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5994322 |
Compositions for preventing dementia
Compositions for preventing or treating memory loss in the brain, comprising an effective amount of a mixture of lecithin and vitamin B 12 .
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5985917 |
Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
This invention is directed to a pharmacologically acceptable composition for inhibiting nitric oxide synthase in a mammal, which includes a mercapto or seleno derivative and a pharmaceutically...
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5985916 |
Polymer-platinum compounds
A polymer-platinum compound for use in tumor treatment is described. The compound is composed of a biodegradable diamido-diamine polymer linked to a platinum species. The platinum species is...
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5968976 |
Pharmaceutical composition containing selected lanthanum carbonate hydrates
Selected lanthanum carbonate hydrates may be administered into the gastrointestinal tract, to treat hyperphosphataemia in patients with renal failure.
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5958372 |
Low viscosity chelating polymers for diagnostic imaging
Disclosed are linear and cross-linked polymers suitable for use as a contrast agent for magnetic resonance imaging containing units comprising the residue of a poly(amine) moiety linked to a...
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5939357 |
Fungicide compositions
This invention provides a novel fungicide composition which has a bicarbonate-containing inorganic salt ingredient which enhances the efficacy of a fungicide ingredient for the treatment of...
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5932190 |
Multinuclear complexes for X-ray imaging
An x-ray contrast medium containing a multinuclear complex of the formula (M 6 (μ 3 B) 8 A v ) x L w , wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; μ 3 B represent a tridentate bridging...
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5922689 |
Cisplatin analogs for cancer treatment
This invention comprises the synthesis and the use of two cisplatin analogs Pt(NH 3 ) 2 Cl(C 10 H 13 N 5 O 5 )!Cl and Pt(NH 3 ) 2 (C 10 H 13 N 5 O 5 ) 2 !Cl 2 , whereby (C 10 H 13 N 5 O...
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5919820 |
Antioxidant medicament
Antioxidative pharmaceutical formulation comprising L-selenomethionine, β-carotene, ascorbic acid (vitamin C), D-α-tocopherylacetate (vitamin E) and L-methionine together with a pharmaceutically...
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5914095 |
Polychelants containg amide bonds
There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA...
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5914097 |
Amino-acyl-type and catecholamine-type contrast agents for MRI
The present invention relates to the preparation of amino-acyl-type and catecholamine-type compounds having multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate...
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5906994 |
Preparation and use of contrast agents
A process for the preparation of multinuclear cluster compounds by reacting a metal carbonyl with iodine, and use of these clusters and clusters derived from them, in diagnostic imaging. Novel...
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5902826 |
Platinum (IV) complex and pharmaceutical composition comprising the same
A diamine-platinum (IV) complex represented by the following formula (1): ##STR1## wherein R 1 and R 2 together represent R 5 O--CH(CH 2 NH 2 ) 2 (R 5 represents hydrogen, acetyl,...
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5902825 |
Composition and method for the palliation of pain associated with diseases of the bone and bone joints
A therapeutic composition and method of using the same for the palliation or relief of pain in patients having diseases which affect the bone and bone joints including metastatic bone cancer,...
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5888993 |
Vanadium compounds in the treatment of elevated blood sugar levels
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5880149 |
Metal complexes as cysteine protease inhibitors
The invention relates to metal complexes used to bind proteins and enzymes.
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5877210 |
Phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase activators for controlling cellular proliferation
A method of inhibiting the proliferation of B cells by using inhibitors of phosphotyrosine phosphatase can be used to regulate the immune response and to treat diseases such as leukemias or...
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5871779 |
Treatment of arthropathies with vanadate compounds or analogues thereof
The present invention relates to the use of vanadate compounds, or analogues of vanadate compounds, to treat arthropathies, and to compositions containing vanadate compounds adapted for such use.
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5866563 |
Vanadium compositions
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5863911 |
Diarylethylene metallocene derivatives, their processes of preparation and pharmaceutical compositions containing said derivatives
Diarylethylene metallocene derivatives, processes for preparing the same and pharmaceutical compositions which contain the derivatives are disclosed. The compounds of the invention can exhibit...
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5861415 |
Bioprotectant composition, method of use and extraction process of curcuminoids
Curcuminoids have been found to have anti-oxidant, anti-inflammatory, antibacterial, antifungal, antiparasitic, anti-mutagen, anticancer and detox properties. The present invention is directed to...
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5856356 |
Use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis
The invention relates to the use of strontium salts and pharmaceutical compositions thereof for the treatment of arthrosis through stimulation of the synthesis of proteoglycans and type II collagen...
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5854266 |
Synergistic antimicrobial composition pyrithione and alcohol
Disclosed herein is an antimicrobial composition characterized by synergistic antibacterial efficacy against Gram-negative bacteria and comprising an antimicrobially effective amount of a...
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5849790 |
(Mono) ethylenediaminenitroplatinum (IV) complexes with ligands of oxides of nitrogen as possible anti-tumor agents
The present invention discloses (mono)ethylenediaminenitroplatinum (IV) complexes of with ligands of oxides of nitrogen, and their synthesis, which, in vivo, may be reduced to produce "cisplatin"...
