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5681544 |
Polymer-bonded complexing agents, their complexes and conjugates, processes for their production and pharmaceutical agents containing them
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
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5672335 |
Use of metal complexes as liver and gallbladder X-ray diagnostic agents
Metal complexes containing a metal of atomic numbers 39-42, 44-51 or 56-83 and a complexing agent can be used for the production of contrast media for use in the contrast-enhanced computer...
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5665771 |
Platinum complexes
Platinum complexes of formula Ia or Ib ##STR1## where each A, is a leaving group and may be the same or different, which is suitably halo, especially chloro, hydroxy, carboxylate or together...
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5651955 |
Method of electrical impedance imaging using ionic metal chelates
A method of electrical impedance imaging (EII) of a subject comprising administering an EII sensitive contrast agent and generating an electrical impedance image of at least part of the subject.
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5648384 |
Anti-tumor platinum (IV) complex
Disclosed is an anti-tumor liposoluble platinum (IV) complexes having Formula I, a Formula VI or a Formula XII. Because these complexes have liposoluble groups, they are effective for various...
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5641519 |
Method of treating endotoxic shock employing gallium compounds
A method of treating endotoxic shock in mammals, comprising administering an effective amount of a pharmaceutically acceptable gallium compound. A preferred gallium compound is gallium nitrate.
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5631284 |
Compositions and methods for relaxing smooth muscles
Compositions and methods for relaxing smooth muscle in a warm-blooded animal are provided, comprising the step of administering to the animal a transition-metal nitrosyl complex. In one aspect, the...
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5628983 |
Squid magnetometry using paramagnetic metal chelates
The present invention relates to the use of paramagnetic materials, such as lanthanide chelates, as contrast agents in magnetometric analysis, especially imaging. The invention is particularly...
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5624661 |
Hypoosmotic compositions comprising a polymer and a complexed contrast agent for MRI
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents...
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5622687 |
Calixarene conjugates useful as MRI and CT diagnostic imaging agents
Calixarene conjugates useful for imaging, particularly magnetic resonance imaging (MRI) and computed tomography (CT) are described. Said calixarene conjugates comprise (i) a calixarene backbone,...
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5621003 |
Maillard reaction inhibitor
A maillard reaction inhibitor comprising, as the principal component, an eight-structural polymer of 3-oxygermylpropionic acid represented by the following stereostructure (I): ##STR1## wherein R...
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5620967 |
Methods of treating hypertension with vanadium compositions
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5618838 |
Gallium complexes for the treatment of free radical-induced diseases
A pharmaceutical composition comprises a gallium complex of desferrioxamine r penicillamine as active ingredients therein, in combination with a pharmacologically acceptable carrier. The gallium...
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5616613 |
Platinum(II) complex and malignant tumor treatment agent
Novel platinum(II) complexes represented by the general formula ##STR1## in which R 1 represents a lower hydrocarbon radical of 1 to 3 carbon atoms, R 2 and R 3 each independently represent a...
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5616312 |
Thiol ligands and complexes for X-ray imaging
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## Wherein R 1 , R 2 , R 3 , R 4 , and R 5 are the same or different and...
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5614553 |
Composition and method for alleviating stress in warm-blooded animals
A method for alleviating stress and/or stress related symptoms in humans and other warm-blooded animals particularly when such symptoms are complicated by intestinal malabsorption of minerals is...
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5614170 |
Paramagnetic complexes of N-alkyl-N-hydroxylamides of organic acids and emulsions containing same for magnetic resonance imaging (MRI)
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an...
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5614168 |
Multinuclear complexes for X-ray imaging
The invention relates to the use as contrast enhancing agents in medical imaging, especially X-ray imaging, of multinuclear complexes, i.e. complexes, such as those of W202 (U20) 2, in which the...
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5604199 |
Method of treating fibrosis in skeletal muscle tissue
A method of treating skeletal muscle fibrosis in mammals. The novel method is effective for reducing the extent of skeletal muscle fibrosis in an individual who suffers from a disorder which...
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5597809 |
Treatment of optic neuritis
Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.
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5596016 |
1,2-disubstituted aromatic chelates
Mineral absorption is promoted in warm-blooded animals by means of a class of 1,2-disubstituted aromatic mineral chelates wherein the 1 and 2 substituents each donates a pair of electrons to a...
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5595725 |
Diagnostic media
A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic...
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5595763 |
Tungsten (VI) compositions for the oral treatment of diabetes mellitus
The pharmaceutical composition contains an effective amount of a tungsten (VI) compound, preferably a tungstate or a isopolytungstate, and more preferably sodium tungstate. In the method of...
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5575986 |
Chelating agent, complex compound of said chelating agent and metallic atom, and diagnostic agent comprising same
A compound of the following formula ##STR1## wherein m is an integer of 1 to 3, R 1 and R 2 are the same or different and each is hydrogen atom or lower alkyl, and R 3 , R 4 , R 5 and R 6 are...
