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5077280 |
Treatment of viral infections
Treatments for viral infections are disclosed based on the finding that uridine can selectively protect and/or rescue uninfected cells, particularly human bone marrow progenitor cells, from the...
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5077279 |
3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
A composition delivering an HIV-inhibitory amount of an active compound of the general formula: ##STR1## wherein R is OH, monophosphate, diphosphate, or triphosphate, or a pharmacologically...
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5070078 |
Antiviral compounds
2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those...
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5059418 |
Synergistic effect of human recombinant interferon-beta on halogenated pyrimidines
A method of treating patients having viral infections exhibiting a synergistic antiviral effect in combination therapy of viral infections is comprised of combining synergistically effective...
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5051425 |
Therapeutic composition for combatting AIDS
A therapeutic composition for combatting acquired immune deficiency syndrome (AIDS) comprising: (A) a pharmaceutically effective amount of at least one carcinostatic agent selected from alkylating...
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5049663 |
Process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt and monohydrate thereof
Disclosed herein are a novel process for producing 1-β-D-arabinofuranosylcytosine-5'-stearylphosphate monosodium salt, which has been expected as an oral antitumor agent, and...
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5028595 |
Method for preventing AIDS in a subject or treating a subject infected with the AIDS virus
A method for treating a subject infected with the AIDS retrovirus without substantial neuropathy by administering 2',3'-dideoxycytidine to the subject at a dose of from 0.001 to 0.05 milligram per...
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5010060 |
Method of treating herpes simplex viral infection employing pyrimidine derivatives
Compounds of the formula ##STR1## wherein R 1 is halogen, C 1 -4 -alkyl, halo-(C 1 -4 -alkyl) or C 2 -4 -alkanoyl, R 2 is hydrogen, hydroxy, C 1 -4 -alkoxy, C 1 -4 -alkylthio or phenyl-(C 1 -4...
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4997818 |
Therapeutic method for selectively treating terminal deoxynucleotidyl transferase-positive neoplastic leukemias and lymphomas
A therapeutic method for specifically treating terminal deoxynucleotidyl transferase-positive neoplastic disease within living subjects is provided which is uniquely effective and selective. The...
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4994442 |
Method for stimulation or repair and regeneration of intestinal gut cells in infants and enhancing the immune response of t-cells
Nucleosides and/or nucleotides are added to infant formula, both milk and non-milk based, to provide a formula having enhanced physiological properties and also closely resemble human milk....
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4992534 |
3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
Derivatives of 5-deoxy-fluorouridine are disclosed of formula (1) ##STR1## in which one of R and R is a substituted furanylmethyl or thienylmethyl group; and the other R and R is a lower alkanoyl...
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4990499 |
Anti-herpes simplex virus activity of 5-alkoxymethyl-2'-deoxycytidimes and their 5-monophosphates
5-alkoxymethyl-2'-deoxycytidines, particularly 5-methoxymethyl-2'-deoxycytidine, are useful in the treatment of infections caused by Herpes simplex virus and the treatment of neoplasms in which...
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4973579 |
Enhancment of absorption of drugs from gastrointestinal tract using choline ester salts
Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.
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4966891 |
Fluorocytidine derivatives
The novel 5'-deoxy-5-fluorocytidine derivatives of formula ##STR1## wherein R 1 , R 2 and R 3 are hydrogen or an easily hydrolyzable radical under physiological conditions, with the proviso that,...
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4963662 |
Fluorinated nucleosides and method for treating retrovirus infections therewith
A method for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula...
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4963556 |
Choline esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities
Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.
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4959212 |
Oxidizing-energizing composition and method for the treatment of diabetes
A non-toxic, oxidizing-energizing composition suitable for use as an accelerator of the carbohydrate oxidative degradation metabolic process or the direct oxidation of glucose which consists...
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4956346 |
Pyrimidine derivatives as an antiviral agent
Compounds of the formula ##STR1## wherein A is C 1 -8 -alkylene, R 1 is halogen, C 1 -4 -alkyl or halo-(C 1 -4 -alkyl), R 2 is hydrogen, hydroxy or acyloxy, R 3 is hydrogen or C 1 -4 -alkyl, R 4...