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5843974 |
Methods of inhibiting melanoma using Benzothiophenes as cytotoxic agents per se
A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are independently hydrogen,...
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5844001 |
Combination platinum chemotherapeutic/antiestrogen therapy for human cancers
The present invention provides a composition of matter for the treatment of non-melanoma cancers, wherein said composition comprises a platinum anti-neoplastic compound and tamoxifen, wherein said...
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5843481 |
Treatment of proliferative disorders, metastasaes, and drug resistant tumors with vanadate compounds and derivatives or analogues thereof
The present invention relates to the use of vanadate compounds, or analogues of vanadate compounds, as antiproliferative and anti-metastatic agents, and to compositions containing vanadate...
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5840759 |
Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5837736 |
Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5821265 |
Inhibitors of cell-mediated disorders
The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The...
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5814667 |
Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric...
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5811463 |
Compositions and method for relaxing smooth muscles
Compositions and methods for relaxing smooth muscle in a warm-blooded animal are provided, comprising the step of administering to the animal a transition-metal nitrosyl complex. In one aspect, the...
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5807586 |
Method of dietary supplementation
The present invention relates to a method of supplementing the dietary needs of women whereby an effective amount of a life stage appropriate dietary supplement is administered to a woman at each...
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5804161 |
Contrast agents
Compounds of formula (I) M 6 Q 8 B n L 6 -n ! x where M is Re or Rh; each Q is a bridging atom selected from O, S, Se and Te; B is a monovalent non-bridging atom or moiety; L is a PR...
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5804164 |
Water-soluble lipophilic contrast agents
The present invention relates to water-soluble, lipophilic contrast-enhancing agents, pharmaceutical compositions thereof and methods for diagnostic analysis, particularly NMR or MRI analysis using...
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5800838 |
Composition that inhibits or destroys at least one unicellular living organism containing fluorine F- and Lithium li+
The invention is directed to a composition and a method for using the same which composition inhibits or destroys unicellular living organisms. The composition is particularly effective in...
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5763480 |
Inhibitors of cell-medicated disorders
The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The...
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5759855 |
Methods for modifying the binding activity of cell adhesion receptors
The invention relates to the regultory role of cations on the dynamics of integrin-mediated cell adhesion and migration. In one aspect, methods of promoting or inhibiting the migration of...
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5756540 |
Methods for in vivo reduction of nitric oxide levels and compositions useful therefor
In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the...
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5753207 |
Use of paramagnetic compounds to measure temperature and pH in vivo
A method for measuring temperature and/or pH in vivo using paramagnetic compounds, e.g., lanthanide complexes, in conjunction with NMR has been developed. The chemical shift of the nuclear spin in...
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5747534 |
Lobaplatin trihydrate
Cis- trans-1,2-cyclobutanebis (methylamine)-N,N'!- (2S)-lactate-O 1 ,O 2 )-platinum (II) trihydrate (lobaplatin trihydrate) and its preparation.
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5746995 |
DTPA derivatives substituted in a novel way, their metal complexes, and their use in diagnosis and therapy
The invention relates to new diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical...
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5738837 |
Lanthanide paramagnetic agents for magnetometric imaging
The present invention relates to the use of paramagnetic materials, such as lanthanide chelates, as contrast agents in magnetometric analysis, especially imaging. The invention is particularly...
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5716988 |
Pharmaceutically stable preparation of oxaliplatinum
A pharmaceutically stable oxaliplatinum preparation for parenteral administration comprises an aqueous solution of oxaliplatinum, in a concentration of 1 to 5 mg/ml, and with a pH in the range of...
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5708022 |
Method for inhibiting immune response
Use of ruthenium complexes as immunosuppressive agents to prevent or significantly reduce graft rejection in organ and bone marrow transplantation is described. The ruthenium complexes can also be...
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5700487 |
Treatment of pulmonary inflammation
A method of treating pulmonary inflammation in mammals, comprising administering an effective amount of a pharmaceutically acceptable gallium compound and wherein said gallium is elected from the...
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5693309 |
Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same
1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4, X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic...
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5693668 |
Acetylcholinesterase inhibitors
This invention relates to silylated aromatic fluoroketones possessing acetylcholinesterase-inhibiting properties and to their use in the treatment of Alzheimer disease and senile dementia.
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5688784 |
Method of suppressing appetite with vanadium complexes
There are provided vanadium compositions for use in the treatment of hypertension, obesity and diabetes, in particular improved oral compositions comprising oxovanadium (IV) chelates of monoprotic,...
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5681544 |
Polymer-bonded complexing agents, their complexes and conjugates, processes for their production and pharmaceutical agents containing them
Polymers comprising a ligand containing a carboxylic acid group, optionally at least one ion of an element of the atomic numbers 21-29, 42, 44 or 57-83 as well as optionally cations of inorganic...
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