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5571498 |
Emulsions of paramagnetic contrast agents for magnetic resonance imaging (MRI).
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an...
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5565184 |
Functionalized tripodal ligands for x-ray & radioactive imaging applications
The present invention provides new and structurally diverse compositions comprising compounds of the general formula: ##STR1## wherein A is N or CR 1 , R 1 is hydrogen, C 1 -C 8 alkyl, or C 6 ...
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5565491 |
Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation
A method of inhibiting the proliferation of B cells by using inhibitors of phosphotyrosine phosphatase can be used to regulate the immune response and to treat diseases such as leukemias or...
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5562925 |
Anti-tumor method
Malignant tumors in animals are treated by parenterally administering to an affected animal a solution containing a complex compound of platinum in an amount effective to cause regression of the...
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5560903 |
Method of enhancing paramagnetism in chelates for MRI
A diagnostic medium contains at least one physiologically well tolerated complex salt comprising an anion of a complexing acid and one or more central ion or ions of an element with an atomic...
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5554357 |
Magnetic resonance imaging agents containing hydrazide moieties
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized...
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5550100 |
Methods of using manganese chloride for improving the wetting of particulates
New and improved compositions comprising particulates and an effective amount of manganese chloride to reduce significantly the wetting time and/or the dispersion time of said particulates relative...
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5547982 |
Anti-tumor platinum complexes
Platinum complexes, having anti-tumor activity, which include at least one functional ketone group or aldehyde, optionally conjugated as a linkable hydrazone complex. The functional ketone and...
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5534542 |
Methods and materials relating to a bi-metallic cross-linking species
Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M 1 is a metal ion species capable of forming a complex of coordination number four or...
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5534240 |
Unchelated manganese composition for MRI of the gastrointestinal tract
A contrasting composition for gastrointestinal tract MRI which contains a trace amount of unchelated manganese is disclosed. The composition has a marked contrasting effect in MRI without causing...
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5532272 |
3-oxygermylpropionic acid polymer, pharmaceutical composition containing same and method of preventing and/or curing symptoms of immune diseases using same
A novel, eight structural polymer of 2-oxygermylpropionic acid having an empirical formula of C 6 H 10 Ge 2 O 7 , a minimum constitutional unit of (O 1 /2) 3 GeCH 2 CH 2 COOH and the...
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5527790 |
Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5516503 |
Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging
A diagnostic composition comprising a binuclear complex between a polyaminopolycarboxylic ligand, such as diethylene triamine pentacetic acid, a paramagnetic metal such as Gd and an endogenous...
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5516748 |
Methods for improving the wetting of agrochemical particulates with zinc chloride
New and improved compositions comprising particulates and an effective amount of one or more effective salt(s) to reduce significantly the wetting time and/or the dispersion time of said...
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5504055 |
Metal amino acid chelate
A water soluble metal amino acid chelate is prepared by adding a metal salt to deaerated water, mixing the salt solution with a mixture of an amino acid and an organic acid and adjusting the pH of...
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5496854 |
Metallocenes as anti-tumor drugs
The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as...
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5494655 |
Methods for detecting blood perfusion variations by magnetic resonance imaging
The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method...
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5494656 |
Second sphere complexes as relaxation agents for image enhancement in magnetic resonance imaging
A second sphere contrast enhancing agent for magnetic resonance imaging comprises a paramagnetic metal ion having catecholate ligands coordinated thereto and having water molecules hydrogen bonded...
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5488050 |
Methods and products for treating presbyopia
This invention is directed to treatment for increasing the accommodative ability of the eye, for the purpose of decreasing the severity of clinically evident presbyopia, an age-related loss of...
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5486538 |
Precious metal humates and their preparations
A precious metal salt of a low molecular humic acid containing 1 to 5% by weight of the precious metal processes for their preparation and a method of stabilizing alkali metal humate and their...
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5482700 |
Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4, X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic...
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5476644 |
Cyclic triamine chelating agents
The present invention provides compounds of the formula ##STR1## chelated with a paramagnetic metal ion wherein Z1 and Z2 each represent the atoms necessary to complete a monocyclic or polycyclic...
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5470586 |
Antifouling coating and method for using same
A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R 1 , R 2 and...
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5470876 |
Topical sod for treating hair loss
SOD for treating hair loss is disclosed. The SOD has utility in a topical pharmaceutical formulation for the cosmetic treatment of hair loss and the cosmetic stimulation of hair growth. The SOD...
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5468467 |
Methods for the in vivo measurement of the concentration of non-imaging nmr-detectable xenobiotic compounds
Methods wherein the concentration of NMR-detectable xenobiotic compounds may be determined in living subjects by in vivo measurement of one or more magnetic resonance signals. In preferred...
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5466439 |
Polymeric contrast enhancing agents for magnetic resonance images
A polymeric contrast enhancing agent for magnetic resonance images having a chelating agent, which can be bound to metal ions having at least one unpaired electron, such as gadolinium. Examples of...
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