from a group of alphahydroxy acids and defined to include an internal architecture of...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7285292 |
Trace elements
The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium and which comprises a...
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7285290 |
Hydrophilized powder and a composition comprising the same
The present invention is hydrophilized powder, wherein the powder is surface treated with polyether-modified silicone having a hydrolyzable silyl group according to the formula (1),
...
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7271161 |
Platinum complexes as antitumor agents in combination with biochemical modulation
The present invention concerns the use of methods and compositions for the treatment of cancer and other hyperproliferative diseases. In certain embodiments, methods are described for the treatment...
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7258875 |
Compositions and methods for topical treatment of skin infection
The present invention describes an extremely effective, simple, novel, inexpensive, safe and quick method to treat both acne and warts, each with a different etiology and different clinical...
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7255881 |
Metal-containing materials
Metal-containing materials, as well as their preparation and use are disclosed. The metal-containing material can be, for example, an antimicrobial material, an anti-biofilm material, an...
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7253209 |
Remedies for cisplatin-tolerant cancer
Preparation of a lipophilic platinum complex being dissolved or suspended in an iodized poppyseed oil fatty acid ethyl ester is useful as an agent for treatment of cisplatin-resistant cancers.
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7241756 |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
A method for the treatment of diabetes mellitus, especially Type 2 diabetes and conditions associated with diabetes mellitus in a mammal such as a human, which method comprises administering an...
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7229645 |
Spray freeze-dried compositions
A process for producing a powder comprises spray freeze-drying an aqueous solution or suspension comprising a pharmaceutical agent, said solution or suspension having a solids content of 20% by...
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7208519 |
Pesticidal compounds and compositions
The invention includes a pesticidal compound comprising at least one organic phenolic compound and at least one salt comprising a divalent cation. Preferably, the organic phenolic compound is...
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7201925 |
Treatment of ungual and subungual diseases
The treatment of ungual and subungual diseases is disclosed.
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7163703 |
Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt,...
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7160908 |
Dynamic anticancer platinum compounds
A series of dynamic platinum compounds for cancer treatment are described. The compounds may become active and inactive reversibly.
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7125546 |
Polymeric micelle containing cisplatin enclosed therein and use thereof
Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene...
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7122209 |
Oral compositions for the treatment of non-diabetic obese mammals, including humans
Oral compositions containing an effective amount of a tungsten compound (VI), preferably a tungstate salt, more preferably sodium tungstate (Na 2 WO 4 ), are useful in controlling...
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7097859 |
Indium supplement compositions and methods therefor
A tablet for oral administration of nutritional indium comprises about 10–50 mg indium sulfate, about 4–20 mg caffeine, about 2–10% by weight cocoa powder, and about 5–10% by weight ethyl...
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