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4954485 |
2',3'-dideoxy-4-thio-uridine derivatives, process for their preparation and antivirus agents using them
2',3'-Dideoxy-4-thio-uridine derivatives represented by a following general formula ##STR1## (wherein R indicates hydrogen or protecting groups such as acetyl group, benzoyl group, trityl groups,...
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4925831 |
Aminoalkyl naphthalenediols as host resistance enhancers against viral infection
Disclosed are specific aminoalkyl naphthalenediol derivatives that enhance natural human host resistance to viral infectious organisms and particularly AIDS-related viruses. Such agents are also...
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4916121 |
Antitumor composition comprising pyrimidine type nucleic acid derivative and 1-[(2-hydroxyethoxy)methyl]uracil derivative
An antitumor agent comprising (i) at least one pyrimidine type nucleic acid derivative having the general formula (I): ##STR1## wherein X represents a fluorine atom or a trifluoromethyl group, R 1 ...
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4894364 |
Method and materials for sensitizing neoplastic tissue to radiation
Tumors are sensitized to radiation by administration of 5-chlorodeoxycytidine (5-CldC) or 5-halo-2'-halo-2'-deoxy-cytidine or -uridine derivatives. Tetrahydrouridane (H 4 U) and/or...
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4882316 |
Pyrimidine derivatives
Compounds of the formula ##STR1## wherein R 1 is halogen, C 1 -4 -alkyl or halo-(C 1 -4 - alkyl), R 2 is hydrogen, hydroxy or acyloxy, R 3 and R 4 each are hydrogen or C 1 -4 -alkyl, R 5 is...
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4880782 |
Method of treating viral infections in humans and compositions therefor
A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: ##STR1## wherein X is an azido group, a methoxy radical or a...
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4879277 |
Antiviral compositions and methods
Compositions containing 2',3'-dideoxycytidine and its triphosphates for use in treating retroviral infections including acquired immune deficiency syndrome (AIDS) are disclosed with preferred...
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4874751 |
Antibacterial treatment
Treatment of susceptible gram-negative infections in animals is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the...
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4873228 |
2-oxo-4-carboxy-pyrimidines and their use as anti-malaria and anti-cancer agents
A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) ##STR1## where either (i) A and B together are S or (ii) A is --H, and B is --COR 2 or...
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4868161 |
Method for promoting nerve regeneration
A method for promoting regeneration of damaged nerve tissue, comprising administering, either alone or in combination, an effective amount of an antimitotic agent or a proton-withdrawing buffer to...
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4849412 |
Methods and compositions for treating viral infections
The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle...
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4789666 |
Cytidine-diphosphocholine salts, particularly suitable for oral use
New cytidine-diphosphocholine (CDP-choline) salts with long-alkyl chain sulphonic acids suitable for injectable pharmaceutical formulations, but more specifically for oral formulations. Said salts...
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4788181 |
5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity
5-substituted 2',3'-dideoxycytidine compounds and their monophosphates are disclosed which have been found to have potent activity against retroviruses. The 5-fluoro-and 5-aza-substituted...
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4780452 |
F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof
This invention discloses a group of compounds of formula (I) ##STR1## wherein R 1 is hydrogen, halo, C 1 -4 alkyl, C 1 -4 alkoxy, COOR 4 (R 4 is H or C 1 -4 alkyl) or trifluoromethyl; R 2 , R 5 ...
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4772594 |
Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
The invention relates to a novel prodrug compound useful in the treatment of tumors, of the formula: A--CO(CH 2 ) m (NHCO) n --R wherein A is a residue of an antitumor substance having...
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4764506 |
N.sup.6 -(benzothien-3-yl)ethyl adenosine; N.sup.6 -(benzothien-3-yl)ethyl adenosine, S-oxide; and N.sup.6 -(benzothien-3-yl)ethyl S,S-dioxide adenosine
Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl adenosine, S,S-dioxide compounds or pharmaceutically acceptable acid addition salts having highly desirable...
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4748158 |
Alkyl glycosides as potentiating agents in antiseptic, disinfecting and cleaning preparations to increase microbicidal activity
Alkyl glycosides are used to greatly increase the microbicidal activity of biguanide compounds, such as chlorhexidine salts. The alkyl glycoside/biguanide agents have a particular utility in teeth...
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4704357 |
Immortalized T-lymphocyte cell line for testing HTLV-III inactivation
This invention is an immortalized T-cell clone, designated ATH8, which is highly sensitive to the cytopathic effect of HTLV-III. The ATH8 T-cell clone is used in mass screening systems to rapidly...
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4689321 |
Oxo propenyl nucleosides and nucleoside related analogs
Certain 3-oxo-prop-1-enyl purine and pyrimidine derivatives and the corresponding nucleosides have been prepared. These compounds exhibit interesting and valuable cytotoxic activity. This...
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4684630 |
Method of parenterally delivering drugs and related compositions
A method of parenterally delivering aqueously unstable drugs that includes the aqueous dilution of a stable, anhydrous organic solution having the drug dissolved therein. The resulting...
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4666892 |
Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
The invention relates to 5-substituted-1-(2'-deoxy-2'-substituted-beta-D-Arabinofuran
oysyl) pyrimidine compounds and their use in a method for the treatment of hepatitis B viruses.
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4659698 |
Pharmaceutical compositions based on xylosides and lyxosides of purine and pyrimidine bases used in a method of treating viruses
Pharmaceutical compositions which contain a xyloside or a lyxoside of a purine or pyrimidine base selected from the following compounds: 1-(β-D-xylofuranosyl)-cytosine,...
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4654326 |
Inhibition of plant viruses with oligonucleotides
Viral diseases in plant parts, such as leaves are inhibited by applying to the plants an effective amount of an agent comprising 2', 5'-oligonucleotide, such as 2, 5-A, linked in 2',...
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4652554 |
Nitro-substituted 1-β-D-arabinofuranosylcytosines
1-(2-O-Nitro-β-D-arabinofuranosyl)cytosine and salts, anti-leukemics.
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4636508 |
5-pyrimidinecarboxyamides and treatment of leukemia therewith
Novel 5-pyrimidinecarboxamides useful for regressing or inhibiting the growth of leukemia and tumors. The compounds have the formula: ##STR1## wherein R 1 is hydrogen or an alkoxy group having...
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4604382 |
3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
This disclosure describes the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in...
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4594339 |
Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides
Veterinarian composition for the treatment of herpes virus in animals comprising a pyrimidine nucleoside, or veterinarianically acceptable acid addition salte thereof, of the formula ##STR1##...
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4578401 |
Mental complexes having an antineoplastic action, and medicaments containing these complexes
Metal complexes of the general formula I [R 1 (CH 2 ) m C(O)CR 3 C(O)R 2 ] 2 M(OR 4 ) 2 -n X n (I) wherein M denotes titanium, zirconium or hafnium, R 1 ...
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4542021 |
Antitumor compositions for non-injection administration
An antitumor composition comprising a pharmacologically effective quantity of an ester of 1-β-D-arabinofuranosylcytosine-5'-phosphate represented by the general formula ##STR1## where R is a...
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4468384 |
Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides
A method for inhibiting the replication of a DNA virus which induces formation of thymidine kinase enzyme, by exposing the virus to an effective concentration of a compound of the formula: ##STR1##...
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4395406 |
5-Halopyrimid-2-ones
Novel derivatives of pyrimid-2-one having interesting pharmacological properties are described. The compounds of the invention have been found to be of use in the control of, and in particular in...
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4386077 |
Pharmaceutical composition for oral administration containing cytidine diphosphocholine
A pharmaceutical composition suitable for oral administration containing cytidine diphosphocholine (CDP-choline) or a salt thereof in association with substances of the phospholipids group.
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